Isifo sikashukela sohlobo 2 sithinta imithambo yegazi futhi sibangela izinkinga ezinkulu ngendlela yezifo zenhliziyo, ezisezingeni eliphezulu kakhulu lazo zonke izifo ze-pathologies futhi ezivame ukubulala. Ngakho-ke, odokotela emhlabeni wonke banaka kakhulu izindlela zokuthibela zalezi zifo. Ukusetshenziswa kweMildronate ngohlobo 2 sikashukela kwenza sikwazi ukulwa nezinkinga zesifo esinamandla ngempumelelo enkulu.
Cabanga ukuthi iMildronate isebenza kanjani emzimbeni womuntu, nokuthi izuza ini ngesifo sikashukela sohlobo 2.
Izici
I-Mildronate (meldonium) yi-ejenti ye-metabolic esheshisa i-metabolism kumaseli ehlaselwa yindlala ye-oxygen ejwayelekile kanye nokuhlaselwa yi-ischemic.
IMeldonium yathuthukiswa esikhungweni se-Organic Synthesis seLatvia Academy of Sciences ngeminyaka yama-70s ngekhulu le-XX. Kuqala, wathola igunya lobunikazi njengomuthi olawula ukukhula kwezitshalo futhi uvuse ukukhula kwezilwane. Ngokuhamba kwesikhathi kwavela ukuthi ukhombisa izakhiwo ezinenhliziyo. Ngakho-ke umbono weza wamthola usetshenziswa emtholampilo.
I-Mildronate bese uthayipha isifo sikashukela esingu-2
Umphumela walokhu kusebenza kwe-metabolic ufundwe kumagundane. Izilwane ezinesifo sikashukela zithole uMildronate isikhathi esingaphezu kwamasonto amane. Ukuhlolwa kukhombise ngokusobala umphumela onamandla we-hypoglycemic kanye nokumiswa kokuthuthukiswa kwenhliziyo kanye nezinkinga zamasipha.
Ngemuva kwalokho, ucwaningo lwaqhubeka ekusebenzeni kwemitholampilo, okufakazele ukuthi i-Mildronate kushukela sikashukela kubantu yehlisa inani likashukela futhi ivimbele ukubonakala kwe-discirculatory encephalopathy, neuropathy, retinopathy (ukulimala kwe-retina) nezinye izifo. Kwaphawulwa futhi ukuthi ukusetshenziswa kweMildronate ngokuhlangana ne-metmorphine akugcinanga nje ngokunciphisa i-insulin ngemuva kokudla, kodwa futhi kwehlise nesisindo somzimba. Ngenxa yezifundo ezinje, odokotela bafika esiphethweni sokuthi kungakuhle ukuthi basebenzise i-meldonium yesifo sikashukela ukuze kunqandwe izinkinga, ngaphezu kwalokho, kubantu asebekhulile nasebasha.
Izinzuzo zeMildronate
- I-ejenti ye-metabolic iboniswa ekwelapheni i-ischemia, ngoba isiza ukugcwalisa izicubu zenhliziyo nomoya-mpilo.
Ngibonga uMildronate, umzimba ugcina ithoni yawo, ubekezelela imithwalo eqinile, futhi usiza ukuthuthukisa ukusebenza kobuchopho, ukhuphula umthamo wokusebenza, okuthi ukwehluleka kwabantu abaphethwe ukukhathala okungapheli kwisifo sikashukela.- Into esebenzayo yesidakamizwa iyakwazi ukufaka imithambo yegazi, okusho ukuthuthukisa ukuhamba kwegazi kuzo zonke izicubu nezitho zomzimba.
- Inika amandla umzimba womuntu ukuba ululame ngokushesha ngemuva kokuhlaselwa yisifo senhliziyo, njengoba wehlisa ukukhula kwezwe le-necrotic.
- Lapho i-angina pectoris isiza izicubu zenhliziyo ukuba zithole inkontileka, iyenza imelane nemithwalo ekhuphukayo, ngenxa yalokho inani lokuhlaselwa liyancipha.
- Inempahla yokubuyisela ukujikeleza kwegazi kohlelo lokubonakalayo olunokuphazamiseka kwe-dystrophic we-fundus.
- Lesi sidakamizwa siphatha ngempumelelo i-pathologies esebenzayo yesistimu yezinzwa ephakathi notshwala.
Ngibonga uMildronate, umzimba ugcina ithoni yawo, ubekezelela imithwalo eqinile, futhi usiza ukuthuthukisa ukusebenza kobuchopho, ukhuphula umthamo wokusebenza, okuthi ukwehluleka kwabantu abaphethwe ukukhathala okungapheli kwisifo sikashukela.
Ithuluzi litholakala ngezindlela ezimbili - isisombululo somjovo we-intravenous kanye namaphilisi (10, 40 noma 60 izingcezu).
Kudingeka nini ukuqokwa kweMildronate
- Ukwelashwa kwe-myocardial infarction, ukuhluleka kwenhliziyo okungamahlalakhona, ingozi yengozi yokuwohloka kwengqondo, i-angina pectoris.
- Ukwandisa ukumelana komzimba kokukhula komzimba okwandayo.
- Lapho ukhathele ngenxa yokusebenza ngokweqile kobuchopho.
- Ukuze kube ngokwejwayelekile ukuhamba kwegazi emzimbeni onesifo sikashukela, i-osteochondrosis, i-hypertension ye-arterial, njll.
- Ngokukhathala okungapheli.
- Okwelashwa ukuhoxiswa kotshwala.
- Esigabeni se-postoperative sokuvuselelwa kwezicubu ngokushesha.
- Nge-pathology ye-retina, engaba khona kushukela.
- Ukuphambuka ohlelweni lwezinhliziyo ekukhuleni kobusha.
- I-Myocardial pathologies eyakheka ngenxa yokwehluleka kwe-hormonal kokuya esikhathini kubantu besifazane.
Yikuphi ukuphambana okukhona nokuthi ungathatha kanjani
Contraindication:
- Ingcindezi ephezulu yangaphakathi.
- Izimpawu zobuchopho zeBenign noma ezilimazayo.
- Ukungezwani komzimba kwizakhi zomenzeli we-metabolic.
- Isimo sePathological ekuhambeni kwegazi kwengqondo.
- Ukuqubuka kwesikhumba komzimba
- Isicanucanu, Ubuhlungu besisu.
- I-Angioneurotic edema.
- Izimpawu zenhliziyo.
- Ukunyuka komfutho wegazi kubantu asebekhulile.
Umphumela omubi nge-overdose
Kufanele kukhunjulwe ukuthi izifundo ngemiphumela yento esetshenziswayo ye-ejenti ye-metabolic kwabesifazane abakhulelwe nezingane ezincane ayizange iqhutshwe.
Ukhuphula umthamo osebenzayo futhi ulondoloze inhliziyo nenhliziyo eyi-vascular ngohlobo 2 sikashukela, iMildronate inqunywa odokotela njengezifundo. Kuyadingeka ukuthatha lo muthi kuphela njengoba kuchazwe uchwepheshe ozozikhethela uqobo irejimidi yokwelashwa efanelekayo, nomthamo ofanele futhi odingekile womuthi wakho, ngezikhathi ezithile phakathi kwezifundo.
Ukuzilawula kusongela ukusebenzisa umthamo obaliwe ngokungalungile, futhi ngenxa yalokho ingozi yokuthola ukungezwani komzimba.
