I-Lyspro insulin iyinto efana ne-insulin yabantu. Yenzelwe labo bantu abaye bathikameza i-glucose. Kulesi simo se-pathological, i-hyperglycemia iba ngenxa yokushoda kwama-insulin.
Igama Lezwe elingafanele
I-Humalog - igama lokuhweba lomuthi eRussia.
ILyspro insulin ingumuthi we-INN.
I-insulin lispro - isiqu se-latin.
I-Lyspro insulin iyinto efana ne-insulin yabantu. Yenzelwe labo bantu abaye bathikameza i-glucose.
I-ATX
Ikhodi kuhlelo lwamakhemikhali lokuhlukaniswa kwamakhemikhali nokwelashwa yi-A10AB04. Ikhodi yeqembu yi-A10AB (ama-insulin asebenza ngamafuphi nama-analogues abo).
Khipha amafomu nokwakheka
Umuthi wenziwa ngefomu letshezi lokujova emithanjeni noma ngaphansi kwesikhumba. Umuthi uyaqhubeka uthengiswa ngohlobo lwe-2:
- kwiphakheji lekhadibhodi enezirinji ezi-5 zePeni elisheshayo (3 ml ngayinye, i-100 IU / ml), ezilungele ukusetshenziswa;
- ebhokisini lekhadibhodi elinamabhokisi we-5 (3 ml lilinye, i-100 IU / ml).
Into esebenzayo yesidakamizwa ibizwa nge- lyspro insulin. Izithako ezingeziwe: i-metacresol, i-glycerol, amanzi omjovo, isisombululo se-10% se-hydrochloric acid, njll.
Isenzo se-Pharmacological
Umuthi unomphumela we-hypoglycemic. Ngemuva kokuphathwa kwe-intravenous noma i-subcutaneous, izinga loshukela wegazi emzimbeni liyancipha. Lo mphumela wenzeka cishe imizuzu eyi-10-20 ngemuva kokusetshenziswa kwesidakamizwa.
Umuthi unomphumela we-hypoglycemic. Ngemuva kokuphathwa kwe-intravenous noma i-subcutaneous, izinga loshukela wegazi emzimbeni liyancipha.
I-Pharmacokinetics
Into esebenzayo inemvelo ngejubane, ngoba inejubane eliphezulu lokufaka kumafuthumeli angaphansi (iyingxenye yeqembu lama-insulin ase-Ultra-short-acting). Ngenxa yalokhu, ngesikhathi esifushane ukugcwaliswa okukhulu kwe-plasma kutholakala (okungenani isigamu sehora kamuva).
Umuthi ungafakwa emgqonyeni noma ngaphansi kwesikhumba ngaphambi nje kokudla. Kuvunyelwe ukubeka umjovo kusengaphambili, ubuningi bemizuzu engu-15 ngaphambi kokudla. Inani eliphakeme lesenzo lenzeka ngemuva kwamahora angama-1-3, futhi isikhathi somuthi sisuka emahoreni amathathu kuya kwayi-5. Ukuqedwa kwesigamu sempilo cishe ihora elilodwa.
Izinkomba zokusetshenziswa
Odokotela banquma umuthi ezigulini zabo abanesifo sikashukela. Ngosizo lomuthi, ukwelashwa kwe-insulin kuyenziwa, okukuvumela ukuthi ulondoloze inani loshukela egazini ngezinga elijwayelekile.
Contraindication
Umuthi awukwazi ukusetshenziswa:
- nge-hypersensitivity kwento esebenzayo noma ezinye izinto ezengeziwe kusuka kuHumalogue;
- ngokwehla kweshukela egazini ngaphansi kwezinga elijwayelekile (3.5 mmol / l).
Ngokunakekela
Kuyadingeka ukufaka umjovo ngokucophelela ukuze ungangeni emgodini wegazi. Ngemuva komjovo, isikhumba asidingi kusatshwa.
Ungayithatha kanjani i-insulin lyspro
Izici zokusebenzisa kanye nomthamo kumele zinqunywe ngabasebenzi bezokwelapha ngawodwana. Ezimweni eziningi, i-insulin ilawulwa ngokungaziphathi. Ukulawulwa kwe-Intravenous kungenzeka kudingekile kwezinye izimo (ngokwesibonelo, esikhathini esiphakathi kokungenelela kokuhlinzwa noma ngemuva kwabo, ngezifo ezenzeka ngamafomu ashubile, ukuntuleka kwe-insulin kanye ne-carbohydrate metabolism).
Lapho usebenzisa umuthi, kubalulekile ukulandela izincomo zokufakwa komjovo. Isiguli sidinga:
- Lungisa umuthi. Kufanele kulingana nezimpawu ezinjengokucaca, ukungabi namabala. Ukwethulwa kwekhambi kuyalahlwa uma kunamafu, kugqame. Umuthi kufanele futhi ube nokushisa kwegumbi.
- Geza izandla zakho bese ukhetha indawo yokujova ngokungenamikhawulo ngokusula.
- Namathisela inaliti kwipeni yesirinji bese ususa ithole lokuvikela kuyo.
- Ngaphambi kokujova isikhumba endaweni ekhethiwe yokuqoqa, ukuze kutholakale isibaya esikhulu, noma wolule.
- Faka inaliti endaweni elungiselelwe bese ucindezela inkinobho.
- Susa ngokucophelela inaliti esikhunjeni bese ufaka i-swab yekotini endaweni yomjovo.
- Usebenzisa cap yokuvikela, susa inaliti. Ngokuzayo lapho usebenzisa umuthi, udinga inalithi entsha.
Isimpawu eseceleni esivamile lapho usebenzisa i-insulin lyspro yi-hypoglycemia.
Imiphumela emibi ye-insulin lyspro
Isimpawu eseceleni esivamile yi-hypoglycemia. Ezimweni ezinzima kakhulu, i-hypoglycemia iholela ekudumeni. Futhi, ngoshukela omncane wegazi kunengozi yokufa.
Ngenqubo yokusebenzisa umuthi, ungahlangabezana nokungezwani komzimba. Ukuvezwa kwayo kuvame ukubonwa endaweni yomjovo. Ezigulini, isikhumba siyanda futhi sikhukhume, ukulunywa kwenzeka. Lezi zimpawu zihamba ngemuva kwesikhashana. Akuvamile ukuthi ukungezwani komzimba kuthinte umzimba wonke. Ukusabela okunjalo komzimba kungaba yingozi empilweni. Izimpawu zokuphendula okujwayelekile komzimba:
- imichilo emzimbeni wonke;
- ukulunywa
- I-edema kaQuincke;
- ukukhuphuka kokujuluka;
- ukwehla kwengcindezi yegazi;
- ukukhuphuka kwenhliziyo;
- ukuphefumula
- umkhuhlane.
Omunye umphumela ongahle ube khona ukunyamalala kwama-subcutaneous fat (lipodystrophy). Lokhu kusabela kwendawo. Kungabonakala engxenyeni yomzimba lapho kwangena khona umjovo wesidakamizwa.
Umthelela ekhonweni lokulawula izindlela
Umuthi ungathinta kabi amandla okushayela imoto nezindlela eziningi eziyinkimbinkimbi ezidinga ukunakwa okwengeziwe nokuqapha, ezimweni ezi-2:
- ngokwethulwa komthamo okhuphukile noma oncishisiwe kanye nokukhula kwe-hyperglycemia noma i-hypoglycemia ngenxa yalokhu;
- ngokubukeka kwe-hypoglycemia njengomthelela oseceleni.
Kuzona zozimbili lezi zinhlobo, amandla okugxila akhubazekile, futhi ukusabela kwe-psychomotor kuyehla. Ukushayela nokusebenza ngemishini eyinkimbinkimbi kunconywa ngokuqapha.
Imiyalo ekhethekile
Ngaphansi kokuqashwa okuqinile kochwepheshe, isiguli kufanele sidluliselwe kwenye i-insulin. Ukulungiswa kwedosi kungadingeka lapho uguqula umenzi, uhlobo lomuthi, indlela yokukhiqiza, njll.
Sebenzisa ebudaleni
Le insulin ingabhekelwa kubantu asebekhulile. Isincomo esibalulekile saleli qembu leziguli - imithamo emiselwe udokotela kufanele ibhekwe ngokuqinile ukuze kuncishiswe ubungozi be-hypoglycemia. Lesi simo siyingozi ekugugeni. Umphumela we-hypoglycemic ungavusa ubunzima be-hypertensive, i-spasm yemikhumbi ye-coronary kanye ne-myocardial infarction, ukulahleka kombono.
Isabelo sezingane
I-Humalogue ingabelwa ingane uma inesifo sikashukela.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa nokuqunjelwa, i-Humalog ingasetshenziswa. Ochwepheshe ababeke lesi sidakamizwa ezigulini zabo abazange baveze imiphumela engafuneki. Ucwaningo luye lwabonisa ukuthi i-analogue ye-insulin yabantu:
- ayiwelani kwi-placenta;
- akubangeli ukungazalwa kabusha;
- akubangeli ukwanda kwesisindo ezinsaneni ezisanda kuzalwa.
I-Humalogue ingabelwa ingane uma inesifo sikashukela.
Ngesikhathi sokukhulelwa, kubalulekile kuphela ukulandela imiyalo kadokotela, uqaphele umthamo. Ezinyangeni zokuqala ezintathu, ukufunwa kwe-insulin kuphansi. Ukusuka ezinyangeni ezi-4, kuyanda, kuthi ngesikhathi sokubeletha nangemva kwawo kungancipha kakhulu. Ngesikhathi sokuncelisa, umthamo uvame ukuguqulwa futhi / noma ukudla kunqunyelwe.
Isicelo sokusebenza kokulimala kwezinso
Izitho eziphazamisekile zohlelo lokuchama, isidingo se-hormone singancipha.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokungasebenzi kahle kwesibindi, ukwehla kwesidingo somzimba se-insulin kungenzeka.
I-Lyspro insulin overdose
Ngokusebenzisa ngokungafanele umuthi, i-overdose kungenzeka kakhulu. Kulesi simo, kuvela izimpawu ze-hypoglycemia:
- ubuqili;
- ukujuluka ngokweqile;
- ukwanda kwesifiso sokudla;
- ukukhuphuka kwenhliziyo;
- ikhanda;
- ukuphazamiseka kokulala;
- Isiyezi
- ukungaboni kahle
- ukuhlanza
- ukudideka;
- ukungasebenzi kahle kwezimoto, okuphawuleka ngokunyakaza okusheshayo kwesiqu noma amalumbo.
Ngesikhathi sokukhulelwa, i-Humalog ingasetshenziswa, ngoba ochwepheshe abaze baveze imiphumela engafuneki.
I-Hypoglycemia idinga ukuqedwa. Ezimweni ezimnene, udinga ukuthatha ushukela noma udle umkhiqizo othile oqukethe ushukela. Ezimweni ezinzima kakhulu nange-coma, usizo lwabachwepheshe luyadingeka. Odokotela abaneziguli ezinezimpawu ze-hypoglycemia injin glucagon (ukungena esikhunjeni noma ngaphansi kwesikhumba) noma isixazululo se-glucose (singene emithanjeni). Ngemuva kwezindlela ezinjalo zokwelapha, kuyadingeka ukuthi udle ukudla okuqukethe ama-carbohydrate amaningi.
Ukuxhumana nezinye izidakamizwa
Ngokuphathwa kanyekanye kwe-insulin kanye nokuvimbela inzalo ngomlomo, ama-glucocorticosteroids, ama-antidepressants ama-tridclic, i-thiazide diuretics neminye eminye imithi, umphumela we-hypoglycemic ungancipha. Ama-Tetracyclines, ama-sulfanilamides, ama-angiotensin aguqula ama-enzyme inhibitors, njll abangela ukwanda kwesenzo se-pharmacological.
Kwenqatshelwe ukuxuba le insulin nemithi equkethe i-insulin yezilwane.
Ukuhambisana notshwala
Ukuphuza iziphuzo eziqukethe utshwala ngenkathi yelashwa ushukela akunconywa. Ngokuhlanganiswa kotshwala ne-insulin, umphumela we-hypoglycemic uyathuthukiswa.
Elinye iqembu lama-insulin e-ultrashort lengezwe yi-insulin aspart.
Ama-Analog
Iqembu le-insulin elisebenzisa kakhulu i-insulin lifaka hhayi i-Humalog kuphela, kodwa futhi nezincazelo zayo - i-Humalog Mix 25 neHumalog Mix 50. Le mishanguzo iyatholakala ngesimo sokumiswa kokuphathwa ngaphansi kwesikhumba.
Elinye iqembu lama-insulin e-ultrashort lifakwa yi-insulin aspart (izidakamizwa: I-NovoRapid Flexpen, i-NovoRapid Penfill) ne-insulin glulizin (izidakamizwa: i-Apidra, i-Apidra SoloStar).
Kukhona futhi nokufakwa kwenkathi yesikhathi esehlukile yokwenza:
- Isenzo esifushane. Imithi eqhamuka kuleli qembu: Rinsulin R, Humulin Regular, njll.
- Izigaba ezimbili (insulin biphasic - "bifazik"). Ukulungiselela: Humodar K25-100, NovoMix 50, Flexpen, NovoMix 30, uPenfill, njll.
- Isikhathi esiphakathi Leli qembu lifaka iBiosulin N, njll.
- Ukwenza into ende. Izidakamizwa ezithile: uLantus, Levemir Penfill.
- Isenzo eside. Leli qembu liqukethe izidakamizwa zesikhathi esiphakathi nezenzo ezinde.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi uthengiswa emakhemisi kuphela unikezwa umuthi.
Intengo ye-Lyspro insulin
Iphakethe leHumalog elinepeni yesirinji libiza cishe ama-ruble ayi-1690. Intengo elinganiselwe yephakeji enama-cartridge angu-5 ngama-ruble ayi-1770.
Izimo zokugcina zomuthi
Umuthi ongakaphrintwa kufanele ugcinwe esiqandisini emazingeni okushisa angawa ngaphansi kwe-2 ° C (isixazululo akumele sibe yiqhwa).
Umuthi osetshenziswa nsuku zonke kufanele ugcinwe emazingeni okushisa asekamelweni (hhayi ngaphezulu kuka-30 ° C). Kufanele igcinwe kude nelanga nemishini yokushisa. Isikhathi sesitoreji akumele sidlule izinsuku ezingama-28.
Umuthi ongakaphrintwa kufanele ugcinwe esiqandisini emazingeni okushisa angawa ngaphansi kwe-2 ° C (isixazululo akumele sibe yiqhwa).
Isikhathi sokuphelelwa yisikhathi
Uma umuthi ungakavulwa, ungagcinwa iminyaka emi-3 kusukela ngosuku lokwenziwa kwawo.
Umkhiqizi
Umenzi we-insulin ngaphansi kwegama lokuhweba elithi Humalog yinkampani yaseFrance iLilly France.
Ukubuyekezwa kwe-Lyspro insulin
UStanislav, oneminyaka engama-55, uTyumen: "Eminyakeni engaba ngu-10 edlule ngatholakala ukuthi nginesifo sikashukela. Amaphilisi anqunywa ekuqaleni kwezokwelashwa. Muva nje, uchwepheshe waphakamisa ukuthi kushintshwe isixazululo sikaHumalog sokuphatha ngokungahambi kahle, ngoba amaphilisi awazange anikeze imiphumela efiselekayo. Ngalandela. izeluleko zikadokotela. Ngathenga lesi sidakamizwa ekhemisi futhi ngaqala ukuwujova amahlandla ama-3 ngosuku ngaphambi kokudla. Ngizizwa ngingcono kunesikhathi lapho amaphilisi engazange asize. "
U-Elena, oneminyaka engama-52, uNovosibirsk: "Nginesifo sikashukela. Ukuze ngigcine ushukela ojwayelekile, ngizifaka umjovo nge-insulin. Ngokokuyalelwa ngudokotela wami, ngithenga njalo uHumalog kumapeni wesirinji. Izinzuzo zalo muthi: ukusetshenziswa kalula, ukusebenza kahle, nemiyalo enemininingwane. Ngizothatha izindleko eziphakeme emaphutheni. "
U-Anastasia, oneminyaka engama-54, uKhabarovsk: "Umuthi uyasebenza uma usetshenziswa kahle. Bengingahlali ngilandela izincomo zikadokotela, ngakho-ke ngangivame ukubhekana nemiphumela emibi. Abantu abanesifo sikashukela abacebisi ukululeka ngokwenza iphutha elifanayo. Sonke sisetshenziselwa ukwelapha ukukhwehlela sisodwa. , umkhuhlane. Isifo sikashukela isifo sikashukela yisifo esidinga indlela efanelekile. Ekwelashweni kwaso, kubalulekile ukulandela ngokuqokwa ukuqashwa kochwepheshe.
