Ngohlobo 2 lwesifo sikashukela, odokotela bavame ukunquma izidakamizwa ezinjengeGlucofage noma iSiofor. Zombili zikhombisa ukusebenza ngempumelelo kulesi sifo. Ngenxa yale mishanguzo, amaseli aqala ukuthinteka emiphumeleni ye-insulin. Imithi enjalo inezinzuzo nobubi.
Isici se-Glucophage
Lesi isidakamizwa se-hypoglycemic. Ukukhishwa ifomu - amaphilisi, into esebenzayo yayo yi-metformin hydrochloride. Isebenzisa ukukhiqizwa kwe-insulin ngokwenza okuthile nge-glycogen synthase, futhi inomphumela onenzuzo we-lipid metabolism, inciphisa ukugcwala kwe-cholesterol ne-lipoprotein.
Ngohlobo 2 lwesifo sikashukela, odokotela bavame ukunquma izidakamizwa ezinjengeGlucofage noma iSiofor.
Lapho kukhona ukukhuluphala esigulini, ukusetshenziswa komuthi kuholela ekwehlisweni ngempumelelo kwesisindo somzimba. Kubekelwe ukuvimbela uhlobo 2 lwesifo sikashukela ezigulini ezinesifiso sokukhula kwalo. Ingxenye eyinhloko ayithinti ukukhiqizwa kwe-insulin ngamaseli e-pancreas, ngenxa yalokho akukho bungozi be-hypoglycemia.
IGlucophage imiselwe isifo sikashukela sohlobo 2, ikakhulukazi ezigulini ezikhuluphele uma umsebenzi wokudla nokudla ungasebenzi. Ungayisebenzisa nezinye izidakamizwa ezinezindawo ze-hypoglycemic, noma nge-insulin.
Contraindication:
- ukuhluleka kwe-renal / kwesibindi;
- isifo sikashukela sikashukela, i-precoma, ikoma;
- izifo ezithathelwanayo ezinzima, ukomisa, ukushaqeka;
- izifo zesistimu yezinhliziyo, ukufakwa kwe-myocardial acute, ukwehluleka kokuphefumula;
- thayipha i-1 isifo sikashukela;
- ukunamathela ekudleni okuphansi kwekhalori;
- uphuzo oludakayo;
- ubuthi obuyingozi nge-ethanol;
- i-lactic acidosis;
- ukungenelela kokuhlinzwa, ngemuva kwalokho kunqunywe ukwelashwa kwe-insulin;
- ukukhulelwa
- ukuzwela ngokweqile kwezakhi.
Ngaphezu kwalokho, ayinqunyelwe ezinsukwini ezi-2 ngaphambi nangemva kokuqaliswa kokusebenza kokuhlolwa kwe-radioisotope noma i-X-ray, lapho kwakusetshenziswa khona umehluko oqukethe iodine
Imiphumela emibi ifaka phakathi:
- isicanucanu, ukuhlanza, isifo sohudo, ukulahleka kwesifiso, Ubuhlungu besisu;
- ukwephula ukunambitheka;
- i-lactic acidosis;
- i-hepatitis;
- ukuqunjelwa, ukulunywa.
Ukusetshenziswa okufanayo kweGlucofage namanye ama-hypoglycemic agents kungadala ukuncipha kokunakwa, ngakho-ke udinga ukuphatha ngokucophelela izimoto nezinqubo eziyinkimbinkimbi.
Ama-analogues afaka: iGlucophage Long, Bagomet, Metospanin, Metadiene, Langerin, Metformin, Glatiniin. Uma kunesidingo sokuthatha isikhathi eside, kunconywa ukusebenzisa i-Glucofage Long.
Isimo sikaSiofor
Lesi sidakamizwa esisiza ukwehlisa ushukela wegazi. Isakhi sayo esiyinhloko yi-metformin. Kwenziwe ngesimo samathebulethi. Umuthi wehlisela ngempumelelo ukugcotshwa koshukela okuyi-postprandial and basal. Akubangeli ukuthuthukiswa kwe-hypoglycemia, ngoba akukuthinti ukukhiqizwa kwe-insulin.
I-Metformin ivimbela i-glycogenolysis ne-gluconeogeneis, ngenxa yalokho ukukhiqizwa kwe-glucose esibindini kuyancipha futhi ukumuncwa kwayo kuthuthukiswe. Ngenxa yesenzo sengxenye eyinhloko ku-glycogen synthetase, ukukhiqizwa kwe-glycogen kwe-intracellular kuyashukunyiswa. Umuthi ubuyisela amandla ukungasebenzi kahle kwe-lipid metabolism. ISiofor inciphisa ukumunca ushukela emathunjini ngo-12%.
Kuboniswa umuthi weziguli ezinesifo sikashukela sohlobo 2, uma ukudla nokuzivocavoca kungalethi umphumela owafunayo. Kunconyelwa ikakhulukazi iziguli ezikhuluphele. Nikeza umuthi njengesidakamizwa esisodwa, noma uhlanganiswe ne-insulin noma ezinye izidakamizwa zikashukela.
I-Siofor yisidakamizwa esiza amazinga aphansi kashukela.
Contraindication ifaka:
- isifo sikashukela sikashukela ne-precom;
- ukuhluleka kwe-renal / kwesibindi;
- i-lactic acidosis;
- Uhlobo 1 sikashukela;
- infarction yakamuva ye-myocardial, ukwehluleka kwenhliziyo;
- isimo sokuthuthumela, ukwehluleka kokuphefumula;
- umsebenzi wezinso ongonakalisiwe;
- izifo ezithathelwanayo ezinzima, ukomisa;
- ukwethulwa kwe-ejenti ehlukile equkethe iodine;
- ukudla okudla ukudla okunama-kilojoule amancane;
- ukukhulelwa nokuqunjelwa;
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
- iminyaka efinyelela kwengu-10.
Ngesikhathi sokwelashwa ngeSiofor, ukuphuza utshwala kufanele kungafakwa ngaphandle, njengoba lokhu kungaholela ekukhuleni kwe-lactic acidosis, i-pathology enzima eyenzeka lapho i-lactic acid ibuthelana egazini.
Imiphumela emibi ivela kaningi. Lokhu kufaka phakathi:
- isicanucanu, ukuhlanza, ukulahlekelwa yinhliziyo, isisu, izinhlungu esiswini, ukunambitheka kwensimbi emlonyeni;
- i-hepatitis, umsebenzi owengeziwe wama-enzyme wesibindi;
- i-hyperemia, i-urticaria, ukulunywa kwesikhumba;
- ukwephula ukunambitheka;
- i-lactic acidosis.
Ngenkathi uthatha uSiofor, umphumela ongemuhle ungavela ngendlela yokucanuzelelwa kwenhliziyo.
Ezinsukwini ezi-2 ngaphambi kokuhlinzwa, lapho kuzosetshenziswa khona i-anesthesia, i-anesthesia noma i-anesthesia yomgogodla, kuyadingeka ukwenqaba ukuthatha amaphilisi. Qhubeka nokusebenzisa kwabo amahora angama-48 ngemuva kokuhlinzwa. Ukuqinisekisa umphumela omuhle wokulapha, uSiofor kufanele ahlanganiswe nokuzivocavoca nokudla kwansuku zonke.
Ukufana kwesidakamizwa kufaka phakathi: i-Glucofage, iMetformin, iGlatini, i-Diaformin, iBagomet, iFommetin.
Ukuqhathanisa kwe-Glucofage ne-Siofor
Ukufana
Ukwakheka kwezidakamizwa kufaka i-metformin. Babekelwe uhlobo 2 lwesifo sikashukela ukuze baqonde isimo sesiguli. Imithi yokwakha amaphilisi iyatholakala. Zinezinkomba ezifanayo zokusebenzisa nemiphumela emibi.
IGlucophage iyatholakala ngesimo sethebhulethi.
Uyini umehluko
Imithi inemikhawulo eyehlukile ekusetshenzisweni. I-Siofor ayikwazi ukusetshenziswa uma kukhona ukukhiqizwa kwe-insulin okwanele emzimbeni, futhi i-glucophage ingaba. Umuthi wokuqala kufanele usetshenziswe kaningana ngosuku, kanti owesibili - kanye ngosuku. Ziyahlukahluka ngentengo.
Yikuphi okushibhile
Intengo yeSiofor ngama-ruble angama-330, iGlucofage - ama-ruble angama-280.
Yikuphi okungcono - iGlucofage noma iSiofor
Lapho ukhetha phakathi kwezidakamizwa, udokotela unaka izici eziningi. IGlucophage ichazwa kaningi, ngoba ayicasuli amathumbu nesisu kangako.
Ngoshukela
Ukwemukelwa kukaSiofor akuholeli emgomeni wehlise ushukela wegazi, futhi uma usebenzisa i-Glucofage, akukho ukweqa okubukhali emazingeni kashukela egazini.
Ukuthatha uSiofor akuholeli ekwehleni okuluthayo koshukela.
Ukwehla kwesisindo
ISiofor yehlisa isisindo ngempumelelo, ngoba icindezela isifiso sokudla futhi isheshise imetabolism. Ngenxa yalokho, isiguli esinesifo sikashukela singalahlekelwa ngamakhilogremu ambalwa. Kepha umphumela onjalo ubonwa kuphela ngenkathi uthatha umuthi. Ngemuva kokukhanselwa kwayo, isisindo sibuyiselwa ngokushesha.
Ngempumelelo kwehlisa isisindo kanye ne-glucophage. Ngosizo lomuthi, i-lipid metabolism ephazamisekile iyabuyiselwa, ama-carbohydrate awaphulwanga phansi futhi amunwa. Ukwehla kokukhishwa kwe-insulin kuholela ekwehleni kwesifiso sokudla. Ukukhishwa kwesidakamizwa akuholeli ekuzuzeni ngokushesha kwesisindo.
Ukubuyekezwa kodokotela
UKarina, i-endocrinologist, Tomsk: "Ngibeka i-glucophage yesifo sikashukela kanye nokukhuluphala. Kuyasiza ukunciphisa umzimba ngaphandle kokulimaza impilo, kwehlisa ushukela wegazi kahle. Ezinye iziguli zingaba nesifo sohudo ngenkathi ziphuza umuthi."
U-Lyudmila, udokotela obambelela emlandweni wezokwelapha: "ISiofor imvamisa ibhalela iziguli ezinesifo sikashukela sohlobo 2, isifo sikashukela. Eminyakeni eminingi yokuzilolonga, usekhombisile ukuthi uyasebenza. Isimo sezulu esibuhlungu nokungaphatheki kahle kwesisu kwesinye isikhathi kungaba nemiphumela emibi ngemuva kwesikhashana."
Ukubuyekezwa kweziguli mayelana neGlucofage ne-Siofor
UMarina, oneminyaka engama-56, u-Orel: "Sekuphele isikhathi eside ngihlaselwa yisifo sikashukela. Ngazama imishanguzo eminingi ehlukahlukene eklanyelwe ukwehlisa ushukela wegazi. Ekuqaleni basizile, kepha ngemuva kokuyisebenzisa ayiphumelelanga. Ngonyaka owedlule, udokotela wanquma i-Glucofage. Ukuthatha lo muthi kusiza ukugcina izinga likashukela. kujwayelekile, futhi akukho kumlutha ngalesi sikhathi okuvelile. "
U-Olga, oneminyaka engama-44, u-Inza: "Isazi se-endocrinologist sanquma uSiofor eminyakeni eminingana eyedlule. Umphumela uvele ngemuva kwezinyanga ezi-6. Amazinga kashukela egazini abuyela ejwayelekile futhi isisindo sami sehlile kancane. Kuqala kwaba nemiphumela emibi efana nesifo sohudo, esanyamalala ngemuva kokuba umzimba uyijwayele kulo muthi. "
