I-Fraxiparin iyisidakamizwa esisebenzayo esine-spectrum eqondile yokwenza, esekwe ku-nadroparin.
Ochwepheshe banquma lo muthi ezigulini zabo njenge-prophylaxis noma ukwelashwa okuyinkimbinkimbi kwe-thrombotic pathologies kubantu abathambekele ekuqhekekeni kwegazi.
Umuthi uhloselwe ukuphatha ngokungashintshi (ezimweni ezingavamile, ngaphakathi emzimbeni). Njengamanje, i-thromboembolism ithathwa njengesinye sezifo eziyingozi kakhulu kubantu. Ukuqhekeka komkhumbi kungadala ukuqala kokuhlasela kwenhliziyo noma i-ischemia ngokushesha, okuvame ukuholela ekukhubazekeni noma ekufeni.
Naphezu kweqiniso lokuthi osokhemisi sebesungule imishanguzo eminingi yesimanje yokuqeda lesi sifo, i-Fraxiparin ithathwa njengesebenzayo kakhulu, ngezimpawu zemithi ongathola kuzo imiyalo.
Izinkomba zokusetshenziswa
Imvamisa, i-Fraxiparin ibekelwa lezo ziguli ezitholwe zinezinkinga ezilandelayo zempilo:
- uhlobo olungazinzile lwe-angina pectoris;
- i-thromboembolism yanoma iliphi ibanga (ukuqhuma okukhulu kwemithambo yegazi ebalulekile nge-thrombus);
- infarction myocardial ngaphandle kwenhlobo yohlobo Q (ukuvimbela kanye nokwelashwa kokuhlaselwa okulandelayo);
- ukungenelela kwamathambo nokuhlinzwa okwenziwa ezigulini ezinokuphefumula noma ukuhluleka kwenhliziyo (ukuvimbela ukubuyela emuva kwe-thromboembolic);
- ukuvimbela ukungasebenzi kwegazi okwenzekile ezigulini ezidinga i-hemodialysis ngezikhathi ezithile.
Imithamo nokuphatha
Abakhiqizi bomuthi i-Fraxiparin bakhombisa ukuthi umuthi ulawulwa ngaphandle kwesisu esiswini kuphela endaweni ephakeme. Kwezinye izimo, ukwethulwa kwezidakamizwa esifundeni sowesifazane kuvunyelwe.
Ukuze ugweme ukulahleka komuthi, ungazami ukukhipha ama-bubble omoya akhona kwisirinji ngaphambi komjovo. Inaliti kufanele ifakwe kuphela perpendicularly esibayeni esincane sesikhumba, okumele sakhiwe ngokucophelela ngeminwe emithathu yesandla samahhala. Indawo yomjovo akufanele ihlikiwe futhi ihlazwe.
Imijovo Fraxiparin 0,3 ml
Ukuze uvimbele ukukhula kwe-thromboembolism embonini yokuhlinza, umthamo ojwayelekile wesidakamizwa ngu-0,3 ml. Kuqala, umuthi uhanjiswa esigulini amahora ama-4 ngaphambi kokuhlinzwa, bese kuthi kanye ngosuku.
Ukwelapha okusebenzayo kufanele kuhlale okungenani isonto, imvamisa isiguli sibekelwa imijovo ye-Fraxiparin kuze kube yilapho isiguli sidluliselwa ekwelashweni okungaphandle kwaso. Ukuze uvuseleleke kahle isiguli ngemuva kokuhlaselwa yisifo senhliziyo noma esimweni se-angina esingazinzile, u-0.6 ml wesidakamizwa uphathwa ngokunqunyelwe izikhathi ezi-2 ngosuku.
Ukwelashwa kufanele kuhlale okungenani isonto. Kulokhu, umjovo wokuqala ulawulwa ngaphakathi, futhi bonke abalandelayo - ngokuzithoba. Imithamo incike ezinkombeni zomuntu ngamunye zesiguli. Ngesikhathi sokukhwabanisa kwamathambo, i-Fraxiparin iphathwa ngendlela ethile ngevolumu encike kwisisindo sesiguli (50 kg - 0.5 ml, 70 kg - 0.6 ml, 80 kg - 0.7 ml, 100 kg - 0.8 ml, ngaphezu kwe-100 kg - 0.9 ml).
Umjovo wokuqala wenziwa emahoreni ayi-12 ngaphambi kokuhlinzwa, bese okulandelayo ngemuva kwenkathi efanayo yesikhathi ngemuva kokuhlinzwa. Ukwelashwa okuqhubekayo, isiguli kufanele sisebenzise i-Fraxiparin kanye ngosuku. Isikhathi sokwelashwa okungenani izinsuku eziyi-10.
Imiphumela emibi
Iningi leziguli libekezelela imijovo ejwayelekile ye-Fraxiparin kahle, kepha ezimweni ezingandile, ukubonakaliswa kokuphendula okubuhlungu komzimba kungenzeka:
- ukopha okungazelelwe;
- ubomvu, ukwakheka kwamaqhubu amancane, ama-hematomas, kanye nokulunywa endaweni yomjovo;
- ukwethuka kwe-anaphylactic;
- i-thrombocytopenia (kufaka phakathi i-immune);
- venous thrombosis;
- i-eosinophilia;
- ukubonakaliswa kokungaphenduki komzimba;
- i-priapism;
- hyperkalemia
Kulokhu, isiguli sidinga ukuxhumana nodokotela ngokuphuthumayo, ukuze singezise isithombe sasemtholampilo sisonke.
Imiyalo ekhethekile
Naphezu kweqiniso lokuthi izifundo eziningi zesayensi azivezwanga umphumela we-teratogenic, kungcono ukwenqaba ukuthatha i-Fraxiparin ku-trimester yokuqala yokukhulelwa.
Ngesikhathi se-trimester yesibili neyesithathu, umuthi ungasetjenziswa ngokukhethekile ngokuya ngeziphakamiso zikadokotela ozokuvikela ukwakheka kwe-thrombosis.
Inkambo ephelele yokwelapha kuleli cala ayenqatshelwe ngokuphelele. Uma isimo sifaka ukusetshenziswa kwe-anesthesia ye-epidural, isiguli kufanele senqabe ukwelashwa nge-heparin okungenani amahora ayi-12 ngaphambi kokuqala kwezinqubo zokwelashwa.
Osokhemisi bathi zonke izingxenye zalo muthi ziphephile ngokuphelele kubantu besifazane abake bangenelwa i-IVF. Ngenxa yokuthi namuhla kunenombolo enkulu yama-analogues, i-Fraxiparin ibekelwe iziguli kuphela uma kunobungozi bokuthuthukisa i-pathologies ye-obstetric.
Isibonelo, uma owesifazane ekhushulelwe ukuqina kwegazi.
Uma ukuphazamiseka kwangaphambi kwezitho zangaphakathi, kutholakala ukuthi isifo samandla esiseduze noma isilonda sesisu, isiguli kumele sazise udokotela ngalokhu.
Ngempela, kuleli cala, kuyadingeka ukuthatha i-Fraxiparin ngokucophelela okukhulu, ngoba ukufa kwe-intrauterine kwesibeletho nokuphuphuma kwesisu kungenzeka. Ngokwehlukana, kubalulekile ukuqaphela ukuthi abanye besifazane bangabekwa ukuthi basebenzise umuthi kuyo yonke le nkathi yokukhulelwa njenge-prophylaxis ethembekile, lapho kuye kwatholakala ukuthi kukhona ukwephulwa okukhulu ekujikelezweni kwe-placenta.
Kepha, uma kungekho njalo uma kufanele wenze izinqumo ezinjalo ngokwakho, ngaso sonke isikhathi udinga ukubonisana nochwepheshe. Umuthi ungabekwa kuphela ngemuva kokuba kwenziwa konke ukuhlolwa okudingekayo kokuqina kwegazi nokuqina kwegazi.
Ngaphezu kwalokho, i-Fraxiparin isiza ukuvimbela izinguquko eziningi ezimbi ze-pathological:
- ukufa kwe-intrauterine kwengane;
- ukuqothuka kokukhulelwa;
- ukukhula kwe-intrauterine ukukhula kwengane;
- ukuthathwa kokuqala kwe-placenta;
- preeclampia;
- ukukhubazeka kwe-bok-placental.
I-Fraxiparin ingaphazamisa ukukhiqizwa kwe-aldosterone, okuthi ngenxa yalokho kuholele ekwakhiweni kwe-hyperkalemia ethize.
Lokhu kuyiqiniso ikakhulukazi kulezi ziguli ezinamazinga e-potassium egazi, noma i-metabolic acidosis noma ukwehluleka kwesibindi okungapheli kutholakele. Lezi ziguli zidinga ukubhekwa ngokucophelela ngochwepheshe.
Contraindication
Umuthi wenqatshelwe ngokuphelele kulezi ziguli ezitholakale zinalezi zifo ezilandelayo:
- ukungabekezeleli i-calcium nadroparin;
- ukulimala ekhanda;
- ukwehluleka kakhulu kwe-renal noma kwesibindi;
- ingozi eyengeziwe yokopha;
- ukuhlinzwa ebuchosheni;
- i-endocarditis;
- imvamisa ye-intracranial hemorrhage;
- ukuhlinzwa kwamehlo kwangaphambilini;
- uhlobo lomonakalo womzimba wezitho zangaphakathi (ngokwesibonelo: ulcerative colitis).
Ngokuqapha ngokweqile, ungasebenzisa umuthi lapho kukhona ama-pathologies alandelayo:
- i-dystrophy (iziguli ezinesisindo esingaphansi kwama-40 kg);
- uhlobo olunamandla lomfutho wegazi ophakeme;
- ifomu lesilonda se-peptic;
- ukusetshenziswa kanye kanye kwezidakamizwa okwandisa amathuba wokopha;
- ukwephulwa kokujikeleza kwegazi okungokwemvelo kwi-retina noma i-choroid.
Izimo zokugcina
Kuyadingeka ukugcina umuthi endaweni ehlukaniswe nezingane, emazingeni okushisa aphakathi kuka + 18 ° C kuya ku + 30 ° C. Ukuchayeka okungamukeleki kwabafudumeza nokukhanya kwelanga ngqo. Impilo yeshelf iyiminyaka emithathu. Kutholakala emakhemisi kuphela ngencwadi kadokotela.
Izindleko
Vele, zonke iziguli zikhathazekile ngecebo lezezimali, ngoba ukwelashwa okunjalo akukwazi ukushibhile.
Izindleko ezijwayelekile zeFraxiparin ziyahlukahluka kusuka kuma-ruble angama-300 ngesirinji esisodwa kuze kufike kuma-ruble angama-3000 wephakheji yonke, equkethe imijovo eyi-10.
Kepha abantu asebethole ukugula okubuhlungu bayazi ukuthi impilo yinto ebaluleke kakhulu. Ngaphezu kwalokho, ezimweni eziningi, iziguli zinemijovo eyanele ye-5-10.
Ama-Analog
Izimakethe zemithi yasekhaya neyangaphandle zinikeza anhlobonhlobo ephezulu yeFraxiparin. Zonke zingamalungu eqembu elilodwa lezidakamizwa, futhi futhi zinendlela yokusebenza efanayo ezinhlelweni zomzimba.
Izidakamizwa ezilandelayo zithathwa njengezithandwa kakhulu:
- Clexane;
- I-Arikstra;
- Ayinangqondo;
- Heparin sodium;
- I-Zibor 3500;
- I-Anfiberi;
- I-Sinkumar;
- EWarfarin;
- Ifulegi;
- IHeparin.
Ukubuyekezwa
Emsebenzini wezokwelapha naku-Inthanethi, ungathola izibuyekezo eziningi mayelana nomuthi i-Fraxiparin, iningi lazo elakhayo, kepha kunemibono engemihle.Iziguli eziningi zikhathazekile ukuthi i-hematomas ebuhlungu ifomu ngemuva kwemijovo.
Kodwa empeleni, imiphumela enjalo ihambisana nokusetshenziswa okungafanele kwemijovo.
Kulokhu, udinga ukuxhumana nochwepheshe umbuze ukuthi angachaza kabanzi inqubo yokujova. Njengoba usufunde ukusebenzisa umuthi ngendlela efanele, awusoze wahlangabezana nokusabela okunjalo okuphambene. Ngokuvamile, zonke iziguli ziyaneliswa ngomphumela wenkambo yokwelapha.
Amavidiyo ahlobene
I-Obstetrician-gynecologist ngendima ye-thrombophilia kanye nokuphazamiseka kwezifo zomzimba ekuphuthweni kwesisu:
Ekuphetheni, singaphetha ngokuthi i-Fraxiparin isidakamizwa sanamuhla esisebenzayo esisetshenziselwe umuthi isikhathi eside. Kubonakala ngokusebenza kahle, isibuko esikhulu sezenzo nokubuyekezwa okuningi okuhle.
Ngenxa yalokhu, iziguli eziningi zikwazile ukubuyisa umsebenzi wesitho somzimba wonke, zenza impilo yazo ibuye futhi zibuyele endleleni yazo yangaphambili.
