I-Latren yezidakamizwa: imiyalelo yokusetshenziswa

I-Latren ingeqembu le-vasodilators yangaphandle. Kusetshenziswa kwezokwelapha ukufeza umphumela we-vasodilating. Umphumela onjalo wokwelapha uyadingeka ukuze kubuyiswe ukuhamba kwegazi okujwayelekile ezindaweni ezithinta izicubu futhi kuthuthukiswe izakhiwo zegazi. Umuthi usiza ukuqeda i-thrombosis, isifo sokuqina kwemizwa kanye nokuphazamiseka kwe-choroid yesitho se-ocular.

Igama Lezwe elingafanele

I-Pentoxifylline.

I-Latren isiza ukuqeda i-thrombosis, isifo sokuqina kwemizwa kanye nokuphazamiseka kwe-choroid yesitho se-ocular.

I-ATX

C04AD03.

Khipha amafomu nokwakheka

Umuthi wenziwa ngendlela yesisombululo sokulungiselela ukumnika. Ifomu lomthamo liku-ampoule wengilazi aqukethe i-100, 200 noma i-400 ml yento esebenza - pentoxifylline. Ngokubukeka, isixazululo siwuketshezi obala we-hue omncane ophuzi noma ongenawo umbala. Njengezithako ezingeziwe zokuthuthukisa ukumuncwa, kusetshenziswa ifomu le-ketshezi le-sodium lactate, amanzi oyinyumba womjovo, i-potassium ne-sodium chloride.

Isenzo se-Pharmacological

I-Pentoxifylline ihlanganiswe kusuka ku-methylxanthine; ingeqembu le-vasodilators abanqenqemeni. Izici ze-Pharmacological kungenxa yokuvinjwa kwe-phosphodiesterase. Ngokufana, into yamakhemikhali inomthelela ekuqongeleleni i-3,5-AMP emisipha ebushelelezi ye-vasotine endothelium, amaseli egazi, ezicutshini nasezitho zomzimba.

I-Pentoxifylline ivimbela ukunamathela kwamangqamuzana abomvu egazi namapuleti egazi, inikeze ukuqina futhi ikhulise ukumelana kwezitho zabo zeseli. Ngenxa yokuncipha kokuhlangana, ukuvela kwegazi kuyancipha, umphumela we-fibrinolytic uyanda futhi izici zokuphamba kwegazi zithuthuka.

Ukwemukela iLatrena kunomthelela ekujuleni kwenhliziyo.

I-Pentoxifylline inegalelo ekwandeni kokuhlungwa kwe-plasma ye-fibrinogen. Kulokhu, into esebenzayo inciphisa ukumelana okuphelele emithanjeni yokwethisa, inomphumela obuthakathaka we-vasodilating emithanjeni yemisipha. Ukuthatha umuthi kusiza ekujuleni kwenhliziyo. Njengomphumela wokuthola umphumela wokwelapha, i-microcirculation yegazi ezindaweni ezi-ischemic iyanda: amathuba okukhulisa indlala komoya-mpilo amaseli ayancipha, izicubu zithola inani elanele lomoya-mpilo nezakhi zomzimba.

Ekuqhubekeni kwezifundo zemitholampilo, imiphumela ephezulu yomuthi embhedeni we-capillary emaphethelweni, isistimu yezinzwa ephakathi, kanye nomphumela omaphakathi emithanjeni yezinso kwaqoshwa. Umuthi unomphumela obuthakathaka ekwandeni kwemikhumbi ye-coronary.

I-Pharmacokinetics

Lapho i-pentoxifylline ingena emithanjeni yegazi, ifinyelela emazingeni ayo aphezulu ku-serum kungakapheli imizuzu engama-60. Endimeni yokuqala nge-hepatocytes, into esebenzayo iba nokuguqulwa okuphelele. Imikhiqizo yokubola idlula isilinganiso se-plasma esiphezulu se-pentoxifylline ngezikhathi ezi-2 futhi ibe nomphumela wokwelapha. Isigamu sempilo singamahora ayi-1,6. I-90% yezidakamizwa ishiya umzimba usesimweni sama-metabolites, ama-4% athulwe ngemichilo ngesimo sayo sokuqala.

Izinkomba zokusetshenziswa

I-Pentoxifylline iyi-vasodilator ethuthukisa umsebenzi wokusebenza kwama-capillaries. Umuthi usiza ukukhulula imisipha yemisipha ebushelelezi yemithambo yegazi, i-bronchospasm. I-vasodilator imiselwe ukuphazamiseka kokujikeleza kwethambo esweni lokulwa nesizinda sezinguquko eziwohlokayo ku-endothelium yemithambo esehlweni lamehlo. Umuthi usiza ukwandisa ukugeleza kwegazi endaweni yezilonda zezimpawu zomzimba noma i-gangrene yamaphethelo aphansi.

Ukucaciswa kwemibango - inkomba yokuqokwa kweLatren.

Umuthi lo usetshenziselwa ukwelapha isifo sikaRaynaud.

I-Latren ibekelwe imithambo ye-varicose.

Umuthi usiza ekwelapheni izifo ezifikayo zamathambo we-paripheral arology kanye ne-atherosclerotic etiology, efana:

• ukwephulwa kwezicubu ezincanyana;
• nobuhlungu emisipha yezandla lapho kuphumule;
• ukukhulumisana isikhashana;
• imithambo ye-varicose.

Umuthi ubuyisela ukujikeleza kwe-cergus kanye nokunikezwa kwegazi egunjini lokuzwa, kusiza ukuqeda i-thrombosis futhi kuthuthukisa i-trophism yezicubu zomzimba ngokumelene nesizinda se-polyneuropathy yesifo sikashukela. Umuthi lo usetshenziselwa ukwelapha isifo sikaRaynaud.

Contraindication

Umuthi wenqatshelwe ukuthi uphathiswe abantu abane-hypersensitivity yezinto ezibumba isisekelo seLatren, kanye ne-xanthine derivatives. Umuthi awunconyelwe ukuthi usetshenziswe phambi kwezifo ezilandelayo kanye nama-pathologies:

• ukopha kakhulu;
• i-hemorrhagic diathesis;
• isifiso sentuthuko noma ubukhona be-infyoctional myocardial;
• isifo se-porphyrin;
• i-retinal hemorrhage;
• ukuphazamiseka kwesigqi senhliziyo;
• ushintsho olukhulu lwe-atherosclerotic ku-endothelium yemithambo ye-coronary and cerebral;
• umfutho wegazi ophansi;
• ukuvuvukala kwengqondo.

Umuthi awunconywa kubantu abanokwehluleka kwesibindi nezinso.

Umuthi awunconywa kubantu abanomfutho wegazi ophansi.

I-Latren ayinconyelwa ukusetshenziswa ku-hemorrhage ye-cerebral hemorrhage.

Abantu abahlushwa isilonda se-peptic sesisu kanye ne-duodenum, iLatren enqunywe ngokuqapha.

Ngokunakekela

Abantu abanenkinga yezilonda ezi-ulcerative-erosive lesisu kanye ne-duodenum badinga ukuqapha isimo senqubo ye-pathological ngesikhathi sokwelashwa neLatren. Kunxuswa abantu abanokuhluleka kwenhliziyo kanye nokuba khona kwesifo sikashukela mellitus. Umuthi ubekwa ngaphansi kokuqashwa okuqinile kwezokwelapha ngemuva kokuhlinzwa kakhulu.

Ungamthatha kanjani uLatren

Umuthi lo uphathwa ngokuhlinzwa njenge-infusion. Umthamo usungulwa udokotela ohambelayo enkambweni yomuntu ngamunye yenqubo ye-pathological kanye nezimpawu zesiguli. Lokhu kufaka phakathi isisindo somzimba, iminyaka, izifo ezikhona, ukubekezelelwa kwezidakamizwa, ubukhulu bezinkinga zokujikeleza kwegazi.

Iziguli ezineminyaka engaphezu kwengu-12 ubudala zinconyelwa ukubeka i-dropper ene-100-200 ml yomuthi. Ukuphathwa kwe-Drip kuyaqhutshelwa amahora angama-1.5-3. Ngokubekezelela okuhle, ukukhuphuka komthamo okufika ku-400-500 ml (okulingana no-300 mg) wokujova kuvunyelwe.

Umthamo omkhulu ovunyelwe ngosuku ufinyelela ku-500 ml. Ngokwesilinganiso, ukwelashwa ngezidakamizwa kuthatha cishe izinsuku ezingama-5-7. Uma kunesidingo, ukwelashwa okuqhubekayo kushintshelwa ekuphathweni komlomo kwama-vasodilators amaphilisi.

Ngoshukela

Umuthi uyakwazi ukuthuthukisa umphumela we-hypoglycemic wezidakamizwa ezilwa nesifo sikashukela, ngakho-ke, ngesikhathi sokwelashwa ngeLatren, kuyadingeka ukulawula izinga le-glucose egazini futhi liphathe ushukela. Lokhu kokugcina kuyadingeka ukuvimbela ukukhula kwe-hypoglycemia.

Ngesikhathi sokwelashwa ngeLatren, kuyadingeka ukulawula izinga le-glucose egazini.

Ukusetshenziswa kweLatren kungadala ukuvuvukala kwe-conjunctiva.

I-Latren iphathwe ngokuhlinzwa njenge-infusion.

Imiphumela emibi uLatrena

Imiphumela emibi yenzeka ngomthamo ongafanele wesidakamizwa.

Engxenyeni yesitho sombono

Mhlawumbe ukwehla kwamandla okubuka, ukuvuvukala kwe-conjunctiva, i-retinal hemorrhage, kulandelwa ukukhutshwa. Ezimweni ezingavamile, ukulimaza okubukwayo kuhambisana nokukhula kwe-scotoma.

Kusuka ezicutshini zemisipha

Kwezinye izimo, kubuthakathaka kwemisipha nobuhlungu.

Amapheshana wesisu

Ngohlelo lokugaya olucasukile, umuntu uqala ukuzizwa ephelelwa yisicanucanu, ukuhlanza. Ezimweni ezingavamile, ukwephulwa kwe-intestinal motility, ukuvuvukala kwesibindi kukhula, i-cholecystitis iyanda. Ukuvela kwe-cholestasis kungenzeka.

Izitho zeHematopoietic

Ukuvinjwa kwe-hematopoiesis yamathambo kuhambisana nokuncipha kwenani lamangqamuzana abomvu egazi namapuleti, okungaholela ekwakhiweni kwe-hypoplastic anemia. Ezimweni ezimbi kakhulu, kunengozi yokufa.

Isistimu yezinzwa ephakathi

Ngomthamo ongafanele, ikhanda liqala ukuzizwa linesiyezi, kuba nekhanda, ukuhanjiswa kwemizwa, ukuqina kwemisipha, ukuphazamiseka kokulala. Umuntu uzizwa ekhathazekile okungenasizathu.

Ngokuphikisana nesizinda sokulashwa ngomuthi, ukuhlaselwa isicanucanu nokuhlanza kungenzeka.

Ngemuva kokusebenzisa iLatren, kuvela ikhanda eliningi, okuyisibonakaliso somphumela wecala.

Ngomthamo ongafanele, uLatren uqala ukuzizwa enesiyezi.

Ngesikhathi sokwelashwa kweLatren, ukwenzeka kwemizwa engemihle njengokuphazamiseka kokulala kuyaphawulwa.

Ngemuva kokusebenzisa iLatren ohlelweni lokuphefumula, i-dyspnea ingaqala ukukhula.

Lapho elashwa noLatren, umuntu angaba nokukhathazeka okungenasisekelo.

Kusuka ohlelweni lokuphefumula

Mhlawumbe ukuthuthukiswa kokuphefumula komoya.

Engxenyeni yesikhumba

Ukushintshwa kwesikhumba kuhambisana nokuxubha, ukulunywa, isifo se-erythema nesifo sikaStevens-Johnson. Ukushuba kwamapuleti ezipikili kuyathuthukiswa.

Kusuka ohlelweni lwezinhliziyo

Isiguli siqala ukuzizwa sishwabana, ukuvuvukala kwemilenze. Kune-tachycardia, ukuguquguquka kwengcindezi yegazi. Ezimweni ezinzima, ukopha kungaqhamuka.

Ngasohlangothini lwe-metabolism

Mhlawumbe ukuthuthukiswa kwe-anorexia, ukwehla kwamazinga e-potassium, ukujuluka nokushisa komzimba, umsebenzi wama-enzymes wesibindi uyanda.

Allergies

Ukuphendula kwe-allergic kuhambisana nokuphendula kwesikhumba kanye ne-anaphylactoid.

Umthelela ekhonweni lokulawula izindlela

Ngokubheka ukwehla okungenzeka kwejubane lokuphendula komqondo nokuhlushwa okulimazayo phakathi nesikhathi sokulashwa kwezidakamizwa, kuyadingeka ukwenqaba ukushayela namadivaysi ayinkimbinkimbi.

Ngemuva kokusebenzisa izimbambo zeLatren zingavuvukala.

Ngokuphikisana nesizinda sokulashwa kwezidakamizwa, i-anorexia ingaqala ukukhula.

Umuthi ubangela ukujuluka ngokweqile.

Imiyalo ekhethekile

Uma kwenzeka i-lupus erythematosus nezinye izindlela zokuthinta izicubu ezithintekayo, kubalulekile ukunquma lesi sidakamizwa kuphela ngemuva kokuhlolwa okuphelele kwezinzuzo nezingozi. Ukuhlolwa kwegazi okujwayelekile kuyadingeka ngenxa yengozi engaba khona ye-aplastic anemia.

Iziguli ezinokwehluleka kwenhliziyo okungapheli zidinga ukufinyelela esigabeni sesinxephezelo sokujikeleza kwegazi ngaphambi kokusebenzisa umuthi.

Iziguli ezimiselwe ukuthuthukiswa kokuphendula kwe-anaphylactic kufanele zihlolwe ukuze zibekezelele umuthi. Uma kwenzeka ukusabela okuhle, umuthi uyakhanselwa.

Sebenzisa ebudaleni

Abantu abangaphezulu kweminyaka engama-50 kufanele banakekele.

Ukunquma uLatren ezinganeni

Izingane ezingaphansi kweminyaka engu-12 ubudala azivamile ukuba zichazwe njengesixazululo seLatren. Ezinganeni, kuyadingeka ukubala umthamo kuya ngesisindo somzimba - 10 ml wesidakamizwa nge-1 kg yesisindo. Ezinganeni ezisanda kuzalwa, umthamo wansuku zonke ubalwa ngendlela efanayo, kepha umthamo omkhulu akufanele udlule i-80-100 ml.

Ukukhulelwa kweLatren kukhulunywa kuphela ezimweni lapho umphumela womuthi ungavimbela usongo empilweni kamama.

Ngesikhathi sokuncelisa, lapho kuqokwa iLatren, kuyadingeka ukuyeka ukuphuma kwe-lactation.

Abantu abangaphezulu kweminyaka engu-50 yobudala kufanele basebenzise i-Latren ngokuqapha.

I-Latren ivunyelwe kuphela lapho kukhona izifo zezinso ezithambile nezilinganiselayo.

Umuthi awuvunyelwe ukuthi usetshenziswe ngabantu abalimele kabi isibindi.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ayikho imininingwane yokuthi kungenzeka ukungena kwe-pentoxifylline nomphumela wayo ekuthuthukisweni kwe-embryonic. Ngakho-ke, ukumfaka kwe-intravenous kunqunywa kuphela ezimweni ezimbi kakhulu, lapho umphumela we-vasodilating womuthi ungavimbela usongo empilweni kanina. Umphumela wokwelapha kufanele udlule engcupheni yokuhlukunyezwa kwe-intrauterine ku-umbungu.

Ngesikhathi sokuncelisa, lapho kuqokwa iLatren, kuyadingeka ukuyeka ukuphuma kwe-lactation.

Isicelo sokusebenza kokulimala kwezinso

Isifo sezinso sandisa i-Half-life yesidakamizwa, Ngakho-ke, ukumithiselwa kwe-Latren kwe-intrenvenia kuvunyelwe kuphela lapho kukhona izifo zezinso ezithambile nezilinganiselayo.

Sebenzisa umsebenzi wesibindi okhubazekile

Umuthi awuvunyelwe ukuthi usetshenziswe ngabantu abalimele kabi isibindi.

I-Latren overdose

Ngokusebenzisa kabi izidakamizwa, kuvela lezi zimpawu ezilandelayo:

• ubuthakathaka bemisipha;
• Isiyezi
• i-neuromuscular arousal;
• ukwehla kwengcindezi yegazi;
• ukudideka nokulahlekelwa ukwazi;
• ukukhuphuka kwenhliziyo;
• ukufiphala kobuso;
• ukugabha kanye nenausea;
• ukopha nokuphefumula ungene emgodini wegaya wokugaya ukudla;
• izicubu zomsipha;
• umkhuhlane.

Isisulu sidinga ukulashwa ngokuphuthumayo esibhedlela. Ukwelashwa kuhloswe ukuvikela ukukhula kwegazi langaphakathi nokuqeda izimpawu zokusebenzisa ngokweqile.

Ukudlula komthamo kaLatren kubangela ukufiphala kobuso.

Ngokukhuphuka komthamo onconyiwe wesidakamizwa, isiguli singalahlekelwa ukwazi.

I-overdose yesidakamizwa ibangela ukwanda kwezinga lokushisa.

I-overdose ethinteka yiLatren idinga ukulaliswa esibhedlela ngokuphuthumayo.

I-Latren ayikwazi ukuhlanganiswa notshwala.

Ukuxhumana nezinye izidakamizwa

I-Pentoxifylline ingavusa ukwehla kokuxinwa ushukela we-plasma ngenkathi usebenzisa ama-hypoglycemic agents noma i-insulin. Ngakho-ke, iziguli ezinesifo sikashukela kufanele zibonisane nodokotela we-endocrinologist ukulungisa umthamo wezidakamizwa ze-antidiabetes.

Emsebenzini wokuthengisa ngemuva, kuye kwaba nezimo zokuncipha kokuqina kwegazi nokusetshenziswa okufanayo kwama-antivitamini K, ama-anticoagulants aqondile futhi angaqondile ne-Latren. Lapho kuhlanganiswa nale mishanguzo, ukuqapha umsebenzi we-anticoagulant kuyadingeka.

I-Pentoxifylline ithuthukisa umphumela we-antihypertensive wezidakamizwa ze-antihypertensive. Ngenxa yalokho, i-hypotension ye-arterial ingahle ivele.

Ukungahambisani ngokomzimba kubonakala lapho kuxuba i-Latren nezinye izixazululo zokwelapha ku-syringe efanayo.

Into esebenzayo inyusa izinga le-Theophylline, yingakho ikhuphula noma ikhulisa imvamisa yokubonakala kwemiphumela emibi kusukela ekusebenziseni Theophylline.

Ukuhambisana notshwala

Imithi ayinakuhlanganiswa nezidakamizwa eziqukethe i-ethanol nemikhiqizo yotshwala. I-Ethyl alcohol iyisitha esiphikisana ne-pentoxifylline, ikhuthaza ukunamathela kwamangqamuzana abomvu egazi, ukuvimbela ukuhamba kwegazi. I-Ethanol ibangela i-vasospasm kanye nokuthuthukiswa kwe-thrombosis. Kukhona ukuntuleka komphumela wokwelapha kanye nokuwohloka.

Ama-Analog

Ukufana kwezidakamizwa ezinezinto ezifanayo zemithi noma ukwakheka kwamakhemikhali:

• Trental;
• Bilobil;
• I-Pentoxifylline;
• I-Flowerpot;
• I-Agapurin;
• Pentilin.

Imibandela yekhefu lekhemisi

Umuthi awuthengiswa ngaphandle kwezinkomba eziqondile zokwelashwa.

Ngingakwazi ukuthenga ngaphandle kadokotela

Kudingeka incwadi kadokotela ngoba intengiso yamahhala yeLatren ilinganiselwe. Imithamo engeyona ye-vasodilator ingaholela kumiphumela emibi ngokweqile noma emibi.

Intengo

Izindleko ezimaphakathi zesisombululo sokungenela ziyahlukahluka kusuka kuma-ruble angama-215 kuya kwangama-270.

Izimo zokugcina zomuthi

Kuyadingeka ukugcina isixazululo emazingeni okushisa we- + 2 ... + 25 ° C endaweni eyomile, ehlukaniswe ukukhanya kwelanga.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-2

Umkhiqizi

IYuri-Farm LLC, eRussia.

I-Trental ingahle ibambele iLatren.

I-Pentoxifylline ibhekiswa kwizifinyezo zesakhiwo somuthi ofanayo entweni esebenzayo.

Uma kunesidingo, iLatren ingashintshwa neWazonit.

Abangaphansi ngemishini yokusebenza efana naleyo bafaka isidakamizwa uBilobil.

I-Agapurin iyi-analogue ephumelelayo yeLatren.

Ukubuyekezwa

Ulyana Tikhonova, oneminyaka engama-56, eSt

Nikeza isixazululo se-thrombosis. Ekuqaleni, abawehlisi beLatren bahlanganiswa nemijovo ye-heparin, ngemuva kwalokho badluliselwa ekuphuzeni amaphilisi. Ukumnika kusize ukuncibilikisa ukugcwala kwegazi, ukuvuvukala sekuhambile Ngicabanga inhlanganisela enhle yamanani nekhwalithi. Kwakungekho miphumela emibi, kepha kwadingeka ngiyeke utshwala nokubhema ngesikhathi sokwelashwa. Udokotela uthe ukulandela ngokuqinile imiyalo esetshenzisiwe ukunciphisa amathuba wezinkinga zempilo.

Leopold Kazakov, oneminyaka engama-37, uRyazan

Ngabhalela umuthi weLatren ngudokotela we-otolaryngologist, engangikhononda ngaye ukuthi wehlise ukuzwa kwezindlebe nokubonakala kwe-tinnitus enkulu. Isizathu kwakuwukukhula kwe-dystonia. I-infusions yasiza ukuqeda ikhanda, kukhala ezindlebeni. Ngabona ukuthi umbono ubejwayelekile. Imiphumela emibi ivele ngendlela yokunciphisa umfutho wegazi. Ukuziqeda, kwakudingeka ukuncishiswa komthamo. Udokotela ohambelayo kufanele enze izinguquko. Angikucebisi ukuthi uguqule umthamo uwedwa, ngoba kukhona ubungozi bokusebenzisa ngokweqile nemiphumela ehlukahlukene emibi emzimbeni.