Isibalo sezidakamizwa ezinciphisa ngempumelelo umfutho wegazi futhi uzigcine zisezingeni elifanele zifaka i-Telsartan 40 mg. Izinzuzo zomuthi: ukuthatha ithebhulethi engu-1 ngosuku, ubude besikhathi somphumela we-antihypertensive, akunamphumela ekushweni kwenhliziyo. Izinkomba zegazi le-systolic ne-diastolic ngangokunokwenzeka zincipha ngemuva kwenyanga yokusebenzisa umuthi njalo.
Igama Lezwe elingafanele
I-Telmisartan
Isibalo sezidakamizwa ezinciphisa ngempumelelo umfutho wegazi futhi uzigcine zisezingeni elifanele zifaka i-Telsartan 40 mg.
I-ATX
Ikhodi: C09DA07.
Khipha amafomu nokwakheka
Umuthi uyithebulethi emhlophe evulekile ngaphandle kwegobolondo, i-convex nhlangothi zombili. Engxenyeni engenhla ngakunye kwabo kunobungozi bokuhlephula kanye nezinhlamvu "T", "L", ezansi - inombolo "40". Ngaphakathi, ungabona izingqimba ezi-2: enye inombala opinki ngombala wokuhlukahluka okuhlukahlukene, enye icishe ibe mhlophe, ngesinye isikhathi ibe nezimpawu ezincane.
Ku-1 ithebhulethi yesidakamizwa esihlanganisiwe - i-40 mg yesithako esiyisisekelo esisebenzayo se-telmisartan no-12,5 mg we-hydrochlorothiazide diuretic.
Izakhi ezisizayo nazo ziyasetshenziswa:
- i-mannitol;
- i-lactose (ushukela wobisi);
- i-povidone;
- i-meglumine;
- i-magnesium stearate;
- i-sodium hydroxide;
- i-polysorbate 80;
- udayi E172.
Ku-1 ithebhulethi yesidakamizwa esihlanganisiwe - i-40 mg yesithako esiyisisekelo esisebenzayo se-telmisartan no-12,5 mg we-hydrochlorothiazide diuretic.
Amacwecwe ama-6, 7 noma ama-10 ama-PC. ifakwe emabhulashini aqukethe i-aluminium foil ne-polymer film. Kufakwe emaphepheni amakhadibhodi 2, 3 noma 4.
Isenzo se-Pharmacological
Umuthi ukhiqiza umphumela ophathelene nokwelashwa okubili: i-hypotensive ne-diuretic. Njengoba ukwakheka kwamakhemikhali kwento esemqoka yokusebenza kwesidakamizwa kuyafana nokwakheka kohlobo 2 lwe-angiotensin, i-telmisartan ikhipha leli hormone ekuxhumaneni ne-receptors yegazi futhi livimbe isenzo salo isikhathi eside.
Ngasikhathi sinye, ukukhiqizwa kwe-aldosterone yamahhala kuvinjelwe, okususa i-potassium emzimbeni futhi kugcinwe i-sodium, okufaka isandla ekwandeni kwethoni ye-vascular. Ngaso leso sikhathi, umsebenzi we-renin, i-enzyme elawula umfutho wegazi, awucindezelwa. Ngenxa yalokhu, ukukhuphuka kwengcindezi yegazi kuyeka, ukuncipha kwawo okuphawulekayo kwenzeka kancane kancane.
Ngemuva kwamahora we-1.5-2 ngemuva kokuthatha umuthi, i-hydrochlorothiazide iqala ukukhipha umphumela wayo. Isikhathi sokusebenza se-diuretic siyahluka kusuka emahoreni ayi-6 kuye kwayi-12. Ngesikhathi esifanayo, umthamo wegazi elijikelezayo uyancipha, ukukhiqizwa kwe-aldosterone kuyanda, umsebenzi we-renin uyanda.
Isenzo esihlanganisiwe se-telmisartan ne-diuretic siveza umphumela ophinyiselwe kakhulu we-antihypertensive kunomphumela wemikhumbi yalowo nalowo munye. Ngenkathi ukwelashwa nomuthi, ukubonakaliswa kwe-myocardial hypertrophy kuyancishiswa, ukufa kuncishisiwe, ikakhulukazi ezigulini esezikhulile ezinobungozi obukhulu bethambo lenhliziyo.
Ngesikhathi ukwelashwa nomuthi, ukubonakaliswa kwe-myocardial hypertrophy kuyancishiswa.
I-Pharmacokinetics
Inhlanganisela ye-telmisartan ene-hydrochlorothiazide ayiguquki i-pharmacokinetics yezinto. I-bioavailability yabo ephelele ingama-40-60%. Izakhi ezisebenzayo zomuthi zidonswa ngokushesha zivela emgodini wokugaya ukudla. Inani eliphakeme lokuqongelela i-telmisartan ku-plasma yegazi ngemuva kwamahora angu-1-1,5 liphindwe izikhathi ezingama-23 kwabesilisa kunabesifazane. I-metabolism enengxenye ivela esibindini, lo muthi udonswa ezindlini. IHydrochlorothiazide ikhishwa emzimbeni icishe ingashintshiwe nomchamo.
Izinkomba zokusetshenziswa
I-Telsartan inqunyelwe:
- ekwelapheni umfutho we-hypertension oyisisekelo nowesibili, lapho ukwelashwa nge-telmisartan noma i-hydrochlorothiazide kuphela kunganikeli umphumela oyifunayo;
- ukuze kuvikeleke ubunzima be-pathologies enhliziyo eqinile kubantu abangaphezulu kweminyaka engama-55-60;
- ukuvimbela izinkinga ezigulini ezinesifo sikashukela sohlobo II (esingaxhomekeki kwe-insulin) ngomonakalo wesitho obangelwa yisifo esiyimbangela.
Contraindication
Izizathu zokwenqabela ukwelashwa ngeTelsartan:
- hypersensitivity ezintweni ezisebenzayo zomuthi;
- isifo sezinso esinzima;
- ukuthatha i-Aliskiren ezigulini ezihluleka yizinso, isifo sikashukela;
- ukwehluleka kwesibindi okubolile;
- ukuvimbela kwe-bile duct;
- ukuntuleka kwe-lactase, ukungabekezelelani kwe-lactose;
- i-hypercalcemia;
- i-hypokalemia;
- ukukhulelwa nokuqunjelwa;
- izingane ezingaphansi kweminyaka engu-18.
Ngokunakekela
Izinyathelo zokuqapha kufanele zithathwe uma lezifo ezilandelayo noma izimo ze-pathological zitholakala ezigulini:
- ukwehla kokujikeleza kwegazi;
- i-stenosis yemithambo ye-renal, valves yenhliziyo;
- ukwehluleka kwenhliziyo okukhulu;
- ukwehluleka kwesibindi okumnene;
- isifo sikashukela
- gout
- i-adrenal cortical adenoma;
- ukuvala i-glaucoma;
- lupus erythematosus.
Ungayithatha kanjani iTelsartan 40
Umthamo ojwayelekile: ukungenisa nsuku zonke ngaphambi noma ngemuva kokudla i-1 ithebhulethi, okufanele ihlanzwe phansi ngenani elincane lamanzi. Umthamo omkhulu wansuku zonke wezinhlobo ezinzima ze-hypertension ufinyelela ku-160 mg. Kufanele kukhunjulwe engqondweni: umphumela ofanele wokwelapha awenzeki ngokushesha, kodwa ngemuva kwezinyanga ezi-1-2 zokusebenzisa umuthi.
Umthamo ojwayelekile: ukungenisa nsuku zonke ngaphambi noma ngemuva kokudla i-1 ithebhulethi, okufanele ihlanzwe phansi ngenani elincane lamanzi.
Ngoshukela
Iziguli ezinalesi sifo zivame ukubekwa ukuvikela ukuthuthukiswa kwezinkinga kusuka enhliziyweni, izinso, amehlo. Kwabanesifo sikashukela abaningi abane-hypertension, kuboniswa inhlanganisela yeTelsartan ne-Amlodipine. Kwezinye izimo, ukugcwala kwe-uric acid egazini kuyakhuphuka, i-gout iyanda. Kunghle kudingekile ukulungisa umthamo wezidakamizwa ze-hypoglycemic.
Imiphumela emibi yeTelsartan 40
Izibalo zokungaphenduki kahle kulo muthi nakuma-telmisartan athathwe ngaphandle kwe-hydrochlorothiazide acishe afane. Imvamisa yemiphumela emibi eminingi, ngokwesibonelo, ukuphazamiseka kwe-izicubu trophism, i-metabolism (hypokalemia, hyponatremia, hyperuricemia), ayihlobene nomthamo, ubulili nobudala beziguli.
Amapheshana wesisu
Umuthi ezimweni ezingavamile ungadala:
- umlomo owomile
- i-dyspepsia;
- ukuthopha;
- Ubuhlungu besisu
- ukuqunjelwa
- isifo sohudo
- ukuhlanza
- i-gastritis.
Izitho zeHematopoietic
Ukuphendula isidakamizwa kungafaka:
- ukwehla kwezinga le-hemoglobin;
- i-anemia
- i-eosinophilia;
- thrombocytopenia.
Isistimu yezinzwa ephakathi
Umphumela wecala ojwayelekile isiyezi. Akuvamile ukwenzeka:
- i-paresthesia (imizwa yama-goosebumps, sensing sensors, pain burn);
- ukuqwasha noma, ngakolunye uhlangothi, ukozela;
- umbono omfushane;
- izimo zokukhathazeka;
- Ukudana
- i-syncope (ubuthakathaka obukhali obungazelelwe), ukufikelwa amandla.
Kusuka ohlelweni lomchamo
Kwesinye isikhathi kuyabonakala:
- ukwanda kokuhlushwa kwe-uric acid, i-creatinine ku-plasma yegazi;
- umsebenzi owandisiwe we-enzyme CPK (i-creatine phosphokinase);
- ukwehluleka kwezinso okwenzeka kakhulu;
- izifo ezithinta umchamo, kubandakanya cystitis.
Kusuka ohlelweni lokuphefumula
Ukusabela okungejwayelekile
- ubuhlungu endaweni yesifuba;
- ukuphefumula
- i-flu-like syndrome, i-sinusitis, i-pharyngitis, i-bronchitis;
- inyumoniya, i-pulmonary edema.
Engxenyeni yesikhumba
Kungavela:
- i-erythema (ubomvu obukhulu besikhumba);
- ukuvuvukala
- ukuqhuma
- ukulunywa
- ukukhuphuka kokujuluka;
- i-urticaria;
- dermatitis;
- eczema
- i-angioedema (iyivelakancane).
Kusuka ohlelweni lwezitho zofuzo
I-Telsartan ayithinti kabi ukusebenza kwendawo yangasese.
Kusuka ohlelweni lwezinhliziyo
Kungakhula:
- i-arterial or orthostatic hypotension;
- i-brady, tachycardia.
Kusuka ohlelweni lwe-musculoskeletal kanye nezicubu ezithintekayo
Ukuphendula okulandelayo kwesistimu ye-musculoskeletal kungenzeka:
- cramping, pain in izicubu, imisipha, amalunga;
- ukugoba, imvamisa emilenzeni engezansi;
- i-lumbalgia (ubuhlungu obukhulu emhlane ongezansi).
Engxenyeni yesibindi ne-biliary
Ngaphansi kwethonya lomuthi ezimweni ezingavamile, lokhu okulandelayo kungabonakala:
- ukuphambuka esibindini;
- umsebenzi owengeziwe wama-enzyme akhiqizwa ngumzimba.
Allergies
Ukushaqeka kwe-Anaphylactic akuvamile kakhulu.
Umthelela ekhonweni lokulawula izindlela
Njengoba kungenakwenzeka ukukhipha ubungozi bokuqina, isiyezi, kunconywa ukusebenzisa ukuqapha lapho ushayela, wenza umsebenzi odinga ukunakwa kakhulu.
Imiyalo ekhethekile
Ngokushoda kwe-sodium ku-plasma noma umthamo onganele wegazi elijikelezayo, ukuqaliswa kokwelashwa kwezidakamizwa kungahle kuhambisane nokwehla komfutho wegazi. Ezigulini ezine-renal vasen stenosis, isifo senhliziyo, kanye nokwehluleka okukhulu kwenhliziyo, i-hypotension ye-arterial acute ihlala iba khona. Ukwehla okubucayi kwengcindezi kungaholela ekushayweni noma ekuqaqanjisweni kwe-myocardial.
Sebenzisa umuthi ngokuqapha nange-stralosis ye-mitral noma ye-aortic.
Ku-diabetes, ukuhlaselwa kwe-hypoglycemia kungenzeka. Kuyadingeka ukuhlola njalo amazinga kashukela egazini, ulungise umthamo wabaphatheli be-hypoglycemic.
Ku-diabetes, ukuhlaselwa kwe-hypoglycemia kungenzeka.
IHydrochlorothiazide njengengxenye yeTelsartan iyakwazi ukukhulisa ukuhlanganiswa kwezakhi ezinobuthi ze-nitrogen uma kwenzeka umsebenzi wezinso ungasebenzi, futhi futhi kubangele ukukhula kwe-myopia eyingozi, i-angle-ukuvalwa kwe-glaucoma.
Ukusetshenziswa kwesidakamizwa isikhathi eside kuvame ukudala i-hyperkalemia. Kungadingeka ukuthi kuqashelwe okuqukethwe ama-electrolyte ku-plasma yegazi.
Ukuyekiswa okwenziwe muva nje komuthi akuholeli ekwakhiweni kokuhoxiswa.
Nge-hyperaldosteronism eyisisekelo, umphumela wokwelapha weTelsartan awukho.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelashwa kwezidakamizwa kuyaphikiswa ngesikhathi sokukhulelwa nokuncelisa.
Ukunquma uTelsartan ezinganeni ezingama-40
Umuthi awuhloselwe ukusetshenziswa yiziguli ezingaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Uma kungekho khona izifo ezi-concomitant ezinzima, asikho isidingo sokulungiswa kwamthamo.
Isicelo sokusebenza kokulimala kwezinso
Ukulungiswa komthamo akudingeki ezigulini ezihluleka ngokwezinso zokuwohluka okuhlukahlukene, kufaka phakathi ngaphansi kwezinqubo ze-hemodialysis.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokwemiphumela yocwaningo oluningi ezigulini ezinokusebenza okuncane kwesibindi kokulingene, umthamo wansuku zonke wesidakamizwa akufanele udlule ama-40 mg.
Ngokwemiphumela yocwaningo oluningi ezigulini ezinokusebenza okuncane kwesibindi kokulingene, umthamo wansuku zonke wesidakamizwa akufanele udlule ama-40 mg.
Ukweqisa kweTelsartan 40
Ukwehla okubukhali kwengcindezi yegazi nge-brady noma i-tachycardia kungenzeka. Ukuqokwa kwe-hemodialysis akunakwenzeka, ukwelashwa okubonakalayo kuyenziwa. Kuyadingeka ukulawula amazinga e-creatinine nama-electrolyte egazini.
Ukuxhumana nezinye izidakamizwa
Ngokusebenzisa kanyekanye nezinye izidakamizwa ezinciphisa umfutho wegazi, umuthi uphakamisa umphumela wazo wokwelapha.
Lapho uthatha iTelsartan nge-Digoxin, ukuhlushwa kwe-glycoside yenhliziyo kukhuphuka kakhulu, ngakho-ke, ukuqapha amazinga we-serum kuyadingeka.
Ukuze ugweme i-hyperkalemia, umuthi akufanele uhlanganiswe nama-ejenti aqukethe i-potassium.
Ukulawulwa okuphoqayo kokuhlushwa kwe-lithiamu egazini ngenkathi usebenzisa umuthi oqukethe amakhambi wale nsimbi ye-alkali, ngoba I-Telmisartan ithuthukisa ubuthi bayo.
I-Glucocorticosteroids, i-Aspirin nezinye izidakamizwa ezingezona ezingama-antiidal ezingena-steroidal zinciphisa umphumela we-antihypertensive womuthi.
Ama-NSAID ngokuhlanganiswa ne-telmisartan angaphazamisa ukusebenza kwe-renal.
Ukuhambisana notshwala
Lapho welapha ngomuthi, akufanele uphuze utshwala wanoma uluphi uhlobo.
Ama-Analog
I-Telsartan ingashintshwa nale mithi elandelayo ngethonya elifanayo:
- UMikardis;
- I-Prirator;
- I-Tanidol;
- Lezi;
- I-Telzap;
- I-Telmisartan;
- I-Telmista;
- I-Telpres
- I-Tsart
- I-Hipotel.
Imibandela yekhefu lekhemisi
Kuthengiswe lapho kwethulwa iresiphi.
Intengo yeTelsartan 40
Izindleko zephakeji engu-1 ngama-30 ama-pcs. - kusuka ku-246-255 rub.
Izimo zokugcina zomuthi
Izinga lokushisa elikhulu lamathebulethi alikho ngaphezulu kuka- + 25 ° C. Indawo yazo yokubeka akufanele ifinyeleleke ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi
Inkampani yemithi yaseNdiya "uDkt Reddy's Laboratories Ltd." (UDkt. Reddy's Laboratories Ltd.).
Lapho uthatha iTelsartan nge-Digoxin, i-glycoside ye-cardiac ikhuphuka kakhulu.
Ukubuyekezwa ku-Telsartan 40
UMaria, oneminyaka engama-47, uVologda
Amaphilisi amakhulu futhi abonakala ephephe kakhulu ekwelashweni okuningi kwesifo se-vascular. Kuyamangaza futhi ukuthi lo muthi ophumelelayo ukhiqizwa eNdiya, hhayi eJalimane noma eSwitzerland. Imiphumela emincane incane. Kwesinye isikhathi isibindi singikhathaza kuphela, kepha kungiphathe kabi isikhathi eside lapho angikaze ngiyithathe iTelsartan.
UVyachelav, oneminyaka engama-58, uSmolensk
Nginomfutho wegazi omude. Futhi ukwehluleka okunzima kwezinso. Imaphi amalungiselelo ayodwa okwakungafanele athathwe iminyaka eminingi yokwelashwa! Kepha ngezikhathi ezithile kumele ziguqulwe, ngoba umzimba uyajwayela, bese ziyeka ukwenza njengakuqala. Bengilokhu ngithatha iTelsartan kamuva nje. Imiyalo yayo inikeza uhlu olubanzi lwemiphumela emibi, kepha ayikho neyodwa yayo eye yavela. Umuthi omuhle obamba ingcindezi ngokuqinile. Iqiniso liyabiza kancane.
U-Irina, oneminyaka engama-52 ubudala, eYekaterinburg
Okokuqala ngqa, lo welaphi wathi kumele kuthathwe i-Amlodipine, kepha ngemuva kwesonto imilenze yakhe yaqala ukuvuvukala. Udokotela wangena esikhundleni sakhe ngo-Enap - ngokushesha okokukhwehlela kwaqala ukungiminyanisa. Ngemuva kwalokho kwadingeka ngishintshele eTelsartan, kodwa kwavela ukuthi nganginokungabekezeleli okuthile kuye. Kube nokuhlaselwa kwenhliziyo, khona lapho kuqhamuke isikhumba sesikhumba. Ngaphinde ngaya emtholampilo. Futhi yilapho kuphela lapho i-Therapist enqunyelwe i-Concor lapho konke kwenzeke endaweni. Anginankinga nalawa maphilisi. Ngakho-ke kubaluleke kakhulu ukuthi udokotela akhethe kahle umuthi ofanele wena.
