I-Ciprolet 500 ingenye yezidakamizwa ezisebenza kahle kakhulu ze-fluoroquinolone ezinhlobonhlobo zezicelo. Ingasetshenziswa ekwelapheni kanye nasekuvinjelweni kwezifo ezahlukahlukene zokuvuvukala nezifo ezithathelwanayo, kepha ngaphambi kokuqala ukwelashwa, kunconywa ukuthi kuqinisekiswe ukutholakala kwamagciwane amancane kuleli gciwane.
I-ATX
Umuthi ungowesigaba se-pharmacological sama-quinolones futhi unekhodi ye-ATX ye-J01MA02.
I-Ciprolet 500 ingenye yezidakamizwa ezisebenza kahle kakhulu ze-fluoroquinolone ezinhlobonhlobo zezicelo.
Khipha amafomu nokwakheka
I-cyprolet yenziwa ngalezi zinhlobo zemithamo elandelayo:
- amaphilisi we-enteric camera;
- ikhambi lokufaka
- iso lihla.
Njengomuthi osebenzayo, i-ciprofloxacin isetshenziswa kuzo.
Umthamo we-500 mg unenguqulo yethebhulethi kuphela. Izibhebhe zimhlophe, zizungezile, zi-convex ezinhlangothini zombili. Ingxenye esebenzayo ngesimo se-hydrochloride ikhona ngesamba esingu-0,25 noma esingu-0,5. Umongo uphinde ufake:
- i-croscarmellose sodium;
- i-microcellulose;
- i-magnesium stearate;
- i-silicon dioxide;
- i-talc yemithi;
- isitashi sommbila.
Ukuhlanganiswa kwefilimu kwenziwa ngengxube ye-hypromellose, dimethicone, titanium dioxide, macrogol, talc, sorbic acid ne-polysorbate.
Izibhebhe eziyishumi isatshalaliswa ngamabhulashi. Iphakethe le-carton engaphandle. Ipuleti eli-1 le-blister nemiyalo yokusetshenziswa ifakiwe kulo.
I-Ciprolet isetshenziswa njengomuthi olwa ne-antibacterial.
Isenzo se-Pharmacological
I-Ciprolet isetshenziswa njengomuthi olwa ne-antibacterial. Isakhi salo esisebenzayo yi-ciprofloxacin, i-synthetic antibiotic yochungechunge lwe-fluoroquinolone. Indlela yokusebenza yaleli khompiyutha kungukuvimbela kwama-topoisomerases ohlobo II no-IV, obhekene nokugqama kwe-bacterial DNA.
Umuthi olwa namagciwane ukhombisa izakhiwo ezingama-bactericidal. Ngaphansi kwethonya lazo, ukukhiqizwa kabusha kweDNA kuvinjiwe, ukukhula nokukhiqizwa kabusha kwama-microorganisms kuyamiswa, ulwelwesi nolwelwesi lwamaseli luyachithwa, okubangela ukufa kwamagciwane. Lokhu kukuvumela ukuthi ubhubhise ama-pathogen angenayo gamu asesigabeni esisebenzayo futhi aphumule. Umuthi futhi usebenza kuma-pathogens ama-gram-positive, kepha kuphela lapho esezingeni lokuzala.
I-Ciprofloxacin ayikhombisi ukumelana namandla nama-penicillin, ama-aminoglycosides, ama-tetracyclines, ama-cephalosporins namanye ama-antibalasanti angavimbeli i-DNA gyrase. Ngakho-ke, kusebenza ngempumelelo lapho le mishanguzo yehluleka. Isebenza ngokulwa namagciwane amaningi, kufaka phakathi:
- Moraxella catarrhalis;
- ISalmonella
- UShigella
- ama-neiseries;
- Klebsiella;
- I-Proteus
- uhlu;
- i-brucella;
- i-entero ne-cytobacteria;
- ama-vibrios;
- amathumbu, i-hemophilic, i-Pseudomonas aeruginosa;
- chlamydia
- ezinye i-staph ne-streptococci.
I-Fecal Enterococcus ne-Mycobacterium avium zidinga ukusetshenziswa komuthi emithini ephezulu. Akusebenzi ngempumelelo ngokumelene ne-pneumococcus, treponema, ureaplasma, mycoplasma, bacteroids, flavobacteria, Pseudomonas maltophilia, Clostridium Hardile, Nocardia asteroide, anaerobes iningi, ayephuli i-microflora yemvelo yamathumbu kanye nowesifazane.
Ukumelana nakho kungahluka ngokuhamba kwesikhathi futhi kuya nge-geolocation. Ukuphikiswa okutholakele kuqala ukukhula kancane.
I-Pharmacokinetics
Ikhompiyutha esebenzayo idonswa emathunjini amancane, ifinyelela ekugxilweni okuphezulu egazini amahora ama-1-2 ngemuva kokuthatha amaphilisi. Ukudla kwehlisa isilinganiso sokumuncwa, kepha kungathinti i-bioavailability, engafinyelela ku-80%. I-antibiotic ingena uketshezi oluhlukahlukene (i-peritoneal, ophthalmic, bile, umchamo, amathe, i-lymph, i-synovia, i-sputum, i-seminal plasma), isatshalaliswa kahle kwizicubu:
- isibindi
- isigaxa senyongo;
- izitho zokuzala zabesifazane;
- amathumbu;
- peritoneum;
- i-prostate;
- amaphaphu kanye ne-pleura;
- ipheshana lezinso nomchamo;
- ukuhlangana kwamalungu;
- izakhiwo zesikhumba nemisipha.
Ngasikhathi sinye, ukugxila kwezicubu kuyizikhathi eziningana (kuze kufike ku-12) eziphakeme kunalezo ze-plasma.
Umuthi udlulela ubisi lwebele, weqa i-placenta kanye nomqobo wegazi-ubuchopho. Okuqukethwe kwe-ciprofloxacin ku-cerebrospinal fluid lapho ingekho inqubo yokuvuvukala ifinyelela kuma-8% wevolumu yayo egazini, futhi ngamalitha angashisi angafika ku-37%. Ukuxhumana ngamaprotheni egazi - 20-40%.
Ukusebenza okuyingxenye kwesidakamizwa i-Ciprolet 500 kwenziwa isibindi, ama-metabolites akhombisa umsebenzi othile.
Ukusebenza kancane kwesidakamizwa kwenziwa yisibindi, ama-metabolites akhombisa umsebenzi othile. Kufika ku-70% womthamo othathwe ukhonjiswa ngendlela yoqobo lwayo. Umthwalo oyinhloko we-excretion uwela ezinso. Ukuqedwa kwesigamu sempilo kungamahora angama-3-6. Ekwehlulekeni kwe-renal okungamahlalakhona, lesi sikhombisi singaphindeka kabili, kepha umuthi awukhuphuki, ngoba ukucubungula kwayo ngokusebenzisa ipheshana lesisu kuyathuthukiswa. Ngomsebenzi ojwayelekile wezinso, indle iyakhululwa i-1% yevolumu yokuqala.
Okusizayo
Umuthi okukhulunywa ngawo uhloselwe ukulwa ne-microflora ye-pathogenic, ezwela i-ciprofloxacin. Izinkomba zokuqokwa kweCyprolet:
- Ukutheleleka kwepheshana lokuphefumula: ukutheleleka ngamandla kokuphefumula, i-bronchitis, i-bronchiectasis, i-bacterial pneumonia, uma kungabangelwa yi-pneumococcus, izinkinga ze-cystic fibrosis, i-legionellosis, i-empyema kanye ne-lung abscess.
- Izifo ze-Otolaryngological: sinusitis, otitis media, mastoiditis, pharyngitis, agranulocytic tonsillitis.
- Ukutheleleka kwe-urogenital: i-pyelonephritis, i-cystitis, i-tubulointerstitial nephritis, i-oophoritis, i-endometritis, i-salpingitis, i-orchitis, i-pesidymitis, i-prostatitis, i-balanoposthitis, i-gonorrhea.
- I-Peritonitis nezinye izilonda zangaphakathi zesisu. Lapha, i-antibiotic isetshenziswa njengengxenye yokwelapha okuyinkimbinkimbi.
- I-Cholecystitis, kufaka phakathi okungacacisiwe, i-cholangitis, umfutho we-gallbladder.
- Izifo zesistimu yokugaya, kufaka phakathi i-shigellosis, umkhuhlane we-typhoid, isifo sohudo sebhakthiriya.
- Ukutheleleka kwama-integpent kanye nezendlalelo ezi-subcutaneous: amathumba, i-phlegmon, i-furunculosis, amanxeba, izilonda, ukushiswa kwezimpawu zokutheleleka kwesibili.
- Izifo ze-musculoskeletal: myositis, bursitis, tendosynovitis, osteomyelitis, isifo samathambo esithathelwanayo.
- I-Sepsis, i-bacteremia, i-anthrax ye-pulmonary, izifo ezigulini ezinokungazweli komzimba (nge-neutropenia noma ngemithi ye-immunosuppressive).
- Ukuvimbela ukutheleleka, kufaka phakathi i-Neisseria meningitidis neBacillus anthracis.
I-Tsiprolet 500 ayikwazi ukusetshenziselwa ukuzala ingane.
Contraindication
Umuthi akufanele usetshenziswe uma ukwakheka kungabekezeleli noma kunomlando we-hypersensitivity kwezidakamizwa ze-fluoroquinolone. Okunye ukuphikisana okunamandla kufaka phakathi:
- i-pseudomembranous enterocolitis;
- ukuthatha i-tizanidine ngenxa yengozi ye-hypotension enzima;
- ebuntwaneni nasebusheni (kuvunyelwe ukusebenzisa i-Ciprolet yezingane ezineminyaka engu-5 ubudala ukucindezela umsebenzi wePseudomonas aeruginosa phambi kwe-cystic fibrosis, kanye nokuqeda nokuvimbela ukutheleleka ngeBacillus anthracis);
- ukuzala ingane;
- ukucaphuka.
Ngokunakekela
Ukulawulwa okubalulekile kuyadingeka ezigulini esezikhulile, iziguli ezinenkinga yokulimazeka kwe-hepatic-renal, insuffability ye-cerebrovascular, lapho kukhona isifo sokuwa.
Ungayithatha kanjani iZiprolet 500
Umuthi usetshenziswa kuphela njengoba kuyalelwe udokotela. Amaphilisi angathathwa ngaphandle kokudla. Uma uphuza esiswini esingenalutho, khona-ke bayokwenza ngokushesha okukhulu. Ziginywa zigcwele futhi zigezwa ngamanzi. Ukusetshenziswa kanyekanye kwalesi sidakamizwa kufakwa kuhlanganiswe neziphuzo zezithelo ezithuthukisiwe ngamaminerali, kanye nemikhiqizo yobisi (kufaka phakathi iyogathi emaphaketheni njenge-probiotic).
Umuthi i-Ciprolet usetshenziswa kuphela njengoba kuyalelwe udokotela.
Imithamo inqunywa ngokuhlukile ngokuya izinkomba, ukutholakala kwe-pathogen, ubukhulu kanye nendawo yesilonda. Abantu abadala baphuza amaphilisi angama-500 mg kabili ngosuku. Uma kunesidingo, kukhushulwa umthamo owodwa. Umthamo wansuku zonke akufanele wedlule i-1.5 g. Uma kudingeka, umuthi uphathwa ngokudonsa ngokushintshwa okulandelayo kokuphathwa komlomo. Imijovo ye-Intramuscular ayenzi.
Kunconywe imithamo yokuqala nokunakekelwa kweziguli ezinenkinga yezinso. Ngokucaciswa kwe-creatinine ngaphansi kwe-30 ml / min, isikhathi esiphakathi kwamakhambi sikhuphukela emahoreni angama-24. Ezinganeni nasentsheni, umuthi wokubulala amagciwane unqunywa lapho kudingeka ngokuphelele, ngoba ungadala i-arthropathy. Imithamo ibalwa ngokuya ngesisindo sengane.
Ezinye izilonda ezithathelwanayo nezivuvukala (ukutheleleka kwezakhi ze-bone-cartilage, izitho zesisu, kanye ne-pelvis) zidinga ukusetshenziswa okufanayo kweminye imishanguzo ye-antibacterial. Isikhathi sokulashwa esijwayelekile singamaviki angama-1-2. Kwesinye isikhathi inkambo yokwelapha ithatha izinyanga ezimbalwa.
Kungenzeka yini ukuthi uphuze umuthi onesifo sikashukela
Akukho okuphikisana ngokusetshenziswa kwe-Ciprolet ngabakwa-diabetes. Amandla omuthi odala ukuguquguquka emazingeni kashukela ohlangothini olulodwa noma kolunye kufanele anakwe.
Lapho uthatha i-Ciprolet, ukuvimbela umsebenzi we-hematopoietic kanye noshintsho ekwakhekeni kwegazi okwenzeka egazini kungenzeka.
Imiphumela emibi
I-antibiotic ibekezelelwa kahle, kepha kwezinye izimo ingadala izehlakalo eziningi ezimbi.
Amapheshana wesisu
Iziguli zikhononda nge-nausea, ukuhlanza, ukuthuthukiswa kwesifo sohudo, ubuhlungu besisu, ukuthopha. Kuyaqabukela, i-candidiasis ye-mucosa yomlomo, ukuvuvukala komzimba, ukuvuvukala kwamanyikwe, ukungasebenzi kahle kwesibindi (kufaka phakathi ukwehluleka kwesibindi), i-hepatitis, izicubu zomzimba, i-cholestasis, umsebenzi owengeziwe wama-enzyme wesibindi, i-pseudomembranous enterocolitis.
Izitho zeHematopoietic
Ukuvinjwa komsebenzi we-hematopoietic kanye noshintsho ekwakhekeni kwegazi kwamaselula, kufaka phakathi i-leukocytosis ne-pancytopenia, kungenzeka.
Isistimu yezinzwa ephakathi
Isiyezi, i-migraines, ukukhathala okukhulu, i-asthenia, ukukhathazeka okukhulu, ukuqwasha, ukudangala, ukuvela komqondo, izinkinga ngokuhlangana kokunyakaza, ukwethuka, ukubonakaliswa okukholisayo, i-paresthesia, i-neuropathy, ukunambitheka kanye nephunga lokuphazamiseka, ukukhala ezindlebeni, ukulahleka kokuzwa okubuyayo, i-diplopia kanye ezinye izinto ezimbi ezibonakalayo.
Kusuka ohlelweni lomchamo
Ukuthatha umuthi wokubulala amagciwane kungadala umsebenzi wezinso ongasebenzi kahle, ukuvela kokutholakala kwegazi emchameni, ukuthuthukiswa kwe-crystalluria, kanye nokwanda kokuhlushwa kwe-creatinine.
Lapho uthatha iCyprolet 500, isiyezi, i-migraine nokukhathala kungenzeka.
Kusuka ohlelweni lwezinhliziyo
I-tachycardia engaba khona, i-hypotension, ukuqubuka okushisayo, ubomvu bobuso, ukunwetshwa kwezikhathi ze-QT ku-cardiogram, pirouette arrhythmia, vasculitis.
Allergies
Ngokuvamile, kuvela isikhumba: ukuqubuka, ukuvuvukala, i-hyperemia, ukulunywa, i-urticaria. Kwesinye isikhathi kuqhamuka ubhikidiki. I-photosensitization, i-erythema enobungozi, i-necrolysis yezinombolo, i-bronchospasm, ukushaqeka kwe-anaphylactic, umkhuhlane, izinhlungu emisipha nasekuhlanganeni kwamalunga kungenzeka.
Imiyalo ekhethekile
Ezilondeni ezinzima, ukutheleleka kwe-streptococcal, izifo ezibangelwa ama-pathogens we-anaerobic, ukwelashwa nge-Tsiprolet kufanele kuxhaswe namanye ama-antimicrobial agents.
Uhudo olwenziwe ngenxa yokuthatha i-antibiotic alunakuqedwa ngosizo lwemithi ecindezela umsebenzi wamathumbu wamathumbu.
I-Ciprofloxacin ingadala ukuqhuma kwe-tendon, ukubanjwa kwesithuthwane, kanye nokuthuthuka kokukhululeka.
Ukuhambisana notshwala
Ngenkathi udla imishanguzo, iziphuzo ezinotshwala kanye nemithi equkethe utshwala akufanele idliwe.
Umthelela ekhonweni lokulawula izindlela
Ukusabela okuvela ohlelweni lwezinzwa nezitho zemizwa kungenzeka, lapho ushayela imoto futhi ulawula izindlela ezingaba yingozi, ukunakekelwa kufanele kuthathwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abesifazane abakhulelwe nabomama abancelisayo ngaphandle kokulumula ingane ebeleni, ukuphuza umuthi kuyaphulwa.
Kuchaza uCyprolet ezinganeni ezingama-500
Umkhawulo wobudala yiminyaka eyi-18. Umuthi ungasetshenziswa ebuntwaneni kuphela ekwelapheni nasekuvimbeleni i-anthrax ye-pulmonary noma ukulwa nePseudomonas aeruginosa ezigulini ezine-cystic fibrosis. Kepha kulezi zimo, kulula kakhulu ukusebenzisa umthamo we-250 mg, kunokuba u-500 mg.
Ukweqisa
Izimpawu zokweqisa:
- ikhanda
- vertigo;
- iminyakazo
- ukuthuthumela
- Ubuhlungu esiswini;
- imibono;
- ukulimazeka kwe-hepatic hepatic;
- i-crystalluria;
- igazi emchameni.
Kuyadingeka ukuthulula isisu futhi wenze ukwelashwa okubonakalayo. Kubalulekile ukuqapha umsebenzi wezinso futhi unamathele kuhlelo lokuphuza olwithuthukisiwe. I-Dialysis ayisebenzi.
Abesifazane abakhulelwe nabomama abancelayo ngaphandle kokulumula ingane ebeleni, ukuthatha i-ciprolet kuyaphulwa.
Ukuxhumana nezinye izidakamizwa
I-Ciprolet inyusa okuqukethwe kwe-Theophylline ku-plasma yegazi, ibambezela ukuqedwa kwama-antidiabetic oral agents, ama-xanthines nama-NSAIDs (ngaphandle kwe-Aspirin), ithuthukisa i-nephrotoxicity yeCyclosporin kanye nokusebenza kweWarfarin. Ukulungiselela i-magnesium, i-iron, i-aluminium ne-zinc kunciphisa ukumuncwa kwe-ciprofloxacin, ngakho-ke udinga ukuyisebenzisa ngokunqamula kwamahora ama-4.
Umuthi okukhulunywa ngawo uhambelana nezinye izidakamizwa ze-antibacterial:
- Metronidazole;
- IVancomycin;
- i-cephalosporins;
- ama-penicillin;
- aminoglycosides;
- tetracyclines.
Ukuqedwa kwayo kwehlise ijubane phambi kwe-Probenecid, futhi ngokuhlanganiswa nama-NSAIDs, ubungozi bokubonakaliswa okuqinisekisayo luyanda.
Analogs of Tsiprolet 500
Ukufana kwezakhiwo zesidakamizwa:
- I-Ciprofloxacin.
- I-Cyprocinal.
- Afenoksim.
- IsiTsiprosan.
- I-Tsiproksin.
- I-Medociprine.
- I-Ciprinol.
- I-Quintor et al.
Izidakamizwa ezihlanganisiwe zenye i-antibiotic ekwakhiweni, isibonelo, i-Ciprolet A ene-tinidazole, ingabekwa.
Imibandela yekhefu lekhemisi
Ikhishwe ngumbhalo.
Intengo
Izindleko zamathebulethi angama-500 mg zisuka kuma-ruble angama-54. ngephakeji ngalinye (ama-10 ama-pcs.).
Izimo zokugcina i-Tsiprolet 500
Umuthi ugcinwa kumnyama mnyama ngamazinga okushisa aze afike ku-25 ° C endaweni engafinyeleleki ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umuthi ugcinwa kumnyama mnyama ngamazinga okushisa aze afike ku-25 ° C endaweni engafinyeleleki ezinganeni.
Ukubuyekezwa mayelana ne-Tsiprolet 500
Umuthi uthola izibuyekezo eziningi ezinhle ezivela kodokotela nasezigulini.
Odokotela
Kartsin N.S., Urologist, Tver
Le antibiotic ye-fluoroquinolone isebenza ngempumelelo ikakhulukazi ekulimazeni komzimba kwamathambo. Kuyelulekwa ukuhlwanyela kwangaphambili.
I-Turimova O. N., isazi sezokwelapha, iKrasnodar
Umuthi unezinto eziningi ezingenziwa. Isebenza ngokushesha. Imiphumela emibi ayivelakancane.
Iziguli
ILyudmila, eneminyaka engama-41 ubudala, idolobha laseKerch
Ngithathe amaphilisi e-angina. Izinsuku zokuqala kwakunzima ukugwinya. Kepha umphumela wathokozisa: umphimbo omuhle futhi akukho miphumela emibi.
U-Anatoly, oneminyaka engama-37, uRyazan
Ngiphuza lo muthi nge-exacerbation ye-bronchitis engapheli yezinsuku ezi-5, yize izimpawu ziphela sezikhona izinsuku ezingama-3-4. Lapho udokotela esebeke enye i-antibiotic, ngenxa yokuthi kwaqala kanjani uhudo olunzima. Ngakho-ke ngizophathwa ngeCyprolet kuphela. Umzimba wakhe ubona kangcono kakhulu.
