I-Movogleken yezidakamizwa: imiyalo esetshenzisiwe

I-Movoglechen yisizukulwane sesibili sulfonylurea esuselwe enomphumela we-hypoglycemic emzimbeni. Indlela yokusebenza isuselwa ekwandiseni ukuzwela kwezicubu ukungena ku-insulin nasekuthuthukiseni ukugcinwa kwe-hormonal amaseli we-pancreatic beta. Ezenzweni zokwelapha, umuthi we-hypoglycemic unqunyelwe uhlobo 2 sikashukela. Kuyenqatshelwa ukusebenzisa nesifo sikashukela esincike ku-insulin.

Igama Lezwe elingafanele

I-Glipizide. NgesiLatin - Glipizide.

I-Movoglecen yezidakamizwa inegama elejwayelekile lomhlaba iGlipizide.

I-ATX

A10BB07.

Khipha amafomu nokwakheka

Umuthi wenziwa ngendlela yemithamo yamathebu amhlophe. Ngasohlangothini olungaphambili lweyunithi yezidakamizwa, ubungozi buqoshwe, kuyilapho ukuqoshwa kwencwadi ethi "U" embuthanweni kubonakale kuphambana. Ifomu le-1 ithebhulethi liqukethe ama-5 mg wekhompiyutha esebenzayo - i-glipizide. Ukhuphula izinga lokufaka kanye ne-bioavailability, umongo wethebhulethi uqukethe izinto ezengeziwe:

• isitashi pregelatinized;
• i-hypromellose;
• ushukela wobisi;
• i-acid entshontsha;
• i-microcrystalline cellulose.

Amathebulethi anomumo oyindilinga oyindilinga, ambozwe esigabeni sokugcina sokukhiqizwa ifilimu ye-enteric. Lesi sakamuva siqukethe i-talc, i-titanium dioxide, i-macrogol. Amayunithi ezokwelapha abekwe emithini egcwele ucezu lwezingcezu ezingama-24. Ebhokisini lebhokisi kufakwa amaphilisi angama-48.

Isenzo se-Pharmacological

Umuthi obizwa ngokuthi yi-hypoglycemic ngomlomo uvela ku-sulfonylurea.

I-Movoglechen yezidakamizwa ithinta ukusebenza kwamanyikwe futhi ngasikhathi sinomphumela owengeziwe we-pancreatic.

Umkhiqizo ohlanganisiwe ungowesizukulwane II. Ukusebenza kwesakhi sengxenye esebenzayo kuthinta umsebenzi wamanyikwe futhi ngasikhathi sinye kube nomphumela owengeziwe we-pancreatic. I-Glipizide isebenzisa inqubo yokukhiqizwa kwe-insulin ngamaseli we-pancreatic beta ngesikhathi sokucasulwa kwezicubu yi-glucose, ithuthukisa ukutholakala kwezicubu emiphumeleni ye-hormone.

Ehlelweni lokuthola umphumela wokwelapha, i-compound esebenzayo ikhulisa amathuba okubopha i-insulin ukuqondisa amaseli, ikhulisa ukukhishwa kwe-hormone ye-pancreatic. Ngenxa yalokho, umphumela we-insulin we-insulin kuma-molecule eglucose uyathuthukiswa, futhi izinga lokufakwa ushukela ngemisipha yamathambo nama-hepatocytes liyanda. Kukhona ukwehla kwe-gluconeogenesis esibindini nasekuqhekekeni kwe-lipid kwezicubu ze-adipose.

Ubukhulu bomphumela wokwelapha kuya ngenani lamaseli e-beta asebenzayo wamanyikwe.

Umuthi ngokungeziwe une-fibrinolytic, diuretic ne-lipid-lowering effect, inhibits adhesion, kulandelwa ukwakheka kwejazi legazi.

I-Movoglechen inhibits ukunamathela kwe-platelet, kulandelwa ukwakheka kwe-thrombus.

I-Pharmacokinetics

Ngemuva kokusetshenziswa, i-ejenti yomlomo ye-hypoglycemic icishe ifakwe ngokuphelele odongeni lwesibeletho esincane ngesivinini esikhulu.

Ukudla ngasikhathi sinye akubangeli ushintsho kumapharamitha we-pharmacokinetic. Kulokhu, isikhathi sokufaka siyanda ngemizuzu engama-45. Lapho umuthi usetshenziselwa ukujikeleza kwe-systemic, amazinga aphezulu we-plasma angalungiswa emahoreni angama-1-3 ngemuva kokusebenzisa i-tablet eyodwa.

I-bioavailability ye-glipizide ifinyelela kuma-90%. Egazini, isakhi esisebenzayo sibopha i-albhamuin ngama-98-99%. Lapho i-glipizide idlula kuma-hepatocytes, into esebenzayo iboshelwe emikhiqizweni ye-metabolic engawubonisi umsebenzi we-hypoglycemic. Ukuqedwa kwesigamu sempilo kwenza amahora angama-2-4. Umuthi ukhishwa 90% ngendlela yama-metabolites ngokusebenzisa izinso, i-10% isesimweni sayo sokuqala.

Izinkomba zokusetshenziswa

Amathebulethi e-Movoglechen anganciphisa ukugcwala kwe-plasma ye-glucose yohlobo 2 sikashukela uma isifo sikashukela esinga-insulin singelashwa ngomuthi wokudla, ukuzivocavoca nezinye izindlela zokunciphisa isisindo ngokweqile.

Contraindication

Ukuphuza umuthi akuvunyelwe emacaleni alandelayo:

• ukuzwela okuzwakalayo kwezakhi zezicubu kuma-sulfonamides, glipizide, izakhi ezingezekile ze-Movogleken noma ezithathwe ku-sulfonylurea;
• thayipha i-1 isifo sikashukela;
• ukungabekezelelani kwe-lactose, i-glucose kanye ne-galactose ukumuncwa kwesifo, ukuntuleka kwe-lactase;
• ukushiswa nokungenelela kokuhlinzwa kwendawo ebanzi yokusebenza, izimo ezinzima zokulimazeka emuva nokulimala, izinqubo zokutheleleka nokuvuvukala;
• isifo sikashukela kanye ne-hyperosmolar coma, isimo esizithandayo;
• ketoacidosis;
• izifo ezinzima zesibindi nezinso.

Ungathathi i-Movoglechen yabantu abanesifo sikashukela sohlobo 1.

Umuthi awunqatshelwe ekungenelweni kokuhlinzwa endaweni ebanzi yokusebenza.

Futhi, i-Movoglecen ayisetshenziselwa izifo ezinzima zesibindi.

Kuyadingeka ukunquma umuthi ngokuqapha ngokucophelela isimo sezimpawu zokuhoxa, abantu abane-adrenal insufficiency, i-leukopenia, umkhuhlane kanye nomonakalo emgudwini we-thyroid, ohambisana nokukhubazeka kokuqothuka kwehomoni yayo.

Ungayithatha kanjani i-Movoglechen

Umthamo ulungiswa nguchwepheshe wezokwelapha ngokuya ngesisindo somzimba kanye nobudala besiguli, kanye nasezimpawu zenqubo ye-pathological.

Udokotela angenza ushintsho irejimeni ye-dosing ngezinguquko eziqinile emazingeni kashukela we-serum.

Ngakho-ke, ukuqapha ngokucophelela ukugxilisa ushukela wegazi kuyadingeka: izinkomba esiswini esingenalutho nangemva kwamahora ama-2 ngemuva kokudla.

Ngoshukela

Kudingeka amaphilisi okulawula ngomlomo imizuzu engama-30 ngaphambi kokudla. Ekuseni ngaphambi kokudla kwasekuseni, kufanele uthathe umuthi ongu-5 mg, uma ungekho umphumela wokwelapha, wandise umthamo ngo-2,5-5 mg, ngokuya ngokubekezelela.

Umthamo omkhulu ovunyelwe nsuku zonke we-Movoglek ngu-40 mg, umthamo wokusetshenziswa okukodwa ngu-15 mg.

Umthamo omkhulu ovunyelwe nsuku zonke ngu-40 mg, umthamo wokusetshenziswa owodwa ngu-15 mg. Amacwecwe kufanele adakwe 1 isikhathi ngosuku. Ngokujwayelekile kwansuku zonke ngenhla kwe-15 mg, kuyadingeka ukuhlukanisa umthamo kuya kumthamo we-2-4.

Imiphumela emibi ye-Movoglyken

Umthelela ekhonweni lokulawula izindlela

Umuthi we-hypoglycemic awuthinti kabi uhlelo lwezinzwa namakhono emoto amahle, ngakho-ke ngesikhathi sokwelashwa akunqatshelwe ukushayela imoto noma ukusebenza ngamadivayisi ayinkimbinkimbi adinga ukuphendula okusheshayo nokuxineka okukhulu.

Ngesikhathi sokwelashwa nge-Movogleken akuvunyelwe ukushayela imoto.

Imiyalo ekhethekile

Umthamo ulungiswa lapho kunezimo ezicindezelayo ezifaka isandla ekulahlekelweni kokulawulwa yimizwelo yengqondo, ezimweni zokuzivocavoca okunzima komzimba, ngokushintshwa kokudla.

Lapho sinquma isifo sikashukela esingancikeli i-insulin futhi lapho sikhipha umsebenzi wokuhlinzwa, kuyadingeka ukubonisana nodokotela wakho mayelana nokwelashwa okungenayo i-insulin.

Ngaphambi kokunquma i-ejenti ye-hypoglycemic, isiguli kufanele saziswe ukuthi amathuba okuthola i-hypoglycemia nesifo sikashukela sikhuphuka ngotshwala, izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala, nokukhathala okungapheli. Lapho uthatha iziphuzo ezidakayo, kungenzeka ukusabela okufana nokwenziwa nge-disulfiram, kubonakaliswa ubuhlungu besisu, ukugabha, kanye nenausea.

Ukunciphisa ubungozi be-hypoglycemia ngenxa yezifo ezithathelanayo, imikhiqizo yokuhlanzeka kumele isetshenziselwe ukuvimba lokhu okwedlule.

Ngokusebenzisa isikhathi eside i-Movoglecen, kungenzeka ukuthuthukisa ukumelana nesenzo somuthi ngokuwohloka okulandelayo komphumela wokwelapha. Kulokhu, kunconywa ukwandisa umthamo wansuku zonke wezidakamizwa noma ukufaka esikhundleni se-ejog ye-hypoglycemic.

Umuthi uvunyelwe izingane ezingaphansi kweminyaka engu-18.

Isabelo sezingane

Umuthi awuvunyelwe ezinganeni ezingaphansi kweminyaka engu-18 ubudala ngenxa yokuntuleka kolwazi mayelana nomphumela we-glipizide ekukhuleni nasekuthuthukisweni komzimba womuntu ebuntwaneni nasebusheni.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Akukaziwa ukuthi ikhemikhali esebenzayo engamakhemikhali ingathinta kanjani inqubo yokukhula kombungu. Kuyinto yokungena okungenzeka kwe-glipizide ngokusebenzisa umgoqo we-hematoplacental ngokwephulwa okulandelayo kwebhukumaka lesistimu ye-musculoskeletal. Ngokuqondene nalawa ma-hypotheses, abesifazane abakhulelwe benqatshelwe ukusebenzisa umuthi we-hypoglycemic ukuphatha ngomlomo.

Kunconywa ukusebenzisa ama-cartridge kanye ne-insulin yomuntu ukunciphisa amazinga kashukela.

Ngesikhathi sokwelashwa nge-Movogleken, kuyadingeka ukuthi udlulise ingane ekudla okungenamsoco futhi uyeke ukuncelisa ibele.

Ngesikhathi sokwelashwa nge-Movogleken, kuyadingeka ukuthi udlulise ingane ekudla okungenamsoco.

Isicelo sokusebenza kokulimala kwezinso

Ezigulini ezinzima zezinso, ukuphuza umuthi akuvunyelwe ngokuphelele, ngoba umuthi ukhishwa emchanjeni.

Sebenzisa umsebenzi wesibindi okhubazekile

Kuyadingeka ukulawula ukusebenza kwesibindi nama-enzyme ayo ngobumnene kuze kube sezingeni eliphakeme lokunganele. Lapho sikhona kwenqubo okuthiwa yi-pathological expression, ukwelashwa kwezidakamizwa akuvunyelwe.

I-Overdose ye-Movoglyken

Ukusetshenziswa kabi kwesidakamizwa kungaholela ku-hypoglycemia. Isimo sihambisana:

• umuzwa wendlala enkulu;
• ukuguquguquka kwemizwelo ngokungazelelwe nge-predominance of irritability kanye nesimo esinolaka;
• ukukhuphuka kokujuluka;
• isimo sesimo sokucindezela;
• ukuqwasha;
• i-hypoglycemic coma;
• ukungasebenzi kahle kwenkulumo nokubona;
• ukunaka kokuphazamiseka kwengqondo;
• ukulahlekelwa ukwazi.

Ukusetshenziswa kabi komuthi kungadala ukujuluka.

Uma isiguli sazi, kuyadingeka ukumnika isisombululo sikashukela. Uma kwenzeka ulahlekelwe yimizwa, isixazululo se-40% dextrose kufanele siphathwe ngaphakathi noma i-dropper kufanele ibekwe ngesisombululo se-glucose esingu-5%. I-1-2 mg ye-glucagon iphathwe ngokungaziphathi. Lapho ejwayela umbuso lapho isiguli siphinda siqaphela, kufanele sidle ukudla okuphezulu kuma-carbohydrate. Lokhu kuyadingeka ukuvimbela ukukhula kabusha kwe-hypoglycemia. Nge-edema ye-cerebral edema, ukwelashwa nge-Dexamethasone noma iMannitol kuyadingeka.

Ukuxhumana nezinye izidakamizwa

Ukungahambisani kwemithi ne-miconazole kuyabonakala.

I-Movoglecen yehlisa umphumela wokwelapha we-furosemide.

Ukusetshenziswa kanyekanye kwezidakamizwa ze-myelotoxic kwandisa ingozi ye-agranulocytosis, kungavusa ukubukeka kwe-thrombocytopenia.

Ukuhambisana notshwala

I-ethyl yotshwala ikhulisa umphumela we-hypoglycemic, ivimbela uhlelo lwe-hematopoietic, ukusebenza kwesibindi futhi ikhuphule amathuba okuthi igazi lixhumeke ngokuhlangana okukhona kwamangqamuzana abomvu egazi namaphaneli. U-Ethanol uthinta kabi uhlelo oluphakathi lwezinzwa ne-trophism yezicubu zezinzwa, ngakho-ke, kuyadingeka ukushiya ukusetshenziswa kotshwala isikhathi sokwelashwa nge-Movogleken.

Ama-Analog

Ungawunqamula umuthi ngomunye wale mithi elandelayo:

• Glenez;
• I-Glibenesis;
• I-Antidiab;
• Isifo sikashukela.

Imibandela yekhefu lekhemisi

Imithi ye-Hypoglycemic ithengiswa ngomuthi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Ngenxa yengozi yokuthola i-hypoglycemic coma, kuyenqatshelwe ukusebenzisa umuthi uwodwa ngaphandle kwezeluleko zezokwelapha.

Intengo ye-Movoglechen

Intengo ephakathi emakethe yezokwelapha ifinyelela kuma-ruble ayi-1,600.

Izimo zokugcina zomuthi

Kunconywe ukugcina amaphilisi akho endaweni eqhelelene nokungena kwe-UV at lokushisa lika + 8 ... + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Izinyanga ezingama-42.

I-analogue ye-Movogleken - isidakamizwa i-Diabeteson sigcinwa endaweni ehlukaniswe nokungena kwe-UV.

Umkhiqizi

IZhuhai United Laboratories Co, China.

Ukubuyekezwa kwe-Movogleken

UKristina Doronina, oneminyaka engama-28, uVladivostok

Umyeni wami unoshukela wegazi ophakeme. Iminyaka eminingana, abakwazanga ukuthola umenzeli ofanele we-glycemic, ukuze banganciphisi ushukela kuphela, kodwa futhi nokugcina amanani ngaphakathi kwemikhawulo ejwayelekile. Ngesikhathi sokubonisana okulandelayo, kuye kwanikezwa amaphilisi we-Movoglecen. Ngemuva kwezinsuku ezingama-30 zokwelashwa, ushukela ubuyela kokujwayelekile, umuthi waqhamuka. Manje ingaphakathi kuka-8.2 mm, kepha ingcono kune-13mm mm, eyayikhona ngaphambili.

U-Yaroslav Filatov, oneminyaka engama-39, uTomsk

Umuthi awuzange usize ekuqaleni. Ngemuva kokufaka i-5 mg ekuseni, ushukela ogcinwe ngaphakathi kwe-10-13 mm, ukuqhuma kwesikhumba kwaqala. Ngokukhuphuka komthamo ukuya ku-20 mg, ushukela wehla kancane kancane emavikini ama-2 kuye kuma-6 mm. Imiphumela emibi yeza ngokwayo. Kepha le nkomba incike ekudleni nasezincomeni emiiyalweni. Umuthi awukwazi ukwehlisa ushukela uma ungondlekile.

Ulyana Guseeva, iminyaka lengama-64, Krasnoyarsk

Eminyakeni engama-62, ushukela wegazi wakhuphukela ku-16 mm mm. Kwaqala entwasahlobo, ngemuva kokuthatha umhlalaphansi. Uqale ukuphila impilo yokuhlala phansi ngenxa yokushoda komsebenzi, okuholele ekutheni inyuke noshukela egazini. I-Gluconorm ehlanganisiwe neSiofor bezingalingani.Ithebhulethi ye-Movoglek ebekiwe. Ushukela wehle ngezikhathi ezi-2. Ngezansi 8 mm ayincishisiwe. Angiqaphelanga imiphumela emibi iminyaka emi-2. Kuze kube manje, uhlala kahle, kepha uma ekhula, kuzoba ngcono ukushintshela kwesinye isidakamizwa.