Umuthi wokunciphisa umzimba kanye nokuguga - UDkt Malysheva mayelana neMetformin

Kuhlelo "Live Healthy" u-Elena Malysheva wenze isitatimende esikhulu esithi i-metformin yandisa impilo.

Ngabe kunjalo ngempela?

Okokuqala udinga ukuthola ukuthi luhlobo luni lomuthi, yiziphi izakhiwo zalo nokuthi kungani lusetshenziswa.

Yini i-metformin?

I-Metformin umuthi wethebhulethi osetshenziselwa isifo sikashukela sohlobo 2. Kungokwesigaba se-Biguanides. Ungomunye wemidala futhi ungomunye wemithi ephumelela kakhulu esetshenziselwe ukwelapha lesi sifo. Kusuka ekilasini lama-Biguanides, lesi kuphela isidakamizwa esingazithinti kabi iziguli ezinokwehluleka kwenhliziyo. I-WHO ikubeke ohlwini lwemithi ebalulekile.

I-Metformin yigama elejwayelekile elenzelwe umuthi. Amagama alandelayo okuhweba avezwa emakethe yamakhemikhali: Glucofage, Glycomet, Bagomet, Diaformin, Insufor, Langerin, Meglifort, Metamine, Metfogamma, Metformin Sandoz, Metformin-Teva, Panfor Sr, Siofor, Zukronorm.

Isikhathi eside, lo muthi wawusetshenziswa kuphela ekwelapheni isifo sikashukela. Ngemuva kweminyaka yocwaningo, kwatholakala ukuthi yehlisa amafutha. Lapho kukhona isifo se-prediabetes, singasetshenziswa ukunciphisa amathuba okukhula kwalesi sifo. Ibuye isetshenziselwe ama-ovini ama-polycystic kanye namanye ama-pathologies lapho ukumelana ne-insulin kubalulekile.

Izinzuzo ze-metformin ziyabonakala:

• nesifo sikashukela;
• nge-metabolic syndrome;
• ekuvinjelweni kwezifo zenhliziyo;
• ekuvimbeleni umdlavuza.

Umphumela oyinkimbinkimbi wesidakamizwa esilwa nokuguga kufakazelwe. Inani elibalulekile - yehlisela umkhawulo wokufa kwabantu ngenxa yezinkinga zenhliziyo. Kubonakala futhi ukuthi kunciphisa ingozi yokuthuthukisa i-oncology ezigulini ezinesifo sikashukela, i-metabolic syndrome. Ukumelana kweHormone kungenye yezingozi zokuthuthukisa isimila. I-insulin ivusa ukukhula kwezicubu, kufaka phakathi hhayi okuhle kakhulu.

Ngabe umuthi usebenza kanjani?

Umuthi wehlisela ukugcwala kweglucose egazini kanye nokwakheka koshukela esibindini. Ngaphezu komphumela we-hypoglycemic, kuthinta kahle i-lipid tata. Ama-Lowers triglycerides ne-cholesterol embi (LDL). Yilo kuphela umuthi, ngokusho kwezifundo, onciphisa inani lokuhlaselwa yinhliziyo nemivimbo.

Enye yezinzuzo zesidakamizwa ukuthi asikhulisi isisindo somzimba uma siqhathaniswa nezinye izidakamizwa ze-hypoglycemic. Kumuntu onesifo sikashukela, kusiza ukwelula nokwenza impilo igcwale futhi ibe sezingeni eliphezulu. Isenzo saso sihloselwe ukwehla kwesisindo. Kubekelwe ukukhuluphala, uma ukwelashwa kokudla kungalethi umphumela ofanele.

Umuthi ucindezela isifiso sokudla kanye nokufakwa kweglucose emgodini wokugaya ukudla. Ukwenza kusebenze i-insulin akwenzeki, umphumela we-hypoglycemic utholakala ngokuthuthukisa ukuzwela kwe-hormone kanye nokufaka ushukela okuthe xaxa. Njengomphumela wokuthatha umuthi, izinqubo ze-pathological ezikhula ngokumelene nesizinda sesifo zihamba kancane. Ingasetshenziselwa i-pathologies ekhombisa ukumelana ne-insulin. Ukusebenza komuthi kukhonjiswa kumaqanda ama-polycystic, i-prediabetes, izifo ezithile zesibindi kanye nokukhuluphala.

I-Metformin inciphisa ukwakheka kwe-glucose esibindini futhi inyusa ukwakheka kwe-glycogen. Ngaphansi kwethonya lomuthi, ukugeleza kwegazi esibindini kusebenze, izinga lama-triglycerides ne-cholesterol liyancishiswa. Ukuthathwa kwe-glucose ngemisipha, umthengi wamandla oyinhloko, kuyenziwa lula. Ukusetshenziswa okuthe xaxa koshukela osetshenzisiwe kuchazwa iqiniso lokuthi kulula ukungena kwezicubu.

Umphumela wokuphuza umuthi:

• ukunciphisa ushukela;
• ukuncishiswa kwesidingo se-insulin yendabuko;
• ukuvimbela ukumelana ne-insulin;
• ukubambezela ukuqhubekela phambili noma ukukhula kwe-atherosulinosis;
• ukwehla kwe-triglycerides ne-LDL;
• ukwehla kwengcindezi, ukwehla kweshukela kwamaprotheni;
• ukuvimba ama-enzyme abulala amaseli;
• ukuvikelwa kwemisipha.

Contraindication

Phakathi kokuphikisana kokusetshenziswa:

• ukungasebenzi kwezinso;
• hypersensitivity kulo muthi;
• izifo ezithathelwanayo esigabeni esibuhlungu;
• ketoacidosis;
• ukungasebenzi kwesibindi;
• ukushaya kwenhliziyo;
• ngaphambi nangemva kokuhlolwa kwe-radiographic ngokwethulwa kokungafani;
• ngaphambi nangemva kokungenelela kokuhlinzwa;
• ubudala
• malabsorption B12.

Ukwelashwa kwesifo sikashukela

Phambilini iMetformin yayisetshenziswa kuphela ekwelapheni isifo sikashukela. Ucwaningo luveze ukuthi umuthi ukhombisa ezinye izakhiwo. Kusetshenziselwa amaqanda ama-polycystic, ukukhuluphala, kanye nokuvimbela isifo sikashukela.

Noma kunjalo, ukugxila okuyinhloko kwe-metformin ukwelashwa kwesifo sikashukela sohlobo 2. Iyanciphisa amazinga kashukela kanye ne-gluconeogeneis, kunciphisa ama-triglycerides nama-LDL, futhi inciphisa kancane iphango. Ukwehla kweshukela kusenzeka kokubili esiswini esingenalutho nangemva kokudla. Izicubu zemisipha zithola inani elikhulu le-glucose ngenxa yokwanda kokusetshenziswa kwayo. Ukufakwa ushukela emgodini wokugaya ukudla kuyancishiswa.

Umuthi awukhuthaze ukukhiqizwa kwehomoni. Umphumela wehlisela ushukela utholakala ngokuthuthukisa ukumuncwa kwe-glucose ngama-tishu. Ngesikhathi sokwelashwa ngeMetformin, isidingo se-insulin sinciphile. Ithuluzi linciphisa ubungozi bezinkinga nokufa kwabantu cishe ngama-35% uma kuqhathaniswa nezinye izidakamizwa ze-hypoglycemic ne-insulin engalashwa.

Izinga likashukela eliphakeme njalo liyingozi ohlelweni lwezinhliziyo. Uhlobo lwefomu le-scum ezindongeni zemikhumbi, i-microcirculation iyaphazamiseka. Ukusuka lapha kukhona izilonda zamehlo, imithambo yegazi yobuchopho nenhliziyo, imithambo yemilenze nokunye okunjalo.

Lapho uthatha umuthi, umphumela oqinile we-hypoglycemic awubonwa. Ngokuya ngezinga loshukela nokumisa i-glycemia, isiguli kungadingeka siphuze enye into. Kepha uma sesinqume umuthi, kungenzeka sinciphise izingozi zezifo zenhliziyo ngengxenye eyodwa kwezintathu.

I-Metformin ayiholeli ekuthuthukisweni kwe-hypoglycemia uma ithathwa kahle. Kwabonakala ezimweni ezingafani nokuzikhandla ngokomzimba noma ukusetshenziswa kwesidakamizwa namanye ama-hypoglycemic agents. Ezigulini ezinempilo, alihlisi ushukela.

Ukuguga komzimba

Njengoba kushiwo ngenhla, u-Elena Malysheva uthe ohlelweni lwakhe iMetformin ivimbela ukuguga. Ukhulume nangokuthi kungenzeka ukuthi andise impilo ephelele futhi esezingeni eliphezulu. Manje ngemininingwane eminingi imininingwane.

"Ukuguga" kungumqondo ongokomfanekiso. Kusho ukuguga ngaphambi kwesikhathi okubangelwa yisifo. Ngamanye amagama, lesi yisikhathi sobudala bomzimba, esingahambisani nophawu olusemaphasiphini.

Umongo wokuguga okunjalo yizinga elikhuphukile leglucose egazini. Ngenxa yalokhu, amaprotheni ashukela (lokhu kufaka amaprotheni esikhumba), okuholela ekwakhekeni kwemibimbi. Ukuqhekeka kwakheka emikhunjini ngaphansi kwethonya ushukela okhuphukayo.

Kusukela ku-1st glucose molecule, ama-molecule ama-2 triglyceride atholakala, i.e. amanoni. Amafutha aqongelela ukuqhekeka, akha izindawo okuthiwa yi-atherosulinotic plaque. Umuthi wenzelwe ukumisa lezi zinqubo ezenzeka emikhunjini.

Kuyo yonke leminyaka lama-20, kwenziwa izifundo ezahlukahlukene zezidakamizwa. Ekupheleni kuka-2015, kwenziwa isifundo sesayensi (seminyaka engama-25) seMetformin e-University of England.

Ababambe iqhaza ocwaningweni babengabantu abanesifo sikashukela sohlobo olubi 2. Ngokusho kwezibikezelo, babeneminyaka engu-8 kuphela yokuphila. Kepha akekho noyedwa owashona phakathi nokuhlolwa. Baphetha ngokuthi umuthi ugxila ngokuqondile ukuqala kokufa nokuguga.

Ividiyo ngokubukezwa kukaDkt Malysheva mayelana neMetformin:

Umphumela isisindo somzimba

I-Metformin ayithinti ukuzuza kwesisindo ngokuqhathaniswa ne-sulfonylureas. Ngokuphambene nalokho, isetshenziswa ekwelashweni okuyinkimbinkimbi kokukhuluphala. Kwatholakala ukuthi umuthi wehlisela isisindo samafutha.

Abantu abanempilo enamazinga kashukela ajwayelekile abafuna ukwehlisa isisindo bangawuthatha umuthi. Ukudla njalo kuqeda isilinganiso samakhilogremu ayi-2,5,3 futhi kunciphise inani lokudla elichithwayo. Kumuntu ophile kahle, umuthi awanciphisi amazinga kashukela, ngakho-ke angasetshenziswa kumthamo olinganiselayo.

Isicelo se-ovary polycystic

I-Metformin umuthi osizayo osetshenziswa ekwelapheni okunzima kokuzala. Abanye ochwepheshe basikisela ukuyisebenzisa njengezidakamizwa zohlu lokuqala, ezinye njenge-line-line.

Ivuselela i-ovulation futhi isize owesifazane ukuba akhulelwe. Futhi njengoba wazi, i-polycystic ovary iyi-pathology ye-endocrinological eholela ekuzalweni. Owesifazane une-insulin ukumelana.

Ngakho-ke, iMetformin ibaluleke kakhulu ekwelashweni kwalesi sifo. Kunqunywe ohlelweni olunama-hormone nezinye izidakamizwa.

Imiphumela emibi

Ngazo zonke izimfanelo ezinhle zomuthi, kufanele ungayi ngokushesha ekhemisi. Uthathwa ngezizathu zezokwelapha futhi njengokuyalelwa ngudokotela. Okokuqala, kubalulekile ukuqonda ukuthi iMetformin ingumuthi. Futhi noma yimuphi umuthi, njengoba wazi, ubangela imiphumela emibi.

Imiphumela emibi ejwayelekile ibonakaliswa ipheshana lesisu. I-nausea iyaqala, ukunambitheka kwensimbi kuvela emlonyeni, izitulo ezikhathazekile. Umuthi ungaphazamisa ukumuncwa kwe-B12, kuholele ekuxhumaniseni okonakele nasenkumbulweni.

Umphumela onqabile kodwa obulalayo wokungalawulwa kokusetshenziswa kwe-Metformin yi-lactic acidosis, icala linye livela izinkulungwane eziyishumi.

Kodwa-ke, izinyathelo zokuphepha kumele zithathwe:

• ukungena kuvunyelwe izinso ezinempilo kanye nokusebenza okufanele kwe-glomerular filtration;
• ayabelwe abantu abadala kakhulu;
• Izinga le-creatinine kufanele libe semkhawulweni ojwayelekile;
• nganoma yikuphi ukulaliswa esibhedlela, ukwamukelwa kuyamiswa, ikakhulukazi ngezifundo ze-x-ray.

I-Metformin inezinzuzo eziningi emiphumeleni yayo yokwelapha, kepha akuyona i-panacea ephelele. Uthathwa njengokuyalelwe ngudokotela nangezizathu zokwelashwa. Kepha uma umuntu etholakala ukuthi unesifo sikashukela, ukuthatha lo muthi kuyalulekwa futhi kuyasebenza.