I-MANINIL: AMA-ANALOGUES AMARUSSIA NAWAKWAMANYE AMAZWE, INTENGO, IRESIPHI YESILATINI

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I-Maninil umuthi onomphumela we-hypoglycemic effect, okuhloswe ngawo ukuphathwa ngomlomo uma ugula unesifo sikashukela esinga-insulin (uhlobo 2).

Ingummeleli wesizukulwane sesibili sulfonylurea (PSM).

Njengezinye izidakamizwa eziningi ze-hypoglycemic, iManinil ine-analogues eRussia nakwamanye amazwe - ishibhile futhi ibiza kakhulu ngokulandelana.

Isici

Ukwenza njengomlawuli we-glucose metabolism, iManin, lapho igxotshwa, inyusa ukuzwela kwama-insulin-receptors, ivuselela ukukhishwa kwe-insulin endulin ngamanyikwe.

Ngaphezu kwalokho, icindezela i-hepatic gluconeogenesis ne-glycogenolysis, ivimbela i-lipolosis ye-glucose, futhi inciphise i-thrombogenicity yegazi. Isikhathi somphumela we-hypoglycemic okhiqizwe umuthi amahora ama-2 ngemuva kokuphatha cishe amahora ayi-12.

Ithebhulethi Glibenclamide Maninyl 3.5 mg

Ingxenye esebenzayo yokwehlisa ushukela weManinil - glibenclamide, eyethulwa ngesimo esibonakalayo, inomphumela obuthambile womzimba, njengoba igxilwa ngokushesha esiswini ngo-48-84%. Ngemuva kokuthatha umuthi, ukukhishwa okugcwele kwe-glibenclamide kwenzeka ngaphakathi kwemizuzu engu-5. Isithako esisebenzayo sephule ngokuphelele esibindini futhi sikhishwe yizinso ne-bile.

Umuthi ukhiqizwa ngefomu lethebhulethi ngokuhlangana okuhlukile kwento esebenzayo ye-1 ithebhulethi:

1,75 mg;
3.5 mg;
5 mg

Amacwecwe abushelelezi-cylindrical ngesimo, abe ne-chamfer nophawu olusetshenzisiwe kokunye okuphezulu, umbala upinki.

Umenzi walo muthi yiFC Berlin-Chemie, emakhemisi ithengiswa kuphela ngomuthi. Umuthi ufakwa emabhodleleni engilazi ecacile, ama-pc ayi-120 lilinye. Ngayinye, amabhodlela uqobo ngokwawo agcwele ebhokisini lekhadibhodi. Iresiphi yesiLatin yeManinil imi ngalendlela elandelayo: Maninil.

Ngokusho kocwaningo, ukunamathela kumthamo owanele lapho uphuza umuthi ngokuthile kunciphisa amathuba okuba nesifo senhliziyo nezinye izinkinga ezibangelwa yisifo sikashukela esingaxhamli ne-insulin, kubandakanya nokufa okuhambisana nalesi sifo.

Izinkomba zokusetshenziswa

UManilin ukhonjiswa ngokutholwa kwefomu elizimele le-insulin ye-mellitus (yohlobo lwesibili). Ingabekwa njengethamo elizimele noma lihlanganiswe neminye imithi ye-hypoglycemic. Okuhlukile ukuphathwa okuhlangene ngama-glinides kanye nokutholakala kwe-sulfonylurea.

Izici zomthamo nokuphatha

Ukufakwa kweManinil kunconyelwa ngaphambi kokudla, kugezwe bese kuhlafunwe.

Umthamo wansuku zonke unqunywa yi-endocrinologist ngokubheka ngakunye:

uma ingeqi amaphilisi ama-2 ngosuku, khona-ke umuthi kufanele uphuzwe kanye, mhlawumbe ekuseni - ngaphambi kokudla kwasekuseni;
lapho unquma umthamo ophakeme, ukusetshenziswa komuthi kwenziwa emithanjeni emi-2 - ekuseni - ngaphambi kokudla kwasekuseni nakusihlwa - ngaphambi kokudla kwakusihlwa.

Izici ezinqumayo zokukhetha uhlobo lonyango ukwelashwa yinombolo yeminyaka, ubukhulu besifo, kanye nokuxhuma kweglucose egazini esiswini esingenalutho nangemva kokudla ngemuva kwamahora ama-2.

Uma kwenzeka ukusebenza okuncane komthamo kadokotela obekiwe, isinqumo singenziwa ukuze sikhuphuke. Inqubo yokwandisa umthamo ukuya ezingeni elifanele yenziwa kancane kancane - kusuka ezinsukwini ezi-2 kuye kwezingu-7, ngaso sonke isikhathi ngaphansi kokuqokwa ngudokotela.

Esimweni sokushintshela eManinil kusuka kwamanye amalungiselelo okwelashwa ngethonya le-hypoglycemic, ukuphathwa kwaso kunqunywe kumthamo wokuqala ojwayelekile, uma kunesidingo, uyanda, wenziwa kahle futhi kuphela ngaphansi kokuqashwa kwezokwelapha.

Umthamo Ojwayelekile Wokuqala weManinil:

equkethe i-1.75 mg yesithako esisebenzayo - amaphilisi angu-1-2 kanye ngosuku. Umthamo omkhulu awudluli amaphilisi ayi-6 ngosuku;
equkethe i-3.5 mg yento esebenzayo - Ithebhulethi engu-1 / 2-1 kanye ngosuku. Isilinganiso esiphezulu ngamathebhulethi ama-3 ngosuku;
equkethe i-5 mg yesithako esisebenzayo - Ithebhulethi engu-½-1 1 isikhathi ngosuku. Umthamo omkhulu ovunyelwe usuku lonke ngamathebulethi ama-3.

Abadala (ngaphezulu kweminyaka engama-70 ubudala), labo abanamathela emikhawulweni yokudla, kanye nalabo abahlushwa ukuqina kwezinso noma i-dysfunction yesibindi, kunconywa ukusebenzisa imithamo yomuthi encishisiwe ngenxa yokusongela i-hypoglycemia.

Uma uphuthelwa umthamo owodwa, umthamo olandelayo weManinil wenziwa ngethamo elijwayelekile (akukho ukwanda) ngesikhathi esijwayelekile.

Imiphumela emibi

Ukuvela kokuphazamiseka ekusebenzeni kwezinhlelo ezithile ngenkathi kuthathwa iManinil kubonakala kakhulu. Ukubonakaliswa kwabo okungejwayelekile kuyenzeka:

kusuka emgodini wesisu - ngesimo se-nausea, i-belching, umuzwa wesisindo esiswini, ukubonakala nokunambitheka kwensimbi emlonyeni, ukuhuda;
kusuka esibindini - ngesimo sokusebenza kwesikhashana kwama-enzyme wesibindi, ukuthuthukiswa kwe-intrahepatic cholestasis noma i-hepatitis;
ohlangothini lwe-metabolism - ngesimo sokuthola isisindo noma i-hypoglycemia enezimpawu zayo zokubonisa - ukwethuka, ukukhuphuka kokujuluka, ukuphazamiseka kokulala, ukukhathazeka, i-migraine, umbono noma inkulumo engasebenzi;
on the immune immune - ngendlela yokusabela okuhlukahlukene okwenziwa esikhunjeni - i-petechiae, ukulunywa, i-hyperthermia, i-photosensitivity nabanye;
kusuka ohlelweni lwe-hematopoietic - ngesimo se-thrombocytopenia, i-hemolytic anemia, erythrocytopenia;
engxenyeni yezitho ezibonakalayo - ngesimo sokwephulwa kwendawo yokuhlala.

Iphuzu eliyisihluthulelo ngenkathi uthatha iManinil ukunamathela ngokuqinile emiyalweni yezokwelapha ephathelene nokudla nokuzihlola kwe-plasma glucose. Uma kwenzeka kune-overdose, i-hypoglycemia enezimpawu zezimpawu kungenzeka.

Uma kwenzeka kuboniswa izimpawu ezincane zokweqisa, kunconywa ukuthi kudliwe ushukela omncane noma ukudla okugcwele ama-carbohydrate angagaya kalula. Mayelana nezindlela ezinamandla zokweqisa, umjovo we-iv wesisombululo se-glucose unqunyelwe. Esikhundleni se-glucose, i-IM noma i-subcutaneous injin ye-glucagon kuvunyelwe.

Ingozi ye-hypoglycemia inyuka uma:

ukuphuza utshwala;
ukuntuleka kwama-carbohydrate;
ikhefu elide phakathi kokudla;
ukugabha noma ukugaya;
ukuzikhandla okukhulu ngokomzimba.

Izimpawu ze-hypoglycemia zingambozwa ngeveyili ngenkathi uthatha iManinyl ngemithi ethinta isistimu yezinzwa ephakathi noma yehlise umfutho wegazi.

Umphumela weManinil ungancishiswa ngenkathi usetshenziswa ngama-barbiturates, ukulawula ukuzalwa kanye nezinye izidakamizwa ezenziwa ngama-hormone. Ngakolunye uhlangothi, ukusetshenziswa kanyekanye kwama-anticoagulants, i-reserpine, i-tetracyclines, ama-anabolic steroid uyakwazi ukuthuthukisa isenzo sawo.

Ukulinganiselwa kanye nokuphikisana

Lapho ulapha ngeManinil, kunconywa ukugwema ukuvezwa isikhathi eside elangeni, kanye nokuqapha lapho ushayela imoto, wenza abanye abadinga ukunakwa, ukugxilisa ingqondo kanye nemisebenzi esheshayo yokusabela.

Umuthi obizwa nge-hypoglycemic utholakala uma kwenzeka ukhona:

isifo sikashukela esincike ku-insulin;
ukwehluleka kwesibindi;
ukuvinjwa kwamathumbu;
isifo sikashukela sikashukela;
isifo sikashukela sikashukela noma i-precoma;
i-paresis yesisu;
i-leukopenia;
ukungabekezelelani kwe-lactose nokuntuleka kwe-lactase;
ukwanda kokucabanga kwengxenye esebenzayo - glibenclamide noma ezinye izakhi ezikhona ekwakhekeni komuthi;
i-hypersensitivity ku-PSM, kanye ne-sulfonamides kanye nama-diuretics aqukethe okususelwa eqenjini le-sulfonamide;
ukususwa kwama-pancreas.

Ukukhanselwa kweManinil nokufakwa esikhundleni kwe-insulin kwenziwa uma:

ukugula okuthelelekayo okuhambisana nokubonakaliswa kokuqina;
ukungenelela okuhlaselayo;
ukusha okukhulu;
ukulimala
ukukhulelwa noma isidingo sokuncelisa ibele.

Ngokuqapha, lesi sidakamizwa kufanele sithathwe lapho kubakhona ukungasebenzi kahle kwe-yegilo yegilo, i-adrenal cortex, ukudakwa kakhulu okubangelwa ukuphuza utshwala.

Umuthi obizwa nge-hypoglycemic ufakwa ezinganeni.

Ungayithatha kanjani indawo yeManinil: ama-analogues kanye nentengo

Njengezidakamizwa eziningi, iManinil inezimpawu ezifanayo nezimpawu. Umphumela ofanayo unemithi emincane ekwehlisa ushukela, isithako esisebenzayo sayo yi-glibenclamide.

IManinyl 3,5 analogues inokulandelayo:

I-Glibomet - kusuka kuma-ruble angama-339;
I-Glibenclamide - kusuka kuma-ruble angama-46;
Maninil 5 - kusuka kuma-ruble ayi-125.

Amapilisi Glybomet

Iziguli maqondana nama-analogues zinemibuzo eminingana, ngokwesibonelo, okuyinto engcono - Maninil noma Glibenclamide? Kulokhu, konke kulula. IGlibenclamide yiManinil. Owesibili kuphela uhlobo oluphakeme lobuchwepheshe obukhethekile.

Futhi yikuphi okungcono - Maninil noma Glidiab? Kulokhu, akukho mpendulo ekhonkolo, ngoba okuningi kuya ngezimpawu zomuntu ngamunye.

Analogues of Maninil for Type 2 sikashukela umphumela wezokwelapha:

I-Amaril - kusuka kuma-ruble angama-350;
IVazoton - kusuka kuma-ruble angama-246;
I-Arfazetin - kusuka kuma-ruble angama-55;
I-Glucophage - kusuka kuma-ruble ayi-127;
Uhlu - kusuka kuma-ruble angama-860;
I-Diabeteson - kusuka kuma-ruble angama-278;
I-Xenical - kusuka kuma-ruble angama-800;
nabanye.

Ukukhetha i-analogue yaseManinil, ochwepheshe batusa ukunika izintandokazi kwezidakamizwa ezenziwe izinkampani zemithi zaseJapan, zaseMelika nezaseNtshonalanga: uGideon Richter, Krka, Zentiv, Hexal nabanye.

Imigomo nemibandela yesitoreji

Isidakamizwa i-hypoglycemic Maninil siyakwazi ukugcina izakhiwo zayo zokuphilisa iminyaka emithathu, inqobo nje uma igcinwa endaweni yokushisa yasekamelweni, endaweni evikelwe ukukhanya nasezinganeni.