IGluconorm Plus isho ama-multicomponent hypoglycemic agents. Ngenxa yokuba khona kwezithako eziningana ezisebenzayo, umphumela omuhle ngesikhathi sokwelapha ungatholakala ngokushesha. Ithuluzi elibhekwayo lihlukile kwi-analogue yegama elifanayo (Gluconorm) kumthamo omkhulu. Ngaphezu kwalokho, zombili lezi zidakamizwa zisesigabeni samanani.
Igama Lezwe elingafanele
I-Metformin + Glibenclamide.
IGluconorm Plus isho ama-multicomponent hypoglycemic agents.
I-ATX
A10BD02.
Khipha amafomu nokwakheka
Umuthi utholakala kuphela ngendlela yamathebulethi. Inezithako ezisebenzayo: glibenclamide ne-metformin hydrochloride. Umthamo kuthebhulethi eyi-1, ngokulandelana: 2,5 no-5 mg; 500 mg Ngaphezu kwalokhu kuhlanganiswa kwezinto, ukwakheka kufaka phakathi izakhi ezisetshenziswayo ezisezingeni elifanele kule ndlela yokukhishwa:
- i-microcrystalline cellulose;
- i-hyprolosis;
- i-croscarmellose sodium;
- i-magnesium stearate.
Amacwecwe ahlanganiswe nenethiwekhi ekhethekile eyehlisa isilinganiso sokukhishwa kwezinto ezisebenzayo. Ngenxa yalokhu, izinga lomthelela onamandla kulwelwesi lwama-mucous lwesisu luyancipha. Ungawuthenga umkhiqizo ngamaphakeji aqukethe amaphilisi angama-30.
Umuthi utholakala kuphela ngendlela yamathebulethi. Inezithako ezisebenzayo: glibenclamide ne-metformin hydrochloride.
Isenzo se-Pharmacological
Umshini we-Gluconorm Plus ususelwa kumphumela ohlangene wezinto ezahlukahlukene. Isakhi ngasinye sisebenza kumgomo waso, kodwana ngasikhathi sinye sithuthukisa umphumela wesinye. Ngenxa yomphumela oyinkimbinkimbi, izinqubo ezahlukahlukene ze-biochemical emzimbeni zimboziwe, okufaka isandla ekwehlekeni okusheshayo kokuqukethwe kweglucose. Ngakho-ke, i-metformin ingeyama-biguanides. Lesi yisisebenzi se-hypoglycemic esisebenza imisebenzi efanayo ngasikhathi sinye:
- Iguqula isilinganiso se-insulin ku-proinsulin futhi siboshwe nge-insulin ukuze sikhululeke, kepha le nqubo ayenziwanga yi-Gluconorm, kodwa ingumphumela wokunye ukuphenduka komzimba okucasulwe lo muthi;
- kunciphisa ukugcwala kwe-glucose egazini, ngenxa yokuvinjwa kokuhlanganiswa kwe-metformin, ngasikhathi sinye inqubo yokuguqulwa kwayo kumaseli.
Ngokuphikisana nesizinda sokwanda kokuthathwa kwe-glucose, ukuzwela kwezicubu kukhuphuka kwe-insulin. Ngasikhathi sinye, ukukhishwa kwamahhala kwamafutha acid kwehla kancane. Amafutha oxidation nawo ahamba kancane. Inani lama-triglycerides, ama-lipoproteins aphansi, nawo liyancipha. Ngenxa yalokhu, izinga lokwakhiwa kwamafutha omzimba liyancishiswa, okuthinta ngqo isisindo somuntu. Ngokuphikisana nesizinda sokudla okufanele, ukudla okunama khalori aphansi kanye nokuzivocavoca okulinganiselayo, ukuthuthukiswa kokukhuluphala kuyama, okubaluleke kakhulu kwabanesifo sikashukela.
Umphumela oqondile wesidakamizwa esilinganisweni sezindlela ezahlukahlukene ze-insulin kungenxa yokunye ukusabela. Ngakho-ke, nge-metformin therapy, akunamphumela enqubweni yokukhiqizwa kwe-insulin, ngoba le nto ikhombisa izakhiwo ze-hypoglycemic, idlula amaseli we-pancreas. Naphezu kweqiniso lokuthi lesi sakhi sephula umsoco we-cholesterol, sinciphisa ukuqoqwa kwe-LDL, ukwelashwa akubeki phansi okuqukethwe kwe-HDL. Ngenxa yalokhu kuphendula, isisindo asigcini nje ukwanda, kepha ukuncipha kwaso kuphawulwa ngaphansi kwezimo eziningi.
Enye impahla ye-metformin yikhono lokuthonya ukwakheka kwegazi okwakhiwe. Ngakho-ke, ngesikhathi sokwelashwa nge-Gluconorm Plus, izakhiwo ze-fibrinolytic zegazi zijwayelekile. Ngenxa yalokhu, izingcezu zegazi ezakhekile ziyachithwa. Le nqubo isuselwe ekuvimbeleni umgqugquzeli we-tishu we-plasminogen.
Enye impahla ye-metformin yikhono lokuthonya ukwakheka kwegazi okwakhiwe.
Ingxenye yesibili esebenzayo (glibenclamide) ingeyeqembu lokuphuma kwe-sulfonylurea. Izindlela zalolu hlobo zisebenza ngempumelelo kunazo zonke izidakamizwa ezikhona ze-hypoglycemic. Umshini wokusebenza kwe-glibenclamide usekelwe emandleni wokuthonya amaseli we-pancreatic beta. Lapho uxhumana nama-receptors abo, ukuvalwa kwe-potassium kanye neziteshi ze-calcium zivulekile.
Umphumela walokhu kusabela kusebenze inqubo yokukhishwa kwe-insulin. Lokhu kungenxa yokungena kwe-calcium emangqamuzaneni. Esigabeni sokugcina, ukukhishwa kwe-insulin okunamandla egazini kuyaphawulwa, okubangela ukwehla kweglucose. Njengoba kunikezwe inqubo yokusebenza kwalokhu, kuyalulekwa ukuyisebenzisa kuphela ekwelapheni iziguli ezinamaseli we-beta asebenzayo we-pancreas. Ngaphandle kwalokho, ukusebenza kwe-glibenclamide kuncishisiwe.
I-Pharmacokinetics
I-Metformin ingena ngokushesha. Izinga lokuhlushwa kwalo ku-serum yegazi likhuphuka liye kumanani alo womkhawulo ngemuva kwamahora we-2. Ukungathandeki kwento kuyisenzo esifushane. Ngemuva kwamahora ayi-6, ukwehla kokuxinwa kwe-plasma ye-metformin kuyaqala, okungenxa yokuphela kwenqubo yokufakwa emzimbeni wokugaya ukudla. Ukuphila kwengxenye kwento kuyancishiswa. Isikhathi saso siyahluka kusuka emahoreni ayi-1.5 kuye kwangama-5.
Ngaphezu kwalokho, i-metformin ayibophele amaprotheni e-plasma. Le nto inamandla okuqongelela izicubu zezinso, isibindi, izidakamizwa zesikhumba se-salivary. Umsebenzi wezinso ongasebenzi kahle uyisici esiyinhloko esinegalelo ekuqongeleleni i-metformin emzimbeni, okuholela ekwandeni kokuxineka kwale ngxenye nokwanda kokusebenza kwayo.
Umsebenzi we-renal ophazamisekile uyisici esiyinhloko esinomthelela ekuqongeleleni kwe-metformin emzimbeni, okuholela ekwandeni kokusebenza kwayo.
IGlibenclamide ihlala isikhathi eside - amahora angama-8 kuya kwayi-12. Inani eliphakeme lokusebenza kahle lisebenza emahoreni angu-1-2. Le nto iboshelwe ngokuphelele kumaprotheni egazi. Inqubo yokuguqulwa kwe-glibenclamide yenzeka esibindini, lapho kwakhiwa khona amakhompiyutha ama-2 angawubonisi umsebenzi we-hypoglycemic.
Izinkomba zokusetshenziswa
Umuthi uvunyelwe ukuthi usetshenziswe ekwelapheni iziguli ezinesifo sikashukela sohlobo 2 kwezinye izimo:
- ukuntuleka komphumela ekwelashweni okwabekelwa ngaphambili kokukhuluphala, uma ngabe kukhona izidakamizwa ezisetshenzisiwe: Metformin noma Glibenclamide;
- ukwenza ukwelashwa okuthatha indawo, inqobo nje uma izinga le-glucose egazini liqinile futhi lilawulwa kahle.
Contraindication
Kunqunyelwe imikhawulo eminingi lapho ithuluzi okukhulunywa ngalo lingasetshenziswa:
- ukungabekezeleli kunoma iyiphi ingxenye ekwakhiweni (kuyasebenza futhi akusebenzi);
- thayipha i-1 isifo sikashukela;
- ukwephulwa kwe-carbohydrate metabolism kushukela;
- isigaba sokuqala sokukhohlisa;
- coma;
- ukwehla okukhulu kweglucose yegazi;
- izimo ezahlukahlukene ze-pathological ezifaka isandla ekuphazamiseni ukusebenza kwe-renal, kungahle kwehle kancane inqubo yokuphanjululwa uketshezi, ukutheleleka, ukushaqeka;
- noma yiziphi izifo ezihambisana nokushoda komoya-mpilo, phakathi kwabo infarction myocardial iyabonakala;
- i-lactic acidosis;
- izimo eziningana ze-pathological eziyisisekelo sokuqokwa kwe-insulin therapy, kulokhu, ukuvuselelwa okwengeziwe kwalesi zinto kungaholela ekwakhiweni kwezinkinga.
Ungayithatha kanjani iGluconorm Plus?
Imvamisa yokuthatha amaphilisi kanye nenani lezinto ezisebenzayo kunqunywa ngawodwana. Isimo sesiguli esinesifo sikashukela i-mellitus, ukuba khona kwezinye izifo, kanye nobudala kuthinta ukukhetha kohlobo lokwelashwa. Umuthi uphuzwa nokudla.
Ngoshukela
Qala inkambo yokwelashwa ngemithamo emincane. Thatha ithebhulethi engu-1 ngosuku. Ngaphezu kwalokho, ukuqoqwa kwezakhi ezisebenzayo kungahluka: 2,5 mg + 500 mg; 5 mg + 500 mg. Kancane kancane, inani le-metformin ne-glibenclamide liyakhuphuka, kepha lingabi ngaphezu kuka-5 mg no-500 mg, ngokulandelana. Ushintsho ekuqoqweni kwezidakamizwa lwenziwa njalo emavikini ama-2 kuze kube yilapho isimo sesiguli sizinza.
Isilinganiso esiphezulu somuthi nsuku zonke singamaphilisi ama-4, kuyilapho imithamo yezithako ezisebenzayo ku-1 pc: 5 mg no-500 mg. Okuhlukile ngamathebulethi ayi-6, kepha inani le-glibenclamide ne-metformin ngokulandelana: 2,5 mg, 500 mg. Imithamo ekhonjisiwe yesidakamizwa ihlukaniswe imithamo eminingana (2 noma 3), konke kuya ngenani lamathebulethi. Okuhlukile kungamacala lapho kubekwa ithebhulethi eyi-1 ngosuku.
Imiphumela Emibi yeGluconorm Plus
Kukhona ubungozi bokulimazeka okubukwayo ngenxa yokwehla kwamazinga kashukela.
Amapheshana wesisu
Ukuqhephuka, okuhambisana nokufikelwa yinhliziyo, ukulahleka kwesifiso, ubuhlungu besisu, ukunambitheka kwensimbi. Ukuvela kwezimpawu ze-jaundice, i-hepatitis akuvamile ukuba kuqashelwe, umsebenzi we-hepatic transaminases uyanda. Lokhu kungumphumela wezinguquko esibindini.
Ukuqhaqhaza okuhambisana nokufikelwa yinhliziyo kungenye yemiphumela emibi yesidakamizwa.
Izitho zeHematopoietic
Izinkinga eziningi ezihambisana nezinguquko ekwakhekeni nasezakhiweni zegazi: i-thrombocytopenia, i-leukopenia, i-anemia, njll.
Isistimu yezinzwa ephakathi
Ukukhathala, ikhanda kanye nesiyezi, ubuthakathaka obujwayelekile, umuzwa ophazamisekile (kuyaqabukela).
I-carbohydrate metabolism
I-Hypoglycemia, izinkomba zazo okuyi-ulaka, ukudideka, ukudangala, umbono ofiphele, ukuthuthumela, ubuthakathaka, njll.
Ngasohlangothini lwe-metabolism
I-Lactic acidosis
Engxenyeni yesikhumba
Kunezimpawu ze-hypersensitivity elangeni.
Allergies
I-Urticaria. Izimpawu eziphambili: ukuqubuka, ukulunywa, umkhuhlane. I-Ethethema iyakhula.
Umuthi ungavusa ukungezwani ngendlela yokulunywa nokuqunjelwa.
Umthelela ekhonweni lokulawula izindlela
Uma ucabanga ukuthi umuthi uvusa ukuphazamiseka kwamehlo, kwesinye isikhathi unomthelela ekuthuthukisweni kwe-hypoglycemia, kunconywa ukuthi uqaphele ngenkathi welapha nge-Gluconorm Plus ngenkathi ushayela.
Imiyalo ekhethekile
Umuthi ubekwa ngokuqapha uma kungaphulwa kakhulu i-yegilo gland, i-pituitary gland, ngomkhuhlane kanye nokungasebenzi kahle kwe-adrenal.
Ngesikhathi sokulashwa, kunconywa ukuthi uqaphe njalo amazinga eglucose (esiswini esingenalutho nangemva kokudla).
Kuyadingeka ukwazisa udokotela ngokuthuthukisa izifo zezitho zangasese. Kulokhu, kungadingeka ushintsho kuhlobo lokwelashwa.
Ngokuphikisana nesizinda sokuphazamiseka kwesibindi nezinso, ukugcwala kwe-metformin esegazini kuyanda, okuwumphumela wokuncipha kokuqedwa kwalolu hlobo. Ngenxa yalokho, i-lactic acidosis iyakhula.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ayabelwe.
Inhloso Gluconorm Plus yezingane
Akusetshenziswanga, ukwelashwa kwabantu abadala kuphela okwamukelekayo.
Umuthi awusetshenziselwa ukwelapha izingane.
Sebenzisa ebudaleni
Umuthi uthathwa ngokuqapha, ikakhulukazi uma isiguli sibhekene nokuzivocavoca ngokweqile komzimba. Kulokhu, ubungozi be-lactic acidosis banda.
Isicelo sokusebenza kokulimala kwezinso
Unganikeli ikhambi lokulimazeka okukhulu kulesi sitho. Kudingeka ukulawula i-Creatinine clearance control. Ngokuncipha okukhulu enkambeni yokwelashwa kuyaphazamiseka.
Sebenzisa umsebenzi wesibindi okhubazekile
Isidakamizwa siyaphulwa uma kwenzeka ukwehluleka kwesibindi.
Ukweqisa kwe-Gluconorm Plus
Leli thuluzi liyingozi uma lisetshenziswa ukwephula irejimeni yokwelashwa. Kulokhu, i-hypoglycemia iyavela, ngoba izinqubo zokukhishwa kwe-insulin zenziwa zasebenza. Ngasikhathi sinye, ukusetshenziswa kwe-glyconeogeneis kanye ne-glucose kuvinjelwe kakhulu. Ngenxa yalokhu, ngokunyuka komthamo we-Gluconorm Plus, kuba nezinkinga.
Ukwelapha kuhilela ukwenziwa okujwayelekile kokudla. Isiguli kufanele sithathe umthamo wama-carbohydrate nganoma yiluphi uhlobo. Uma kuvela isimo esibucayi se-pathological, sihambisana nethambo, ukwelashwa kwenziwa esibhedlela: isixazululo se-dextrose sisebenza ngokuhlinzwa.
Lapho umthamo we-Gluconorm Plus unyuka, i-lactic acidosis ingahle ikhule. Lesi simo se-pathological sidinga ukwelashwa esibhedlela. Ngaphezu kwalokho, i-lactate ne-metformin zisuswa ngempumelelo emzimbeni ngokusebenzisa i-hemodialysis. Ukususa i-glibenclamide, le ndlela ayifanele, ngoba le nto iboshelwe ngokuphelele kumaprotheni egazi.
Isidakamizwa siyaphulwa uma kwenzeka ukwehluleka kwesibindi.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa okufanayo kweGluconorm Plus neMiconazole kunomthelela ekuthuthukisweni kwe-hypoglycemia.
Imikhiqizo equkethe i-iodine ayisetshenziswa kanye nomuthi okukhulunywa ngawo. Lokhu kufanele kubhekwe lapho kwenziwa ucwaningo oludinga ukusetshenziswa kokuthuthukisa okuhlukile ngezinto eziqukethe iodine.
I-Phenylbutazone ithuthukisa isenzo somuthi okukhulunywa ngawo - inomthelela ekwehlelweni okukhulu kwamazinga kashukela.
UBesontan uphakamisa ukwanda kwemiphumela enobuthi esibindini.
Inani lezidakamizwa nezinto ezidinga ukuqashelwa:
- I-Chlorpromazine;
- I-GCS;
- ama-beta-adrenergic agonists nama-block adrenergic;
- okokugcobisa;
- UDanazole;
- Ama-inhibitors e-ACE.
Ukuhambisana notshwala
Iziphuzo eziqukethe notshwala azikwazi ukuhlanganiswa ne-Gluconorm Plus.
Ama-Analog
Ukufakwa esikhundleni okusebenzayo:
- I-Glibomet;
- UJanumet;
- I-Metglib;
- IGlucophage nabanye.
Imibandela yekhefu lekhemisi
Umuthi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo ye-Gluconorm Plus
Izindleko ezimaphakathi: ama-ruble ayi-160-180.
Izimo zokugcina zomuthi
Ibanga lokushisa elinconyelwe: kufika ku- + 25 ° С.
Isikhathi sokuphelelwa yisikhathi
Izici zesidakamizwa zigcinwa iminyaka emi-2 kusukela ngosuku lokukhishwa.
Umkhiqizi
I-Pharmstandard-Tomskkhimfarm OJSC, eRussia.
Ebudaleni, umuthi uthathwa ngokuqapha, ikakhulukazi uma isiguli sithola ukusebenza ngokweqile komzimba.
Ukubuyekezwa kwe-Gluconorm Plus
Odokotela
IValiev A.A., i-endocrinologist, eneminyaka engama-45, uVladivostok
Ikhambi elisebenzayo. Umphumela oyifunayo wokwelashwa ungatholakala ngokushesha, kepha izinkomba ezinjalo zihambisana nengozi yezinkinga. Ukwehla okusheshayo kweglue glucose kuholela ku-hypoglycemia, ngakho-ke ungaphuza umuthi kuphela ngemuva kokubonana nodokotela.
UShuvalov E. G., udokotela wezokwelapha, oneminyaka engama-39 ubudala, uPerkov
Leli khambi lisebenza ngokuphelele. Kungathathwa kuphela ngesifo sikashukela sohlobo 2. Ngiphawula inani elikhulu lemiphumela emibi, i-contraindication. Ngibona inzuzo njengentengo engabizi, okubalulekile, ngoba iziguli zivame ukuthatha amaphilisi.
Iziguli
UVeronika, oneminyaka engama-28, uYaroslavl
Ngisanda kuthola isifo sikashukela. Ngenkathi ngifunda ukuhlala naye, ngidinga ukudla nokuqapha i-glucose ejwayelekile. Nami ngithathe lo muthi, uyasiza ngokushesha, futhi lokhu kuhlanganiswa, ngoba ukwesaba kwami okukhulu ukukhohlisa ngokumelene nesizinda sokwehla kwamazinga kashukela.
U-Ana, oneminyaka engama-44, uSamara
Umuthi awuzange uwanane. Umphumela wemiphumela emibi. Ubuhlungu bekhanda, isicanucanu, ukungaboni kahle - Ngazihlangabezana nazo zonke lezi zimpawu kimi. Udokotela ekuqaleni wayekholelwa ukuthi lolu daba lukudosi, kepha ngisho nohlobo lokwelashwa olungelusizo kakhulu aluzange luxazulule inkinga.
