Izinkomba nendlela yokusebenzisa insulin Glargin

Ekwelapheni isifo sikashukela, kusetshenziswa izinhlobo ezahlukene zemithi. Ziyahluka ngokwakhiwa nendlela yokusebenzisa.

Abantu abaningi abanesifo sikashukela badinga i-insulini ukuze benze impilo yabo ibe ngokwejwayelekile. Enye yezinhlobo zayo ezisetshenziswe njengomjovo i-insulin Glargin.

Imininingwane ejwayelekile

Lesi sidakamizwa singokweqembu le-insulin. Igama layo lokuhweba iLantus. I-ejenti isetshenziselwa ukwelapha i-mellitus yesifo sikashukela. Iyatholakala njengomjovo. Uketshezi awunawo umbala futhi ucishe ubonakale.

I-Insulin Glargin iyi-analogue ye-insulin yabantu ekhiqizwa izindlela zamakhemikhali. Ubunzima ekusebenzeni isikhathi eside. Umuthi usiza ukwehlisa inani loshukela egazini lesiguli.

Isakhi esiyinhloko sokuqanjwa yi-Glargin insulin.

Ngaphezu kwakho, ikhambi lifaka:

• glycerol;
• i-zinc chloride;
• metacresol;
• i-hydrochloric acid;
• i-sodium hydroxide;
• amanzi.

Umuthi uvunyelwe ukuthi usetshenziswe kuphela ngemvume yongcweti nakulo umthamo obekwe kuye, ukuvikela ubunzima.

Izici ze-Pharmacological

Umphumela omkhulu walesi sidakamizwa ukwehla kwamazinga kashukela. Lokhu kwenzeka ngokwakhiwa kwesibopho phakathi kwawo nama-insulin receptors. Umgomo ofanayo kakhulu wesenzo ubonakala nge-insulin yomuntu.

Ngaphansi kwethonya lomuthi, i-glucose metabolism iyathuthukiswa, njengoba izicubu zephutha ziqala ukusisebenzisa ngamandla.

Ngaphezu kwalokho, i-Glargin ivimbela ukukhiqizwa kwe-glucose esibindini. Ngaphansi kwethonya lazo, inqubo yokukhiqiza amaprotheni iyasheshiswa. Inqubo ye-lipolysis, kunalokho, yehlisa ijubane.

Ngemuva kokungena kwekhambi lesidakamizwa emzimbeni, lingathathi hlangothi, kwakhiwa ama-microprecipitate. Into esebenzayo ihlanganiswe kubo, ekhishwa kancane kancane. Lokhu kunomthelela ubude besikhathi somuthi nobushelelezi bawo, ngaphandle kwezinguquko ezinkulu.

Isenzo sikaGarlgin siqala ihora ngemuva komjovo. Iyaqhubeka cishe usuku.

Izinkomba, indlela yokuphatha, imithamo

Ukwelashwa okusebenzayo, imiyalo yokusebenzisa umkhiqizo kufanele ilandelwe. Imithetho yokwamukelwa imvamisa ichazwa udokotela oholayo.

I-Insulin Glargin inqunywa kuphela uma kunesizathu. Ukusetshenziswa kwaso kuyadingeka ohlotsheni olungena kwisifo sikashukela - lokhu kusho ukuthi lesi sifo yisizathu sokuqokwa kwaso.

Noma kunjalo, lo muthi awunconywa kuwo wonke umuntu - uchwepheshe kufanele afunde isithombe somtholampilo sesi sifo esimweni ngasinye.

Ukusetshenziswa kwayo kuvunyelwe kushukela sohlobo lokuqala nolwesibili. Kuhlobo lokuqala lwesifo, umuthi usetshenziswa njengomuthi oyinhloko. Kokunye, i-Glargin ingabekelwa zombili ngesimo se-monotherapy kanye nokuhlanganiswa nezinye izidakamizwa.

Umthamo uhlala ubalwa ngawodwana. Lokhu kuthintwa isisindo sesiguli, iminyaka yakhe, kepha isici esibaluleke kakhulu yizimpawu zesifo. Ngesikhathi sokwelashwa, ukuhlolwa kwegazi kwenziwa ngezikhathi ezithile ukuqonda ukuthi umuthi usebenza kanjani, futhi wehlise noma wandise umthamo ngesikhathi.

Umuthi lo usetshenziswa ngendlela yemijovo, okufanele yenziwe ngokungaziphathi. Imvamisa yemijovo iba kanye ngosuku. Ngokusho kwemiyalo, kufanele ukwenze cishe ngasikhathi sinye - lokhu kuqinisekisa ukusebenza kahle kanye nokungabikhona kokungahambi kahle kokunye. Imijovo ibekwa ehlombe, ethangeni noma ezingxenyeni ezinamafutha eziswini zesisu. Ukuze uvikele ukungahambi kahle, shintsha ezinye izindawo zokuphatha.

Isifundo sevidiyo yesirinji-ekuphatheni kwe-insulin:

Contraindication kanye nemikhawulo

Ukusetshenziswa kwesidakamizwa ngasinye kufanele kube ngokucophelela ngenxa yokuthi bonke banokuphambana. Ukusetshenziswa kwezidakamizwa ngaphandle kokubhekelwa kwemingcele kanye nemikhawulo kungadala izinkinga.

Leli khambi linokuphikisana okumbalwa. Lokhu kufaka ukungabekezelelani ngakunye kwezakhi, ngenxa yokuvela kokungqubana komzimba.

Elinye icala lapho ukusetshenziswa kwalo muthi kufanele kulahlwe kuyinto iminyaka yesiguli ingaphansi kweminyaka engu-6. Ngokuphathelene nezingane, ukusebenza ngempumelelo kwalo muthi akukaphenywa, ngakho-ke akukho mininingwane eqondile mayelana nokwenzeka nokuphepha kokuphathwa kwawo.

Ukulinganiselwa kufaka phakathi:

1. Izinkinga ekusebenzeni kwezinso. Ngalesi sehlakalo, i-insulin metabolism ingabambezeleka. Lokhu kusho ukuthi isiguli sizodinga umuthi omncane ukuze silawule ushukela wegazi.
2. Ukuguga (ngaphezulu kweminyaka engama-65). Ezigulini ezikulesi sikhathi, umsebenzi wezitho zangaphakathi, kubandakanya nezinso, uya ukhula. Ngakho-ke, zingadinga ukwehla komthamo womuthi.

Ukulinganiselwa kusho ukuqwashisa kukadokotela lapho ebeka umuthi. Uma kutholakala, umuthi unganconywa, kepha kuphela emva kokuqinisekiswa.

Ukukhulelwa nokukhulelwa

Azikho izifundo eziningiliziwe ezenziwayo maqondana nokusebenzisa isidakamizwa i-Insulin glargine ngesikhathi sokuzala kwengane. Imiphumela yokuhlolwa okuthile ikhombisa umthelela omncane ongemuhle wento esebenzayo enkambweni yokuthinta nokukhula kwengane.

Ngakho-ke, akunconywa ukusebenzisa leli thuluzi ekwelapheni abesifazane abakhulelwe. Kungabekwa uma inzuzo yomuthi kamama iphakeme kunobungozi enganeni.

Ngasikhathi sinye, ukubhekwa ngokucophelela kwezokwelapha kuyadingeka, ngoba ngesikhathi sokukhulelwa izinga loshukela wegazi lesiguli lungahluka ngokuya ngesikhathi. Odokotela kufanele bahlole njalo ukugcwala koshukela ukuze balungise umthamo womuthi.

Nge-lactation, lesi sidakamizwa naso sinqunyelwe njengoba kunesidingo. Ukuthi kungenzeka ukuthi i-insulin ingene ebisini lwebele ayikasungulwa.

Noma kunjalo, le nto ithathwa njengephephile, ngoba inemvelo yamaprotheni, ngakho-ke, ayinakulimaza umntwana osanda kuzalwa. Kepha uma ulisebenzisa nomama osenkulisa, udinga ukukhetha umthamo ofanele, futhi futhi ulandele izincomo eziphathelene nokudla.

Imiphumela emibi kanye ne-overdose

Noma unquma udokotela ngomuthi, awunakuqiniseka ukuthi ukusetshenziswa kwawo kuzokwenza ngaphandle kobunzima. Ngaphandle kokulandela imiyalo, izidakamizwa kwesinye isikhathi zinomphumela ongalindeleki, ohambisana nezimpawu zomzimba ngamunye. Ngakho-ke, imiphumela emibi yenzeka.

Uma usebenzisa umuthi, ubunzima kungaqubuka njengoku:

1. I-Hypoglycemia. Le nto yenzeka ngokweqile kwe-insulin emzimbeni. Imvamisa, ukubukeka kwayo kuhlotshaniswa nethamo elikhethwe kabi lomuthi, kepha kwesinye isikhathi izizathu zivela emzimbeni. Ukwephulwa okunjalo kuyingozi kakhulu, ngoba kuthinta ukusebenza kohlelo lwezinzwa. Nge-hypoglycemia enzima nokuntuleka kosizo, isiguli singafa. Lokhu kuphambuka kubonakaliswa yizimpawu ezinjengokulahlekelwa ingqondo, i-palpitations, cramps, nesiyezi.
2. Ukulimazeka kokubonakalayo. Ngokwelashwa kwe-insulin, ukuvela okungazelelwe kwesilinganiso se-glucose kwesinye isikhathi kuyabonakala, okungaholela ku-retinopathy. Isiguli kungenzeka ukuthi sasingaboni kahle, size sibe bumpumputhe.
3. I-Lipodystrophy. Lokho okubizwa ngokuthi ukwephulwa kwenqubo yokutholwa kwento yokwelapha. Le pathology ingagwenywa ngosizo lokushintshwa okungapheli kwezindawo zokujova.
4. Allergy. Uma izivivinyo ezidingekayo zokuzwela umuthi zenziwa ngaphambi kokusebenzisa i-Glargin, ukusabela okunjalo kwenzeka kakhulu futhi akufani ngobukhulu. Izimpawu ezibonakaliswa kakhulu kulokhu: ukuqunjelwa kwesikhumba, ubomvu kwesikhumba nokulunywa endaweni yomjovo.

Uma uthola izici ezinjalo, kungakhathalekile ukuthi ziningi kangakanani, udinga ukubonana nodokotela. Kwezinye izimo, ungaziqeda ngokushintsha umthamo womuthi. Futhi kwesinye isikhathi ushintsho olusha lwezidakamizwa luyadingeka.

Ukuhambisana nemiyalelo kadokotela kuvimbela imiphumela emibi ehambisana ne-overdose. Kepha kwesinye isikhathi lokhu akusizi. Uma kwenzeka kweqa ngokweqile, i-hypoglycemia ivame ukwenzeka. Ukuqedwa kwaso kuncike ekujuleni kwesimpawu. Kwesinye isikhathi ungamisa ukuhlasela ngokudla ama-carbohydrate ashesha ukugaya. Ngokuhlasela kanzima, usizo lukadokotela luyadingeka.

Ukuxhumana nezinye izinto, ama-analogues

Lapho umuntu enamanye ama-pathologies ngaphandle kwesifo sikashukela, kunesidingo sokuphathwa kanyekanye kwezidakamizwa ezahlukahlukene. Ukuhlanganiswa okunjalo akuvikelekile ngaso sonke isikhathi - yingxenye yokuthi kungani kunganconywa ukuzindla.

Lapho uthatha i-insulin ye-Glargin, ukuqapha kuyadingeka futhi, ngoba ukusetshenziswa kwayo kanyekanye nezinye izidakamizwa kungadala izinkinga. Ngakho-ke, udokotela kufanele aqaphele yonke imithi esetshenziswa isiguli.

Ingozi ukuthi ukuthatha imishanguzo ethile kungakhuphula umphumela we-hormone. Lokhu kuholela emphumeleni okwandayo emzimbeni futhi kudala ingozi ye-hypoglycemia.

Le mithi ifaka phakathi:

• ama-hypoglycemic agents ekuphatheni kwangaphakathi;
• Ama-inhibitors e-ATP;
• ama-salicylates;
• imicu;
• ama-antimicrobial agents wemvelaphi ye-sulfanilamide;
• i-monoamine oxidase inhibitors.

Ukusetshenziswa kwalezi zidakamizwa ngasikhathi sinye ne-insulin Glargin kuvunyelwe, kepha kuyadingeka ukunciphisa inani lezinto eziphathisiwe.

Uma usebenzisa ezinye izidakamizwa, kungabonakala ukuthobeka kwomphumela walesi sidakamizwa. Umphumela uba ukwehla kwekhwalithi yokulawulwa kokugxila kwe-glucose.

Phakathi kwale mithi yile:

• ama-estrogens;
• okokugcobisa;
• glucocorticosteroids;
• ama-antipsychotic (amanye);
• ama-hormone egilo.

Uma le mishanguzo ingakhanselwa, khona-ke ekwelashweni okusebenzayo udinga ukwandisa umthamo we-Insulin glargine.

Okuyingozi kakhulu ukuhlanganiswa okungabangela ukusabela okungalindeleki komzimba. Lapho usebenzisa umuthi ekubuzweni kanye nabakwa-beta-blockers, i-Pentamidine, Clonidine noma utshwala, umphumela wawo ungaqobisa futhi wande. Ngakho-ke, ukunakekelwa okukhethekile kuyadingeka ngalezi zidakamizwa nezinto.

Izici eziqhathanisayo ze-insulin Lantus neLevemir:

Kwesinye isikhathi kuye kudingekile ukuthi ungene esikhundleni se-Glargin nezinye izidakamizwa. Imvamisa isizathu salokhu ukungabekezeleleki kulo muthi, kodwa inani lentengo lomuthi nalo libhekwa njengesici esibaluleke ngokulinganayo.

Ungayifaka esikhundleni ngezidakamizwa ezinjenge-Lantus (intengo evela kuma-ruble ayi-690.00), uLantus SoloStar (kusuka kuma-ruble ayi-690,00), iTujeo SoloStar (kusuka kuma-ruble angama-951.00)

Udokotela kufanele asuse umuthi nge-analog yakhe ngemuva kokuhlolwa. Ukwenza lokhu ngokwakho akuvunyelwe.