I-Bagomet - umuthi wehlisa ushukela wegazi. Imiyalo yokusebenzisa

I-Bagomet umuthi onamakhono we-hypoglycemic, asetshenziselwa ukunxephezela ukungalingani kwe-insulin-technology (mMititus (DM)), uma ukwelashwa kwe-sulfonylurea kungasebenzi ngokwanele.

Izici ze-Pharmacological zeBagomet

I-Bagomet umuthi we-hypoglycemic wehlisela phansi ushukela wokuzila nokusebenza kwawo ngemuva kokudla. Umuthi awuthinti ukwakheka kwe-insulin. Phakathi kwemiphumela emibi yamacala we-hypoglycemia ayilungisiwe. Amathuba okwelapha avela ngemuva kokuvinjelwa kwe-glycogenolysis ne-gluconeogeneis, okuvusa isithiyo se-glycogen esibindini.

IBagomet ithuthukisa ukusebenza kahle kwe-enzyme esheshisa ukwakheka kwe-glycogen, ikhuphule amandla okuhamba we-membrane glucose transporter. Isidakamizwa sithuthukisa i-lipid metabolism - ngesifo sikashukela sohlobo 2 sinamathuba wokunciphisa umzimba.

IBagomet iqhathaniswa kahle nabalingani bayo ngokuya nge-digestibility esheshayo futhi ngokuphelele.

Uma ungenile, umuthi udonswa masinyane emgodini wokugaya ukudla, ukugxilisa okuphezulu kufinyelelwa kungakapheli amahora amabili nesigamu. Ibamba phansi amathuba okudla izidakamizwa okufana nalokhu. Izinkomba ze-bioavailability ka-Bagomet zingafika ku-60% wevolumu yomuthi wonke olethwe ezithweni.

Ngokwemiphumela yocwaningo lwe-pharmacokinetic, singaphetha ngokuthi umuthi ugxwala ngokushesha kwizicubu, uwenze nge-plasma. Izakhi zomuthi azibophele amaprotheni, zingangena kumaseli abomvu egazini, kepha egazini zincipha kakhulu uma ziqhathaniswa ne-plasma.

Lezi zivivinyo zikuqinisekisile ukuthi umuthi osemzimbeni awuthelwanga umzimba - izinso ziyawukhipha njengasekuqaleni. Kulokhu, isigamu sempilo singamahora ayisithupha nesigamu. Ukuphuma kweBagomet kuthukutheliswa ukucwaswa okusebenzayo kwe-glomerular kanye ne-renal tubule excretion, ngakho-ke, zonke iziguli ezine-renal pathologies zisengozini.

Isigamu sempilo siyakhuphuka, okusho ukuthi kunobungozi bokuqongelwa kwezidakamizwa.

Izinkomba nendlela yokusebenzisa

IBagomet ihloselwe ukwelashwa kwabanesifo sikashukela ngohlobo oluzimele lwesifo kanye nokukhuluphala (lapho kungekho ketoacidosis kanye nokuphendula okunganele ekwelapheni nge-sulfonylureas).

Umuthi wenzelwe ukusetshenziswa kwangaphakathi. Swall ithebhulethi yonke ngamanzi. Lokhu kuvame ukwenzeka ngokudla noma ngokushesha emva kwawo. Umthamo wokuqala ngu-500-100 mg / ngosuku, kuye ngezinga le-glycemia. Ungaguqula umthamo kuphela ngemuva kwamasonto amabili wokudla njalo nokubheka izinkomba ze-glycemic.

Uma udokotela engazange enze isinqumo ngamanye maqondana nesiguli, khona-ke isilinganiso sokwelashwa esisezingeni elifanele sinqunywe kusuka ku-1500 kuye ku-2000 mg. Akunakwenzeka ukwedlula isilinganiso esiphezulu. Uma umuthi uvusa ukuphazamiseka kwesitulo, ungaphula into ejwayelekile nsuku zonke izikhathi ezingama-2-3.

Ngokwelashwa okuyinkimbinkimbi "iBalomet kanye ne-insulin amalungiselelo", umthamo ojwayelekile ngu-1500 mg / ngosuku. Kumathebhulethi anamakhono okuhlala isikhathi eside, umthamo ophelele nsuku zonke ngu-850 mg -1000 mg. Ngokubekezelela okujwayelekile, bayama ngezinga lokugcina lika-1700 mg / ngosuku, nomkhawulo - 2550 mg / ngosuku. Ekwelashweni okuyinkimbinkimbi nezinye izidakamizwa ezinciphisa ushukela, kunikezwa ithebhulethi eyodwa (850 mg noma 100 mg).

Ebusheni obukhulu, iBagomet ayithathi ngaphezu kwe-1000 mg / usuku. Ungabhalela umuthi wezingane ezingaphezu kweminyaka eyi-10. Izingane, kanye nabantu abadala, badinga ukuqala inkambo yokwelashwa nge-500-850 mg / ngosuku. Ebuntwaneni, umthamo omkhulu wansuku zonke ngu-2000 mg.

Imiphumela emibi

Ngokuvamile, umuthi ubekezelelwa kahle yiziguli eziningi, kepha, njenganoma yimuphi umuthi, kungahle kube nemiphumela emibi.

Ukuqashelwa kwasekuqaleni kukhombisile ukuthi iBagomet ayikukhuthazi ukungabi namuntu kwemizwa, ukudalwa kwamalungu omzimba nokuqina komhlaba. Umphumela wayo wokungathathi hlangothi emsebenzini wokuzala ufakazelwe.

Contraindication

Akunconywa ukuthatha iBagomet ngezifo ezilandelayo:

• I-ketoacidosis yesifo sikashukela, ukukhohlisa kwesifo sikashukela nezimo zokhokho;
• Izinkinga zokuphefumula;
• I-inhliziyo yenhliziyo, ikakhulukazi ekuhlaselweni yisifo senhliziyo;
• Ukuphazamiseka kwegazi kwe-cerebral;
• I-Lactic acidosis;
• Ukusetshenziswa kabi kotshwala, ukomisa;
• Ukungasebenzi kahle
• Ukusongela okukhulu kwezithako zefomula yeBagomet;
• Ukusebenza okudinga ukushintshwa kwamathebule ngomjovo we-insulin;
• Ukwehluleka kwesibindi;
• Ukukhulelwa nokuncelisa ibele;
• I-X-ray isebenzisa iodine njengomehluko (umkhawulo - okwezinsuku ezi-2 ngaphambi nangemva kokuhlolwa);
• Ukudla kwe-Hypogalogy;
• Ukuvuthwa (emva kweminyaka engama-60) yobudala, ikakhulukazi ngemithwalo esindayo yemisipha evusa i-lactic acidosis;
• Izingane (kuze kube iminyaka eyi-10 ubudala) ubudala.

Izincomo zokukhulelwa

Ukuhlolwa kwemitholampilo akuqinisekisanga izakhiwo ze-mutagenic ne-teratogenic ze-Bagomet, kepha azinqunyelwe abesifazane abakhulelwe. Umuthi ungangena ubisi lwebele, uma kungenye indlela ye-Bagomet, ingane kufanele idluliselwe ekunikezeni ukudla okwenziwe ngamakhanda.

Imiphumela Yokusebenzelana Kwezidakamizwa

Amandla weBagomet we-hypoglycemic athuthukiswa ngama-sulfonamides, i-insulin, i-acarbose, izidakamizwa ezingezona ze-steroidal anti-inflammatory, ACE ne-MAO inhibitors, oxytetracycline, β-blockers.

I-Glucocorticosteroids, i-GOK, i-epinephrine, i-glucagon, izidakamizwa ze-thyroid ye-hormonal, ama-sympathomimetics, i-thiazide ne-"loop" diuretics, i-phenothiazine ne-nicotinic acid exivatives zivimbela umsebenzi wayo.

Ukususwa kweBagomet kwizitho zomzimba kuvinjelwa yi-cimetidine. Amandla we-anticoagulant we-Coumarin derivatives inhibits Bagomet.

Ukusetshenziswa kotshwala ngesikhathi esifanayo kuphakamisa i-lactic acidosis. Ukubonakaliswa kwayo ukwehla kwezinga lokushisa lomzimba, i-myalgia, ukungahambi kahle emathunjini asesiswini, ukuphazamiseka kwesisu, ukuphefumula komoya, ukuphazamiseka kwesitulo, ukufoka. Ekusololweni okokuqala kwesisulu, bangeniswa esibhedlela kanti ukuxilongwa kwabo kucaciswa ngokubheka ukugcwala kwama-lactate ezithweni nasezithanjeni.

Izimpawu ze-overdose

Uma imithamo yeBagomet ingaphezulu kwesilinganiso esivumelekile esiphezulu, i-lactic acidosis enemiphumela emibi kakhulu ngohlobo lokukhohlakala ngisho nokufa kungenzeka. Imiphumela efanayo ibangelwa ukugcwala okuwedlula konke komuthi emzimbeni onezinkinga ngokuphuma kwawo yizinso. Inkinga iba khona emahoreni ambalwa futhi ihambisana nezimpawu zobuntu:

• Ukuphazamiseka kwe-dyspeptic;
• I-Hypothermia;
• Ukwephulwa kwesigqi sokunyakaza kwamathumbu;
• Ubuhlungu esiswini;
• I-Myalgia;
• Ukulahleka kokuxhumana;
• Ukwehla kwesibindi kanye nesifo sikashukela.

Uma okungenani ezinye zezimpawu ezisohlwini zivele, iBagomet kufanele ikhanselwe ngokushesha, futhi ohlukunyeziwe kufanele alaliswe esibhedlela.

Ukukhishwa ifomu, ukwakheka, izimo zokugcina

Amathebulethi angaba nobumba nemibala ehlukene, kuye ngomthamo: omhlophe, uyindilinga futhi u-convex - 500 mg lilinye, ngesimo samakhompiyutha - ama-850 mg aluhlaza okwesibhakabhaka ngombala no-1000 mg ngombala omhlophe. Lezi zamuva zinezindawo ezinde. Isici sefomu lokukhishwa umugqa wokuhlukanisa kanye ne-logo yomkhiqizi, efakwe kuwo wonke amaphilisi.

Ithebhulethi elilodwa liqukethe kusuka ku-500 kuye ku-100 mg wesithako esisebenzayo se-metformin hydrochloride plus excipients ngesimo se-croscarmellose sodium, i-povidone, i-stearic acid, isitashi sommbila, i-lactose monohydrate.

Ikhithi losizo lokuqala olunemithi kufanele lubekwe endaweni engafinyeleleki ezinganeni, emazingeni okushisa afinyelela ku-25 ° C. Gcina iBagomet ingadluli iminyaka emibili.

Izithonjana nezifanekiswane zomuthi

Ukuqondanisa kweBagomet kufaka phakathi izidakamizwa lapho khona iqembu (izidakamizwa zomlomo we-antidiabetic) nezakhi ezisebenzayo (metformin) ziyahlangana.

1. Methamine;
2. I-NovoFormin;
3. IFommetin;
4. IFomu.

Ama-analog weBagomet yimithi okungenani isifo noma isimo esisodwa esifana ngaso ebufakazini, kulokhu uhlobo 2 sikashukela.

1. Avandia
2. I-Apidra
3. I-Baeta;
4. UGlemaz;
5. UGlidiab;
6. Glucobay;
7. IGlurenorm;
8. I-Lymphomyozot;
9. Levemir Penfill;
10. Levemir Flekspen;
11. I-Multisorb;
12. Methamine;
13. I-NovoFormin;
14. I-Piroglar;
15. IFommetin;
16. IFomu.

Ngokulashwa okuyinkimbinkimbi neminye imithi yomphumela ofanayo, kubalulekile ukucabanga ngamathuba we-hypoglycemia. Umuthi uyakwazi ukuphazamisa ukusebenzisana futhi unciphise ukusabela kwe-psychomotor, ngakho-ke lapho usebenza ngezindlela ezinembile noma ngenkathi ushayela, kungcono ukwenqaba ukuthatha lo muthi. Ukusetshenziswa kweBagomet kudinga ukunamathela okuphoqelekile ekudleni okune-carb ephansi olawula ukungena kwama-carbohydrate egazini.

Ukubuyekezwa mayelana neBagomet

Mayelana ne-Bagomet yezidakamizwa, ukubuyekezwa kodokotela kakhulu okuhle. Ngokusho kochwepheshe, ukuthatha isidakamizwa esidumile kunikeza ukulawulwa okuzinzile kwe-glycemic kashukela wegazi amahora ayi-12. Amathuba anjalo amqinisekisa izinzuzo ezithile: unganciphisa imvamisa yokuphuza umuthi, uthuthukise ukuqapha kwezinqubo ze-metabolic. Ngasikhathi sinye, ukumunyaniswa kwento esebenzayo evela endaweni yokugaya ukudla kuyathuthukiswa futhi nengozi yokuthuthukisa imiphumela emibi incishisiwe.

Ukuchazwa kwomuthi ngeke kusetshenziswe njengesiqondiso sokusetshenziswa. Ngaphambi kokuthenga, kufanele uthintane nodokotela we-endocrinologist, futhi ngaphambi kokuthatha umuthi iBagomet, funda imiyalo yokusebenzisa kumenzi. Imininingwane mayelana neBagomet ihlinzekelwe ukujwayelwa jikelele ngamakhono ayo futhi akusona isiqondisi sokuzilapha. Uhlobo oluqondile lokwelashwa, kucatshangelwa ubunzima besifo sikashukela, izifo ezifanayo kanye nesimo sempilo jikelele sesifo sikashukela, singakhiwa kuphela uchwepheshe.