I-Hyperinsulinism yisifo esenzeka ngesimo se-hypoglycemia, okuyisimo eseqisayo esivamile noma ukwanda ngokuphelele ezingeni le-insulin egazini.
Ukudlula kwaleli hormone kubangela ukukhuphuka okuqinile kokuqukethwe ushukela, okuholela ekushodeni kwe-glucose, futhi futhi kubangele ukulamba kwe-oksijini yobuchopho, okuholela emsebenzini wezinzwa ongalunganga.
Ukuvela nezimpawu
Lesi sifo sivame kakhulu kwabesifazane futhi sivela eminyakeni engama-26 kuye kwengama-55. Ukuhlaselwa kwe-hypoglycemia, njengomthetho, ziziveza ekuseni ngemuva kokuqina okusheshayo okwanele. Ukulimala kungasebenza futhi kubonakale ngasikhathi sinye sosuku, noma kunjalo, ngemuva kokudla ama-carbohydrate.
Ukuzila nje okungapheli isikhathi eside kungavusa i-hyperinsulinism. Ezinye izinto ezibalulekile ekubonakalisweni kwalesi sifo kungahle kube yimisebenzi ehlukahlukene yomzimba kanye nokuhlangenwe nakho kwengqondo. Kwabesifazane, izimpawu eziphindaphindekayo zalesi sifo zenzeka kuphela esikhathini sokuzala.
Izimpawu ze-Hyperinsulinism zinokulandelayo:
- umuzwa oqhubekayo wendlala;
- ukukhuphuka kokujuluka;
- ubuthakathaka obujwayelekile;
- i-tachycardia;
- pallor
- i-paresthesia;
- diplopia;
- umuzwa ongapheli wokukhathazeka;
- ukuphazamiseka kwengqondo;
- ukuzamazama kwezandla nemilenze ethuthumela;
- izenzo ezingavunyelwanga;
- dysarthria.
Kodwa-ke, lezi zimpawu zisekuqaleni, futhi uma ungaziphathi futhi uqhubeke ngokungasinaki lesi sifo ngokuqhubekayo, khona-ke imiphumela ingaba mibi kakhulu.
I-hyperinsulinism eyi-Absolute ibonakaliswa yizimpawu ezilandelayo:
- ukulahleka okungazelelwe kokungazi;
- ukoma nge-hypothermia;
- ukoma nge-hyporeflexia;
- ama-tonic cramps;
- ukugoqeka emitholampilo.
Ukuhlaselwa okunjalo kuvame ukwenzeka ngemuva kokuphelelwa ngamandla ukwazi.
Ngaphambi kokuqala kokuhlaselwa, kuqhamuka izimpawu ezilandelayo:
- kwehlise ukusebenza kwememori;
- ukungazinzi ngokomzwelo;
- ukunganaki okuphelele kwabanye;
- ukulahleka kwamakhono ochwepheshe;
- i-paresthesia;
- Izimpawu zokuntuleka kwe-pyramidal;
- ingqondo.
Izimbangela zokwenzeka
Izimbangela ze-hyperinsulinism kubantu abadala nasezinganeni zihlukaniswe izinhlobo ezimbili zalesi sifo:
- pancreatic. Le ndlela yalesi sifo iba ne-hyperinsulinemia ngokuphelele. Kwenzeka kuzo zombili i-neoplasms ezinobungozi kanye ne-benign neoplasms, kanye ne-pancreatic beta cell hyperplasia;
- okunga-pancreatic. Le ndlela yalesi sifo ibangela ukwanda kwe-insulin.
Uhlobo olungenasifo se-pancreatic lwalesi sifo luba kulezo zimo:
- izifo ze-endocrine. Baholela ekunciphiseni kwama-hormone we-contrainsulin;
- ukulimala kwesibindi kwama-etiologies ahlukahlukene. Izifo zesibindi ziholela ekwehleni kwamazinga e-glycogen, kanye nokuphazamisa izinqubo ze-metabolic futhi kuhlotshaniswa nokukhula kwe-hypoglycemia;
- ukuntuleka kwama-enzymeabathinteka ngqo ezinqubweni ezibhekene ne-glucose metabolism. Kuholela ku-hyperinsulinism yesihlobo;
- ukudla izidakamizwa okungalawulwaokuhloswe ngalo ukwehlisa amazinga kashukela kushukela. Kungadala izidakamizwa hypoglycemia;
- izinkinga zokudla. Lesi simo sifaka phakathi: isikhathi eside sokubulawa yindlala, ukulahleka okuthe xaxa koketshezi kanye noshukela (ngenxa yokuhlanza, ukuphuma kwenhliziyo, isifo sohudo), ukukhulisa ukusebenza komzimba ngaphandle kokudla ukudla kwe-carbohydrate, okubangela ukwehla okusheshayo koshukela wegazi, ukudla kakhulu ama-carbohydrate amaningi , ekhulisa kakhulu ushukela wegazi.
I-Pathogenesis
I-glucose mhlawumbe isakhi sesakhi esibaluleke kakhulu sesistimu yezinzwa yomuntu futhi iqinisekisa ukusebenza okujwayelekile kobuchopho.
I-Hypoglycemia ingadala ukuvimbela kwe-metabolic kanye nezinqubo zamandla.
Ngenxa yokwephulwa kwenqubo ye-redox emzimbeni, kukhona ukuncipha kokusetshenziswa kwe-oksijeni ngamangqamuzana e-cortex yamakhorali, ngenxa yokuthi ikhula kanjani i-hypoxia.
I-Hypoxia yobuchopho ibonakaliswa njenge: ukwanda kokuqina, ukunganaki kanye nokuvinjwa. Esikhathini esizayo, ngenxa yokuntuleka kweglucose, kukhona ukwephulwa kwazo zonke izinqubo ze-metabolic emzimbeni womuntu, kanye nokwanda okukhulu kokugeleza kwegazi kuye ebuchosheni, kuvela isikhala semithambo yegazi.
Ukuhlukaniswa kwezifo
I-Hyperinsulinism syndrome ihlukaniswa ngokuya ngezimbangela zokuvela kwayo:- okuyisisekelo. Kungumphumela wenqubo yesimila, noma i-hyperplasia yamaseli e-beta we-islet apparatus yama-pancreas. Ngenxa yokwanda okukhulu kwamazinga e-insulin, ama-benign neoplasms akhiwa, futhi kwesinye isikhathi amaqhubu ayabonakala nawo. Nge-hyperinsulinemia enzima, imvamisa kunokuhlaselwa kwe-hypoglycemia. Isici esibonakalayo ukwehla koshukela egazini ekuseni, okuvame ukuhlotshaniswa nokudla ukweqa;
- okwesibili. Kuwukushoda kwama-hormone we-contra-hormonal. Izimbangela zokuhlaselwa kwe-hypoglycemia yilezi: ukuzila isikhathi eside, ukweqisa izidakamizwa ze-hypoglycemic, ukuzikhandla okukhulu ngokomzimba, ukushaqeka kwengqondo. Ukwanda kwesifo kungenzeka, noma kunjalo, akuhlotshaniswa nokudliwa kwasekuseni.
Izinkinga
Okuqala kwenzeka ngemuva kwesikhashana esifushane ngemuva kokuhlaselwa, kufaka phakathi:
- isifo sohlangothi;
- i-myocardial infarction.
Lokhu kungenxa yokwehla okukhulu kakhulu kwe-metabolism yemisipha yenhliziyo nobuchopho bomuntu. Icala elinzima lingabangela ukukhula kwe-hypoglycemic coma.
Izinkinga zamuva ziqala ukuvela ngemuva kwesikhathi eside ngokwanele. Imvamisa emva kwezinyanga ezimbalwa, noma ngemuva kweminyaka emibili kuya kwemithathu. Izimpawu zokubonakala kwezinkinga sekwephuzile yi-parkinsonism, i-encephalopathy, inkumbulo ephazamisekile nenkulumo.
I-Hyperinsulinism: ukwelashwa nokuvimbela
Ngokuya ngezizathu eziholele ekutheni kubonakale i-hyperinsulinemia, amaqhinga wokwelapha lesi sifo anqunywa. Ngakho-ke, esimweni se-organic genesis, kunikezwa ukwelashwa okuhlinzwa.
Kuqukethe ukukhushulwa kwe-neoplasms, resection ngokwengxenye yama-pancreas, noma i-pancreatectomy ephelele.
Njengomthetho, ngemuva kokungenelela kokuhlinzwa, isiguli sine-hyperglycemia yesikhashana, ngenxa yalokho, ukwelashwa okulandelayo kwezidakamizwa nokudla okuphansi kwe-carb. I-Normalization yenzeka inyanga ngemuva kokuhlinzwa.
Ezimweni zama-tumor ezingasebenzi, kubekwa i-palliative therapy, okuhloswe ngayo ukuvikela i-hypoglycemia. Uma isiguli sinama-neoplasms amabi, khona-ke ngokungeziwe udinga i-chemotherapy.
Uma isiguli sine-hyperinsulinism esebenzayo, khona-ke ukwelashwa kokuqala kuhloswe kwisifo esikubangele.
Zonke iziguli zinconyelwa ukudla okulinganiselwe kwe-carb ngokudla okunomsoco. Ukubonisana nodokotela wezengqondo nakho kubekiwe.
Eziqeshini ezinzima zesifo ngokukhula okulandelayo kokukhohlisa, ukwelashwa kwenziwa kwizikhungo zokunakekelwa kakhulu, i-detoxification infusion therapy yenziwa, i-adrenaline ne-glucocorticoids iyabhalwa. Ezimweni zokubanjwa ngamandla kanye ne-psychomotor overexcitation, kuvezwa izidakamizwa nokujovwa kwama-tranquilizer.
Amavidiyo ahlobene
Kuyini i-hyperinsulinism nokuthi ungawuqeda kanjani umuzwa wokulamba njalo, ungathola le vidiyo:
Singasho nge-hyperinsulinism ukuthi lesi yisifo esingaholela ezinkingeni ezinkulu. Iqhubeka ngesimo se-hypoglycemia. Eqinisweni, lesi sifo sihluke ngokuphelele kwisifo sikashukela, ngoba ngaso sikhona ukukhiqizwa okubuthakathaka kwe-insulin noma ukungabikho kwayo ngokuphelele, futhi nge-hyperinsulinism iyakhuphuka noma iphelele. Ngokuyisisekelo, lokhu kuxilongwa kwenziwa yingxenye yabesifazane.
