I-Tricor 145 yi-ejenti yomlomo ye-hypolipidemic esetshenziselwa ukwenza umtholampilo ukwehlisa i-cholesterol ephezulu ne-triglycerides. Ukuqedwa kwe-hypercholesterolemia kuyadingeka ukunciphisa ingozi yokuhlakulela isifo sokuqina kwemithambo nokuvikela ukwakheka kwezigcawu ze-atherosclerotic ezindongeni zomkhumbi. Umuthi unciphisa ubungozi bokuqhekeka kwegazi ngenxa yokucindezelwa kokuhlanganiswa kwamapuleti egazi.
Igama Lezwe elingafanele
Fenofibrate.
I-Tricor 145 isetshenziselwa ukwehlisa i-cholesterol ephezulu ne-triglycerides.
I-ATX
C10AB05.
Khipha amafomu nokwakheka
Umuthi uyatholakala ezibhebheni ezimhlophe zokulawulwa komlomo. Utho ngalunye lwesidakamizwa luqukethe i-145 mg yento esebenza - i-fenofibrate nanoparticles. Izakhi ezilandelayo zisetshenziselwa ukukhulisa ijubane nokuphelela kokufakwa emzimbeni kuhlangene nento esebenzayo:
- i-crospovidone;
- i-hypromellose;
- i-microcrystalline cellulose;
- i-sodium lauryl sulfate kanye ne-docusate;
- ushukela wobisi, i-sucrose;
- i-silloon dioxide ye-colloidal dehydrate;
- i-magnesium stearate.
I-Tricor 145 itholakala kumathebulethi amhlophe okuphatha ngomlomo futhi iqukethe i-145 mg yento esebenza - fenofibrate nanoparticles.
Amacwecwe embozwe ulwelwesi lwefilimu ngaphezulu, oluncibilika ngaphansi kwesenzo samathumbu wamathumbu. Ifilimu liqukethe i-polyvinyl alcohol, i-titanium dioxide, i-talc, i-soya lecithin, i-xanthan gum.
Amafomu angekho:
- ijeli;
- imijovo kuma ampoules.
Isenzo se-Pharmacological
Umuthi we-hypoglycemic ungokaqembu lama-fibrate. Indlela yokusebenza yesakhiwo esisebenzayo isuselwe kusebenze kwe-alpha receptors. Njengomphumela wokwandisa umsebenzi wabo osebenzayo, i-lipolysis kanye ne-excretion yama-lipoprotein enezinga eliphakeme lama-triglycerides ayathuthukiswa.
I-Fenofibrate yenziwa kusuka ku-fibric acid, ekwazi ukuthinta izinga lama-lipid emzimbeni womuntu ngenxa yokuqalwa kwama-alpha receptors. Ngenxa yokufezeka komphumela wokwelapha, ukugcwala kwama-low density lipoproteins (LDL) kuyancipha bese kuthi ingxenye yezinga eliphakeme lokuxinana (HDL) inyuke. Ukuhlolwa kwangaphambilini kwembula ukwehla kwe-cholesterol ephelele ngamaphesenti angama-25, ama-triglycerides ngo-45-55% kanye nokwanda kokuxoshwa kwe-HDL ngo-10-30%.
Ngesikhathi sokwelashwa okulondoloziwe, ubungozi bokuqhamuka nezinguquko ze-atherosulinotic ku-vasot end endhelium buyancipha futhi amathuba okuba kwakheke ama-cholesterol plaque ezindongeni zomgodi wegazi kuncishisiwe. Ngokusebenzisa isikhathi eside umuthi, inani lezimpawu zokulimala liyancipha. Lapho kukhona i-hyperuricemia, iziguli zithola enye inzuzo ngendlela yokuncipha kwama-25% emazingeni e-uric acid.
I-Tricor 145 - isidakamizwa se-hypoglycemic singokweqembu lama-fibrate.
I-Pharmacokinetics
Uma zingena emathunjini, amaphilisi ahanjiswa yi-esterases ukuze enze i-fenofibroic acid. Umuthi uyahluka ungene egazini, lapho ufinyelela khona amanani aphakeme kungakapheli amahora angama-2-4. Umkhiqizo we-metabolic osebenzayo udonswa odongeni lwamathumbu ngesimo se-nanoparticles, ngakho-ke ukusetshenziswa okufanayo kokudla akukuphazamisi isilinganiso sokutholwa kanye nokuphelela kwe-bioavailability. Emithanjeni yegazi, i-99% ye-fenofibroic acid isebenza ngendlela eyinkimbinkimbi nge-plasma albhamuin.
Izinto zokwelapha aziguquli emangqamuzaneni esibindi. Ukuphila kwengxenye ye-metabolite esebenzayo kungamahora angama-20. Umuthi ushiya umzimba ngomchamo kungakapheli isonto.
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa i-cholesterol ephakeme kanye ne-triglycerides noma i-dyslipidemia ephumelela ngokusebenza okuphansi kokulapha ukudla, ukwanda komzimba nezinye izindlela ezingezona izidakamizwa lapho ulwa nokukhuluphala. Ikakhulu phambi kwe-hypertension ye-arterial nemikhuba emibi.
Ekusebenzeni kwemitholampilo, isidakamizwa singasetshenziswa ukuqeda i-metabolic syndrome ne-hyperlipoproteinemia kuphela uma izinga elikhulayo lama-lipoprotein liphikelela uma ukwelashwa kwenqubo ye-pathological yokuqala kungasebenzi.
I-Tricor 145 isetshenziselwa i-cholesterol ephakeme kanye ne-triglycerides noma i-dyslipidemia exubile ngokuphathwa kabi kokudla.
Contraindication
Umuthi uphethwe ngokuphelele emacaleni alandelayo:
- nge-galactosemia enzima, ukuntuleka kwe-lactase kanye ne-fructose, i-galactose-glucose syndrome, i-sucrose-isomaltase malabsorption;
- ukuba khona kokuzwela okwengeziwe kokukhanya, ezingxenyeni zezakhiwo zeTricorra;
- ukwehluleka kwesibindi nezinso;
- i-Phototoxicity ngesikhathi sokwelashwa ngeKetoprofen, i-fibrate;
- inqubo ye-pathological gallbladder;
- ukusabela kwe-anaphylactic kumantongomane, soya kanye nebhotela lamantongomane.
Ngokunakekela
Kuyadingeka ukuqapha isimo sesiguli lapho sinqunyelwe ngokumelene nesizinda sezifo ezilandelayo:
- imnene kokulingana kwezinso nokulinganiselwa kwe-hepatic;
- uphuzo oludakayo;
- ubudala
- uhlobo lwofuzo lwesifo semithambo yethambo;
- ukwelashwa okuhambisanayo ngama-anticoagulants angaqondile kanye nama-blocker we-HMG-CoA wokunciphisa kabusha.
Kuyadingeka ukuthi kuqashelwe isimo sesiguli lapho kunqunyelwa emelana nemvelaphi yotshwala obungamahlalakhona.
Ungayithatha kanjani iTricor 145 mg
Izibhebhe kumele zithathwe ngomlomo ngaphandle kokuhlafuna. Ukulimazeka kulolwazana lwefilimu kungaholela ekwehlelweni kokuguqulwayo kwe-fenofibrate ibe yi-fenofibric acid esebenzayo. Umuthi ungaphuzwa usuku lonke, kungakhathalekile ukuthi udla ini. Iziguli zabantu abadala zidinga ukuphuza i-1 ithebhulethi ye-145 mg ngosuku kanye.
Umphumela wokwehlisa i-lipid uyasebenza lapho ukudliwa kokudla kuyaqhubeka nangezimo zomsebenzi owengeziwe womzimba. Iziguli ezelashwa nge-160 mg yesidakamizwa azidingi ukwehliswa kancane kancane komthamo ukuya ku-145 mg.
Ukuthatha umuthi wesifo sikashukela
Umuthi awuthinti amazinga kashukela egazini kanye nomsebenzi wamaseli we-pancreatic beta. Ngakho-ke, iziguli ezinesifo sikashukela i-mellitus azidingi ukulungiswa komthamo wemithi ye-insulin ne-hypoglycemic.
Imiphumela emibi
Ukuphendula okungalungile komzimba kuvela ngenxa yomthamo okhethwe ngokungafanele we-fenofibrate.
Amapheshana wesisu
Ukuphazamiseka kwesistimu yokugaya ukudla kuvezwa njengobuhlungu ku-epigastrium, ukugabha, ukwakheka kwegesi kanye nohudo olulinganiselayo. I-pancreatitis kungenzeka.
Iziguli ezinesifo sikashukela i-mellitus azidingi ukulungiswa komthamo kwemithi ye-insulin kanye ne-hypoglycemic.
Izitho zeHematopoietic
Ezimweni ezingavamile, ngokuvinjwa kwezinhlelo zokujikeleza nokuqina kwama-lymphatic, ukuntuleka kwe-leukocyte kanye nokwanda kwe-hemoglobin.
Isistimu yezinzwa ephakathi
Ukuphazamiseka kwesistimu yezinzwa kubonakala kukhwalithi yokungasebenzi kwe-erectile, ikhanda.
Kusuka ohlelweni lwe-musculoskeletal kanye nezicubu ezithintekayo
Ezimweni ezingavamile futhi ezihlukile, ukuthuthukiswa kwe -useuse myalgia, izicubu zomsipha kanye ne-spasms, ubuthakathaka, i-myositis, i-necrosis eshubile yezicubu zemisipha yemisipha yamathambo kungenzeka.
Kusuka ohlelweni lokuphefumula
Kunobungozi obuncane bokuqhakambisa i-pneumopathy ye-interstitial.
Engxenyeni yesikhumba namafutha angaphansi
Ukuvela kokuvela kwesikhumba se-allergic, kubonakaliswa ukuvela kokuqhuma, i-urticaria, ukulunywa kanzima. Kwezinye izimo, ukuzwela ukukhanya kukhuphuka esikhunjeni, umuntu uqala ukulahlekelwa izinwele. I-photosensitivity ingahle ihambisane ne-erythema, ukwenzeka kwamaqubu.
Kusuka ohlelweni lwezitho zofuzo
Ukwanda okungenzeka kwe-serum creatinine namazinga e-uric acid okuphikisana nesizinda sokugcinwa komchamo.
Kusuka ohlelweni lwezinhliziyo
Ukuphazamiseka kwemisipha kubonakaliswa yi-venous thromboembolism, kufaka phakathi i-pulmonary embolism kanye ne-venous thrombosis emaphethelweni aphansi.
Uhlelo lwe-Endocrine
Mhlawumbe ukukhuphuka kokujuluka.
Engxenyeni yesibindi ne-biliary
Ezimweni eziningi, umsebenzi uyakhuphuka kanye nenqwaba yama-hepatic aminotransferase ku-serum yegazi inyuka. Kwezinye izimo, i-cholelithiasis iyakhula, mhlawumbe ukuvuvukala kwesibindi ngezikhathi ezithile. Uma kuvela izimpawu ze-hepatitis ngesimo se-jaundice kanye nokulunywa, kunconywa ukuthi kwenziwe izivivinyo zaselebhu ukuze kuqinisekiswe ukutholakala kwale nkinga. Ngemuva kokuthola imiphumela emihle, ukusetshenziswa kwamafenofibrate kukhanseliwe.
Imiyalo ekhethekile
Ngaphambi kokuqala ukwelashwa ngezidakamizwa, kuyadingeka ukuqeda izimbangela zobudlova be-hypercholesterolemia yesibili, engenzeka ngokumelene nesizinda sohlobo 2 lwesifo sikashukela, udakwa. Ukusebenza kokwelashwa kunconyelwa ukuthi kuhlolwe izinkomba zaselebhu zamazinga wamafutha we-serum. Uma kungekho isenzo sokwehlisa i-lipid kungakapheli izinyanga ezi-3, kuyadingeka ukubonisana nodokotela wakho mayelana nokubuyiselwa komuthi.
Kwezinye izimo, ngokumelene ingemuva lokwelashwa ngezidakamizwa, ukuthuthukiswa kwenqubo yokuvuvukala kumanyikwe kungenzeka.
Kwezinye izimo, ngokumelene ingemuva lokwelashwa ngezidakamizwa, ukuthuthukiswa kwenqubo yokuvuvukala kumanyikwe kungenzeka. Izimbangela ze-pancreatitis zingaba ngamatshe kanye nokuqunjelwa kwe-bile gallbladder, umphumela wokwelashwa onganele ngokumelene nesizinda se-hypertriglyceridemia enzima.
Umthelela ekhonweni lokulawula izindlela
Umuthi awuphenduli doping noma psychotropic, awuchaphazeli kabi umsebenzi wesistimu yezinzwa ephakathi nendawo. Ngakho-ke, ngesikhathi sokwelashwa nge-Triicore, kuvunyelwe ukulawula izindlela eziyinkimbinkimbi nemoto, edinga ukukhuphuka okukhulu kokuqina kanye nokusabela okusheshayo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukuthatha umuthi okwehlisa i-lipid kuvinjelwe ngesikhathi sokukhulelwa. Lapho unquma umuthi ngesikhathi sokuncelisa, kubalulekile ukudlulisa ingane ekudleni ngezingxube zezingane futhi ukhansele i-lactation.
Ukunquma i-TRICOR 145 mg ezinganeni
Umenzeli we-Oral hypolipidemic wenqatshelwe ukuthatha iminyaka engu-18 ubudala ngenxa yokuntuleka kolwazi ngomphumela we-fenofibroic acid ekuthuthukisweni komzimba womuntu esenkulisa nasentsheni.
Sebenzisa ebudaleni
Abantu abadala kuneminyaka engama-70 kufanele baqaphe ngokucophelela isimo sabo ngenkathi belashwa nge-fenofibrate.
Isicelo sokusebenza kokulimala kwezinso
Umuthi ubhekene ne-contraindication ekwehlulekeni okunamandla kwezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Umuthi awuvunyelwe ukusetshenziswa ngabantu abanezifo ezinzima zesibindi.
Ukweqisa
Umenzeli othize ophikisayo akakhiwa. Lokhu kungenxa yokungabikhona kwamacala okweqa ngokweqile. Ngokusebenzisa okukodwa komthamo omkhulu wamathebulethi, kungenzeka ngokomqondo ukwandisa imiphumela emibi futhi wandise imvamisa yokuvela kwayo. Uma usola izimpawu zokweqisa, kufanele ufune usizo lodokotela. Umuthi awudalulwa yi-hemodialysis.
Kuyenqatshelwe ngokuphelele ukuphuza utshwala ngesikhathi sokwelashwa ngeTricor.
Ukuxhumana nezinye izidakamizwa
I-Fenofibrate nemikhiqizo yayo ye-metabolic ayizona izithiyo ze-cytochrome P450 isoforms.
Ukuhambisana notshwala
Kuyenqatshelwe ngokuphelele ukuphuza utshwala ngesikhathi sokwelashwa ngeTricor. I-ethyl utshwala ingenza buthaka umphumela we-lipid-wehlise, ibangele ukuvimbela kwesistimu ye-hepatobiliary neyezinzwa.
Inhlanganisela ehlanganisiwe
I-Fenofibroic acid ithuthukisa umphumela wokwelapha wama-anticoagulants ukusetshenziswa komlomo. Ngenxa yale nhlanganisela, ukopha kwangaphakathi kungenzeka. Umphumela ongemuhle ubangelwa ukukhishwa kwe-anticoagulant kusuka endaweni ebopha amaprotheni ye-plasma.
Ekuqaleni kokwelashwa kwezidakamizwa nge-fenofibrate, kunconywa ukubonana nodokotela ngesidingo sokunciphisa umthamo wansuku zonke wama-anticoagulants yi-⅓. Ukukhetha umthamo okulandelayo kwenziwa ngokuya ngemigomo ye-INR.
Ngokusebenzisa okukodwa komthamo omkhulu wamathebulethi, kungenzeka ngokomqondo ukwandisa imiphumela emibi futhi wandise imvamisa yokuvela kwayo.
Akuhlanganisiwe ukuhlanganisa
Ngenxa yengozi ephezulu yemiphumela enobuthi emisipha, ukusetshenziswa kwe-fenofibrate ene-HMG-CoA reductase blockers kanye nokususelwa kwe-fibrate akukhuthaziwe.
Inhlanganisela edinga ukuqashelwa
Kunconywa ukuthi kuqashwe njalo ukusebenza komsebenzi wezinso ngenkathi kuqokwa uTricor nge-cyclosporine noma imishanguzo elwa namagciwane. Lapho kuhlanganiswa, kunengozi yokwehluleka kwezinso okunzima. Ngokushintshwa okuqinile kwamapharamitha welebhu, udinga ukuyeka ukuthatha iTricor.
Ama-Analog
Umuthi ungathathelwa indawo ngomunye walezi zinhlobo ezilandelayo:
- I-Lipantyl;
- I-Fenofibrate Canon;
- Gofibrat;
- Okupholile.
Izimo zeholide zeTreicor 145 mg kusuka emakhemisi
Amaphilisi atholakala ngokululekwa ngqo kwezokwelapha.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi awuthengiswa ngaphandle kwemithi kadokotela ngenxa yengozi ephezulu yemiphumela emibi uma isetshenziswe ngendlela engafanele.
Intengo
Izindleko ezijwayelekile zamacwecwe ama-ruble angama-931.
Izimo zokugcina zomuthi
Kuyadingeka ukuqukethe umuthi endaweni ethile yomswakama ephansi kude nemisebe ye-ultraviolet emazingeni okushisa aze afike ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi Tricor 145 mg
Reciphon Fontaine, eFrance.
Umuthi ungashintshwa nge-analog Fenofibrat Canon.
Ukubuyekezwa mayelana neTricor 145 mg
Kumaforamu aku-inthanethi, odokotela kanye neziguli bashiya imibono eminingi emihle Ukubuyekezwa okungalungile kuvela ngenxa yokuvela kwemiphumela emibi.
Odokotela
URomanov Denis, udokotela wobugqila, uSt
Lesi sidakamizwa se-hypolipidemic, kepha uTricor wehlisela i-triglycerides yegazi ngezinga elikhulu. Ngincoma ukuyisebenzisela i-dyslipidemia yezinhlobo ze-IIa, IIb, III ne-IV. Umthamo kanye nesikhathi sokwelashwa kusungulwa ngawodwana. Akukho miphumela emibi eye yabonwa ezigulini. Ngikuxwayisa ukuthi uma usebenza, umuthi unomphumela ophansi wokwehlisa i-cholesterol. Iithebhulethi ziyalelwa kubantu abanokungasebenzi kahle kwesibindi.
Iziguli
UGennady Likhachev, oneminyaka engama-38, eYekaterinburg
Ngishiya isibuyekezo esingesihle ngeTricor. Udokotela unikeze lesi sidakamizwa njengento esikhundleni seTorvacard, ngoba kwakunesilinganiso esiphansi se-HDL. Ngemuva kwezinyanga ezi-4-5 zokwamukelwa, ngabona ukuvela kwezikhathi zokuqhakaza, isicanucanu, nokuhlanza. Ezinyangeni eziyi-8-9 zokwelashwa okuqinisa umzimba ngokuqhakaza nokubonakala kwe-colic emthanjeni, kwaqalwa umsebenzi ohleliwe. Ukuphinda ubonwe gallbladder kwembula i-viscous bile namatshe amaningi. Ngemuva kokuhlinzwa, ukuhlaselwa kuyema.
USorokin waseRoma, oneminyaka engama-53 ubudala, uStavropol
Ngine-retinopathy yesifo sikashukela, lapho ngathola khona i-laser nokuhlinzwahlinzwa emehlweni ami kaningi. Ukusheshisa ukululama, ngamukela uTricor, obhekana ngempumelelo nomsebenzi wawo. Kulesi simo, umuthi uvimbela ukugcwala kwe-cholesterol egazini kumazinga ajwayelekile. Ngiphuza lesi sidakamizwa njalo ezinyangeni eziyi-10, kulandele ikhefu lezinyanga ezi-2. Angiqaphelanga imiphumela emibi nokungezwani komzimba ngesikhathi sokudla konke.
