I-Novapim iyi-antibiotic ebanzi ebanzi esetshenziswa ekwelapheni izifo ezithathelwanayo zokuphefumula, uhlelo lwezitho zofuzo kanye nezinombolo zesikhumba.
Igama Lezwe elingafanele
Isikhathi sasekuseni.
I-ATX
I-J01DE01 - ama-ejenti we-cefepime antimicrobial agents.
I-Novapim iyi-antibiotic ebanzi ebanzi esetshenziswa ekwelapheni izifo ezithathelwanayo zokuphefumula, uhlelo lwezitho zofuzo kanye nezinombolo zesikhumba.
Khipha amafomu nokwakheka
I-antibiotic ikhiqizwa ku-powder, lapho kulungiswa khona isisombululo somjovo. Umbala wempuphu umhlophe noma uphuzi okhanyayo. Isixazululo esiphelile sivele sobala, siphuzi.
Izinto eziphambili yi-cefepime chloride ne-L-arginine 500 mg noma i-1000 mg ngayinye.
Isenzo se-Pharmacological
Lesi sidakamizwa esilwa ne-antibacterial esiseqenjini le-IV isizukulwane se-cephalosporins. Kukhombisa ukusebenza kahle ngokumelene namagciwane angama-gram-positive ne-gram-negative. Isenzo somuthi ukwehlisa izinqubo zokwenziwa ku-membrane yeseli:
- ama-aerobes wegrama-i-gram-positive: ama-Streptococcus viridans, iStaphylococcus epermidis, iStaphylococcus aureus, kanye nezinye izinhlobo ze-staphylococci;
- ama-gram-negative aerobic microorganisms: Serratia, Acinetobacter calcoaceticus, Staphylococcus epidermidis, H. rarainfluenzae;
- ama-anaerobic pathogens: I-Mobiluncus spp, Clostridium perfringens.
I-Novapim ikhombisa ukusebenza kahle kokulwa namagciwane angena gram kanye ne-gram-negative.
I-Pharmacokinetics
Ngemuva kokuphatha, umuthi usatshalaliswa ngokuphelele emzimbeni wonke. Ukuhlushwa kwe-Plasma kuncike eminyakeni yobudala nesiguli. Ukwelashwa okuphathelene nesikhathi senkomo ngemuva kokujovwa umjovo owodwa ku-bile, umchamo, secretion okhiqizwe yi-bronchi, ezithweni ezithambile ze-prostate gland kanye ne-appendicitis. Amaphesenti okubopha kwe-antiotic kumaphrotheni e-plasma aze afike ku-19%.
Isikhathi esidingekayo sengxenye yempilo singamahora ama-2, kungakhathalekile umthamo. I-Excretion evela emzimbeni yenziwa ngokuhlunga i-renal glomeruli, cishe ama-85% wesikhathi sasemuva akhishwa emzimbeni ngomchamo.
Izinkomba zokusetshenziswa
Kunqunyelwe ekwelashweni okuyinkimbinkimbi ezimweni ezilandelayo zomtholampilo:
- izifo ezithathelwanayo zezitho ezingezansi zohlelo lokuphefumula;
- i-bronchitis;
- inyumoniya;
- izifo ezithinta umchamo;
- ukulimala kwezinso okungatheleleki, ukuthuthukiswa kwe-pyelonephritis emnene;
- ukulimala kwesikhumba ngamagciwane;
- ukutheleleka kwezicubu ezithambile;
- ukutheleleka kohlobo lwe-intra-esiswini, kufaka phakathi amacala e-peritonitis nezifo zamapheshana angumgogodla;
- febrile neutropenia;
- i-septicemia - ukungena kwezifo ungene egazini.
Iphinde isetshenziselwe ukwelapha iziguli ezinomkhuhlane we-neutropenic ngesizathu esingaziwa sesifo.
Izinkomba zokusetshenziswa kwamagciwane ezilwa namagciwane ezingane zingokulandelayo: inyumoniya, i-pyelonephritis, i-bacterial meningitis.
Contraindication
Kwenqatshelwe ukuthatha i-antibiotic kubantu abanokungabekezelelani komuntu ngamunye ezingxenyeni ezithile zomuthi nokuzwela kuma-antibacterial agents weqembu le-cephalosporin.
Ngokunakekela
Imiyalo yokusebenzisa isexwayisa nge-contraindication ehlobene nokusetshenziswa kwe-antibiotic - isifo sohlelo lokugaya ukudla. Ukuqapha ngokweqile kuyadingeka lapho usebenzisa umuthi ngabantu abane-colitis, kungakhathalekile ukuthi hlobo luni. Kulokhu, ukuthatha i-antibiotic kuvunyelwe kuphela uma umphumela omuhle wokusebenzisa kwayo udlula ubungozi bokuqhamuka nezinkinga ezingakhona.
Ungayithatha kanjani iNovapim?
Imijovo ye-antibiotic inikezwa ngokungena ngaphakathi noma emzimbeni. Umthamo kanye nendlela yokuphatha kunqunywa ngawodwana.
Isilinganiso esinconyelwe ngokwesilinganiso seziguli ezindala:
- ukutheleleka kohlelo lwe-genitourinary, kungakhathalekile ukuthi lubucayi kangakanani: kusuka ku-500 mg kuya ku-1 g, olimale intramuscularly noma ngaphakathi emzimbeni njalo emahoreni ayi-12;
- izifo zesikhumba: 2 g ngokuxhunywa ngaphakathi kokuphumula kwamahora ayi-12;
- ukutheleleka kwezicubu ezithambile: 2 g ngokungena kabili ngosuku;
- induna: kusuka ku-1 kuye ku-2 g nge-intravenly njalo emahoreni ayi-12;
- ukutheleleka kwe-intra-isisu: 2 g ukungena emzimbeni;
- Ukwelashwa kwe-febrile neutropenia: 2 g ngokungena ngaphakathi kwamahora ayi-8.
Imijovo ye-antibiotic inikezwa ngokungena ngaphakathi noma emzimbeni.
Sebenzisa i-Novapim njenge-prophylactic ukuvikela ukutheleleka ngemuva kokungenelela kokuhlinzwa: Ihora eli-1 ngaphambi kokuhlinzwa, yazisa umuthi ongu-2 g, bese nesixazululo seMetronidazole (500 mg).
Ngoshukela
Umthamo unqunywa ngamunye ngokuya ngokuqina kwecala lomtholampilo noma ngokuya ngohlobo lwama-antibiotic anconywayo.
Imiphumela emibi yeNovapima
Ukwephulwa komthamo noma imithetho yokuphatha kubangela ukusabela okungathandeki:
- Uhlelo lomzimba: izimpawu ezandisiwe ze-hypersensitivity. Akuvamile - anaphylaxis, ukuthuthukiswa kokuthuthumela kwe-angioedema.
- Ipheshana esiswini: isicanucanu nokuhlanza, ukuthuthukiswa kwe-candidiasis yolwelwesi lwamafinyila lomlomo wesibeletho, isisu sohudo. Okuncane kakhulu - ukubukeka kwe-pseudomembranous colitis, ukuqunjelwa, ukuhlanekezela kokuqonda ukunambitheka.
- Isistimu yezinzwa ephakathi nendawo: ukukhanda ikhanda nesiyezi, ukuphazamiseka kokulala, ukuguquka kwengqondo. Akuvamile - ukuthuthukiswa kwe-encephalopathy, ukuhoxa. Kuyaqabukela - ukubonakala kwama-hallucinations, ikhefana, i-stupor.
- Ukutheleleka: ukukhula kwe-superinfection, i-vaginitis, i-candidiasis yangasese.
- Inhliziyo nesistimu ye-vascular: ukubonakala kwe-tachycardia, izinhlungu emisipha yenhliziyo, i-edema yangaphandle.
- Uhlelo lwe-Lymphatic: i-thrombocytopenia, i-anemia, uhlobo lwesikhashana lwe-leukopenia, i-eosinophilia.
- Uhlelo lokuphefumula: ukukhwehlela owomile, ukufushane komoya, ubuhlungu umphimbo lapho ukugwinya.
- Izitho zomchamo: kuyaqabukela - ukukhula kokwehluleka kwezinso.
Ezinye izimpawu eziseceleni ezingenzeka ngenkathi uthatha i-Novapim: i-hemolytic hlobo anemia, ukusebenza kwesibindi okungajwayelekile, ukubonakala kwe-cholestasis, i-nephropathy enobuthi.
Umthelela ekhonweni lokulawula izindlela
Kungavusa ukwanda kwesilinganiso sokuphendula kohlobo lwe-psychomotor, maqondana nalokho kunconyelwa ukwenqaba ukushayela imoto nokusebenza ngamasu ayinkimbinkimbi.
Imiyalo ekhethekile
Ungafaka kuphela isisombululo esisanda kulungiswa somjovo. Umuthi usetshenziswa ngokucophelela ngokuhambisana nezinye izidakamizwa ze-antibacterial, ngenxa yezingozi eziphezulu zokuqhakambisa izimpawu ze-hypersensitivity.
Ukugcwala kwama-antibiotic ku-plasma yegazi emadodeni anolawulo olulodwa kuphakeme kunabesifazane.
Ngemuva kwe-hemodialysis amahora ama-3, ngaphezu kwe-68% yomthamo owamukelekile we-antibiotic ukhishwa emzimbeni, ngenxa yalokho, ukuphathwa okuphindaphindiwe komthamo obekiwe ngemuva kweseshini ngasinye kuyadingeka.
Isikhathi sokwelashwa sisuka ezinsukwini eziyisikhombisa kuya kweziyi-10. Ngenkambo enkulu yokutheleleka ngesithombe esibonakalisiwe, inkambo yokwelashwa inganwetshwa.
Ngomjovo we-intramuscular we-antibiotic, kunconywa ukuthi uguqule indawo yomjovo njalo ukuze uvikeleke ukubonakala kobuhlungu bemisipha nokuvuvukala.
Sebenzisa ebudaleni
Iziguli eziseqenjini leminyaka yobudala engama-65, uma kungekho okuphambukayo ekusebenzeni kwezinso, asikho isidingo sokulungisa umthamo.
Isabelo sezingane
Ukuqashwa njalo kwesimo sempilo sezingane ezinesisindo somzimba esingaphansi kwama-40 kg esibekiwe ngaleli gciwane kuyadingeka. Ngezifo zezinso noma zesibindi, umthamo ophakanyisiwe kufanele unqanyulwe.
Esigabeni sobudala kusukela ezinyangeni ezi-1 kuye kwezingu-2, i-antibiotic inqunywa kuphela ngokuya ngemiyalo ekhethekile. Umthamo ungama-30 mg kilo nganye yesisindo somzimba, ophathwe njalo emahoreni ayi-8 noma ayi-12, ngokuya ngamandla kwenkambo yesifo esithathelwanayo. Imithamo yezingane enesisindo esisuka ku-40 kg ngu-100 mg nge-kg yesisindo ngosuku (50 mg njalo ngamahora angama-8-12).
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ayikho imininingwane ngokuphepha kokusetshenziswa kwama-antibiotic kwabesifazane abakhulelwe nangesikhathi sokuqunjelwa. Njengoba kunikezwe ubungozi obungahle bube nomphumela ongemuhle kuzungu lengane, akunikezwa umuthi.
Uma kuwukuphela kwesidakamizwa esinganikeza umphumela owufunayo wokwelapha kwabesifazane asebekhulile, ukunqunyelwa komzimba kumele kuphazanyiswe isikhathi sokulashwa.
Isicelo sokusebenza kokulimala kwezinso
Ezigulini ezinokuphambuka ekusebenzeni kwezinso, uma imvume ye-creatine ingafika kuma-30 ml ngomzuzu, umthamo omaphakathi we-antibiotic kufanele unqanyulwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Umthamo onconyiwe uyancishiswa.
Ukweqisa okweqile kweNovapim
Liziveza ngokwanda kokuqina kwezimpawu eziseceleni. Ukwelapha ngokweqile kuyimpawu. Ngokuthuthukiswa kokuphendula kwe-anaphylactic, ukuphatha ngokushesha kwe-adrenaline kuyadingeka. Ngomthamo omkhulu we-antibiotic esegazini (ngokususwa kwawo ngokushesha emzimbeni), i-peritoneal dialysis iyadingeka.
Ukuxhumana nezinye izidakamizwa
Isixazululo esihambisanayo se-antibacterial nezixazululo ezinjalo: 0,9% sodium chloride, 10% ushukela wekhambi, isixazululo sikaRinger.
Akunconyelwe ukuthathwa ngasikhathi sinye neGentamicin Sulfate, Vancomycin, Metronidazole.
Ukusetshenziswa kanyekanye kweNovapim ngama-aminoglycosides nama-diuretics kukhishwe. Le nhlanganisela iholela ekwakhiweni komphumela we-nephrotic.
Ukuhambisana notshwala
Iziphuzo eziqukethe utshwala nezine-alcohol zenqatshelwe ngokuphelele ngesikhathi sokwelashwa ngemithi elwa namagciwane.
Ama-Analog
Imithi enobubanzi besenzo esifanayo: I-Abipim, iMaxicef, iPiccef, iFocepim, iCefuroxime, iCefi.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Akuthengiswa ngaphandle kwefomu lokuyalelwa.
Intengo yeNovapim
Izindleko zomuthi zivela kuma-ruble angama-75.
Izimo zokugcina zomuthi
Amazinga okushisa aze afike ku- + 25 ° С.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
ILupine Limited, eNdiya.
Ukubuyekezwa mayelana neNovapima
UMarina, oneminyaka engama-35, uVorkuta: "Lesi yisithasithabazi esisusa ngokushesha zonke izinkomba zokutheleleka. Kepha sinenkinga enkulu - imijovo ibuhlungu kakhulu. Ungafaka umjovo weLidocaine kuphela. Nokho, leli yithuluzi elisebenzayo, futhi ngentengo ephansi."
UKsenia, oneminyaka engama-41, u-Perm: “Imijovo kaNovapim yanqunywa ngudokotela ukuba aphathe amathumba ebusweni nasemzimbeni, ngoba ngahlupheka iminyaka eminingi, kepha akukho okusizile. Inkambo yokwelashwa ngemithi elwa namagciwane yahlala izinsuku eziyi-10, imijovo yayibuhlungu, kodwa ibekezeleleka neLidocaine. Iminyaka engu-1.5 ngemuva kokwelashwa, kepha kuze kube manje azikho izibilini ezivelile. "
U-Eugene, oneminyaka engama-38, uDnipro: "Umfowethu uthathe le-antibacteria ukwelapha isifo esibuthaka njenge-gonorrhea. Konke kwahamba ngesonto, ezinye izinsuku ezingama-3 wenza imijovo ye-prophylaxis ukuqeda ngokuphelele ukusulelwa yilesi sifo. ikhanda kwesinye isikhathi lalihlukumezeka ngezikhathi ezithile. Ngaphandle kwalokhu, umuthi olwa namagciwane ulungile, ungabizi futhi uyasiza ngokushesha. "
