I-Atorvastatin noma i-Simvastatin inqunyelwe ukwehlisa i-cholesterol futhi ithuthukise izinqubo ze-metabolic. Yomibili le mithi isenesikhathi eside isetshenziswa kwezokwelapha, ngakho-ke, izitholele ngokwayo ukwelashwa kanye nokuvinjelwa kwezifo zenhliziyo.
Isici se-Atorvastatin
I-Atorvastatin isho izidakamizwa ezokwehlisa i-lipid eqenjini lama-statins. I-Atorvastatin calcium trihydrate (10.84 mg) yinto esebenzayo ebandakanyeka ekuhlanganiseni kwe-cholesterol. Le ndawo isiza ukunciphisa inani lama-low density lipoproteins (LDL) kanye ne-high density (HDL), ngaleyo ndlela ivikele ukwakheka kwama-cholesterol plaques.
I-Atorvastatin noma i-Simvastatin inqunyelwe ukwehlisa i-cholesterol futhi ithuthukise izinqubo ze-metabolic.
Ngemuva kokungena, ithebhulethi ingena emathunjini amancane, lapho ingena khona ngokushesha ekujikelezweni kwe-systemic odongeni lwayo. Ukuqina kwe-bioavailability kwengxenye esebenzayo kungama-60%. Ama-enzymes we-Hepatic acubungula ingxenye ethile yomuthi, kanti izinsalela zemvelo zidonswa emzimbeni ngezindunduma, umchamo kanye nesithukuthuku.
I-cholesterol ephakanyisiwe ku-atherossteosis, ukuba khona kwamathafa ezindaweni ezinkulu nezincane kuyizinkomba eziphambili zokusebenzisa i-Atorvastatin. Kuyalule futhi ukunquma umuthi wokuvimbela lezi zifo ezilandelayo:
- uhlobo 2 sikashukela;
- ukushaya kwenhliziyo;
- isifo sohlangothi;
- umfutho wegazi ophakeme
- angina pectoris;
- ischemia yenhliziyo.
I-Atorvastatin isho izidakamizwa ezokwehlisa i-lipid eqenjini lama-statins.
I-Atorvastatin inamandla okuqongelela emzimbeni ngokusetshenziswa isikhathi eside nama-pathologies athile, ngokwesibonelo, uma umsebenzi wesibindi noma wezinso uphazamiseka. Kulokhu, umphumela onobuthi wesidakamizwa uyabonakala. Isiguli singakhalaza ngomkhuhlane, ikhanda, ubuthakathaka obujwayelekile, nokusebenza ngokweqile ngokushesha. Uma ungazinaki zonke lezi zibonakaliso, khona-ke amathuba okuthi ubuthi obujwayelekile bomzimba aphezulu.
Izici ze-simvastatin
Umuthi uSimvastatin ubuye weqembu lama-statins. Isakhi esisebenzayo somuthi yi-simvastatin. Abangenayo bafaka:
- titanium dioxide;
- i-lactose;
- i-povidone;
- i-citric acid;
- ascorbic acid;
- i-magnesium stearate, njll.
ISimvastatin inezinga eliphakeme lokufaka. Ukuqoqeka okuphezulu kwento esebenzayo egazini kutholakala emahoreni angama-1-1,5 ngemuva kokuphathwa. Ngemuva kwamahora ayi-12, leli zinga lehliswa ngo-90%. Umzila oyinhloko we-excretion udlula emathunjini, ngokusebenzisa izinso, u-10-15% wengxenye esebenzayo uthululiwe.
Inhloso eyinhloko yesidakamizwa ukwehlisa i-cholesterol ekuphazamisekeni kwenhliziyo. Umuthi unqunywe ezimweni ezinjalo:
- ingozi enkulu yokuhlakulela isifo sokuqina kwemizwa;
- i-hypercholesterolemia (uhlobo II a no-II b);
- i-hypercholesterolemia ne-hypertriglyceridemia;
- ekuvinjelweni kwe-myocardial infarction, unhlangothi, ukuhlaselwa nge-ischemic, isifo sokuqina kwemithambo yegazi yemithambo yenhliziyo.
Inhloso enkulu yokusebenzisa iSimvastatin ukwehlisa i-cholesterol ekuphazamisekeni kwenhliziyo.
Ukuqhathanisa kwe-Atorvastatin neSimvastatin
Nikeza umuthi futhi ukhethe irejimeni yemthamo kuphela kufanele ube uchwepheshe onaka hhayi kuphela inkambo yesifo, kodwa nezimpawu zomzimba ngamunye.
Ukufana
Zombili lezi zidakamizwa zisetshenziswa ngenkuthalo ekwelashweni kwenhliziyo ekwelapheni nasekuvimbeleni izifo zenhliziyo nezemithambo.
Bobabili i-Atorvastatin ne-Simvastatin izidakamizwa ezisebenzayo futhi zinenjongo eyodwa - yehlisa i-cholesterol yegazi.
Bahlanganiswe futhi yizinto ezilandelayo:
- Izidakamizwa zinezithako ezisebenzayo ezahlukahlukene, kepha i-lactose ikhona kuzo zombili. Ngakho-ke, kufanele zinqunywe ngokucophelela ngokuzwela kule ngxenye yokusiza.
- Umphumela wecala ngendlela yesiyezi ubonakala ngayo yomibili le mishanguzo. Ngalesi sizathu, ngesikhathi sokwelashwa, kufanele wenqabe ukushayela imoto futhi usebenze ngezinqubo ezinembile.
- Imithi i-contraindication kanye nemithi yokwehlisa i-lipid, ngoba i-myopathy ingahle ikhule. Uma, ngokumelene nesizinda sokwelashwa nge-Atorvastatin noma i-Simvastatin, izinga lokushisa lenyuka nobuhlungu bemisipha kwavela, khona-ke umuthi kufanele ushiywe, ubeke okunye esikhundleni sawo nge-analogues.
- Ukukhulelwa nokukhulelwa kungokunye ukuphikisana. Abesifazane ngesikhathi sokulashwa kumele basebenzise inzalo.
- Ngokusetshenziswa isikhathi eside kanye ne-overdose, amathuba emiphumela emibi aphezulu. Ezimweni ezinjalo, izinso nesibindi kuhlupheka kakhulu. Ngakho-ke, kwenqatshelwe ngokuphelele ukwedlula umthamo obekwe udokotela.
Uyini umehluko
Umehluko omkhulu ukuthi ukwakheka kwamalungiselelo akuyona into efanayo esebenzayo. Ngakho-ke, i-atorvastatin ibhekisela kuma-static synthetic, anomphumela omude wokwelapha. I-Simvastatin yi-statin yemvelo enomphumela wesikhathi esifushane.
Into esebenzayo ye-Atorvastatin inamandla ngokwedlulele, ngakho-ke, lo muthi une-contraindication ethe xaxa. Lokhu kufaka phakathi:
- ukukhulelwa nokuqunjelwa;
- iminyaka efinyelela eminyakeni eyi-10;
- uphuzo oludakayo;
- inani elinyukayo lama-transaminases egazini;
- ukusabela komzimba we-lactose;
- izifo ezithathelwanayo esigabeni esibuhlungu.
ISimvastatin ayinconywa ukusetshenziswa emacaleni alandelayo:
- hypersensitivity kuzakhi zomuthi;
- isifo sesibindi
- iminyaka emincane;
- ukukhulelwa nokuqunjelwa;
- ukulimala kwemisipha.
I-Atorvastatin ayifiseleki ukuthi isetshenziswe ngasikhathi sinye nama-antibacterial and antimicrobial agents. ISimvastatin nayo ingahlanganiswa ne-HIV proteinase inhibitors nama-anticoagulants. Ungadli i-grapefruit noma uphuze ujusi we-grapefruit lapho uphatha amaphilisi. le nhlanganisela iyakwazi ukwedlula ukuqoqwa kwento esebenzayo egazini.
Imiphumela emibi elandelayo ingenzeka ngenkathi uthatha i-Simvastatin:
- izinkinga zokugaya;
- ukuqwasha
- ikhanda
- ukwephula ukunambitheka kanye nombono (kuyaqabukela);
- ukukhuphuka kwe-ESR, ukuncipha kwamaplatelet namaseli egazi abomvu.
Ngesikhathi sokwelashwa nge-Atorvastatin, iziguli zingathola i-tinnitus, izinkinga zememori, kanye nomuzwa wokukhathala okungapheli.
Ngokuphikisana nesendlalelo sokuthatha i-Simvastatin, ukuqhuma kwekhanda kungenzeka.
I-Hemodialysis iboniswa ezimweni zokweqisa kwe-simvastatin. Inqubo enjalo ibizoba yize endaweni yesimo esifanayo ne-Atorvastatin.
Yikuphi okushibhile
Intengo yezidakamizwa incike ezweni lokukhiqiza nomthamo.
ISimvastatin ikhiqizwa emazweni amaningi, kubandakanya iRussia, iFrance, iSerbia, iHungary, neCzech Republic. Izindleko zephakethe lamathebhulethi angama-30 wama-20 mg azoba ama-ruble angama-50-100. Intengo yokufaka umuthi (ama-20 ama-PC. I-20 mg) ekhiqizwe eCzech Republic icishe ibe ngama-ruble angama-230-270.
I-Atorvastatin yokukhiqiza yaseRussia ingathengwa emakhemisi ngaleli nani:
- I-110 rub - ama-30 ama-pcs. I-10 mg ngayinye;
- I-190 rub - ama-30 ama-pcs. 20 mg ngamunye;
- 610 rub - ama-90 ama-PC. 20 mg ngamunye.
Yikuphi okungcono - i-atorvastatin noma i-simvastatin
Udokotela okhona kuphela ongasho ukuthi yisiphi isidakamizwa esingcono ngemuva kokuhlola isiguli, kepha kunezici ezibalulekile zemithi:
- Umphumela omuhle osheshayo ungatholakala nge-Atorvastatin, njengoba iqukethe into esebenzayo enomphumela onamandla ngokwengeziwe.
- I-Simvastatin ibanga imiphumela emibi emincane, okuyiyo inzuzo yalesi sidakamizwa. Uma zisetshenziswa kahle, izakhi ezinobuthi empeleni aziqongeleli emzimbeni.
- Njengomphumela wokuhlaziywa kwemitholampilo ngemithi, kwafakazelwa ukuthi iSimvastatin yehlisa i-cholesterol eyingozi ngo-25%, ne-Atorvastatin - ngo-50%.
Ngakho-ke, ekwelashweni kwe-pathologies yesikhathi eside, i-Atorvastatin kufanele ikhethwe, futhi ukuvimbela ukuphazamiseka kwemithambo, kungcono ukusebenzisa i-Simvastatin.
Ukubuyekezwa kweziguli
U-Olga, oneminyaka engama-37, uVeliky Novgorod
Ngemuva kokuhlaselwa yisifo senhliziyo, ubaba wanikezwa uSimvastatin ukuthi ehlise i-cholesterol. Ukwelashwa kuhlale izinyanga ezi-4 kanti ngalesi sikhathi bekungekho miphumela emibi. I-plus engaphikisi yesidakamizwa yintengo, ususa - ukusebenza kahle okuphansi. Ukuhlaziywa okuphindaphindwayo kukhombisa ukuthi izinga le-cholesterol embi lehlile kancane. Ubaba wayecasukile, ngoba wayenamathemba aphezulu Umuthi. Ngikholwa ukuthi i-simvastatin iyasiza ezimweni ezinobuncane, hhayi kulabo asethuthukile. Manje seselashwa ngomunye amakhambi.
UMaria Vasilievna, oneminyaka engama-57, uMurmansk
Ekuhlolweni okulandelayo, udokotela wathi cholesterol inyuswe kancane futhi watusa ukuthatha ama-statin. Ngathatha iSimvastatin, ngalandela indlela yokudla futhi ngangilandela umzimba omncane ongabalulekile. Ngemuva kwezinyanga ezimbili ngidlulise ukuhlaziywa kwesibili, lapho zonke izinkomba zibuyele kokujwayelekile. Angizisoli ukuthi ngiphuze lesi sidakamizwa, yize abaningi bexwayisa ngokulimala kwaso nokungabi naluhlobo kohlobo lwegazi lami. Ngiyajabula ukuthi umphumela uzuziwe. Ngiyayincoma!
UGalina, oneminyaka engama-50, eMoscow
Ngashaqeka lapho ngizwa kudokotela ukuthi kune-cholesterol engaphezu kuka-8. Bengicabanga ukuthi ukwelashwa kuzoba isikhathi eside futhi kube nzima. Atorvastatin kwanqunywa. Angizange ngikhombe amathemba athile kulo muthi, kodwa ngehluleka. Ngemuva kwezinyanga ezimbili zokwelashwa, i-cholesterol yehle yaya ku-6. Bengingalindele ukuthi umuthi uzosiza. Ngifuna ukuqaphela ukuthi ngaphuza ngokungahambisani nokunconywa udokotela futhi akubanga namiphumela emibi.
Zombili lezi zidakamizwa zisetshenziswa ngenkuthalo ekwelashweni kwenhliziyo ekwelapheni nasekuvimbeleni izifo zenhliziyo nezemithambo.
Odokotela babuyekeza nge-Atorvastatin ne-Simvastatin
U-Egor Alexandrovich, oneminyaka engama-44, eMoscow
Angivami ukunquma iSimvastatin, ngoba Ngikubheka njengomuthi wekhulu leminyaka elidlule. Manje kunama-statin anamuhla asebenza kangcono futhi aphephile. Isibonelo, i-atorvastatin. Lo muthi awukwazi ukwehlisa izinga le-cholesterol embi kuphela, kepha futhi wehlisa nengozi yokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Indlela elula yokukhishwa.
U-Lyubov Alekseevna, oneminyaka engama-50 ubudala, u-Khabarovsk
Kwezokwelashwa, ngizama ukunquma i-Atorvastatin ezigulini uma kungekho okubhekiswayo. Ngikholelwa ukuthi lesi sidakamizwa sisebenza ngobumnene ngokwengeziwe, ngaphandle kokuphazamisa ukusebenza kwezitho zangaphakathi nezinhlelo zomzimba. Iziguli azivamile ukukhononda ngemiphumela emibi, kubalulekile. Ngemuva kwakho konke, iningi labadla impesheni liza nenkinga efanayo, esevele inezifo ezingamahlalakhona.
