Imboni yezemithi ayimi ngxi - njalo ngonyaka inikela ngemithi eyinkimbinkimbi futhi esebenza ngempumelelo.
I-insulin nayo iyodwa - kunezinhlobo ezintsha ze-hormone, eziklanyelwe ukwenza impilo ibe lula kwiziguli ezinesifo sikashukela, unyaka nonyaka iba ngokwengeziwe.
Enye yezinto ezintsha zesimanje yi-insulin Raizodeg evela enkampanini iNovo Nordisk (eDenmark).
Izici nokwakheka kwe-insulin
I-Ryzodeg yi-insulin esebenza isikhathi eside. Luwuketshezi olungenabala umbala.
Yatholwa ngobunjiniyela bezakhi zofuzo ngokufaka esikhundleni se-molecule ye-DNA ephindayo yabantu kusetshenziswa uhlobo lwe-yeast Saccharomyces cerevisiae.
Esakhiweni sayo ama-insulin amabili ahlanganisiwe: I-Degludec - esebenza isikhathi eside ne-Aspart - imfishane, ngokwesilinganiso sama-70/30 amayunithi ayi-100.
Ku-1 unit ye-insulin, iRyzodegum iqukethe u-0.0256 mg we-Degludec no-0,055 mg we-Aspart. Ipeni elilodwa lesirinji (i-Raizodeg Flex Touch) liqukethe isixazululo esingu-3 ml, ngokulandelana amayunithi angama-300.
Inhlanganisela eyingqayizivele yabaphikisi be-insulin banikeze umphumela omuhle kakhulu we-hypoglycemic, ngokushesha ngemuva kokuphatha futhi kuhlala amahora angama-24.
Indlela yokusebenza iyindlela yokuhlanganisa umuthi ophathisiwe kanye nama-insulin receptors. Ngakho-ke, umuthi uyatholakala futhi umphumela wemvelo we-hypoglycemic uyathuthukiswa.
I-Basal Degludec yakha ama-microcamera - amadepho athize esifundeni esisenkingeni. Ukusuka lapho, i-insulin isikhathi eside ihamba kancane futhi ingawuvimbeli umphumela futhi ingaphazamisi ukumuncwa kwe-insulin emfushane.
I-Insulin Rysodeg, ngokuhambisana neqiniso lokuthi ikhuthaza ukuqhekeka kwe-glucose egazini, ivimba ukuhamba kwe-glycogen esibindini.
Imiyalo yokusebenzisa
Isidakamizwa iRyzodeg senziwa kuphela emafutheni angaphansi kwengqondo. Akunakufakwa injila ngaphakathi noma ngaphakathi.
Ngokuvamile kuphakanyiswa ukuthi kwenziwe umjovo esiswini, ethangeni, akuvamile emahlombe. Kuyadingeka ukuguqula indawo yomjovo ngokuya ngemithetho ejwayelekile ye-algorithm yesingeniso.
Uma umjovo wenziwa iRyzodeg Flex Touch (ipeni lesirinji), khona-ke kufanele unamathele kule mithetho:
- Qinisekisa ukuthi zonke izingxenye zisendaweni yokuthi i-cartridge eyi-3 ml iqukethe i-300 IU / ml yesidakamizwa.
- Bheka izinaliti ezilahlayo i-NovoFayn noma i-NovoTvist (8 mm ubude).
- Ngemuva kokususa cap, bheka isixazululo. Kufanele kube sobala.
- Setha umthamo owuthandayo kwilebula ngokuguqula okukhethi.
- Ukucindezela "ukuqala", bamba kuze kube yilapho sekuvela ithonsi lekhambi kunenalithi.
- Ngemuva komjovo, ikhawunta yedosi kufanele ibe ngu-0. Susa inalithi ngemuva kwemizuzwana eyi-10.
Kusetshenziswa ama-Cartridge ukugcwalisa "izibaya". Okwamukelekayo kakhulu yiRyzodeg Penfill.
I-Rysodeg Flex Touch - ipeni lesirinji elisebenzisekayo. Qiniseka ukuthi uthatha izinaliti ezintsha zomjovo ngamunye.
Itholakale ekuthengisweni kweFlexpen isirinji sepeni lokulahlwa elinepeni (i-cartridge).
I-Ryzodeg ibekelwe iziguli ezinesifo sikashukela sohlobo 1 nohlobo 2. Kunqunywe isikhathi esingu-1 ngosuku ngaphambi kokudla main. Ngaso leso sikhathi, kusetshenziswa i-insulin efushane ngaphambi kokudla ngakunye.
Isifundo sevidiyo yomjovo wepeni
Umthamo ubalwa ngokubheka njalo ushukela egazini lesiguli. Kubalwa ngakunye esigulini ngasinye yi-endocrinologist.
Ngemuva kokuphatha, i-insulin igxilwa ngokushesha - ukusuka emizuzwini engu-15 iye kwihora eli-1.
Umuthi awunazo iziphikiso zezifo zezinso nezinso.
Akunconywa ukusebenzisa:
- izingane ezingaphansi kweminyaka engu-18;
- ngesikhathi sokukhulelwa;
- ngenkathi uncelisa ibele;
- nokuzwela okukhulayo komuntu ngamunye.
Ama-Analog
Ama-analogues amakhulu aseRyzodeg abhekwa njengamanye ama-insulin asebenza isikhathi eside. Lapho uthatha isikhundla seRyzodeg ngalezi zidakamizwa, ezimweni eziningi akaguquki nomthamo.
Kulezi, ezaziwa kakhulu:
- Glargin
- Tujeo;
- I-Levemir.
Ungaziqhathanisa ngokusho kwetafula:
| Izidakamizwa | Izici ze-Pharmacological | Isikhathi sokusebenza | Ukulinganiselwa nemiphumela emibi | Khipha ifomu | Isikhathi sokubeka |
|---|---|---|---|---|---|
| Glargin | Isisombululo esisebenza isikhathi eside, esicacile, i-hypoglycemic, sinikeza ukwehla okubushelelezi kweglucose | Isikhathi esingu-1 ngosuku, isenzo senzeka ngemuva kwehora eli-1, sithatha amahora angama-30 | I-Hypoglycemia, ukungaboni kahle, i-lipodystrophy, ukusabela kwesikhumba, i-edema. Izindlela zokuqapha lapho uncelisa ibele | I-0,3 ml ingilazi eyi-cartridge ebonakalayo enomshini werabha ne-aluminium cap, igcwele i-foil | Endaweni emnyama ku-t 2-8ºC. Ngemuva kokuqala ukusebenzisa amaviki ama-4 ku-t 25º |
| Tujeo | I-glargine esebenzayo yezinto, ehlala isikhathi eside, yehlisa ushukela kahle ngaphandle kokugxuma, ngokuya ngezibuyekezo zeziguli, umphumela omuhle usekelwa isikhathi eside | Ukuhlushwa okuqinile, ukulungiswa komthamo njalo kuyadingeka | I-Hypoglycemia kaningi, i-lipodystrophy kuyaqabukela. Ukukhulelwa nokuncelisa ibele kungathandeki | I-SoloStar - ipeni lesirinji lapho kufakwa khona ibhokisi lamabhokisi amayunithi angama-300 / ml | Ngaphambi kokusebenzisa, iminyaka engu-2,5. Ebumnyameni endaweni ye-t 2-8ºC musa ukubanda. Okubalulekile: Ukubonakala obala akusona izinkomba zokungasebenziseki |
| I-Levemir | Into yokusebenzisa into esebenzayo, ende | Umphumela we-Hypoglycemic kusuka emahoreni amathathu kuya kwayi-14, uthatha amahora angama-24 | I-Hypoglycemia Kuze kube yiminyaka emi-2 akunconyiwe; ukulungiswa kuyadingeka kwabesifazane abakhulelwe nababambisayo | I-Cartridge (i-Penfill) ka-3 ml noma ipeni lesirinji le-FlexPen elahlekile ngesinyathelo somthamo we-1 UNIT | Esiqandisini ku-t 2-8ºC. Vula - kungadluli izinsuku ezingama-30 |
Kuyadingeka ukuthi unake izethulo ngokuthatha iTujeo: kuhle futhi ngokucophelela ukubheka ukusebenza kwepeni ye-SoloStar, ngoba ukungasebenzi kahle kungaholela ekuqothulweni okungafanele kokuthola isilinganiso. Futhi, i-crystallization yayo esheshayo yaba yisizathu sokuvela kwezibuyekezo ezimbalwa ezingezinhle kumaforamu.
Intengo yezidakamizwa
Kunconywa ukuthi iningi le-insulin elimale ekwelapheni uhlobo lwe-1 yesifo sikashukela yiRysodeg.
Uhlobo lwe-2 yesifo sikashukela se-insulin ye-Ryzodegum insulin kufanele inikezwe nsuku zonke.
Kunezibuyekezo eziningi ezakhayo mayelana nokusebenza kwomuthi - uthandwa kakhulu, yize kungekho lula kakhulu ukuthenga umuthi emakhemisi.
Intengo izoncika kwifomu lokukhululwa.
Intengo yeRyzodeg Penfill - iklabishi elingama-300-unit ingilazi engu-3 ml lilinye lizoqhamuka ku-6594, 8150 kuya ku-9050 ngisho nama-ruble ayi-13000.
I-Raizodeg FlexTouch - ipeni lesirinji engu-100 UNITS / ml ka-3 ml, No. 5 kwiphakheji, ungathenga kuma-ruble angama-6970 kuya kwangama-8737.
Kuyadingeka ukuthi unake iqiniso lokuthi ezifundeni ezahlukahlukene namakhemisi azimele azohluka.
