IManinil umuthi wethebhulethi osetshenziswa ekwelapheni isifo sikashukela sohlobo 2. Into esebenzayo yi-glibenclamide. Kutholakala emabhodleleni amaphilisi ayi-120 wokulawulwa ngomlomo. Ama-5 mg glibenclamide akwithebhulethi eyodwa.
Imiphumela yokusetshenziswa
UManin wehlisa inani loshukela egazini, ungokwesigaba sokuphuma kwe-sulfonylurea.
I-Maninil yesifo sikashukela:
- Yehlisa i-postprandial (ngemuva kokudla) i-hyperglycemia.
- Awunawo umthelela obalulekile kumazinga kashukela okusheshayo.
- Yenza kusebenze ukwakheka kwama-b-cell ama-pancreas we-insulin yayo uqobo.
- I-Lowers i-insulin yokuntuleka kwe-insulin.
- Kwandisa ukwanda kwama-receptors akhethekile nezicubu eziqondiwe ku-insulin.
- Akuthinti kakhulu ukumelana ne-insulin.
- Icindezela ukuhlukana kwe-glycogen kanye nokwakheka kwe-glucose esibindini.
- Inomphumela we-antiarrhythmic, wehlisa ukwakheka kwezigaba zegazi.
- Kwehlisa amathuba okuba nezinkinga ezilandelayo zesifo sikashukela: angiopathy (vasion lesion); isifo senhliziyo (isifo senhliziyo); i-nephropathy (i-renal pathology); i-retinopathy (i-pathology ye-retina).
Umphumela ngemuva kokuthatha i-mannyl uphikelela isikhathi esingaphezu kwamahora ayi-12.
Ukwelashwa kwesifo sikashukela kufanele kube okubanzi futhi kungafaki ukwelashwa kwezidakamizwa kuphela, kodwa futhi nokudla
Izinkomba
IManinil iyanconywa ngokuqokwa kohlobo 2 sikashukela i-mellitus (ifomu elingelona i-insulin) elinomphumela ongagculisi wezindlela zokwelapha ezingezona izidakamizwa (ukudla, ukuzivocavoca okulinganiselayo).
Contraindication
Umuthi awusetshenziselwa isifo sikashukela sohlobo 1 (ifomu lokuncika le-insulin), ukwehlisa amazinga kashukela egazini ngaphansi kwezinombolo ezejwayelekile, ukubonakala kokuphuma kwe-acetone emchameni, egazini, noma ekukhuleni komqondo wesifo sikashukela. I-Maninil akufanele ithathwe ngesikhathi sokukhulelwa nokuqunjelwa. Kuphinde kuhlukaniswe neziguli ezinezindlela zokuwohloka kwezifo zesibindi nezinso, ngokubekezelela komuntu ngamunye umuthi.
Imithamo nokuphatha
Umthamo wesidakamizwa kanye nesikhathi sokwelashwa kunqunywa yi-endocrinologist kuya ngezinga lesinxephezelo ngalesi sifo. Njengomthetho, amaphilisi athathwa izikhathi ezi-2 ngosuku, isigamu sehora ngaphambi kokudla. Ngesikhathi sokwelashwa, umthamo wesidakamizwa uyaguqulwa kuze kube yilapho kutholakala umphumela wokwelapha otholwayo. Umthamo ophansi wokwelapha umuthi ngamathebulethi ayi-0,5, umthamo omkhulu ovunyelwe nsuku zonke ngamathebulethi ayi-3-4
IManinil ine-dosage elula, ekuvumela ukuthi ukhethe irejimeni yokwelapha ngayinye yesiguli ngasinye
Imiphumela emibi
Imiphumela emibi elandelayo ingavela ngenkathi yelashwa nge-maninil:
- i-hypoglycemia;
- isisindo somzimba;
- imivimbo yesikhumba;
- ukulunywa
- ukuphazamiseka kokugaya ukudla;
- izinhlungu ezihlangene
- ukuphazamiseka kokuqalwa kwegazi;
- i-hyponatremia (ukwehla kwezinga le-sodium esegazini);
- i-hepatotoxicity;
- ukubonakala kwamaprotheni emchameni.
Ngobunzima bemiphumela emibi, umuthi ukhanseliwe futhi kunikezwe okunye ukwelashwa.
Imiyalo ekhethekile
Sebenzisa ngokuqapha lapho uthatha i-clonidine, ama-b-blockers, i-guanethidine, i-reserpine ngenxa yobunzima bokuthola izimpawu ze-hypoglycemia. Ngesikhathi sokwelashwa nge-mannil, ukudla nokuqapha ushukela wegazi kuyadingeka.
IManinil idinga ukugcinwa endaweni emnyama.
Ngokuvamile, lesi sidakamizwa sisebenze kahle ku-monotherapy yohlobo 2 sikashukela, futhi sihlangana nezinye izidakamizwa ezinciphisa ushukela.
