I-Dalacin C yi-ejenti elwa namagciwane asetshenziselwa ukuqeda izinqubo zokuvuvukala ngemuva kwesizinda sokutheleleka ngamagciwane we-pathogenic. Umuthi olwa namagciwane usiza ekulweni namagciwane amagciwane aerobic a-gram-positive. Umuthi uyakwazi ukukhipha imiphumela ye-bacteriostatic ne-bactericidal kumagciwane. Umphumela wesidakamizwa usekelwe ku-clindamycin, etholakala ngokutholakala ku-lincosamide. I-ejenti elwa namagciwane ayihloselwe ukusetshenziswa ngabesifazane abakhulelwe.
Igama Lezwe elingafanele
Clindamycin.
I-antibiotic Dalacin C isiza ukulwa namagciwane ama-aerobic gram-positive bacteria.
I-ATX
J01FF01.
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngamafomu omthamo ama-2 kuphela.
Isixazululo
Isixazululo somjovo sihlakazwa sibe ngama-ampoules we-2, 4 noma we-6 ml. Izindlwana zigcwele emaphaketheni amakhadibhodi e-1 noma angu-10. I-1 ml yefomu lomthamo we-liquid liqukethe i-150 mg yento esebenza - clindamycin phosphate. Izinto ezingeziwe ezakha ikhambi zihlanganisa utshwala be-benzyl, usawoti we-disodium namanzi angcolile wokujova.
Amakhandlela
Into esebenzayo i-powder emhlophe ye-clindamycin hydrochloride ngethamo lika-150 noma lama-300 mg, ofakwe egobolondweni elinzima lama-capsules.
Into esebenzayo i-Dalacin C iyi-powder emhlophe ye-clindamycin hydrochloride, efakwe egobolondweni elinzima lama-capsules.
Ngokuhlangana nokuxhumeka kwamanje kuqukethe izinto ezengeziwe:
- ushukela wobisi;
- isitashi sommbila;
- i-magnesium stearate;
- titanium dioksidi kanye ne-gelatin yakha igobolondo elingaphandle.
Amaphakethi apendwe amhlophe, aqoshwe ebusweni ngo- "P&U 395". Amayunithi omuthi afakwe emigqonyeni ye-blister ye-8 pcs. Iphakethe lekhadibhodi liqukethe ama-2 amanxeba (amakhompiyutha ayi-16).
Uhlobo olungekho
Umuthi awutholakali ngohlobo ukhilimu namathebulethi.
Isenzo se-Pharmacological
Umuthi olwa namagciwane ungowesigaba se-lincosamide antimicrobials. Umuthi osekwelashweni elincane wenza i-bacteriostically, uphazamisa ukwahlukaniswa kwe-mitotic ye-microplora ye-pathogenic. Ngokunyuka komthamo wokusetshenziswa okukodwa, i-clindamycin iqala ukwenza njenge-bactericidal: ayiphazamisi kuphela inqubo yokuzalwa kweseli, kodwa futhi ichitha nezinto eziqukethe amaprotheni kulwelwesi lweseli lwe-microorganism.
I-Dalacin C iphazamisa inqubo yokuzalwa kabusha kwamaseli, futhi futhi ichithe nezinto ezihlanganiswe ngamaprotheni engqamuzaneni yeseli ye-microorganism.
Ngokulahleka kwamandla kwegobolondo elingaphandle, ingcindezi ye-osmotic iphula i-bacterium.
I-Pharmacokinetics
Into esebenzayo igxiliswa odongeni lwamathumbu iyongena embhedeni we-arterial. Ngemuva kokuphathwa ngomlomo, ukugxila okuphezulu kwe-serum ye-clindamycin kulungiswa ngemuva kwemizuzu engama-45. Ukudla kwehlisa ijubane lokufakwa kokufakwa kwesidakamizwa, kepha akukuthinti ukuphelela kokufaka kanye ne-bioavailability.
Ngokuphathwa kwe-v / m, i-clindamycin phosphate ifinyelela ekugxilweni okuphezulu ngemuva kwamahora angama-1-3, ngokungenisa imizuzu engu-18-20.
Ezitsheni, umuthi ubopha amaprotheni ngo-40-90%. Kulokhu, umuthi awuqongeleli ezingxenyeni zezicubu zomzimba, usatshalaliswa ngokulinganayo ngokugxila kwinqubo ye-pathological. IClindamycin icishe iguqulwe ngokuphelele kuma-hepatocytes wesibindi. Ukuqedwa kwesigamu sempilo kwenza imizuzu engama-90-210. I-10-20% yezidakamizwa ishiya umzimba ngendlela yoqobo lwayo ngokusebenzisa ipheshana lomchamo, u-4% udonswa indle. Konke okunye kudalulwa ku-bile noma ngokusebenzisa amathumbu ngesimo esingasebenzi.
Umuthi okukhulunywa ngawo cishe uguqulwa ngokuphelele kuma-hepatocytes wesibindi.
Kubekelwe ini?
IClindamycin iyasebenza ngokuchasene nezinqubo zokutheleleka nokuvuvukala okubangelwa amagciwane agxile ekuthinteni okusebenzayo:
- ukunqotshwa kwesilinganiso esingezansi (i-bacterial bronchitis, empnema, cumulation of purulent exudate in the lung, pneumonia) and top (ukuvuvukala kwezicubu nezono, ukutheleleka kwendlebe okuphakathi, umkhuhlane obomvu) womgudu wokuphefumula;
- amanxeba athelelekile kanye nokulimala kwezicubu ezithambile, izifo ezithinta isikhumba, kufaka phakathi i-furunculosis, i-streptococcal acne, impetigo, i-abscesses engxenyeni yamafutha angaphansi, i-erysipelas, paronychia;
- ithumba le-peritoneum nokugaya ukudla, i-peritonitis (i-clindamycin ihlanganiswe nezidakamizwa ezisebenza ngokumelene ne-anaerobes);
- izifo ezithathelwanayo zohlelo lwe-musculoskeletal: osteomyelitis, isifo samathambo;
- i-endocarditis, i-periodontitis;
- encephalitis ebangelwa i-toxoplasma, ne-pneumocystis pneumonia ngenxa yokutheleleka nge-HIV.
IClindamycin isebenza ngokulwa namagciwane wezifo zesifo sezinhlungu (ukuqongelela kwe-purulent exudate emgodini we-ovary, amashubhu we-fallopian, izinqubo zokuvuvukala ezithweni zezitho zomzimba, izilonda ze-cuff yesitho sangasese sowesifazane sangasese). Ngesikhathi sokulimala kokutheleleka komlomo wesibeletho yi-chlamydia ngesikhathi sokuvivinywa kwemitholampilo, kwatholakala ukuthi i-monotherapy yezidakamizwa ene-clindamycin ingayiqeda ngokuphelele i-bacterium pathogenic microflora.
Contraindication
Umuthi ubekwa nge-contraindication lapho kukhona ukwanda kokutholakala kwezicubu zezinto ezakha umuthi.
Ngokunakekela
Isidakamizwa sinconywa ukuthi sisetshenziswe ngaphansi kokubhekelwa okuqinile kwezokwelapha kubantu abanezilonda eziwohlokayo nezilonda zokugaya, ukugaya kwe-myasthenia kanye nokwehluleka okukhulu kwesibindi.
Ungayithatha kanjani iDalacin C?
I-antibiotic yenzelwe ukujova umjovo we-intramuscular or infravenous infusion. Iziguli zabantu abadala ekwelashweni kwezifo ezinzima esibelethweni, izitho zangasese kwabesifazane noma izinkinga zibekelwa umthamo wansuku zonke wama-2400-2700 mg wesidakamizwa. Umthamo uhlukaniswe ngemijovo eyi-2-4. Ngenkambo emnene futhi elinganiselayo yenqubo ye-pathological, i-1,1-1,8 g ngosuku, ihlukaniswe imijovo eyi-3-4, kwanele ukufeza umphumela wokwelapha.
Umthamo ophakanyisiwe uphelele ngu-4.8 g ngosuku.
Ngengeniso / m, umthamo owodwa akufanele udlule ku-600 mg.
Ngokuvuvukala kwezitho zomzimba we-pelvic, umuthi uphathwa ngaphakathi ku-900 mg ngekhefu phakathi kwemithamo yamahora ayi-8.
Udokotela oholayo kuphela onelungelo lokushintsha uhlobo lwemithamo, kuya ngokuthi impumelelo yezokwelapha, isithombe somtholampilo wesilonda esithathelwanayo, kanye nezimpawu zesiguli ngasinye:
| Inqubo ye-Pathological | Imodeli yokwelapha |
| Ukutheleleka kweBeta Hemolytic Streptococcus | Inkambo yokwelashwa iyizinsuku eziyi-10. Ama-1200-1800 mg anqunyelwe ngosuku, ahlukaniswe kwezokuphatha ezi-3. |
| I-pneumocystis pneumonia ezigulini ezinengculaza | I / O 0.6-0.9 g njalo emahoreni ayi-6 noma ama-900 mg ngokuphumula kwamahora angama-8 izinsuku ezingama-21. |
| Ukuvuvukala Kwe-Pelvic | 900 mg iv ngesikhala phakathi kwemithamo yamahora ayi-8. Kunconywa ukuhlanganisa ukwelashwa kwe-antibacterial nezidakamizwa ezisebenza ngokulwa ne-aerobes yegramu. IClindamycin ilawulwa i-iv ezinsukwini ezi-4 nezinsuku ezi-2 ngemuva kokuphuculwa kwesimo esejwayelekile sesiguli. Ngemuva komjovo, bashintshela ekuphathweni komlomo kwamaphilisi e-Dalacin C ngethamo lika-450-600 mg ngokuphumula kwamahora ayi-6. Inkambo yokwelashwa ihlala kusuka ezinsukwini eziyi-10 kuye kwezingu-14. |
| Ukuvimbela ukutheleleka ngesikhathi sokuhlinzwa ekhanda nasentanyeni | I-900 mg yesidakamizwa ifakwa ku-1000 ml yesisombululo se-isotonic 0.9% se-sodium chloride futhi siniselwa ngesikhathi sokuhlinzwa amanxeba ekhanda nentamo ngaphambi kokufaka imiphetho. |
| I-Toxoplasma encephalitis ngenxa yokutheleleka nge-HIV | In / ukwethulwa kwe-0.6-1.2 g njalo emahoreni ayi-6 amasonto ama-2, kulandelwa ukuphathwa ngomlomo kwamaphilisi angama-1-2 ama-300 mg njalo emahoreni ayi-6. I-antibiotic ihlanganiswe nomthamo we-pyrimethamine we-25-75 mg. Ngokwethulwa komthamo ophakeme, i-folinic acid inqunywe i-10-25 mg. |
| Ukuvimbela i-endocarditis lapho kukhona i-hypersensitivity eqenjini le-penicillin | IV 600 mg ihora elilodwa ngaphambi kokuphathwa kwe-penicillin. |
Ngoshukela
Iziguli ezinesifo sikashukela zinconywa ukuqokwa kohlobo lokujwayelekile lomthamo.
Iziguli ezinesifo sikashukela zinconywa ukuqokwa kohlobo lokujwayelekile lomthamo.
Imiphumela emibi yeDalacin Ts
Ukuvela okungalungile kukhula ngomthamo ongafanele wesidakamizwa noma umthamo owodwa womuthi omkhulu.
Amapheshana wesisu
Ngokuthuthuka kwemiphumela emibi ohlelweni lokugaya ukudla, okulandelayo kungenzeka:
- Ubuhlungu be-epigastric;
- ukuqunjelwa;
- dysbiosis yamathumbu;
- umlomo owomile
- i-esophagitis;
- i-cholestatic jaundice;
- ukuphazamiseka kwesibindi;
- pseudomembranous enterocolitis.
Isistimu yezinzwa ephakathi
Ayikho imiphumela emibi yesidakamizwa emsebenzini wezinzwa etholakele.
Kusuka ohlelweni lomchamo
Kukhona ithuba le-vaginitis.
Eminye yemiphumela emibi ye-Dalacin C amathuba okuba i-vaginitis.
Kusuka ohlelweni lokuphefumula
Ezinganeni ezisengaphambili, ngenxa yokuba khona kotshwala be-benzyl ekwakhiweni kwekhambi le-Dalacin C, ukuthuthukiswa kwesifo se-gasping kungenzeka.
Engxenyeni yesikhumba
Lapho kuphathwa nge-intramuscularly, ukucasuka kwesikhumba kungavela, kuthi ukuqina kanye ne-abscess kungavele. Kwezinye izimo, i-thrombophlebitis yabonwa.
Allergies
Ezigulini ezithambekele ekubonakalisweni kokungafani komzimba, ezimweni eziningi, ukuqubuka okuhleliwe kwakubonwa esikhunjeni sobunzima obukhulu nobulinganiselayo. Ukuqhuma kufana ngokufana nesimungumungwane.
Odokotela baphawule ukuvela kokuqhuma kwe-maculopapular, ukulunywa, i-urticaria.
Ezimweni ezingavamile, uStevens-Johnson erythema multifocal erythema, ukushaqeka kwe-anaphylactic, i-angioedema kanye ne-dermatitis exfoliative.
Ezigulini ezivame ukusabela kokungezwani komzimba, lapho kuthathwa i-Dalacin C, ukuqubuka okuhleliwe kwaphawulwa esikhunjeni.
Umthelela ekhonweni lokulawula izindlela
Umuthi awuvimbeli umsebenzi wokusebenza kwezitho zohlelo oluphambili lwezinzwa futhi akubangeli ukuphazamiseka kwengqondo. Ngakho-ke, ngesikhathi sokwelashwa nge-clindamycin, ukushayela kuvunyelwe, ungazibandakanya nemidlalo eyedlulele futhi uphathe amadivaysi ayinkimbinkimbi adinga ukugxilisa ingqondo kanye nesilinganiso sokuphendula okuphezulu ngesikhathi somsebenzi.
Imiyalo ekhethekile
Ukwakheka kwesixazululo sokwelapha kufaka i-benzyl alcohol. Ingxenye esetshenzisanayo ingadala i-gesi-spitting syndrome noma i-dyspnea syndrome, engaholela ekufeni kwezingane ezisanda kuzalwa.
Esikhathini sokumaketha ngemuva, amacala okuvela kwe-pseudomembranous colitis ngemuva kwesizinda sohudo isikhathi eside aqoshwa, ngakho-ke, ngokuvela kwezitulo ezikhululekile, kuyadingeka ukubekela eceleni ubungozi besifo.
Uma kukhona izinsolo zokuthuthukiswa kwe-pseudomembranous enterocolitis, kuyadingeka ukumisa ukubamba noma ukujova kweDalacin C.
Lapho ukutholwa kuqinisekisiwe, i-antibiotic iyakhanselwa. Amathuba esifo akhula uma izigaxa zegazi zikhona kulondawo.
Kubalulekile ukukhumbula ukuthi ama-antimicrobials avimbela ama-microflora wemvelo emgodini wamathumbu.
Kubalulekile ukukhumbula ukuthi ama-antimicrobials avimbela ama-microflora wemvelo emgodini wamathumbu. Lokhu kungavusa ukukhula kwe-clostridia kanye nokuvinjelwa kokuhlanganiswa kwe-Vitamin K. Clostridium Hardile kungadala i-pseudomembranous colitis, inkambo ebukhali lapho kudinga ukubuyiselwa kwemali esele ye-electrolyte. Ubuthi beClostridium kuzosiza ukuqeda ukuqothuka kwe-150-500 mg kwe-vancomycin.
Sebenzisa ebudaleni
Abantu abaneminyaka engaphezu kwengama-65 ubudala kufanele bathathe umthamo onconyiwe.
Ukunquma uDalacin Ts ezinganeni
Ebuntwaneni, kusukela enyangeni eyi-1, umthamo wansuku zonke unqunywa ngesilinganiso se-20-40 mg nge-1 kg yesisindo somzimba. Umthamo uhlukaniswe ngemijovo engama-3-4. Ezinganeni ezisanda kuzalwa ezifika ezinsukwini ezingama-30 zokuphila, kunconywa ukuphatha umuthi izikhathi ezine ngosuku ngomthamo we-15-20 mg nge-1 kg yesisindo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
IClindamycin inganqamula emngceleni we-placental. Ngesikhathi sokukhula kwesibeletho ngaphansi kwethonya le-antibiotic, ukubeka kwe-cartilage nezicubu zomsipha kungathikamezeka.
Kwabesifazane abakhulelwe, umuthi unqunyelwe kuphela ezimweni ezibucayi.
Kwabesifazane abakhulelwe, umuthi unqunywa kuphela ezimweni ezibucayi, lapho amathuba we-intrauterine pathology okwenzeka embungweni aphansi kunobungozi empilweni kamama.
Ngesikhathi sokwelashwa, kuyadingeka ukumisa ibele.
Ukweqisa kwe-Dalacin Ts
Azange kube namacala okweqa ngokweqile. Ezigulini ezichazwe ngaphambilini, ukusabela kwe-anaphylactoid kungahle kube khona, kuphakamisa ukubukeka kwe-angioedema kanye nokuthuthukiswa kokuqhaqhazeka kwe-anaphylactic. Kulokhu, ukwethulwa kwe-adrenaline noma i-GCS (glucocorticosteroids) kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Ngesikhathi sokufunda ngemithi, ngokungena kanyekanye kwe-clindamycin kanye ne-erythromycin esiseleni, umphumela wokuphikisana uyabonakala. Izidakamizwa azinawo umphumela wokwelapha. Ngaphansi kwezimo ezinjalo, ubuthi kumaseli buyanda, yingakho izidakamizwa zingafakwanga ekwelashweni okuyinkimbinkimbi.
Kukhona ukungahambisani kwemithi kwe-Dalacin C enokuvuselela izicubu zemisipha ngenxa yokuvinjwa kokudluliselwa kwethonya le-neuromuscular by clindamycin.
Le nhlanganisela isetshenziswa kuphela ezimweni ezimbi kakhulu. Lapho unquma zombili lezi zidakamizwa, ukuqapha isiguli ngokucophelela kuyadingeka.
Ifomu lomthamo wekhambi le-Dalacin C alihambelani ne-ciprofloxacin.
Uhlobo lomthamo wesisombululo aluhambisani ne-Ampicillin, i-barbiturates, i-sodium bicarbonate, i-Ciprofloxacin.
Ukuhambisana notshwala
Ekwelashweni nge-Dalacin C, utshwala akufanele buqedwe. I-ethyl alcohol iyakuthinta kabi ukusebenza kwesistimu yezinzwa ephakathi, izitho zokujikeleza kwesibindi kanye nesibindi. I-Ethanol ingadala ukuba buthaka komphumela wokwelapha, inyuse izehlakalo zemiphumela emibi.
Ama-Analog
Iqembu lokufakwa esikhundleni okunezakhiwo ezifanayo zemithi nokwakhiwa kwamakhemikhali kufaka phakathi:
- Dalmatia
- Clindamycin;
- Amaphilisi weClindacil;
- Clindacin.
Udokotela ohambelayo unelungelo lokufaka esikhundleni samaphilisi noma isixazululo se-Dalacin C lapho kungekho mphumela owelaphayo noma ukwenzeka kwemiphumela emibi.
Imibandela yekhefu lekhemisi
Usokhemisi ngeke asithengise lesi sidakamizwa ngaphandle kadokotela.
Intengo yeDalacin Ts
Izindleko ezijwayelekile zamaphilisi zingama-ruble angama-700, isisombululo somjovo - ama-ruble ayi-1789.
Izimo zokugcina zomuthi
Kunconywa ukugcina umuthi endaweni enomugqa ophansi womswakama, uvikelekile elangeni, emazingeni okushisa afinyelela ku + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi
Ukukhiqiza i-Pfizer, Belgium.
I-analogue ye-Dalacin C - isidakamizwa Clindacin sinconywa ukuba sigcinwe endaweni nge-coefficient ephansi yomswakama.
Ukubuyekezwa mayelana Dalacin Ts
U-Antonina Efimova, oneminyaka engama-27, uRyazan.
Amaphilisi anqunyelwe i-Dalacin C gynecologist. Ngibe nokungahambi kahle kokuya esikhathini ngenxa yokukhula kwe-bacterium microflora. Ngemuva kwamaviki ama-2 elashwa, ukuvuvukala kwahamba, ukukhula okuthe xaxa kwamagciwane kwamiswa. Umuthi ubhekane kahle nomsebenzi wawo. Kumele kukhunjulwe ukuthi ama-antibiotic ayingozi ukugaya.Imithi kufanele ithathwe ezimweni ezeqile njengokuyalelwa udokotela, ngokuqinile ngokwemiyalo.
U-Lidia Fedotova, oneminyaka engama-34, uKrasnodar.
Ngithathe amaphaphu njengoba kubekwe udokotela wamazinyo. I-antibiotic yayidingeka ukuvikela ukutheleleka ngesikhathi sokuhlinzwa okuyinkimbinkimbi. Angibonanga imiphumela emibi, bekungekho zinkinga ngemuva kokuhlinzwa. Kepha bekukhona inkinga ngamathumbu. I-dysbacteriosis yathuthukiswa, ngenxa yayo okwakudingeka ukuthatha ama-probiotic.
