I-Ramipril-C3 iyisidakamizwa esisebenzayo esetshenziselwa ukwelapha umfutho wegazi ophezulu we-arterial. Sinciphisa ngokushesha umfutho wegazi ngaphandle kokufaka umthelela olimazayo kwezinye izitho zomzimba. Dinga ukunakekelwa kwezokwelapha ngenkathi welashwa.
Igama Lezwe elingafanele
URamipril
I-Ramipril-C3 iyisidakamizwa esisebenzayo esetshenziselwa ukwelapha umfutho wegazi ophezulu we-arterial.
I-ATX
C09BA05
Khipha amafomu nokwakheka
Amaphilisi
Kutholakala kumathebulethi we-2,5, 5 no-10 mg wento esebenzayo.
Uhlobo olungekho
Ama-Capsules ayindlela yesidakamizwa engekho ngokuthengiswa.
Isenzo se-Pharmacological
Kubhekiselwa kuma-inhibitors e-ACE. Lesi yisidakamizwa lapho i-ramiprilat yakheka khona ngesikhathi se-metabolism. Umuthi uphungula ngempumelelo ukuqina kokukhiqizwa kwe-angiotensin-converting hormone, okuholela ekwakhekeni kwe-angiotensin-2, enikeza i-vasoconstriction.
Ngenxa yokwehla kwezinga le-angiotensin-2, umsebenzi we-plinma renin uyanda. Umuthi ubuyekeza ukugeleza kwegazi emithanjeni yamaphaphu, ukhuphula umthamo wenhliziyo futhi ukumelana kwayo nokucindezela. Yehlisa amathuba okufa okungazelele ezigulini ngemuva kokuhlaselwa yisifo senhliziyo nangokwehluleka kwenhliziyo okuqhubekayo. Yehlisa amathuba okulaliswa esibhedlela ngenxa yesifo senhliziyo esibuhlungu.
Umuthi unciphisa amathuba okukhula kokubandakanyeka kweziguli ezisengozini futhi uvezwe kulezi zinto:
- isifo senhliziyo;
- i-pathology yemikhumbi yangaphandle, kufaka phakathi i-stroke;
- isifo sikashukela mellitus;
- i-microalbuminuria;
- umfutho wegazi ophakeme
- ukwanda kwe-cholesterol yegazi;
- ukubhema
- ukusetshenziswa kabi kotshwala.
Umuthi wehlisa inani le-albhamuin emchini futhi uvimbele ukuthuthukiswa kwe-nephropathy ezigulini ezinesifo sikashukela.
Umuthi unciphisa amathuba okuqalwa kwe-myocardial infaration ezigulini ezisengozini.
I-Pharmacokinetics
Umphumela weRamipril-C3 uqala kubantu abadala cishe ihora ngemuva kokuphathwa ngomlomo, ufinyelela inani eliphakeme ngemuva kwamahora angama-3-6 futhi uqhubeka cishe ngosuku.
Izinkomba zokusetshenziswa
Isidakamizwa sikhonjiswa ukusetshenziswa ne:
- i-arterial hypertension;
- ukwehluleka kwenhliziyo okungapheli;
- isimo ngemuva kokuhlaselwa yinhliziyo;
- isifo sikashukela se-nephropathy;
- Umsebenzi wokuphazamiseka okungapheli wezinso.
Kubhekiselwe iziguli ezihlaselwe yisifo senhliziyo, i-percutaneous translateuminal coronary angioplasty noma i-coronary artery bypass grafting.
Kukuziphi izingcindezi?
Yamukelwa kuphela ekucindezelweni okuphezulu.
Contraindication
Kubhaliswe ku:
- hypersensitivity to ACE inhibitors;
- umlando we-angioedema;
- iminyaka yesiguli ingafika eminyakeni eyi-18 (ngokwesenzo abukho ubufakazi mayelana nokuphepha kwalesi sidakamizwa ezinganeni).
Ngokunakekela
Kuyadingeka ukuthatha umuthi ngokuqapha ngokuthambekela kwe-edema, ukulimala izinso noma isibindi.
Ungayithatha kanjani i-ramipril C3?
Ithebhulethi aligwenyiwe futhi ligwinyiwe lonke, ligezwe ngenani elanele lamanzi (hhayi ujusi, itiye), kungakhathalelwa ukuthi kudliwani ukudla. Umthamo kanye nesikhathi sokwelashwa kukhethwe udokotela ngokwahlukana, kucatshangelwa izinkomba.
Ngomfutho wegazi ophakeme, umthamo wokuqala ngu-2,5 mg, othathwa kanye ngosuku ekuseni. Uma ngemuva kwamaviki ama-3 ingcindezi ingabuyelanga ejwayelekile, umthamo unyuswa waba ngu-5 mg. Umthamo omkhulu onconyiwe ngu-10 mg wesidakamizwa. Ngomthelela onganele we-hypotensive, ama-diuretics nama-calcium tubule blockers anqunyelwe.
Ekuhlulekeni kwenhliziyo okungapheli, umthamo wokuqala uhhafu wethebhulethi ka-2,5 mg. Kungakhuphula ukubheka impendulo yomzimba ekwelashweni. Ngomthamo wethebhulethi engaphezu kwe-1, kufanele ihlukaniswe ngemithamo eminingana ngezikhathi ezithile. Isilinganiso esiphezulu ngamathebulethi ayi-10.
Ukuze unciphise ubungozi bokuhlaselwa yisifo senhliziyo noma unhlangothi, umthamo wokuqala ngu-2,5 mg ngokukhuphuka kancane kancane kufinyelela ezingeni lesondlo le-10 mg. Ukudlula leli nani akunakwenzeka, ngoba akukho kusebenza okufakazelwe.
Ekuhlulekeni kwenhliziyo okungapheli, umthamo wokuqala uhhafu wethebhulethi ka-2,5 mg.
Esimweni esidalwe ukuhlaselwa yisifo senhliziyo esibuhlungu (ezinsukwini ezi-2 kuye kwezingu-9 ngemuva kokuhlaselwa ngamandla), umthamo wokuqala ngu-5 mg (uhlukaniswe ngemithamo emi-2). Ngokuncipha ngokweqile kwengcindezi, umthamo uyancishiswa. Isilinganiso esiphezulu somuthi yi-10 mg. Kunconywa ukwandisa kancane kancane umthamo ukuze kungabikho ukwehla ngokweqile kwengcindezi, okusongela ukuya esimweni se-collaptoid.
Ngokuhluleka okukhulu kwenhliziyo, kunconywa ukuqala ukwelashwa ngomthamo omncane wengxenye yepilisi, uyandisa kancane kancane.
Ngoshukela
Uma kwenzeka ukulimala kwezinso okunesifo sikashukela kanye nezinye izindlela ezisondelene nazo, umthamo wokuqala uhhafu wethebhulethi, onokwenyuka kancane kancane uye ku-5 mg. Ngokwanda komthamo ngaphezu kwalokhu, ukusebenza ngempumelelo kokwelashwa akukaze kufakazelwe.
Imiphumela emibi yeRamipril C3
Ezimweni ezingavamile, umuthi ungadala ukwehla kwesisindo somzimba, ukwanda kwesilinganiso se-nitrogen, i-urea ne-creatinine yegazi, i-angioedema. Kuqabukela kakhulu ukuthi iziguli zishintshe okushiwo kuwo wonke amanani egazi.
Amapheshana wesisu
Amaphilisi angadala ukugabha, isifo sohudo kanye nenausea. Ezimweni ezingavamile, kuba nomuzwa wokoma, noma, ngakolunye uhlangothi, ukwanda kwenani lamathe. Kuyaqabukela, iziguli zinciphise iphango (kuze kufinyelele ku-anorexia), ukuphazamiseka kokugaya ukudla okucashile, ukwephulwa kwesibindi ngendlela yomsebenzi owengeziwe we-transaminase.
Izitho zeHematopoietic
Mhlawumbe ukwehla kwenani lamaplatelet namaseli egazi abomvu.
Isistimu yezinzwa ephakathi
Iziguli zingaphazanyiswa isiyezi, izinhlungu ekhanda, i-asthenia. Ezimweni ezingavamile, inkumbulo, ukwehluleka, ukudangala, ukuqwasha noma ukozela, ukuphazamiseka kwamehlo okungaboni, ukulahleka kokuzwa kukhubazekile.
Kusuka ohlelweni lomchamo
Ezigulini ezingavamile, amaprotheni angavela kumchamo. Kwesinye isikhathi inani lomchamo liyancipha, ukuvuvukala kwenzeka.
Kusuka ohlelweni lokuphefumula
Iziguli zingaqala ukukhwehlela, i-pharyngitis, i-sinusitis, i-bronchospasm.
Allergies
Ukuvela kwe-allergic kubonakala njenge-rash ne-urticaria.
Imiyalo ekhethekile
Ukusetshenziswa kweRamipril C3 kufanele kwenzeke kuphela ngokuqapha ngokucophelela kwezokwelapha ngokuhambisana ngokuphelele nemiyalo. Ngaphambi kokuqala ukwelashwa, ama-diuretics anqunywe njengezidakamizwa ze-antihypertensive kufanele akhanseliwe. Ezigulini ezinesimo esibi se-hypertension, ukuhoxa kwenziwa kancane kancane. Uma lokhu kungenzeki, bese ulungisa ibhalansi yamanzi ne-electrolyte.
Ngesikhathi sokulashwa, iziguli zidinga ukubhekwa njalo kwesithombe segazi. Kuyadingeka ukuqapha izinkomba ze-urea nitrogen, i-creatinine. Ngokuthuthukiswa komzimba, umthamo uguqulwa.
Ngesikhathi sokwelashwa, ukusetshenziswa kophuzo oludakayo kufanele kuqedwe ngokuphelele.
Ngesikhathi sokwelashwa, ukusetshenziswa kophuzo oludakayo kufanele kuqedwe ngokuphelele.
Ukunquma uRamipril C3 ezinganeni
Umuthi awubekelwe izingane ngenxa yokuntuleka kobufakazi bokuphepha komuthi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Lo muthi u-contraindicated ekukhulelweni nasekunceliseni ibele. Uma ukukhulelwa sekwenzekile ngesikhathi sokwelashwa, lapho-ke udinga ukufaka umuthi esikhundleni salokho ngokushesha okukhulu. Ngaphandle kwalokho, kunengozi enkulu yemiphumela emibi ku-fetus ku-trimester yokuqala. Umuthi ubangela i-intrauterine pathologies:
- ukulimala kwentuthuko;
- ukwehlisa umfutho wegazi (hypotension ye-fetus);
- umsebenzi wezinso ongonakalisiwe;
- kwehlise izinga le-potassium egazini le-umbungu;
- ukulimala kugebhezi nobuchopho;
- ukuncishiswa kwenani le-amniotic fluid;
- ukulimala kwezingalo.
Ngesikhathi sokulashwa, kuyadingeka ukuyeka ukuncelisa usana.
Ukweqa ngokweqile kukaRamipril C3
Nge-overdose yalesi sidakamizwa, i-vasodilation yangaphandle iba. Izibonakalisa ukwehla ngokweqile kwengcindezi nokushaqeka. Iziguli zakha i-bradycardia, ukungasebenzi kahle kwe-electrolyte metabolism, kanye nokwehluleka kwezinso okuyingozi.
Ukwelashwa kungukuqhuma kwesisu. Iziguli kufanele zithathe ama-adsorbents ne-sodium sulfate (ngokushesha ngangokunokwenzeka). Ukubuyisela umthamo ojwayelekile wokujikeleza kwegazi nge-arterial hypotension, kwethulwa iDopamine neNorepinephrine (ngendlela yemijovo). Endabeni ye-bradycardia ephikelelayo, i-pacemaker yokufakelwa imiswa okwesikhashana.
Akunconyelwe ukuthi kunikezwe ama-diuretics e-potassium-sparing ngasikhathi sinye.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kwe-dextran sulfate kuhlanganiswe ngenxa yengozi yokusabela kwe-anaphylactic. Akunconyelwe ukuthi kunikezwe ama-diuretics e-potassium-sparing ngasikhathi sinye, ngoba kunengozi yokwanda okukhulu kwenani lale nto egazini.
Ezinye izidakamizwa ze-antihypertensive zinqunywa ngokuqapha (ngenxa yengozi engaba khona yokwehla okukhulu komfutho wegazi). Okufanayo kusebenza kumaphilisi okulala, kanye ne-vasopressor sympathomimetics.
I-Allopurinol, procainamide, cytostatics, imishanguzo ye-glucocorticosteroid nama-immunosuppressants ingaphazamisa ibhalansi yamaseli egazi. Mhlawumbe ukuthuthukiswa kwe-leukopenia ne-neutropenia.
Ukuthatha abameli be-hypoglycemic ngomlomo kanye neRamipril C3 kungadala ukuhlaselwa kwe-hypoglycemia. I-sodium chloride yenza buthakathaka izakhiwo ze-hypotensive zomuthi. Ama-estrogens angadala ukugcinwa kwamanzi emzimbeni.
Ungangena kanjani esikhundleni?
Ama-anemags alo muthi:
- I-Amprilan;
- Dilaprel;
- I-Corpril;
- I-Ramepress;
- URamigamm
- Umkhondo;
- IHartil.
Imibandela yekhefu lekhemisi
Ikhishwa ngomuthi kuphela.
Intengo Ramipril C3
Izindleko zokupakisha zimayelana nama-ruble angama-220. I-Ukraine ayiwukhululi lo muthi.
Izimo zokugcina zomuthi
Kuyadingeka ukugcina umuthi endaweni eyomile futhi emnyama, emazingeni okushisa afinyelela ku + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Ilungele ukusetshenziswa iminyaka emi-3.
Umkhiqizi
I-Severnaya Zvezda CJSC, Ozon LLC (Russia), njll.
Ukubuyekezwa kweRamipril C3
U-Irina, oneminyaka engama-55, eMoscow: "Ngivame ukuba nezinkinga ezinkulu kakhulu, ngakho-ke udokotela ubeke izibhebhe zikaRamipril C3 ukuthi zingavinjelwa. Ngiqale ukuthatha lesi sidakamizwa kwithebhulethi engu-2,5 mg, ngaphenduka kancane kancane ngaya ku-10 mg. Ngiyakwazi ukubekezelela umuthi kahle, ukufundwa kwe-tonometer ngokwemikhawulo ejwayelekile futhi kuyaqabukela kudlule kuyo. Akunamiphumela emibi ebonwa. "
U-Elena, oneminyaka engama-50, uTula: "Ngemuva kokuba senginenkinga ye-hypertension, ngadinga umuthi oqinile futhi osebenzayo wokulwa ne-hypertension. Kwavela ukuthi lesi sidakamizwa. Bengilokhu ngisebenzisa umthamo wokulungisa we-5 mg izinyanga eziningana manje. Ngenxa yalokho, bengilokhu ngigcina ingcindezi ejwayelekile, amaconsi ayo akavamile. Akunamiphumela emibi evela ekwelashweni eye yabonwa. "
U-Oleg, oneminyaka engu-56, uSamara: "Ngosizo lweRamipril C3 kungenzeka ukulawula umfutho wegazi. Ngilandela ukudla, ngenqaba ukuphuza utshwala nokubhema. Ngenxa yalezi zinyathelo, anginankinga ne-hypertensive. Isimo sami sempilo siyenelisa."
