Phakathi kwezidakamizwa ezisetshenziselwa ukwelapha isifo sikashukela, isidakamizwa okuthiwa i-Onglisa siyaziwa.
Kufanelekile ukutadisha imiyalo yalo muthi, ukukhomba izici zawo ezisemqoka nezinzuzo, kanye nokuthola ukuthi iziphi izindlela ezizosiza ukuvikela ukuthuthukiswa kwemiphumela emibi ngenxa yokusebenzisa kwayo okungafanele.
Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa
Lesi sidakamizwa sikashukela siyatholakala e-United States. Yakhelwe ukulawula izinga loshukela wegazi weziguli. Inomphumela we-hypoglycemic. Ukuyisebenzisa kufanele kunconywe udokotela kuphela, ukuze kungalimazi impilo yakho. Kungakho ungathenga u-Ongliz kuphela ngomuthi obhalwe phansi.
Isisekelo somuthi yinto uSaksagliptin. Yenza umsebenzi ophambili kulesi sidakamizwa. Ingxenye isetshenziselwa ukumisa izimpawu ze-hyperglycemia ngokwehlisa amazinga kashukela egazini.
Uma isiguli sephula izincomo zokwelashwa, khona-ke umuthi ungadala ukuthuthukiswa kwemiphumela emibi nezinkinga.
Ukuqanjwa kubandakanya izithako ezisizayo:
- i-lactose monohydrate;
- i-croscarmellose sodium;
- i-hydrochloric acid;
- i-magnesium stereate.
Ngaphezu kwalokho, umuthi uqukethe inani elincane ledayi, okudingekayo ukudala ukuhlanganiswa kwefilimu ngamathebulethi (umuthi unefomu lethebhulethi). Zingaba ophuzi noma zipinki ngombala oluhlaza okwesibhakabhaka. Kuthengisiwe, ungathola amaphilisi ngomthamo ongu-2,5 no-5 mg. Zombili zithengiswa emaphaketheni amaselula ama-10 pcs. Amaphakheji anjalo ayi-3 abekwa ephaketheni.
I-Pharmacology ne-pharmacokinetics
Umphumela wesidakamizwa ku-diabetesic kungenxa yesakhi sawo esisebenzayo. Uma ungena emzimbeni, i-saxagliptin ivimbela isenzo se-enzyme DPP-4. Ngenxa yalokho, amaseli we-pancreatic beta asheshisa ukuhlanganiswa kwe-insulin. Inani le-glucagon ngalesi sikhathi liyancipha.
Ngenxa yalezi zici, i-glucose egazini lesiguli incishisiwe, okuholela ekuthuthukisweni enhlalakahleni (ngaphandle kokuthi izinga layo lehla liye kumazinga abucayi). Isici esibalulekile sento okukhulunywa ngaso ukungabikhona kokuthonya kwaso emzimbeni wesiguli. Iziguli ezisebenzisa i-Ongliza azitholi isisindo.
Ukufakwa kwe-saxagliptin kwenzeka ngokushesha okukhulu uma uphuza umuthi ngaphambi kokudla. Ngasikhathi sinye, ingxenye ebalulekile yento esebenzayo iyangenwa.
USaksagliptin akanawo umkhuba wokuzibandakanya namaprotheni egazi - ukubukeka kwalezi zibopho kuthinta inani elincane lezinto. Umphumela omkhulu wesidakamizwa ungatholakala cishe emahoreni amabili (izakhiwo zomzimba ngazinye zithinta lokhu). Kuthatha cishe amahora ama-3 ukungathathi hlangothi kwengxenye ye-Saxagliptin engenayo.
Izinkomba kanye ne-contraindication
Kubaluleke kakhulu ukulandela imiyalo ephathelene nezinkomba zokuqokwa kwalo muthi. Ukusetshenziswa kwama-Onglises kubeka ingozi enkulu empilweni nasempilweni. Imithi enomphumela we-hypoglycemic kufanele isetshenziselwe kuphela labo bantu abanamazinga aphezulu kashukela, nakwabanye leli khambi liyingozi.
Lokhu kusho ukuthi inkomba yalesi sidakamizwa uhlobo 2 sikashukela. Ithuluzi lisetshenziswa ezimweni lapho ukudla kanye nokuzivocavoca komzimba kungabi nomphumela owufunayo ekuhlushwa ushukela.
I-Onglisa ingasetshenziswa ngokuhlukile futhi ngokuhlanganiswa nezinye izidakamizwa (i-Metformin, i-sulfonylurea derivatives, njll.).
Umuthi une-contraindication:
- Uhlobo 1 sikashukela;
- ukukhulelwa
- ukondla kwemvelo;
- ukungezwani nokwakheka komuthi;
- ukuntuleka kwe-lactase;
- i-ketoacidosis ebangelwa isifo sikashukela;
- ukungabekezelelani kwe-galactose.
Ukuba khona kwento okungenani eyodwa ohlwini kusuka kuyisizathu sokwenqaba ukusetshenziswa kwamathebulethi.
Futhi hlukanisa amaqembu abantu abavunyelwe ukusebenzisa i-Onglisa, kodwa ngaphansi kokuqashwa ngokucophelela ngokwelashwa. Lokhu kufaka phakathi asebekhulile, kanye neziguli ezihluleka ngokwezinso.
Imiyalo yokusebenzisa
Sebenzisa lesi sidakamizwa ngokuya ngemithetho. Uma udokotela engazange anqume umthamo ohlukile, khona-ke isiguli kufanele sisebenzise umuthi ongu-5 mg ngosuku. Kuthathwa idosi elifanayo ngokusetshenziswa okuhlanganisiwe kwe-Onglisa ne-Metformin (okuhlinzekwa nsuku zonke yiMetformin ngama-500 mg).
Ukusetshenziswa kwesidakamizwa kungaphakathi kuphela. Ngokuqondene nokudla, akukho okubonisa ukuthi ungaphuza amaphilisi ngaphambi nangemva kokudla. Isifiso kuphela ukusebenzisa umuthi ngewashi.
Lapho weqa umthamo olandelayo, akufanele ulinde isikhathi esibekiwe sokuphuza umuthi ophindwe kabili womuthi. Kuyadingeka ukuthatha ingxenye ejwayelekile umuthi ngokushesha nje lapho isiguli simkhumbula.
Imiyalo ekhethekile
Ukuphazamiseka okungenzeka kungavinjelwa ngokubheka izinyathelo zokuphepha kubantu abanezifo ezilandelayo:
- Ukwehluleka kwangempela Uma lesi sifo simnene, awudingi ukushintsha umthamo womuthi. Kepha ngasikhathi sinye, udinga ukubheka izinso ngezikhathi ezithile. Ngesigaba esilinganiselwe noma esinzima salesi sifo, kuyadingeka ukunquma umuthi kumthamo ophansi.
- Ukwehluleka kwesibindi. Imvamisa, izidakamizwa ze-hypoglycemic zithinta isibindi, ngakho-ke lapho zisetshenziswa yiziguli ezihluleka yisibindi, kubalulekile ukulungisa isilinganiso somuthi. Ngokuqondene ne-Onglisa, lokhu akudingekile, lezi ziguli zingasisebenzisa lesi sidakamizwa ngokohlelo olujwayelekile.
Umuthi awunawo amandla okulimaza ukuvumelanisa kokunyakaza, ukushesha kokuphendula, njll. Kepha la mathuba angaba buthaka ngokuthuthukiswa kwesimo se-hypoglycemic. Ngakho-ke, lapho usebenzisa umuthi kufanele uqaphele ngenkathi ushayela.
Imiphumela emibi kanye ne-overdose
Ukuvela kwemiphumela emibi kusukela ekusetshenzisweni kwe-Onglisa akuhlangene ngaso sonke isikhathi nokungabekezelelani kwayo. Kwesinye isikhathi zibangelwa yisitho esingabhapathizwanga emiphumeleni yaso. Noma kunjalo, uma betholwe, kunconywa ukwazisa udokotela ngabo.
Imiyalo yesidakamizwa ikhombisa imiphumela emibi efana nale:
- izifo ezithinta umchamo;
- ikhanda
- isicanucanu
- izinhlungu zesisu;
- i-sinusitis
- i-nasopharyngitis (nokusetshenziswa kanyekanye ne-metformin).
Izimpawu zokwelapha zisetshenziselwa ukuqeda lezi zinkinga. Kwezinye izimo, udokotela usula ngokushesha lesi sidakamizwa.
Akunamininingwane mayelana nezici ze-overdose enomuthi. Uma kwenzeka, ukwelashwa okubonakalayo kuyadingeka.
Ukusebenzisana kwezidakamizwa kanye nama-analog
Ukusetshenziswa ngesikhathi esisodwa kwe-Onglisa ngezidakamizwa ezithile kudinga ukwanda komthamo, ngoba umsebenzi weSaxagliptin uyancipha.
Lezi zimali zifaka:
- I-Rifampicin;
- I-Dexamethasone;
- I-Phenobarbital, njll.
Kunconywe ukunciphisa umthamo we-Onglisa lapho usetshenziswa ngokuhambisana nezinsizakalo ze-sulfonylurea.
Imithi engathatha lesi sidakamizwa ifaka phakathi:
- Galvus;
- UJanuvius;
- UNesina.
Ngaphandle kokuncoma uchwepheshe, ukusebenzisa noma yimaphi la mathuluzi akuvunyelwe.
Imibono yesiguli
Ngemuva kokufunda ukubuyekezwa mayelana nomuthi u-Onglisa, singaphetha ngokuthi umuthi wehlisa kahle isilinganiso se-glucose egazini, kodwa awulungele wonke umuntu futhi udinga indlela yomuntu ngamunye nokulawula.
Imiphumela evela ngomuthi muhle kakhulu. Ushukela wami usuzinzile manje, bekungekho miphumela emibi futhi cha. Ngaphezu kwalokho, kulula kakhulu ukuyisebenzisa.
UDmitry, oneminyaka engama-44
Umuthi ka-Ongliz wabonakala kimi ubuthakathaka. Izinga le-glucose alishintshile, ngaphezu kwalokho, ngangihlukunyezwa ikhanda elihlala njalo - ngokusobala, kwakuyimphumela waseceleni. Ngathatha inyanga futhi angikwazanga ukuyiluma; kwakufanele ngibuze omunye umuthi.
U-Alexander, oneminyaka engama-36
Sekuphele iminyaka emithathu ngisebenzisa u-Onglise. Kimi, leli ithuluzi elihle kakhulu. Ngaphambi kokuthi aphuze izidakamizwa ezahlukahlukene, kepha noma ngabe imiphumela yayiphansi kakhulu, noma ehlukunyezwa yimiphumela emibi. Manje ayikho inkinga enjalo.
U-Irina, oneminyaka engama-41
Inkulumo yevidiyo yezidakamizwa ezintsha zesifo sikashukela:
Umuthi uphakathi kwezinto ezibiza kakhulu - intengo yephakethe ngalinye ingama-30 ama-pcs. cishe 1700-2000 rub. Ukuthenga imali, udinga incwadi kadokotela.
