Ukunquma ukuthi yikuphi okungcono: I-Phasostabil noma i-Cardiomagnyl, kufanele uqhathanise le mithi ngezimpawu ezisemqoka. Ngakho-ke, kuqala inombolo yokuphambana, izinkomba, imiphumela emibi, indlela yokusebenza yezidakamizwa kanye nesethi yezindawo zabo ezifundwayo. Lapho ukhetha, umthamo wezingxenye ezisebenzayo kanye nendlela yokukhululwa idlala indima.
Phasostabil isimilo
Umuthi osebenzayo yi-acetylsalicylic acid (ASA) ne-magnesium hydroxide. Umuthi uyatholakala ngesimo samathebulethi. Kungokweqembu lama-antiplatelet agents. Ithebhulethi eyi-1 iqukethe ama-75 mg e-ASA ne-15.2 mg ye-magnesium hydroxide. Ukwakheka kufaka nezinye izinto ezingakhombisi umsebenzi we-antiplatelet:
- i-microcrystalline cellulose;
- i-croscarmellose sodium;
- i-povidone-K25;
- i-magnesium stearate.
Ukunquma ukuthi yikuphi okungcono: I-Phasostabil noma i-Cardiomagnyl, kufanele uqhathanise le mithi ngezimpawu ezisemqoka.
Amathebulethi afakwe kumafilimu, esiza ukunciphisa izinga lokukhishwa kwe-ASA futhi ivikele ulwelwesi lwama-mucous esiswini, kanye ne-duodenum emiphumeleni yokulutha yomuthi. I-Acetylsalicylic acid iyi-ester enosawoti ye-acetic acid. Le nto ingeyama-NSAIDs (izidakamizwa ezingezona ze-steroidal anti-inflammatory). Kubonakala ngomphumela ohlanganisiwe: I-ASA iziveza njenge-analgesic, isuse izimpawu zokuvuvukala, futhi iguqule izinga lokushisa lomzimba.
Umgomo wokusebenza kwale ngxenye ususelwa ekuvinjelweni komsebenzi we-COX isoenzymes ethintekayo ekwenziweni kwe-prostaglandin kusuka ku-arachidonic acid ne-thromboxane. Ngenxa yalokhu, ubukhulu bomphumela wabo omubi emzimbeni uyancipha. Ngakho-ke, ama-prostaglandins abamba iqhaza ekukhuleni kwenqubo yokuvuvukala. Zithinta indlela yokwandisa ukuzwela kwama-receptors, ngaleyo ndlela inomthelela ekwandeni kobukhulu bezinhlungu.
Ngaphansi kwethonya le-prostaglandins, ukumelana kwezikhungo ze-hypothalamic ezibhekele i-thermoregulation ethonyeni elibi lezinhlayiya ze-pathogenic kuyancipha. I-ASA ngasikhathi sinye icindezela zonke izinqubo ezichaziwe, ngenxa yalokho ukuncipha kwezinga lokuvuvukala, ubuhlungu kanye nokwehla kwezinga lokushisa lomzimba kuqashelwa ngokushesha.
Umuthi osebenzayo yi-acetylsalicylic acid (ASA) ne-magnesium hydroxide.
Ngaphezu kwalokho, le ngxenye ithinta nenqubo yokuhlanganisa ama-platelet. Lokhu kungenxa yokuthi i-ASA ivimbela umsebenzi we-endo native thromboxane proaggregant. I-ASA yi-ejenti ephumelela kakhulu ye-antiplatelet evela kuma-analogues amaningana, ngoba ithinta ngqo ukusebenza kwe-thromboxane.
Kodwa-ke, i-acetylsalicylic acid inikeza umphumela omnene wokulwa nokuvuvukala. Lokhu kungenxa yokuthi le nto ivimbela i-COX-1 ngezinga elikhulu. Ama-Isoenzymes aleli qembu abandakanyeka ezinqubweni ezahlukahlukene: athinta ulwelwesi lwegayiti yokugaya ukudla, ukuphuma kwegazi lezinso.
I-Acetylsalicylic acid ithinta kancane i-enzymes ye-cycloo oxygenase COX-2, okusho ukuthi ingaphansi kwenombolo yama-analog ekusebenzeni kahle kwe-anti-inflammatory, analgesic. Ngaphezu kwalokho, ngesikhathi sokwelashwa ngomuthi oqukethe le nto, inani elikhulu lemiphumela emibi liyabonakala.
I-Phazostabil iqukethe enye into esebenzayo - i-magnesium hydroxide. Le nto iqhamuka eqenjini lama-antacid. Kubonakala ngomphumela omuhle emzimbeni. Ngakho-ke, ngenkathi uthatha i-acetylsalicylic acid ne-magnesium hydroxide, kukhishwa i-magnesium chloride compact, ngenxa yalokho umphumela omubi we-hydrochloric acid owakhiwe ngesikhathi se-metabolism ye-ASA ungathathi hlangothi.
Lapho i-magnesium chloride ingena emathunjini, iziveza njenge-laxative.
Ngaphezu kwalokho, lapho i-magnesium chloride ingena emathunjini, izibonakalisa njenge-laxative. Lokhu kungenxa yokuthi le nto ayimunwa. Ngaphezu kwalokho, ukwanda kwengcindezi ye-osmotic emathunjini kuyaphawulwa. Futhi, i-chloride eyenziwe ngesikhathi sokuguqulwa kwe-magnesium hydroxide magnesium chloride activates peristalsis. Lokhu kungenxa yokwanda kokuqukethwe kwamathumbu nokwanda kwengcindezi ezindongeni zayo.
Ngenxa ye-magnesium hydroxide, ukwelashwa kwe-ASA akunikeleli emiphumeleni emibi. Ezimweni ezimbi kakhulu, ngesikhathi sokwelashwa, ukusabela okungekuhle kukhulunywa kancane ngaphansi kwezimo lapho kusetshenziswa i-aspirin emsulwa.
Pharmacokinetics of Phasostabil
Umuthi okukhulunywa ngawo uguqulwa isikhashana. Ngaphezu kwalokho, umzimba ukwenzeka ukumuncwa.
I-Acetylsalicylic acid iguqulwa ibe isibindi esikhudlwana, lapho kukhishwa khona ama-metabolites, asatshalaliswa kulo lonke izicubu nezitho zomzimba. Ngemuva kwemizuzu engama-20, izinga eliphakeme kakhulu lokuhlushwa kwe-ASA liyatholakala. Amandla okubopha kumaphrotheni e-plasma ngokuya ngethamo lomuthi.
Ngenqubo yokususa i-acetylsalicylic acid, izinso zithinteka. Lokhu kusho ukuthi iningi lezinto likhishwa ngokuchama. Uma kungekho ukululama kwezinso, lesi sidakamizwa sikhishwa ngokuphelele ngemuva kwezinsuku ezingama-1-3. Uma izifo zalesi sitho ziqala ukwanda, i-ASA iyaqokeleleka kancane kancane emithonjeni yemithombo yezindaba (uketshezi nezicubu). Umphumela wokukhulisa ukugcwala kwale nto ukukhiqizwa kwezinkinga, ngoba ama-metabolites e-acetylsalicylic acid anomthelela omubi emzimbeni.
Ngenqubo yokususa i-acetylsalicylic acid, izinso zithinteka.
Izinkomba kanye ne-contraindication, imiphumela emibi
I-Phasostabil ichazwe ezimeni ezinjalo:
- ukuvimbela ukuthuthukiswa kwe-pathologies yesifo senhliziyo, ikakhulukazi, ukuhluleka kwenhliziyo, i-thrombosis lapho kunezici zobungozi, phakathi kwazo kukhona isifo sikashukela, i-hyperlipidemia, umfutho wegazi ophakeme;
- ukuvimbela kwezimpawu zokuphindaphindeka kwe-myocardial infarction;
- Ubuhlungu besifuba obukhulu;
- ukwehla okungathi sína kwe-venous lumen ngemuva kokuhlinzwa kwamathambo.
Umuthi okukhulunywa ngawo uphethwe emacaleni amaningi:
- ukungabekezeleli izingxenye ezisebenzayo ze-phasostabil noma esinye isidakamizwa esingelona se-steroidal anti-inflammatory;
- i-corrhea hemorrhage;
- ukusweleka kwe-Vitamin K, okuyisici esiyisisekelo esivimbela ukuvela komkhuba wokuphuma kwegazi;
- ukwehluleka kwenhliziyo okungapheli;
- ukuhlaselwa kwe-asthma ye-bronchial;
- inhlanganisela yezimo eziningana ze-pathological ezifaka isandla ekuphazamiseni umsebenzi wokuphefumula: i-asthma ye-bronchial, i-polyposis yamakhala, ukungabekezeleli ku-acetylsalicylic acid;
- isikhathi sokukhula kwesilonda esiswini;
- ukopha kwesisu;
- ukusetshenziswa okufanayo kwe-phasostabil ne-methotrexate;
- ukuntuleka kwe-glucose-6-phosphate dehydrogenase;
- umsebenzi okhubazekile we-renal kanye we-hepatic;
- i-lactation nokukhulelwa (i-trimesters ye-I ne-III);
- izingane ezingaphansi kweminyaka engu-18.
I-Phasostabil inemiphumela emibi eminingi, ekhonjiswa yizimpawu ezilandelayo:
- ukuguguleka kolwelwesi lwe-mucous lwesisu namathumbu;
- Ubuhlungu esiswini;
- isicanucanu
- ukuqunjelwa;
- ukushisa kwenhliziyo;
- ukugcotshwa kwezindonga zendlela yokugaya;
- ukuvuvukala nge -izationation ye-lesion emathunjini;
- i-bronchospasm;
- ukwehla kwamazinga e-hemoglobin ane-anemia;
- ushintsho ekwakhekeni nasezakhiweni zegazi ezihambisana nemibandela efana ne-thrombocytopenia, leukopenia, njll;
- ukopha
- ukuphazamiseka kokulala;
- i-corrhea hemorrhage;
- ukuthikamezwa kwezindlebe.
Isici seCardiomagnyl
Ungathenga leli thuluzi ngesimo samathebulethi. Ukuqanjwa kubandakanya izakhi ezifanayo ezisebenzayo njengasesimweni esecatshangelwe ngaphambili: acetylsalicylic acid, magnesium hydroxide. Kodwa-ke, lesi sidakamizwa sivezwa ezinhlotsheni ezahlukahlukene ezinomthamo ohlukile wezinto ezisebenzayo. Ithebhulethi eyi-1 iqukethe: i-75 noma i-150 mg ye-ASA; I-15.2 noma i-30.39 mg ye-magnesium hydroxide. Ngakho-ke, iCardiomagnyl ibonakala ngomshini wesenzo esifana nePhasostubil.
I-Cardiomagnyl ingathengwa kwifomu lethebhulethi. Ukuqanjwa kubandakanya izakhi ezisebenzayo njenge-acetylsalicylic acid, i-magnesium hydroxide.
Ukuqhathanisa Izidakamizwa
Ukufana
Into esemqoka ehlanganisa imali okukhulunywa ngayo ukwakheka okufanayo. Ukusetshenziswa kwezinto ezifanayo ezisebenzayo ekukhiqizweni kukuvumela ukuthi uthole imali esebenza ngomgomo owodwa. Ngenxa yalokhu, uCardiomagnyl noPhasostabil bavusa imiphumela emibi efanayo. Ukulinganiselwa lapho kuqokwa le mithi nakho kuyafana. Sebenzisa izidakamizwa ezicatshangelwe ekwelashweni kwezimo zokomoya zento efanayo.
Uyini umehluko?
I-Cardiomagnyl imelwe izinhlobo ezimbili ezihlukile kumthamo. Enye yezinketho i-analogue eqondile yePhazostabil (ngethamo eliphansi le-ASA ne-magnesium hydroxide). Ngakho-ke, lapho kunquma i-Cardiomagnyl equkethe izithako ezisebenzayo enanini le-150 ne-30.39 mg (kwithebhulethi eli-1), umuntu angathembela kumphumela othuthukisiwe. Umphumela omuhle utholakala ngokushesha. Kodwa-ke, imiphumela emibi ikhula ngokujulile. Lokhu kusho ukuthi ingozi yezinkinga ikhuphuka, ikakhulukazi kusuka ekugayeni kokugaya.
Yikuphi okushibhile?
I-Phasostabil isidakamizwa esingabizi kakhulu. Ingathengwa ngama-ruble ayi-130. (ipakethe eliqukethe amaphilisi ayi-100). I-Cardiomagnyl enomthamo ofanayo (75 mg no-15.2 mg) ibiza ama-ruble ayi-130, kodwa kulokhu kuvezwa intengo yephakeji enamathebhulethi angama-30.
I-Cardiomagnyl imelwe izinhlobo ezimbili ezihlukile kumthamo.
Yikuphi okungcono: Phasostabil noma Cardiomagnyl?
Uma siqhathanisa amalungiselelo nomthamo ofanayo wezithako ezisebenzayo, babonakala ngokusebenza okufanayo. Ngasikhathi sinye, izinga lokufakwa kwezinto zomuthi lihlala lingashintshiwe, njengoba kwenzeka nengxenye yempilo yezingxenye ezisebenzayo. Ngokwamandla okufinyeleleka kokusebenza kwesiqongo, le mithi nayo iyafana.
Ingabe i-Cardiomagnyl ithathelwa indawo yiPhasostabil?
Lawa ngamathuluzi angaguquguqukayo. Kodwa-ke, ezimweni lapho isiguli sihlakulele ukusabela okungekuhle kunoma yiziphi izingxenye eziseCardiomagnyl, i-Phazostabil ayinakusetshenziswa, ngoba zombili lezi zidakamizwa ziqukethe izinto ezifanayo.
Ukubuyekezwa kodokotela
I-Kartashova S.V., isazi sezinhliziyo, oneminyaka engama-37, uTambov
I-Cardiomagnyl ichazwa kaningi kwiziguli ezingaphezulu kweminyaka engama-40. Ithuluzi lisebenza kahle: lisebenza cishe ngaso leso sikhathi, ngaphezu kwalokho, imiphumela emibi ayivelisi ukuthuthukisa. Uma ulandela uhlelo olunqunyelwe ngesikhathi sokwelashwa, khona-ke izinkinga ngeke zivele.
UMaryasov A.S., udokotela ohlinzayo, oneminyaka engama-38, uKrasnodar
I-Phasostabil ishibhile kune-Cardiomagnyl, kepha umgomo wokusebenza uyefana. Zombili lezi zidakamizwa ziyasebenza. Kodwa-ke, uma ukusetshenziswa isikhathi eside kudingekile (ngokwesibonelo, ukunciphisa ukuhlanganiswa kweplatelet nokuvimbela ukushayeka kwegazi), ngithanda i-Phasostabilus ngenxa yentengo ephansi.
Ukubuyekezwa kweziguli kwe-Phasostable ne-Cardiomagnyl
UGalina, oneminyaka engama-46, uSaratov
Izindleko zeCardiomagnyl ziyisilinganiso, kepha ngiyaneliseka ngokuphelele ngaleli thuluzi zombili ngokusebenza kahle kanye nezinga lokulwa okunamandla esiswini. Ngibekezelela umuthi kahle kuze kube nemiphumela emibi. Ngalesi sizathu, angizicabangeli ezinye izifaniso, kufaka phakathi i-generics, noma ngabe ishibhile.
U-Eugenia, oneminyaka engama-38, iSt
Kimi, i-Phasostabil iyithuluzi elihle kunazo zonke esigabeni salo, ngoba iyasebenza, iyasiza ekuqedeni izimpawu ezinzima zokuhluleka kwenhliziyo.
