Umfutho wegazi ophakeme, izingxabano ezivusa umfutho wegazi, lapho ubuchopho, imithambo yegazi nenhliziyo kuhlupheka khona, kutholakala kumaphesenti angama-30 abantu abasha nabangama-70% bezwe lethu. Izidakamizwa ezinomphumela we-antihypertensive oqinile weLozapan neLozartan kuhloswe ukuthi zinciphise inani le-pathologies yezinhliziyo nezinkinga zazo ezilandelanayo, ezinjenge-ischemic stroke noma ukushaya kwenhliziyo.
Isimilo se-Lozap
Isithako esisebenzayo somuthi yi-losartan potassium. Indlela yokudedelwa - amaphilisi ezincwadi ezahlukahlukene (12.5 mg, 50 mg, 100 mg). Ngaphezu kwento esebenzayo, ukwakheka kubandakanya:
- yokudla fiber uginindela;
- i-silicon dioxide sorbent;
- i-magnesium stearate emulsifier;
- i-hypertellose plasticizer;
- i-enterosorbent povidone;
- i-laxative element macrogol;
- i-talc;
- udayi omhlophe titanium dioxide;
- i-diuretic mannitol.
Izenzo zikaLozap noLozartan kuhloswe ngazo ukunciphisa inani lama-pathologies wezinhliziyo nezinkinga zabo.
I-Lozap inqunyelwe:
- ekucindezelweni;
- njenge-prophylaxis yezinkinga zemithambo yegazi;
- ngokuhlanganiswa ekwelapheni ukwehluleka kwenhliziyo;
- ngesifo sikashukela se-nephropathy;
- nge-hypertrophy ye-ventricle yesobunxele;
- nge-hyperkalemia (njenge-diuretic).
Contraindication:
- i-renal artery stenosis (unciphisa);
- hypotension;
- phazamisa izifo ezithinta izicubu;
- ukungabekezelelani ngakunye;
- isikhathi sokukhulelwa nokukhulelwa;
- izingane nentsha engaphansi kweminyaka eyi-18.
Uma kwenzeka ukungasebenzi kahle kwe-renal kanye ne-hepatic, ukwelashwa ngomuthi kungenzeka, kepha ngaphansi kokuqokwa futhi njengoba kushiwo ngudokotela, ukuqala komthamo ngamafomu amancane.
Isimo se-losartan
Umuthi uyatholakala ezibhebheni ze-25 mg, 50 mg, 100 mg. Imisebenzi yayo eyinhloko i-hypotensive. Umsebenzi wesidakamizwa kule ndlela unikeza isithako esifanayo esisebenzayo - i-potassium losartan. Izinto ezingeziwe zifaka:
- i-fiber (i-fiber cellulose yokudla);
- i-silicon dioxide sorbent;
- i-magnesium stearate emulsifier;
- i-hypertellose plasticizer;
- i-enterosorbent povidone;
- i-macrogol e-laxative;
- i-talc;
- udayi omhlophe titanium dioxide;
- ushukela wobisi (i-lactose monohydrate);
- i-croscarmellose sodium ukudla solvent;
- utshwala be-polyvinyl (i-E1203 njenge-ejenti glazing).
ILosartan ilawula umfutho wegazi futhi ivimbele imikhumbi ukuthi inciphise.
I-Losartan isiza ukubuyisela ukusebenza okujwayelekile komzimba wonke:
- kulawula ingcindezi;
- kuvimbela imikhumbi ukuthi inciphise;
- kunciphisa ithoni emithanjeni yamaphaphu;
- kunciphisa i-myocardial hypertrophy.
Contraindication:
- i-renal artery stenosis;
- isifo sikashukela i-mellitus (ngenxa yokuba khona kwe-lactose ekwakhiweni kwayo);
- i-hypertension ye-arterial;
- izifo ezithinta izicubu;
- hypersensitivity;
- ukukhulelwa nokuqunjelwa;
- izingane nentsha engaphansi kweminyaka eyi-18.
Ngokunganeleki kwe-renal and hepatic, ukwelashwa kwenziwa ngaphansi kokuqashwa kukadokotela, kuqala ngemithamo emincane.
Ukuqhathanisa kukaLozap noLozartan
Le mishanguzo i-analogues efana nomgomo wesenzo. Ziqukethe into efanayo esebenzayo - i-potassium losartan, imisebenzi yayo ihlose ukuvimba ama-angiotensins, abangela i-vasoconstriction kanye nokwanda komfutho wegazi (BP). Umehluko omkhulu obhekwe ngesikhathi sokuqokwa yizakhiwo zezinto ezingeziwe ezifakiwe ekwakhiweni, lapho imibandela yobungozi kanye nobungozi bemiphumela emibi kuncike khona.
Ukufana
Inhloso enkulu yazo zombili lezi zidakamizwa ukwehlisa umfutho wegazi. Umsebenzi we-losartan potassium ukuphazamisa ukubuyiselwa kwesiteshi kwama-electrolyte wezinso, okwandisa ukuphuma kwe-chlorine nesodium. Ngenxa ye-hydrochlorothiazide ekhiqizwa ngumzimba, inani le-aldosterone lenyuka, i-renin icushiwe ku-plasma yegazi, futhi ukwanda kokuqukethwe kwe-potassium kwenzeka e-serum. Zonke izinqubo eziqhubekayo ziholela, kumphumela wokugcina, kulezi zinkomba ezilandelayo:
- umfutho wegazi uyalingana;
- umthwalo enhliziyweni uyancipha;
- osayizi benhliziyo babuyela kokujwayelekile.
Isenzo se-Pharmacological se-Lozap ne-Lozartan:
- izingxenye zemithi zidonswa kalula amaseli wesisu;
- metabolism kwenzeka esibindini;
- ukwanda okuphezulu kwamaseli egazi kubonwa ngemuva kwehora;
- umuthi ukhishwa ngefomu elingashintshiwe ngomchamo (35%) ne-bile (60%).
Ezinye izici ezifanayo:
- isakhi esisebenzayo se-losartan potassium asikwazi ukungena nge-GEF (isihlungi segazi-segazi) singene ohlelweni lwezinzwa oluphakathi, sivikele amangqamuzana obuchopho obuthakathaka ubuthi;
- umphumela ovela enkambweni yokwelapha uvela kungakapheli inyanga;
- umphumela uphikelela isikhathi eside;
- umthamo ophelele ovunyelwe ngu-200 mg ngosuku (kumithamo eminingana).
Imiphumela emibi efanayo eyenzeka ngama-overdoses ifaka:
- ukuthuthukiswa kwesifo sohudo (ku-2% yeziguli);
- i-myopathy - isifo sezicubu ezithintekayo (ku-1%);
- ehlise i-libido.
Imiphumela emibi efanayo eyenzeka lapho kuthatha iLosartan neLozap ifaka phakathi ukuthuthukiswa kwesifo sohudo.
Uyini umehluko
Umehluko phakathi kwezidakamizwa mncane kakhulu kunokufana, kepha kumele ubhekwe lapho ukhetha umuthi.
Njengoba i-Lozap ifaka i-mannitol diuretic, izinkomba ezilandelayo zokusebenzisa kufanele zibhekwe:
- akufanele kuthathwe ngokuhlangana namanye ama-diuretic agents;
- Ngaphambi kwekhambi lokwelashwa, kufanele kwenziwe ucwaningo lwelebhu lwezinkomba ze-VEB (ibhalansi yama-electrolyte);
- ngesikhathi sokwelashwa uqobo, kunconywa ukuthi uhlole njalo okuqukethwe usawoti we-potassium emzimbeni.
ILosartan inohlu olubanzi lwezinto ezengeziwe ezengeziwe. Ngalesi sizathu, kunethuba elikhulu lokubonakaliswa komzimba kanye:
- ngokungafani ne-Lozap, ukuqokwa kukhonjiswa ekwelashweni okuyinkimbinkimbi lapho kusetshenziswa izidakamizwa ze-diuretic;
- I-Losartan ine-analogues eminingi, isebenzisa yona, kuyadingeka ukutadisha izithako ezingeziwe ngokuningiliziwe;
- ILosartan ishibhile kakhulu.
Hlukanisa izidakamizwa nomenzi. ILozap ikhiqizwa yiSlovak Republic (inkampani yeZentiva), iLozartan iyisidakamizwa somkhiqizi wasekhaya uVertex (ama-analogues ahlinzekwa yiBelarus, iPoland, iHungary, neNdiya).
Yikuphi okushibhile
Izindleko Ezilahlekile:
- Ama-30 ama-pcs 12,5 mg - ama-ruble ayi-128;
- Ama-30 ama-pcs 50 mg - ama-ruble angama-273;
- Ama-60 ama-PC. 50 mg - ama-ruble angama-470;
- Ama-30 ama-pcs 100 mg - 356 rub .;
- Ama-60 ama-PC. I-100 mg - ama-ruble ayi-580;
- Ama-90 ama-PC 100 mg - 742 rub.
Izindleko ze-losartan:
- Ama-30 ama-pcs 25 mg - ama-ruble angama-78;
- Ama-30 ama-pcs 50 mg - ama-ruble angama-92;
- Ama-60 ama-PC. 50 mg - ama-ruble ayi-137;
- Ama-30 ama-pcs 100 mg - ama-ruble ayi-129;
- Ama-90 ama-PC 100 mg - 384 rub.
Yini engcono lozap noma losartan
Ngokusho kochwepheshe, lezi izidakamizwa zilingana nenqubo yokusebenza, ehlukile ngamagama, intengo nomenzi. Kepha zidinga ukuthathwa njengokuyalelwe ngudokotela, ukuze zingakhuphi ukusebenza kwezenzo ezihambisanayo zezithako ezisizayo. Ukukhathazeka okuyinhloko kuhlobene nama-supplements we-diuretic. Ngeseluleko se-Myasnikov A.L. (i-cardiologist), lapho ukhetha imishanguzo ye-antihypertensive, kuyadingeka ukuqondiswa yizinga le-uric acid egazini. Ngokuqukethwe kwayo okwandisiwe nokusetshenziswa kwezidakamizwa ngaphandle kwe-diuretics, kunengozi ye-arthrosis.
Ukubuyekezwa kweziguli
UKaterina, oneminyaka engama-51, uKursk
Udokotela wamisa uLozap, kodwa wathenga uLozartan (intengo yayikhululekile). Angizange ngithande umphumela, i-pressure jumps, i-tachycardia yatholakala. Ngemuva kwenyanga kamuva, kwavela imiphumela emibi efana ne-thrombosis (kukhona into enjalo emiyalweni yomuthi). Ngakho-ke qaphela.
UMaria, oneminyaka engama-45 ubudala, eSt
Kuyadingeka ukwehlisa ingcindezi, kepha lokhu akuselaphi lesi sifo. Ngezwa ukuthi abantu besilisa bahlala bethatha izidakamizwa ze-antihypertensive basongela ukungabinamandla. Kuyadingeka ukucinga imbangela. Ngokunokwenzeka, lezi izinzwa, ukungondleki kahle, ukuntuleka kokulala, ukuhamba okuncane. Ngemuva kwakho konke, konke kuya eholidini futhi nengcindezi ihambile.
U-Alexandra, oneminyaka engama-42, uPenza
I-Lozap akufanele ithathwe ebusuku. Ama-analogs kaLozartan (Tevo, Richter) nawo anezelwa ngokuhlinzwa, lokhu kufanele kukhunjulwe engqondweni. Ngincoma ukwamukela ekuseni, ukuchama ebusuku kubangela ukuphazamiseka.
Inhloso eyinhloko yezidakamizwa i-Lozap ne-Lozartan ukwehlisa umfutho wegazi.
Ukubuyekezwa kodokotela ngeLozap neLozartan
M.N. UPetrova, owelaphi, u-Omsk
Le mishanguzo inembuyiselo ejwayelekile - iyasebenza kuphela ngenkambo ende, futhi uma ingekho imiphumela emibi. Ngeke bakwazi ukwelapha ngokushesha umfutho we-arterial hypertension; ngeke basindiswe esimweni esibi kakhulu.
S.T. USmirnov, udokotela wezifo zenhliziyo, Ukuqina kwamehlo
Lezi zingqimba ze-angiotensin 2 zihlangabezana nezinkomba eziphambili ezamukelwa ngokuvamile zokusetshenziswa: umfutho we-arterial, umfutho okhuphukile ngenxa yokwenyuka kwevolumu ye-ventricle yangakwesobunxele, i-nephropathy yohlobo 2 sikashukela, ukuhluleka kwenhliziyo. Imithi kadokotela ayinakunqunyelwa yona.
T.D. UMakarova, udokotela wenhliziyo, u-Ivanovo
Izidakamizwa ziyefana. Banqunyelwe umlando omude womlando (ngokubekezelela okuhle kanye nokungabikho kokuphulwa kwemithetho, ungayithatha impilo yonke). Isifundo, umthamo wethamo, ama-analogues - akhethwe kuphela uchwepheshe. Ukuzelapha ngokwakho ezifweni zenhliziyo akuvunyelwe.
