I-Augmentin iyi-antibiotic yokuhlanganisa yesimanje. Iyatholakala ngesimo samathebulethi, i-powder yokulengiswa, isixazululo somjovo. I-Augmentin Syrup iyona kuphela ifomu elingatholakali.
Amafomu akhona akhishwe kanye nokwakheka
Izinto ezisebenzayo zomkhiqizo yi-amoxicillin ne-clavulanic acid.
Ithebhulethi liqukethe (i-amooticillin trihydrate + clavulanic acid, mg):
- 250 + 125;
- 500 + 125;
- 500 + 125;
- 875 + 125.
Izibhebhe zi-oval, zimhlophe noma ziphuzi. Ngaphambili kukhona umbhalo othi "Augmentin", "AC" noma "A", "C". Ngesikhathi sekhefu, zimhlophe noma ziphuzi.
I-Augmentin iyi-antibiotic yesimanje ehlanganisiwe, etholakala ngesimo samathebulethi, i-powder yokulengiswa, isixazululo somjovo.
Amandla wokumiswa. Umuthi umhlophe. Kuyatholakala kuzinguqulo ezinje (kususelwa ku-5 ml):
- i-amoxicillin trihydrate: 125 mg, 200 mg, 400 mg;
- i-clavulanic acid: 31.25 mg, 28,5 mg, 57 mg.
Okuqukethwe kwezakhi ezisebenzayo ku-powder kulungiswa isisombululo sezokuphatha i-iv (i-amoxicillin + clavulanic acid, mg):
- 500 + 100;
- 1000 + 200.
Igama Lezwe elingafanele
INN: amoxicillin + clavulanic acid / amooticillin + clavulanic acid.
I-ATX
I-J01CR02 Amoxicillin ehambisana ne-beta-lactamase inhibitor.
Isenzo se-Pharmacological
I-Amoxicillin iyasebenza ngokulwa namagciwane amaningi angena gram kanye nama-gram-negative. Kepha ubhujiswa yi-beta-lactamase - i-enzyme evikelwe ngamagciwane. Umuthi olwa namagciwane uqobo awubhubhisi ama-bacterium anjalo. Ingxenye yesibili yi-clavulanic acid, ebhubhisa izigaba 2-5 beta-lactamases. Isebenzisana ne-enzyme futhi iyayisebenzisa. Umsebenzi we-Amoxicillin uyabuyiselwa.
Ezinkinobhweni emuthini: zinhlobo Acinetobacter, Enterobacter, Mycoplasma, Providencia, Pseudomonas, Serratia, futhi Citrobacter freundii, Coxiella burnetti, chlamydia pneumoniae, chlamydia psittaci, Hafnia alvei, Legionella pneumophila, Morganella morganii, Stenotrophomas maltophilia, Yesinia enterolitica.
I-Pharmacokinetics
Izithako ezisebenzayo zithakwa ngokuphelele futhi ngokushesha zisuka ohlelweni lokugaya ukudla lapho zithathwe ngendlela yomlomo.
Izinto ezisebenzayo zibopha kabi amaprotheni e-plasma - 18% amoxicillin ne-25% clavulanate. Indlela enkulu yokususa i-renal. Emahoreni okuqala ayi-6 ngemuva kokungena, iningi lezinto ezisebenzayo (60-70%) zishiya umzimba ngomchamo ungashintshiwe.
Izinkomba zokusebenzisa i-Augmentin
Umuthi ukhonjelwa izifo ezithathelwa esikhumbeni nezicubu ezithambile, amathambo, amalunga. Ku-gynecology, isetshenziselwa ukutheleleka komgudu wokuzala kanye nezitho zangasese zabesifazane.
I-Augmentin isebenza kahle kwizifo zepheyisi yokuphefumula engenhla nephansi, izifo zokuvuvukala zezitho ze-ENT (bronchitis, tonsillitis, sinusitis, pneumonia), kufaka phakathi lezo ezikhula njengezinkinga ngemuva komkhuhlane noma i-SARS.
Izinto ezisebenzayo ziyasebenza nge-sepsis: i-intra-isisu, ngemuva kokuhushula isisu, ukuzala kwengane ne-peritonitis. Ithuluzi lisetshenziselwa izinjongo ze-prophylactic ngemuva kokusebenza, ngesikhathi sokufakwa okuhlanganisiwe.
Kungenzeka yini ngesifo sikashukela
U-Augmentin ubekezeleleka kahle kulesi sifo.
Contraindication
Ngokusho kwemiyalo u-Augmentin uphinyiselwe kulezo zimo:
- i-hypersensitivity kwenye yezakhi zemithi elwa nezidakamizwa noma ze-beta-lactam;
- Ukwelashwa okwedlule kwe-jaundice, ukungasebenzi kahle kwesibindi okwenzeka ngaphambili nokusetshenziswa kwe-amoxicillin kuhlangene ne-clavulanate.
Okunye ukwephulwa:
- nge-powder - phenylketonuria, 200 + 28,5 mg, 400 + 57 mg - umsebenzi wezinso ongasebenzi kahle nge-creatine imvume ukufika ku-30 ml / min;
- zamathebulethi - isisindo somzimba kuze kufike ku-40 kg, kumthamo we-875 + 125 mg - umsebenzi wezinso ongasebenzi kahle nge-creatine imvume ukufika ku-30 ml / min.
I-Augmentin ngefomethi yethebhulethi akufanele ithathwe ngabantu abanesisindo esingaphansi kwama-40 kg.
Ungamthatha kanjani u-Augmentin
Umthamo ukhethwe udokotela. Kufanele kukhunjulwe ukuthi amaphilisi ama-2 we-250 + 125 mg awafani no-500 + 125 mg. Ukwehlisa umthwalo emgodini wokugaya ukudla, umuthi uphuzwa ngomlomo ngaphambi kokudla.
Ukumiswa kwalungiswa ngaphambi kokuqala kokusebenzisa. I-powder ixutshwe no-60 ml wamanzi abilisiwe t ° + 20 ... 22 ° C ngqo ebhodleleni bese inyakaziswa kuze kube bushelelezi, shiya imizuzu eyi-5. Kufakwa amanzi amaningi ukuze ivolumu yokumiswa ifane nelebula ku-vial. Ngaphambi kokwamukelwa ngakunye, isitsha siyanyakaziswa. Linganisa kahle ukumiswa nge-cap kusuka kit.
I-Powder yokuphathwa kwe-intravenous ifakwa emanzini ngomjovo, isisombululo se-sodium chloride (0.9%), izixazululo ze-Ringer noma zeHartman. Isixazululo sihanjiswa ngaphakathi kwejet noma i-drip.
Zingaki izinsuku okufanele uthathe
Inkambo encane iyizinsuku ezi-5. Inkambo engaphezulu kwezinsuku eziyi-14 ngaphandle kokuhlolwa kwesimo sesiguli ayemukeleki.
Isixazululo sihanjiswa ngaphakathi kwejet noma i-drip.
Imiphumela emibi ye-Augmentin
Udokotela kufanele axwayise isiguli ngemiphumela emibi yomuthi. Lokhu ukusabela kokungezwani komzimba, kufaka phakathi i-anaphylaxis, i-candidiasis yolwelwesi lwama-mucous nesikhumba.
Amapheshana wesisu
Ukuphendula okuhlukile kwesisu:
- isicanucanu ku-doses ephezulu, isifo sohudo, ukugabha;
- ulimi olumnyama "olunezinwele", i-stomatitis, ezinganeni - ukubekwa kwamazinyo (ukuvimbela - ukunakekela umgodi womlomo);
- i-gastritis.
Izitho zeHematopoietic
I-leukopenia, neutropenia, thrombocytopenia, anemia, kufaka phakathi i-hemolytic, i-eosinophilia ne-thrombocytosis, akuvamile ukuba ikhule. Ukopha isikhathi eside kungenzeka.
Isistimu yezinzwa ephakathi
Isiyezi, i-cephalgia, ukuqina kwethambo, ukuquleka (ikakhulukazi ngomsebenzi wezinso ongasebenzi kahle nokuqokwa komthamo omkhulu), ukuqwasha, ukuguquka kokuziphatha, izimo ezikhathazayo azivamile.
Kusuka ohlelweni lomchamo
Kuyaqabukela, i-nephritis e-interstitial kanye ne-crystalluria, i-hematuria.
Isikhumba nolwelwesi lwe-mucous
Ukulunywa kungenzeka, i-rash, i-urticaria. I-Erythema, i-necrolysis enobuthi, i-pustulosis ebaluleke kakhulu, uStephen-Jones cider, i-dermatitis enobuthi exakile. Ezimweni ezinjalo, ukwelashwa kuyamiswa.
Kusuka ohlelweni lwezinhliziyo
Akucacisiwe.
Engxenyeni yesibindi ne-biliary
Ukwenza kusebenze kwe-AST, ALT kungabandakanywa. I-Hepatitis, kufaka phakathi i-cholestatic, akuvamile ukuba ikhule, kanye nokunyuka kwe-bilirubin ne-alkaline phosphatase. Ukuphazamiseka esibindini kuvame ukuqoshwa emadodeni, kuyaqabukela ezinganeni. Izimo ezifakwe kuhlu ziyaphindiselwa. Ezimweni ezingavamile, kufa.
Imiyalo ekhethekile
I-antibiotic ayisetshenziselwa i-mononucleosis esolisayo, ngoba i-amooticillin kwesinye isikhathi ibangela ukuqubuka okufana nesimungumungwane futhi yenza kube nzima ukutholwa. Njengomphumela wokwelashwa okuhlala isikhathi eside, ukumelana kwama-antiotic kwamagciwane kwenzeka. Ngaphambi kokuqokwa, isimo sezinso, isibindi, ukwakheka kwegazi kuyahlolwa.
Lapho kuthathwa ngomlomo, ukugcwala kwe-amoxicillin kumchamo kuyanda, okuholela emaphutheni ekulinganiseni ukugcwala kwe-glucose kumchamo.
Sebenzisa ebudaleni
Iziguli ezinje azishintshisi umthamo, ngaphandle kweziguli ezingasebenzi kahle izinso.
Isabelo sezingane
Amacwecwe awabekelwe izingane ezingaphansi kweminyaka engu-12. Ukumiswa kwama-200 + 28,5 mg, ama-400 + 57 mg kubekwe ngemibono kwezingane ezisanda kuzalwa kufinyelela ezinyangeni ezi-3.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi okhulelwe awunqunyelwe, ikakhulukazi ku-trimester yokuqala. Okuwukuphela kokwehluka kuyizimo lapho inzuzo kumama inkulu kunobungozi enganeni. Ucwaningo luye lwabonisa ukuthi i-amooticillin ne-clavulanate zinqamula kwi-placenta.
Umuthi udlula ubisi lwebele. Lapho usebenzisa umkhiqizo ezinganeni, kuqubuka uhudo noma i-candidiasis ye-mucosa yomlomo ingavela.
Ukuhambisana notshwala
U-Augmentin akahambisani notshwala.
U-Augmentin akahambisani notshwala.
Umthelela ekhonweni lokulawula izindlela
Kunconywa ukwenqaba ukushayela.
Isicelo sokusebenza kokulimala kwezinso
Umthamo uguqulwa ngokuya ngamanani avumayo womuthi namandla okuhlanza izinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Iziguli ezinjalo ziyaqashelwa, ukwelashwa kwenziwa ngokuqapha.
Ukweqisa
Imithamo ephakeme kunaleyo ephakanyisiwe yokumba ukugaya kanye nebhalansi kasawoti wamanzi. I-Amoxicillin crystalluria iyakhula, kwesinye isikhathi okuvusa inkathazo yesibindi.
Ukwelashwa kuqukethe ukuqeda izimpawu, ukubuyisa ibhalansi yama-electrolyte. I-Hemodialysis isusa izinto ezisebenzayo.
I-Hemodialysis isusa izinto ezisebenzayo uma kungenzeka kusetshenziswe ngokweqile.
Ukuxhumana nezinye izidakamizwa
Ukuhlanganiswa nezidakamizwa ezinjalo kungaba yingozi:
- i-probenecid;
- i-allopurinol;
- methotrexate;
- izindlela zokuvimbela inzalo ngomlomo.
Ingangezela i-INR uma ihlanganiswa ne-acenocoumarol noma i-warfarin. Uma kunesidingo, qapha i-PV ne-INR, lungisa umthamo wama-anticoagulants.
Ama-Analog
Ukulungiselela okunengoma efanayo:
- Panklav;
- I-Amoxiclav;
- Flemoklav.
Imibandela yekhefu lekhemisi
Udinga iresiphi ongayithenga.
Intengo
Izindleko ze-Augmentin:
- i-powder yokumiswa - kusuka kuma-ruble ayi-152;
- amaphilisi - kusuka kuma-ruble angama-286;
- i-powder yokuphathwa kwe-intravenous - kusuka kuma-ruble ayi-120.
Izimo zokugcina zomuthi
Ngamathebhulethi kanye ne-powder yokuphathwa kwe-intravenous, izinga lokushisa lika + 25 ° C livunyelwe. Ikhithi losizo lokuqala libekwa ezindaweni lapho izingane zingakwazi ukufinyelela. Ukumiswa kugcinwa esiqandisini, ungabi yiqhwa.
Isikhathi sokuphelelwa yisikhathi
Usuku lokukhiqiza nesikhathi sokusetshenziswa kukhonjisiwe kwiphakheji nakuzo imiyalo. Ukumiswa okuqediwe akulungile ngaphezu kwezinsuku eziyi-7 kusukela ngosuku lokulungiswa. Amatafula apakishwe ku-foam aluminium foil kufanele asetshenziswe kungakapheli izinsuku ezingama-30 kusukela esikhathini sokuvula. Isixazululo se-ampoules sisetshenziswa ngokushesha.
Umkhiqizi
USmithKlein Beech PiC, e-UK.
Ukubuyekezwa
Odokotela
U-Utochkina, udokotela odokotela, uSyzran: "U-Augmentin umuthi osebenzayo. Kepha ufaka ingcindezi esibindini nasezinso, ngakho-ke kufanele kuthathwe kuphela ngaphansi kokuqondisa udokotela."
U-A. Naumov, udokotela ohlinza amazinyo, u-Orekhovo-Zuevo: "Nginikeza lesi sidakamizwa kwiziguli ngaphambi kokuhlinzwa endaweni yomlomo njengokuvimbela izinkinga."
Iziguli
U-Elena, oneminyaka engama-55, uRamenskoye: "U-Augmentin uthathe i-sinusitis eyingozi. Kuhlanganiswe nokuxubha impumulo nokufakwa. Isimo saba ngcono ngemuva kokuthatha amaphilisi amathathu."
U-Alesia, oneminyaka engama-32, u-Perm: "Udokotela ubeke lesi sidakamizwa i-sinusitis. Ngemuva kwepilisi lesibili, ukuqaqamba nobuthakathaka, kwavela uhudo."
UDiana, oneminyaka engu-26 ubudala, uVoronezh: "Ngithathe umuthi we-cystitis njengoba kuchaziwe ngudokotela wezifo zamazinyo. Ezinsukwini ezintathu ngemuva kokuqala kwekhosi, ukulunywa umzimba wonke wavela, yize bengingakaze ngibe nokungezwani komzimba ngaphambili.
