Umuthi Ocijiswe: Imiyalo esetshenzisiwe

I-Irume isidakamizwa esisetshenziswa kakhulu ekwelapheni umfutho wegazi ophakeme kanye neminye imigudu yenhliziyo nemithambo yegazi ehlotshaniswa nengcindezi ekhuphukayo emithanjeni yemithambo yegazi. Uma kusetshenziswe ngokungafanele, kungaholela emiphumeleni esongela impilo, ngakho-ke ungaqala ukuthatha umuthi kuphela ngemvume kadokotela.

Igama Lezwe elingafanele

I-Lisinopril - igama lezinto ezisebenzayo zomuthi.

I-Irume isidakamizwa esisetshenziswa kakhulu ekwelapheni umfutho wegazi ophakeme kanye neminye imigudu yenhliziyo nemithambo yegazi.

I-ATX

I-С09АА03 - ikhodi yokuhlukaniswa kwamakhemikhali-okwelapha-amakhemikhali.

Khipha amafomu nokwakheka

Umuthi unendlela yokukhishwa kwithebhulethi. Ukwakheka kwethebhulethi ngayinye kufaka phakathi:

• i-lisinopril dihydrate (10 noma 20 mg);
• i-mannitol;
• isitashi samazambane;
• calcium phosphate dihydrate;
• i-iron oxide ephuzi;
• i-silicon dioxide i-anhydrous;
• isitashi samazambane pregelatinized;
• i-magnesium stearate.

Amacwecwe ahlinzekwa ngamaseli we-polymeric amaseli angama-30, abekwe emaphaketheni ekhadibhodi kanye nemiyalo.

Isenzo se-Pharmacological

ILisinopril iyi-inhibitor ye-ACE enezakhiwo ezilandelayo:

• kwandisa inani lama-vasodilator prostaglandins angaphakathi;
• yehlisa ijubane lokuphendula kwamakhemikhali lapho uhlobo 1 lwe-angiotensin luguqulwa lube uhlobo 2 lwe-angiotensin, olufaka isandla ekwandeni komfutho wegazi;
• kunciphisa i-vasopressin ne-endothelin, enezakhiwo ze-vasoconstrictor;
• kunciphisa ukumelana kwe-capillary kanye nengcindezi yemithambo;
• yenza imisebenzi engafaniyo yomsipha wenhliziyo ivuselele ukubekezelelana kwenhliziyo ukuze icindezeleke kubantu abanokuhluleka kwenhliziyo;
• Inomphumela obizwa ngokuthi yi-hypotensive, oqhubeka okungenani ngosuku;
• ivimbela umsebenzi wohlelo lwe-renin-angiotensin lwe-myocardium, ivimbela ukuqina kwemicu yemisipha nokwanda kwe-ventricle yesobunxele;
• kunciphisa ingcindezi kuma-capillary we-pulmonary;
• kunciphisa inani lokufa phakathi kweziguli eziye zathola ukumalwa kwemizwa, ukuphazamiseka okuthe xaxa kokugeleza kwegazi emithanjeni emikhulu noma isifo senhliziyo.

I-Irume igcizelela umsebenzi wesibeletho wenhliziyo.

I-Pharmacokinetics

Lapho usebenzisa ifomu le-Irosed le-tablet, into esebenzayo isingena masinyane ohlelweni lokujikeleza. Ukudla akuguquki amapharamitha we-pharmacokinetic we-lisinopril. Ukugxila okuphezulu kakhulu kwento esegazini kunqunywa ngemuva kwamahora ayi-6. ILisinopril ayihlangani nezinto ze-plasma futhi ayilungiswa. Umuthi onomchamo awuguquki. Ingxenye yomuthi olungiselelwe ishiya umzimba kungakapheli amahora ayi-12.

Okunqunyelwe

Izinkomba zokuqokwa kwe-Irumed yilezi:

• umfutho wegazi ophezulu (njengowukuphela kwe-ejenti yokwelapha noma ehlangene nezinye izidakamizwa);
• ukwehluleka kwenhliziyo okungapheli (kuhlangene ne-diuretics noma i-glycosides ye-cardiac);
• ukuvimbela kanye nokwelashwa kwe-myocardial infarction (ngosuku lokuqala, isidakamizwa sikhishwa ukuze kulondolozwe amapharamitha we-hemodynamic kanye nokuvimbela ukwethuka kwe-cardiogenic);
• ukulimala kwezinso zesifo sikashukela (ukunciphisa inani le-albhamuin okukhishwe emchamo kubantu abanesifo sohlobo 1 nohlobo 2).

U-Irume uboniswa ngokwehluleka kwenhliziyo okungamahlalakhona.

I-Iramed imiselwe ukulimala kwezinso likashukela.

I-edema kaQuincke edluliselwe ngaphambili kungukuphikisana nokuqokwa kuka-Irume.

Contraindication

Umuthi awunqunyelwe ukuthi:

• ukungahambi kahle kwe-lisinopril namanye ama-inhibitors e-ACE;
• i-edema kaQuincke yangaphambilini ebangelwa ukuthatha izidakamizwa ze-antihypertensive;
• ufuzo angioedema;
• ukuphathwa kanyekanye kwezidakamizwa okusekelwe ku-aliskiren.

Ngokunakekela

Ukuhlukumeza okuhlobene nokusetshenziswa kwezidakamizwa ze-antihypertensive yilezi:

• kumenyezelwe ukunciphisa imithambo ye-reso;
• ukufakelwa kwezinso kwakamuva;
• amazinga aphezulu e-nitrogen ne-potassium egazini;
• i-coronary artery stenosis;
• i-cardiomyopathy evimbayo;
• i-hypertension ye-arterial;
• ukuphazamiseka kokujikeleza ebuchosheni;
• isifo sohlangothi;
• ukulimala kwe-ischemic kwimisipha yenhliziyo;
• ukubola kwenhliziyo okungalapheki;
• izilonda ezithinta izicubu ze-autoimmune;
• ukunamathela ekudleni okungenawo usawoti;
• ukomisa komzimba;
• ukuphazamiseka kohlelo lwe-hematopoietic;
• kokuba ku-hemodialysis;
• kuhlelwe noma kuhlehliswe ukungenelela kokuhlinzwa.

Ukwephulwa okuhlobene nokusetshenziswa kwomuthi ukuchitheka komzimba.

Ukuba ku-hemodialysis kungukuphula umthetho okuhlobene nokuqokwa kuka-Irume.

Umuthi awubekelwe izilonda ze-ischemic zemisipha yenhliziyo.

I-Stroke kuwukuphikisana nokusetshenziswa kwe-Irumed.

Nge-hypertension ye-arterial, isidakamizwa asinqunyelwe.

Kusetshenziswa amaphilisi a-Iramedred time 1 ngosuku, ebheka irejimenti yokwamukelwa.

Ungayithatha kanjani i-Irume

Amacwecwe asetshenziswa isikhathi esingu-1 ngosuku, ebheka irekhodi lokwamukelwa. Umthamo uncike ohlotsheni lwenkambiso yezifo:

1. I-Arterial hypertension - emasontweni okuqala okwelashwa thatha u-10 mg ngosuku. Ukusuka emavikini amathathu, umthamo uqala ukukhuphuka kancane kancane uye kumthamo wokulungisa (20 mg). Kungathatha okungenani inyanga ukuthuthukisa imiphumela ye-hypotensive. Uma ngemuva kwalesi sikhathi umphumela omuhle ungabhekwa, umuthi kufanele ushintshwe.
2. I-renovascular hypertension - qala ukwelashwa nge-2,5-5 mg ngosuku. Ukwelashwa kuhlanganiswa nokusebenza kokuhlola izinso.
3. Ukwehluleka kwenhliziyo - ngaphambi kokuthatha i-Irumed, banciphisa umthamo wezidakamizwa ezaziphuzwe ngaphambili. Ukwelashwa kuqala ngokufakwa kwe-2,5 mg ye-lisinopril ngosuku. Ngokuzayo, umthamo wansuku zonke uyandiswa ube ngu-10 mg.
4. I-acute myocardial infarction - thatha u-5 mg ngosuku lokuqala, kuthathwe umthamo ofanayo ngemuva kwamahora angama-48 ngemuva kwesicelo sokuqala. Ngokuzayo, umuthi uthathwa ku-10 mg ngosuku izinsuku ezingama-45.

Ngoshukela

Uhlobo lwe-1 bese uthayipha iziguli ezinesifo sikashukela ezi-2 ezithatha ama-10 mg we-lisinopril ngosuku.

Imiphumela emibi ye-Irumed

Amapheshana wesisu

Ukuphazamiseka kokugaya ukudla okwenzeka lapho kuthatha i-Irume, kuyabonakala:

• umlomo owomile
• ukuphefumula kwenhliziyo kanye nokuhlanza;
• ukwehla kwesifiso sokudla;
• ukulimala kwamanyikwe;
• ukuphazamiseka kwe-dyspeptic;
• i-cholestatic jaundice;
• ukuvuvukala kwesibindi;
• Ubuhlungu besisu.

Izimpawu ezivame ukwenzeka ngemuva kokuphuza amaphilisi zithathwa njengezinhlungu esiswini.

Ukuthatha umuthi kungahle kuhambisane nokuvuvukala kwesibindi.

Ngokuphikisana nesizinda sokuphuza umuthi, ukuhlaselwa inhlokomo kanye nokuhlanza kungenzeka.

Ngenkathi uthatha i-Irume, ukwehla kwesifiso sokudla kungabukwa.

I-Irmed inomthelela ekuthuthukiseni i-anemia.

Umphumela womuthi ubuchopho ubonakaliswa yizinkinga zokulala.

Ngenkathi yokwelashwa, kuvela kwemiphumela emibi efana nokugawulwa kwemisipha yethole.

Izitho zeHematopoietic

Umuthi ungaba nomthelela ekuwohlokeni kokuqanjwa kwefanelo kanye nobungako begazi. Ngokusetshenziswa isikhathi eside, i-anemia iyavela futhi ukuwohloka kwegazi kuyancipha.

Isistimu yezinzwa ephakathi

Umphumela we-lisinopril ebuchosheni uyabonakala:

• ukuguquguquka kwemizwa;
• ukuncipha kokuzwela kwezitho;
• inkathazo yokulala;
• imisebe yemisipha yamathole;
• ubuthakathaka bemisipha.

Kusuka ohlelweni lokuphefumula

Ngokuphikisana nesizinda sokuthatha umuthi, ukuhlaselwa i-asthma ye-bronchial kanye nokuphefumula kungenzeka.

Kusuka ohlelweni lwezinhliziyo

Izimpawu zomonakalo enhliziyweni nasemithanjeni yegazi ezenzeka ngenkathi kuthathwa i-Irume:

• ukucindezela izinhlungu esifubeni;
• ukwehla kwegazi elijikelezayo;
• ukwehla okukhulu komfutho wegazi;
• ukuwa kwamathambo;
• i-bradycardia;
• i-tachycardia;
• ukwephulwa kwe-atrioventricular conduction;
• i-myocardial infarction.

Ngokuphikisana nesizinda sokuthatha i-Irumed, i-bradycardia iyenzeka.

Ukuthatha i-Irumed kungadala i-tachycardia.

Ngemuva kokuthatha umuthi, ezinye iziguli ziba ne-myocardial infaration.

Ukungezwani komuthi kukhonjiswa ngemichilo ngendlela ye-urticaria.

Ukuthatha umuthi kungahle kuhambisane nokushaqeka kwe-anaphylactic.

Lapho usebenzisa umuthi, ungahlangabezana nokubonakaliswa okungekuhle njengoku nesiyezi.

Ngokuphikisana nesizinda sokuthatha umuthi, ukuhlaselwa i-asthma ye-bronchial kungenzeka.

Ngasohlangothini lwe-metabolism

Lapho uthatha i-Irume, amazinga egazi e-sodium, potassium, ne-bilirubin anganda. Umsebenzi wama-hepatic transaminases awuvamile ushintsho.

Allergies

Ukungezwani nomuthi kuyabonakala:

• ukuvuvukala kobuso nomphimbo;
• ukuluma nokubomvu kwesikhumba;
• ama-rashes ngendlela ye-urticaria;
• ukwethuka kwe-anaphylactic.

Umthelela ekhonweni lokulawula izindlela

Umuthi ungadala isiyezi, okunciphisa ukugxila. Ngakho-ke, ngesikhathi sokulashwa, udinga ukwenqaba ukusebenza ngamadivayisi ayinkimbinkimbi.

Imiyalo ekhethekile

Sebenzisa ebudaleni

Ekwelashweni kwe-hypertension kubantu abangaphezu kweminyaka engama-65, amaphilisi asetshenziswa ngokuqapha.

Isabelo sezingane

Ukuphula umthetho kusetshenziswa i-Irumed kungeminyaka yobudala bezingane (kuze kube yiminyaka eyi-18).

Lapho ukukhulelwa kwenzeka, ukwelashwa nge-Irumed kumiswa ngokushesha.

I-Iramed ingathinta kabi isimo sengane, ngakho-ke awukwazi ukuphuza amaphilisi ngesikhathi sokuqunjelwa.

Ukuphula umthetho kusetshenziswa i-Irumed kungeminyaka yobudala bezingane (kuze kube yiminyaka eyi-18).

Ekwelashweni kwe-hypertension kubantu abangaphezu kweminyaka engama-65, amaphilisi asetshenziswa ngokuqapha.

Lapho usebenzisa umthamo omkhulu we-lisinopril, umfutho wegazi wehla kakhulu.

Ukwelashwa kwe-overdose yesidakamizwa kubandakanya ukuphathwa koshwele kwe-saline.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Lapho ukukhulelwa kwenzeka, ukwelashwa nge-lisinopril kumiswa ngokushesha. Umuthi osebenzayo uthululwa obisini futhi ungasithinta kabi isimo sengane, ngakho-ke akufanele uphuze amaphilisi ngesikhathi sokuqunjelwa.

Isicelo sokusebenza kokulimala kwezinso

Ngokulimazeka okukhulu kwezinso, ukuthatha umuthi kudinga ukubhekwa njalo kwemingcele ebalulekile.

Sebenzisa umsebenzi wesibindi okhubazekile

Kwezifo ezinzima zesibindi, umuthi awunqunyelwe.

Ukweqisa kwe-Irume

Lapho usebenzisa umthamo omkhulu we-lisinopril, umfutho wegazi wehla kakhulu, ukuwa kwe-orthostatic kuba. Kukhona ukugcinwa komchamo nezindunduma, ukoma okukhulu. Ayikho into evimbela imiphumela ye-lisinopril. Ukwelashwa kufaka ukusetshenziswa kwama-sorbyts kanye nama-laxatives, ukuphathwa kwe-saline okufakwa ngaphakathi.

Umuthi ungasuswa yi-hemodialysis.

Ukuxhumana nezinye izidakamizwa

Ngokusetshenziswa kanyekanye kwe-Irumed nge:

• i-potassium-sparing diuretics ne-cyclosporine ikhulisa amathuba okulimala kwezinso;
• ama-beta-blockers athuthukisa umphumela we-hypotensive we-lisinopril;
• Ukulungiswa kwe-lithium, i-excretion yokugcina ingehla;
• ama-antacid, ukumunca umuthi we-antihypertensive kukhubazekile;
• izidakamizwa ezinciphisa ushukela zandisa ingozi ye-hypoglycemia;
• izidakamizwa ezingezona ezemvelo zokulwa nokuvuvukala okusebenzayo kwe-lisinopril kuncishisiwe.

Ukuhambisana notshwala

Ukuphuza utshwala ngesikhathi sokwelashwa kuthinta kabi isimo sezinto zokugaya, izitho zokuzala kanye nezinzwa.

Ama-Analog

Ukufana kwemithi kwe-Irume yile:

• Lisinopril;
• Diroton;
• ILisinotone;
• ILysiprex;
• ILysigamma.

Imibandela yekhefu lekhemisi

Ngingakwazi ukuthenga ngaphandle kadokotela

Akunakwenzeka ukuthi uthenge amaphilisi ngaphandle kadokotela.

Intengo

Izindleko ezijwayelekile zamathebulethi angama-30 ngama-ruble angama-220.

Izimo zokugcina zomuthi

Amacwecwe agcinwa endaweni epholile, eyomile, evikelwe ekuvezelweni ekukhanyiseni.

Isikhathi sokuphelelwa yisikhathi

Ingasetshenziswa zingakapheli izinyanga ezingama-36 kusukela ngosuku lokwenziwa.

Umkhiqizi

Lesi sidakamizwa senziwa yinkampani yezokwelapha iBelupo eCroatia.

I-analogue yesakhiwo ye-Irume yisidakamizwa iLisinopril.

Izitho ezingezansi ezinendlela efanayo yokusebenza zifaka isidakamizwa iLysinoton.

UDiroton unomphumela ofanayo emzimbeni.

Faka umuthi esikhundleni somuthi onjengeLysigamma.

Ukubuyekezwa

USofia, oneminyaka engama-55, eMoscow: "Kudala ngihlushwa umfutho wegazi ophakeme. Ingcindezi iyenyuka ngezikhathi ezithile, ebangela ikhanda nokubuthakathaka. Bengingafuni ukuphuza noma imiphi imishanguzo, ngakho-ke ngazama izithasiselo zokudla ezahlukahlukene ezinganikanga yimiphumela. Udokotela weluleke u-Irumed amaphilisi. Ngabona umphumela omuhle enyangeni. Kwisigamu sonyaka ingcindezi igcinwe ngaphakathi kwemikhawulo ejwayelekile. "

UTamara, oneminyaka engama-59, uNarofominsk: “Umama ubephethwe yisifo sikashukela isikhathi eside, futhi ngenxa yokuguga, lesi sifo saqala ukugoqa imithambo yegazi nezinso. Ingcindezi yayiqhubeka ikhula njalo, ngenxa yokuthi umama wakhe wayevame ukuyiswa esibhedlela. "Kanye ngosuku - lokhu kwanele ukugcina ingcindezi ejwayelekile. Lo muthi ongabizi kakhulu awubangeli imiphumela emibi."