Uhlobo 2 sikashukela i-mellitus yisifo esivamile se-multifactorial, esivezwa ukwephulwa kwe-carbohydrate metabolism. Indlela eyinhloko yokwelashwa umsebenzi womzimba, ukwelashwa kokudla, ukwelashwa ngezidakamizwa. Umuthi owodwa obekelwe uhlobo 2 lwesifo sikashukela yi-glibenclamide.
Imininingwane ejwayelekile mayelana nomuthi
I-Glibenclamide isidakamizwa esinciphisa ushukela esisetshenzisiwe emazweni ahlukene, ikakhulukazi eRussia, kusukela ekuqaleni kweminyaka yama-70s. Ungummeleli we-sulfonylurea derivatives (isizukulwane sesi-2). Umuthi usetshenziselwa ukwelapha isifo sikashukela sohlobo 2.
Umuthi owethulwe ukhombisa izakhiwo ezengeziwe ezizuzisayo zomzimba. Eminyakeni engama-45 eyedlule, izidakamizwa nezidakamizwa ezithuthukisiwe ezibulala izidakamizwa ngenqubo ehlukile yokusebenza ziye zavela emakethe yamakhemikhali. Kepha iGlibenclamide isaqokwa odokotela futhi ayilahli ukuhambisana kwayo.
Ngokungafani nabandulelayo bayo, umuthi ubekezelela futhi usebenza kakhulu. Kunqunyelwe lapho ungekho khona umphumela wokungalapheki kwezidakamizwa nokungamelana nezinye izidakamizwa.
Izakhiwo zamakhemikhali nokubunjwa
Umphumela wesidakamizwa yi-hypocholesterolemic, hypoglycemic. Kwandisa inani elidingekayo lokunyuka kwe-insulin yi-pancreas, kuvusa ngentshiseko umsebenzi wamaseli we-beta wezinto ezisetshenziswayo ze-islet. Umuthi uvimba iziteshi ze-potassium ezixhomeke (iziteshi ze-ATP).
Ukugqugquzelwa kwamagreyi asetshenziswa ngokufihlakala nge-insulin kwenzeka futhi, ngenxa yalokho, izinto eziphilayo zingena egazini kanye noketshezi olugeleza emzimbeni.
Ngaphezu kwesenzo esikhulu, into inomphumela we-thrombogenic futhi yehlisa i-cholesterol. Inikeza ukuqothuka okusheshayo nokumunyisa emgodini wokugaya ukudla. Ukuhlanganiswa kwamaprotheni e-plasma kwenzeka cishe ngokuphelele (98%). Umuthi ulolongwa esibindini. Ukuhlushwa okuphezulu egazini kufinyelelwa kungakapheli amahora ama-2.
Umuthi usebenza amahora angama-12. Isikhathi sokuphila ngemuva kokuphathwa ngomlomo singamahora ayi-7, siphela ngezinsuku ezingama-2-3. Igcotshwa ikakhulu nge-bile nomchamo. Ukwehla kokusebenza kwesibindi, ukuphuma kwethreyi kubambeka kancane, futhi ngokwehluleka kwe-renal ngokulinganayo, kunalokho, kuyanda.
Igama lezinto ezisebenzayo ngesiLatini yi-glibenclamide. Ukukhishwa ifomu: amaphilisi ayizicaba ayizicaba. Ngamunye uqukethe i-5 mg yento esebenzayo.
Izinkomba kanye ne-contraindication
Inkomba yokusetshenziswa: isifo sikashukela esinga-insulin, uma nje kungabikho mphumela wokulungiswa kwe-glucose ngokungalapheki kwezidakamizwa.
Contraindication ukusetshenziselwa kufaka:
- ukungabekezeleli into esebenzayo;
- ukungasebenzi kahle kwesibindi;
- imetabolism ngokuthambekela kwe-acidization yomzimba;
- i-precoma noma isifo sikashukela;
- ukukhulelwa
- umsebenzi wokuphazamiseka kwezinso;
- inkathi yokuhlanza;
- ukwehluleka okuphindaphindiwe kokwelashwa;
- isifo sikashukela esincike ku-insulin (DM 1);
- abantu abangaphansi kweminyaka eyi-18.
Imiyalo yokusebenzisa
Ukuguqulwa kwe-glibenclamide kwenziwa kahle, umuthi unqunywe ngamaphilisi ayi-0.5 ngosuku. Abantu asebekhulile abanama-organ dysfunctions bayanconywa ukuthi bandise umthamo ohleliwe kancane.
Lokhu kuyiqiniso ikakhulukazi kubantu abanesisindo esingama-50 kg. Ngosuku, umthamo ungama-2,5-5 mg wesidakamizwa (kuze kufike ku-1 ithebhulethi). Uma kunesidingo, engeza umthamo kancane kancane. Isimo sansuku zonke sifinyelela kumathebulethi amathathu.
Umuthi uphuzwa ngaphambi kokudla. Ngomthamo wethebhulethi engaphezu kwe-1, kunconywa ukulandela isilinganiso 2: 1 (ekuseni: kusihlwa). Ukwemukelwa kwenziwa ngasikhathi sinye ngaphandle kwekhefu elibukhali. Ngesikhathi sokwelashwa, isimo sokusebenza kwemetabolism siyabhekwa.
Ngokuqapha, umuthi kufanele usetshenziswe yile mikhakha elandelayo yeziguli:
- ukuguga;
- abantu abangasebenzi kahle isibindi;
- iziguli ezinomsebenzi we-thyroid oncishisiwe;
- ngezimpawu zesifo sokuqaqamba kwamabele.
I-Alcohol ngesikhathi sokulashwa ngendlela ehlelekile ingathinta i-ambiguidal - ukukhulisa noma ukwenza buthaka umphumela womuthi. Idayi E124 ibangela ukungezwani kweziguli ezisengozini. Uma noma yisiphi isifo (noma esivele sikhona) senzeka, kuyadingeka ukwazisa udokotela. Iziguli akufanele ziyeke ngokuzimela ukuthatha umuthi noma zilungise umthamo ngaphandle kokubonana nodokotela wazo.
Imiphumela emibi kanye ne-overdose
Phakathi kwemiphumela emibi ebaliwe:
- isisindo somzimba;
- ukugabha, isicanucanu, usizi emgodini wokugaya ukudla, uhudo;
- i-pruritus, i-rash, i-anemia;
- ukungasebenzi kahle kwesibindi;
- ukukhuphuka kwamapharamitha we-biochemical;
- ukungaboni kahle
- i-hypoglycemia;
- ukungahambi kahle komzimba;
- thrombocytopenia, leukocytopenia, erythrocytopenia, granulocytopenia;
- umphumela wokuqina obuthakathaka.
I-overdose (ukukhula isikhathi eside kwezinga elincane noma lesikhathi esisodwa) ezimweni eziningi kuholela ku-hypoglycemia.
Izimpawu zayo yilezi:
- ukujuluka
- indlala yesikhumba;
- ukukhuluma okungahambi kahle nokuzwela;
- izibuko, amakhaza;
- ngesimo esithuthukayo - i-hypoglycemic coma.
Ezimweni ezinzima, kuyadingeka ukuthi uhlambe isisu bese ufaka umjovo weglucose. Uma kunesidingo, i-glucagon iyabhalwa. I-hypoglycemia emnene ingaqedwa ngokwayo ngokudla ushukela.
Ukuxhumana neminye imithi kanye nama-analogues
Imithi ekhulisa umphumela weGlibenclamide ifaka phakathi: iMiconazole, imithi elwa nama-tetracycline, ama-anabolic steroid, ama-antidepressants, ama-insulin kanye nezidakamizwa ezinesifo sikashukela, ama-hormone abesilisa.
Imithi enciphisa lo mphumela ifaka phakathi: ama-hormone egilo, ama-corticosteroids, ama-nicotinates, ama-glucagon, ama-beta-andrenoblockers, ama-hormone ocansi abesifazane, ama-diuretics, ama-barbiturates.
Imithi engathinta i-glibenclamide ngenkani (ikhulisa noma, ngokuhlukile, ephansi) ifaka: I-Clonidine, i-Reserpine, i-H2 receptor blockers, i-pentamidine.
Imithi yesenzo esifanayo:
- i-analogue ephelele yiManinil (into esebenzayo iyafana);
- iqembu lezidakamizwa eline-glimepiride - Amapirid, Amaril, Glibetic, Glimax, Diapride;
- amalungiselelo neGliclazide - Glidia, Glicada, Gliclazide, Diagnizid, Panmicron-MV;
- Izimali no-Glipizidom - Glynez, Minidiab.
Izinto zevidiyo ezivela kuDkt Malysheva mayelana nemikhiqizo enciphisa ushukela kushukela futhi ingasetshenziswa njengesengezo emithini:
Imibono yesiguli
Ukusuka ekubuyekezweni kweziguli ezithatha i-Glibenclamide, singaphetha ngokuthi intengo yomuthi ingabizi impela futhi yehlisa ushukela kahle, kepha ngemuva kokuwusebenzisa, imiphumela emibi ivame ukuvela esimweni sokucanuzelelwa kwenhliziyo kanye nokulahlekelwa isifiso sokudla.
Sekuphele iminyaka engu-12 ngigula nginesifo sikashukela. Kwabekwa izidakamizwa ezahlukahlukene, kodwa uGlibenclamide wazibonakalisa efanele kakhulu. Ekuqaleni belashwa nge-Metformin - akubanga namiphumela ekhethekile ekujwayiseni ushukela ngisho nangemva kokuphakamisa umthamo. Ngemuva kokukhishwa kwe-Glibenclamide. Imiphumela emibi ngendlela yokulahlekelwa isifiso sokudla kanye ne-nausea yayisenyangeni yokuqala, khona-ke konke kubuyela kokujwayelekile. Izinga likashukela ngokusetshenziswa komuthi liyancipha futhi ligcina kungakapheli u-6. Ngesikhathi sasemini ngizizwa ngijwayelekile, futhi kuyathandeka.
U-Irina, oneminyaka engama-42, uSamara
Umama wami usanda kuthola isifo sikashukela sohlobo 2. Udokotela obekhona washeshe wamyalela uGlibenclamide futhi wanikeza umuthi. Esikhathini esingangesonto ngemuva kokusetshenziswa kwaso, ngaqala ukuzizwa ngicanuzelelwa inhliziyo futhi ngiphelelwe yisifiso sokudla. Kepha, njengoba esho, lokhu akubalulekile ngokuqhathaniswa neqiniso lokuthi i-glucose igcinwa ku-6-7. Ngesikhathi sokuthola ukwelashwa, kuyadingeka ukulawula amapharamitha wesibindi ngaphezu kwezinga le-glucose. Kepha umama, kanye noGlibenklemin, bazizwa belungile.
USergey, oneminyaka engama-34, eYekaterinburg
Ushukela wami uneminyaka engaba yisithupha ubudala. Ngokwemvelo, ushukela awukwazanga ukuguqulwa. Kwakufanele ngithathe umuthi. Ngizwa umphumela kuphela uvela ku-Glibenklemin - ushukela wehliselwa ku-6.5. (Ngihlala ngisebenzisa imitha). Ngaphambi kwalapho, angikwazanga ukufeza inkomba enjalo isikhathi eside, ngaphansi kuka-7 ushukela akukaze kwehle. Ekugcineni ngabamba isidakamizwa sami. Ekuqaleni ngathola isisindo esincane, kodwa ngemuva kwalokho ngaguqula indlela engidla ngayo. Phakathi kwemiphumela emibi: ngezikhathi ezithile isicanucanu, ngezikhathi ezithile - isifo sohudo kanye nokuphelelwa yisifiso sokudla.
U-Oksana, oneminyaka engama-51, uNizhny Novgorod
Intengo yesidakamizwa sokuqala isukela kuma-ruble angama-90 kuye kwangama-120. Umuthi usatshalaliswa kuphela ngomuthi odingekayo.
I-Glibenclamide iyisidakamizwa esisebenza kahle sokwehlisa amazinga kashukela. Ibekiwe ngodokotela ngentshiseko futhi ayilahli ukuhambisana kwayo, yize kutholakala izidakamizwa zesampula entsha.
