I-Metformin yindlela ephumelelayo yokulwa noshukela omkhulu wegazi. Ngaphezu kokwelashwa kokulondolozwa kwesifo sikashukela, isidakamizwa sisetshenziselwa ukunciphisa umzimba. Lokhu kungokwesigaba se-Biguanides. Kunezifundo eziningana eziqinisekisa ukuthi, ngaphezu kwezakhiwo zayo ze-hypoglycemic, i-metformin hydrochloride iyasiza ukunciphisa ingozi yomdlavuza we-pancreatic.
Igama Lezwe elingafanele
I-Metformin.
I-Metformin yindlela ephumelelayo yokulwa noshukela omkhulu wegazi.
I-ATX
A10BA02.
Khipha amafomu nokwakheka
IMetformin Zentiva iyatholakala kumathebulethi efilimu. Into esebenzayo yesidakamizwa yi-metformin hydrochloride enanini le:
- 500 mg;
- 850 mg;
- 1000 mg
Isenzo se-Pharmacological
Umphumela oyinhloko weMetformin ukwehla kokuhlushwa kwe-glucose glucose. Kodwa-ke, akukuvuseleli ukukhiqizwa kwe-insulin, ngenxa yalokhu akukho bungozi be-hypoglycemia.
Umphumela wokwelapha umuthi ubangelwa amandla ayo okusebenzisa i-peripheral receptors, okwandisa ukuzwela kwawo ku-insulin. Ngaphezu kwalokho, i-metformin:
- kuvimbela inqubo yokukhiqiza ushukela esibindini;
- kuvimbela ukufakwa kwe-glucose emathunjini;
- ivuselela ukusetshenziswa kwe-glucose kwe-intracellular kanye nokuhlanganiswa kwe-glycogen;
- kwandisa isibalo sabahambisa ushukela emalungeni amaseli;
- kusebenze imetabolism yamafutha, kunciphisa okuqukethwe kwama-triglycerides, ama-lipoprotein aphansi kwabantu ne-cholesterol ephelele.
Umphumela oyinhloko weMetformin ukwehla kokuhlushwa kwe-glucose glucose. Kodwa-ke, akukuvuseleli ukukhiqizwa kwe-insulin, ngenxa yalokhu akukho bungozi be-hypoglycemia.
I-Pharmacokinetics
Ukuthatha umuthi esiswini esingenalutho kusheshisa ukufezekiswa kwenani lokuhlushwa kwento esebenzayo kuplasma yegazi. Le nto ayibophele amaprotheni egazi, isatshalaliswa ngokulinganayo kwizicubu. Kufika ku-20-30% wezidakamizwa okhishwa ngamathumbu, okusele - yizinso.
Okunqunyelwe
Ukwemukelwa kwalesi sidakamizwa kukhonjiswa ngohlobo 2 lwesifo sikashukela, ikakhulukazi okuyinkimbinkimbi ukukhuluphala. Ngenxa yekhono lakhona lokuthuthukisa izinqubo ze-metabolic, umuthi uyithuluzi elisebenzayo lokulwa nesisindo ngokweqile.
Ukusetshenziswa kweTrental 100 kukhuthaza ukwenziwa kwegazi kwegazi futhi kuthuthukise isimo semithambo yegazi.
Izinqubo zokuvuvukala ezivela kumagciwane, kusetshenziswa amaphilisi eGentamicin. Funda kabanzi lapha.
Umuthi i-Victoza: imiyalelo yokusetshenziswa.
Contraindication
Ukuthatha lo muthi kuphambaniswe ku:
- ukwanda kokucabanga kwezakhi zayo;
- isifo sikashukela sikashukela;
- isifo sikashukela nesifo sokuwa;
- ukwehluleka kwe-renal okusesilinganisweni noma okunzima;
- ukomisa kanye nezinye izimo ezingaholela ekusebenzeni kahle kwe-renal;
- ukwehluleka kokuphefumula nezinye izimo ezidala izicubu ze-izicubu;
- i-lactic acidosis;
- ukungasebenzi kahle kwesibindi, ukudakwa kakhulu;
- utshwala nezidakamizwa;
- ukukhulelwa
- ukusilela kwekalori (ukudla ukudla okungaphansi kwe-1000 kcal / ngosuku);
- ukwenza ukuhlinzwa noma izifundo ezisebenzisa into eyi-radiopaque.
I-Metformin ikhonjiswa ngohlobo 2 lwesifo sikashukela, ikakhulukazi okuyinkimbinkimbi yokukhuluphala.
Ngokunakekela
Ezimweni ezilandelayo, ukusetshenziswa kwalo muthi kuyamukeleka, kepha isimo sesiguli kufanele sibe ngaphansi kokuqashwa ngudokotela:
- inkathi yokuhlanza;
- iminyaka engaphezu kwengu-60;
- ukusebenza kanzima ngokomzimba;
- ukungalingani kahle kwezinso.
Ukuze wehlise isisindo, kungakuhle ukuthatha iMetformin izikhathi ezi-3 ngosuku ngama-500 mg noma amahlandla ama-2 ngosuku ku-850 mg amasonto ama-3.
Ungayithatha kanjani iMetformin Zentiva
Ngaphambi noma ngemuva kokudla
Naphezu kweqiniso lokuthi uma uthathwa esiswini esingenalutho, i-metformin hydrochloride idonswa ngamandla, kubalulekile ukuphuza amaphilisi ngemuva kokudla noma ngesikhathi sokudla. Ngaphandle kwalokho, ingozi yokwanda kwezimpawu ze-dyspeptic iyanda.
Ukwehla kwesisindo
Ukuze wehlise isisindo, kungcono ukuthatha lesi sidakamizwa amahlandla ama-3 ngosuku ama-500 mg noma amahlandla ama-2 ngosuku ama-850 mg amasonto ama-3. Ngemuva kwalokhu, ikhefu okungenani inyanga kufanele lithathwe.
Kubalulekile ukuthi i-Metformin kuphela ingaholeli ekunciphiseni isisindo, into edingeka kuqala ekudleni ngemuva kokulashwa nalesi sidakamizwa.
Ngoshukela
Umthamo wokuqala otuswe ngumenzi wohlobo 2 lwesifo sikashukela 1 ithebhulethi eliqukethe 500 mg ye-metformin izikhathi ezingama-2-3 ngosuku. Ukungezelela umthamo kungenzeka ngemuva kwezinsuku eziyi-10-15. Isinqumo sokwanda kufanele sincike emiphumeleni yokuhlolwa kwegazi ngoshukela. Umthamo omkhulu ovunyelwe nsuku zonke ngu-3 g, umthamo ojwayelekile wokwelapha u-1.5-2 g. Ukwanda okuthe chu kwesilinganiso somuthi kanye nokuhlukaniswa kwawo kumithamo engu-2-3 kuyadingeka ukunciphisa amathuba okuvela okungalungile ohlelweni lokugaya ukudla.
Umthamo ohlanganisiwe we-insulin ukhethiwe ngokuhlukile ukuze ulondoloze izinga leshukela elijwayelekile. Inani leMetformin lihlala lifana ne-monotherapy
Umthamo ohlanganisiwe we-insulin ukhethiwe ngokuhlukile ukuze ulondoloze izinga leshukela elijwayelekile.
Imiphumela emibi yeMetformin Zentiva
Lapho uthatha iMetformin, ukuhlanekezela kwemizwa yokunambitheka kungenzeka, kanye nokukhula:
- i-hepatitis;
- i-encephalopathy;
- i-hypomagnesemia;
- i-anemia.
Ngaphezu kwalokho, ukubonakaliswa okungenzeka kokusabela okungekuhle kusuka ezinhlelweni zomzimba ezahlukahlukene.
Amapheshana wesisu
Esigabeni sokuqala sokwelashwa kuvame ukuvela:
- isicanucanu
- isifo sohudo
- Ubuhlungu besisu
- ukwehla kwesifiso sokudla.
Lezi zimpawu ezimweni eziningi zinyamalala zizodwa njengoba umzimba ujwayela umuthi.
Engxenyeni yesikhumba
Akuvamile ukwenzeka:
- i-urticaria;
- i-erythema;
- ukulunywa
- ukuzwela okukhulayo ukukhanya.
Ngasohlangothini lwe-metabolism
Ezimweni ezingavamile, ukuthuthukiswa kwe-lactic acidosis kanye nokumuncwa kwe-Vitamin B12 okungenampilo, okungaholela ku-peropheral neuropathy.
Uhlelo lwe-Endocrine
Lapho uthatha iMetformin, ukwehla kokuxineka kwe-hormone ekhuthaza i-thyroid ku-plasma kungenzeka.
Allergies
Ukungezwani komzimba kungavela njengokuqhuma kwesikhumba.
Umthelela ekhonweni lokulawula izindlela
I-Metformin monotherapy ayithinti amandla okulawula izindlela. Lapho kuthathwa ngokubambisana namanye ama-hypolytics, ukuthuthukiswa kwe-hypoglycemia kungenzeka, okuholela ekwehleni kokuxineka nobunzima bokusebenza ngamasu wokusebenza.
I-Metformin monotherapy ayithinti amandla okulawula izindlela.
Imiyalo ekhethekile
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Yize kukhona ukutholakala kobufakazi bokuthi ukwelashwa ngalesi sidakamizwa akukukhulisi ubungozi bokulimala kokukhula kwesibeletho, abesifazane abakhulelwe bayakhonjiswa ukuthi basebenzise i-insulin.
I-Metformin hydrochloride iyakwazi ukudlula kubisi lwebele; akukho datha ethembekile ngokuphepha kwayo kwezingane ezisanda kuzalwa. Ngakho-ke, uma kunesidingo, kunconywa ukuyeka ukondla.
Ukunquma iMetformin Zentiva ezinganeni
Nge-mellitus yesifo sikashukela eqinisekisiwe, kokubili i-monotherapy nokuhlanganiswa ne-insulin kuvunyelwe ezinganeni nasentsheni. Imithamo yokuthoma neyokwelapha iyafana nalena enconyelwe abadala. Imvamisa nobunjalo bemiphumela emibi ebangelwe yilesi sidakamizwa azimele iminyaka.
Sebenzisa ebudaleni
Ebudaleni, ingozi yokuthola ukwahluleka kwe-renal, okungaba yi-asymptomatic, iyanda. Ngakho-ke, kuyadingeka ukukhetha imithamo futhi uqhube ukwelashwa njalo, kuqashwe ukusebenza kwalesi sitho.
Ebudaleni, ingozi yokuthola ukwahluleka kwe-renal, okungaba yi-asymptomatic, iyanda.
Isicelo sokusebenza kokulimala kwezinso
Umthamo omkhulu ovunyelwe yi-1 g ngosuku. Nge-Metformin therapy, imvume ye-creatinine kufanele ilawulwe kuze kube izikhathi ezine ngonyaka
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokusho kwemiyalo yomenzi, umuthi ubekwa ngemfihlo ukuze usetshenziswe uma kungasebenzi kahle isibindi. Ngaphandle kokutholakala kwemininingwane yokuthi iMetformin iyakwazi ukuthuthukisa isimo ngokuwohloka kwamafutha alesi sitho, singathathwa kuleli cala kuphela ngemuva kokubonisana nodokotela wezifo zamathambo.
I-overdose yeMetformin Zentiva
Ukweqisa kwe-metformin hydrochloride kungaholela ekwakhiweni kwezimo ezinjenge-lactic acidosis ne-pancreatitis. Lapho zivela, umuthi kufanele uyekwe. Ngokukhishwa okusheshayo kwento esebenzayo emzimbeni, kukhonjiswa i-hemodialysis. Ukwelashwa kwezimpawu kuyanconywa futhi.
Ukweqisa kwe-metformin hydrochloride kungaholela ekwakhiweni kwezimo ezinjenge-lactic acidosis ne-pancreatitis.
Ukuxhumana nezinye izidakamizwa
Ukuhlanganiswa kwezinto eziqukethe iodine e-iodine kuqinisekisiwe. Ngesikhathi sokwelashwa ngeMetformin, ukuphathwa kwezidakamizwa eziqukethe i-ethyl alcohol akunconywa. Ukuqapha ngokucophelela ushukela kanye / noma umsebenzi wezinso kuyadingeka lapho kuhlanganiswa nezinto ezifana:
- UDanazole;
- I-Chlorpromazine;
- glucocorticosteroids;
- okokugcobisa;
- ama-estrogens nama-hormone egilo;
- ama-bta2-adrenomimetics ngendlela yemijovo;
- imithi eyenzelwe ukwehlisa umfutho wegazi, ngaphandle kwe-ACE inhibitors;
- i-aracbose;
- izinto ezithathwe kuma-sulfonylurea;
- ama-salicylates;
- INifedipine;
- Mao inhibitors;
- I-Ibuprofen namanye ama-NSAID
- I-Morphine nezinye izidakamizwa ze-cationic.
Ukusetshenziswa okuhlangana nalezi zidakamizwa kungadinga ukuthi uguqule umthamo weMetformin.
Ngaphezu kwalokho, iMetformin inciphisa ukusebenza kwe-Fenprocumone therapy.
Ngesikhathi sokwelashwa ngeMetformin, ukuphathwa kwezidakamizwa eziqukethe i-ethyl alcohol akunconywa.
Ukuhambisana notshwala
Into esebenzayo yalo muthi ayihambelani ne-ethanol.
Ama-Analog
I-analogue yisiphi izidakamizwa eziqukethe i-metformin hydrochloride ezivela kubakhiqizi abahlukahlukene, abanjengo:
- UGideon Richter;
- Izvarino Pharma;
- I-Akrikhin;
- I-LLC "Merk";
- ICanon Pharma Production.
Izidakamizwa zingaba namagama ahlukene okuhweba, isibonelo i-Glucofage noma iSiofor.
Uyini umehluko phakathi kweMetformin neMetformin Zentiva
Umehluko kuphela phakathi kweMetformin Zentiva neMetformin yinkampani yamathebulethi. Akukho mehluko kumthamo noma kwesenzo se-pharmacological.
Imibandela yekhefu lekhemisi
Lesi sidakamizwa singumgqumo, futhi imfuneko yokukhishwa kwaso ekhemisi kufanele sibe ngukuncwadi, lapho, ngokwemithetho, igama liboniswa ngesiLatini.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ukuthengisa lo muthi ngaphandle kadokotela kungukwephula umthetho, noma kunjalo, amanye amakhambi kule ndaba ahlalisa amakhasimende.
Intengo yeMetformin Zentiva
Izindleko zanoma yisiphi isidakamizwa zincike kunqubomgomo yamanani ekhemisi lapho zithengwa khona. Kumakhemisi online, amanani alandelayo:
- Ama-60 ama-PC. I-1 g ngayinye - ama-ruble ayi-136.8;
- Ama-60 ama-PC. I-0.85 g ngayinye - ama-ruble ayi-162.7;
- Ama-60 ama-PC. I-1 g ngayinye - ama-ruble ayi-192.4.
Izimo zokugcina zomuthi
Lo muthi awudingi ukwakhiwa kwezimo ezikhethekile. Ungayigcina kunoma iyiphi indawo engatholakali ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
Inkampani yezokwelapha yaseRussia uSanofi.
Ukubuyekezwa mayelana neMetformin Zentiva
Odokotela
UGalina, udokotela wobugqila wezingane, oneminyaka engama-25, eMoscow: "Inzuzo enkulu kaMetformin ukuthi ilungele ngisho nokwelapha ingane. Into esemqoka wukuxilonga isifo ngaphambi kokuqala ukwelashwa."
USvetlana, udokotela wobuchopho, oneminyaka engama-47, uTyumen: "Ngicabanga ukuthi iMetformin iyisidakamizwa esisebenzayo se-hypoglycemic. Noma kunjalo, yize ithandwa njengendlela yokunciphisa isisindo, ngiyaqiniseka ukuthi lo muthi kufanele uthathwe kuphela yilabo abatholakala benesifo sikashukela, futhi kungcono ukunciphisa isisindo ngosizo lwezemidlalo kanye ukudla. "
Ukulahlekelwa isisindo
UGulnaz, oneminyaka engama-26, uKazan: "Umdwebi wezokwelapha weluleke ukusebenzisa izidakamizwa eziqukethe iMetformin ukwehlisa isifiso sokudla. Uncome ukuthi kuthengwe imikhiqizo kulo mkhiqizi, wathi uyabethemba ikhwalithi nedumela lakhe. Ngiyajabula ukuthi ngalandela izeluleko zakhe. Isidingo sokudla sehlile kakhulu. Angiwubonanga umuthi. "
UVenus, oneminyaka engama-37 ubudala, uSterlitamak: "Ukuphuza iMetformin kwenyusa izinga lokuncipha kwesisindo. Noma kunjalo, ngaphezu kokulahlekelwa kwesifiso sokudla, kube nomphumela omubi onjengokuthi isicanucanu."
