I-ejenti elwa nesifo sikashukela. IVosulin-R yi-insulin esebenza ngokushesha, kanti uH uphakathi. Kusetshenziswa ekwelapheni i-psychology yesifo sikashukela yezinhlobo zokuqala nezesibili. Umsebenzi we-insulin unqunywa umthamo womuthi, indawo nendlela yokuphatha.
Igama Lezwe elingafanele
INN: I-insulin yabantu.
IVosulin yi-ejenti elwa nesifo sikashukela.
I-ATX
Ikhodi ye-ATX: A10AC01.
Khipha amafomu nokwakheka
Kutholakala ngesimo sokumiswa komjovo, kuqukethe amakristalu amade, akha isisindo esingenakubalwa ngokuvusa.
Into esemqoka esebenzayo kwizixazululo yi-insulin isophan kumthamo we-100 IU. Izinto ezingeziwe eziyingxenye yokwakhiwa yilezi: metacresol, protamine sulfate, zinc oxide, phenol, sodium phosphate, sodium hydroxide, hydrochloric acid, citric acid, glycerin, amanzi ahlanziwe ngokukhethekile ngomjovo.
Ifakwe emabhodleleni ayi-10 ml, kuma-cartridge we-3 ml kanye ne-cartridge efakwe esibayeni sesirinji (ngevolumu engu-3 ml).
Isenzo se-Pharmacological
Ungumuthi ophindaphindayo we-DNA. Umshini wokusebenza uhlose ukuhlela amazinga eglucose ejwayelekile. Umuthi nawo unomphumela othile we-anabolic. Lolu hlobo lwe-insulin luhlinzeka ngokushesha ngokuhambisa ushukela ngaphakathi kwamaseli wezicubu zomsipha. Isheshisa inqubo ye-anabolism yezakhi zamaprotheni.
Ngaphansi kwethonya le-insulin, ushukela osesibindi uguqukela ngokushesha ku-glycogen, bese kuthi gluconeogeneis ijezeke phansi. Ukuguqulwa kweglucose eyeqile emafutheni kuyakhuthazeka.
Umuthi ufakelwe ku-10 ml vials.
I-Pharmacokinetics
Ukuphuza nokusabalalisa kunqunywa yindawo nendlela yokuphatha umuthi, umthamo. Ukuhlushwa okuphezulu kakhulu kwe-insulin egazini kubonwa amahora ambalwa ngemuva komjovo. I-Bioavailability nokubopha amaprotheni kuphansi kakhulu.
I-Metabolism yenzeka ikakhulu esibindini ngokwakhiwa kwama-metabolites amakhulu, asevele abhekwa njengongasebenzi. Isigamu sempilo singamahora amahlanu.
Izinkomba zokusetshenziswa
Kunezinkomba ezimbalwa eziqondile zokusetshenziswa kweVosulin. Phakathi kwazo kukhona:
- ukwelashwa kohlobo lwe-1 isifo sikashukela (inqobo nje uma ukudla nokuzivocavoca umzimba kunganciphisi amazinga kashukela egazini aye emazingeni adingekayo);
- isifo sikashukela esijwayelekile;
- Uhlobo 2 sikashukela;
- ukungasebenzi kahle kwezidakamizwa ze-hypoglycemic zomlomo;
- ukungenelela kokuhlinzwa;
- thayipha ukwelashwa kwesifo sikashukela ngesikhathi sokukhulelwa lapho ukudla kungasizi;
- isifo sikashukela;
- ukuphazamiseka kwe-carbohydrate metabolism.
Contraindication
Ukuphikisana ngokuphelele nokusetshenziswa kweVosulin yi-hypoglycemia kanye ne-hypersensitivity ezingxenyeni zomuthi.
Ngokuqapha okukhulu kunikezwe abantu abanokungezwani komzimba kanye ne-insulin ngokushesha. Ngokushintshwa okubukhali kule insulin, ukusabela okuphathelene nokuvikela umzimba phakathi kwezilwane ne-insulin yomuntu kungenzeka.
Ungayithatha kanjani i-Vosulin?
Umthamo uncike ekujuleni kwesimo, ekudleni, ekusebenzeni ngokomzimba, ezingeni likashukela wegazi.
Umuthi lo uqukethe i-100 IU / ml ye-insulin. Kubantu abadala abathola ukwelashwa kwe-insulin okokuqala, umthamo wokuqala ngu-8-24 IU, izingane - akukho ngaphezu kwe-8 IU.
Umuthi udlalwa ngokungahambeki imizuzu engu-15 ngaphambi kokudla. Ukugwema ubunzima, kungakuhle ushintshe indawo yomjovo ngaso sonke isikhathi. Ezimweni ezihlukile kuphela, ukuphathwa kwe-intravenous noma kwe-intramuscular kungenzeka. Ukuze usebenzise umjovo kuphela ama-syringes aphothule ku-100 IU / ml. Akunakwenzeka ukuxuba izinhlobo ezahlukahlukene zama-insulin kwisirinji esisodwa.
Umuthi ufakwa ngenkani ngesitho sepeni.
Imithetho yokupheka
Umuthi ufakwa ngenkani ngesitho sepeni. Isixazululo somjovo ngaso sonke isikhathi kufanele sibe sobala futhi sifane, ngaphandle kokudwayela, emazingeni okushisa asekamelweni. Ngaphambi kokuqala kwemithi, ikhava iyasuswa. Ngokuya ngomthamo obekiwe, umoya uthathwa kwisirinji se-insulin bese ungeniswa kwi-vial ye-insulin. Ngemuva kwalokho i-vial iguqulwe ngesirinji bese kuthathwa inani lesisombululo.
Ngaphambi kokusebenzisa, ipeni lesirinji i-Vosulin pen Royal liphendulwa kaningana ukuze induku yengilazi ngaphakathi iqale ukuhamba kalula. Lokhu kwenziwa ukuze isixazululo sibe homogeneous. Ngemuva kwalokho i-valve yenaliti yangaphandle iyasuswa bese imicu etholakala ekugcineni kwebhokisana iqiniswe ngokuqinile. Susa isicoco esivikela inalithi bese ususa wonke umoya kuso.
Isisebenzisi sisetshenziselwe zero. Lapho wenza umjovo, qiniseka ukuthi ucindezela i-dispenser kuze kube sekupheleni. Uma iyeka ukumaka u-0, lokhu kusho ukuthi ithamo alifakiwe futhi kuyadingeka ukufaka inani elilahlekile le-insulin kwisirinji. Ngemuva kwemizuzwana eyi-10, inaliti iyasuswa ngaphansi kwesikhumba. I-cap yokuvikela iphinde ifakwe ngenalithi. Ngemuva kwalokho, inaliti ilahlwa.
Imiphumela emibi yeVosulin
Indlela yokusabela ejwayelekile ejwayelekile ebalulwe emiyalweni yokusetshenziswa yi-hypoglycemia, ebangela ukulahleka kwengqondo. Amazinga kashukela wegazi kwehla kakhulu, okuhambisana nezimpawu ezilandelayo:
- ikhanda;
- umuzwa ongapheli wendlala;
- isicanucanu
- ukuhlanza
- ukukhathala;
- ulaka;
- ukunciphisa isikhathi sokunakwa;
- ukuphazamiseka emizweni;
- ukuthuthukiswa kobumpumpu be-posthypoglycemic;
- i-paresthesia yezingalo nomlomo;
- iminyakazo
- i-bradycardia;
- ukulahleka kwengqondo;
- Isifo sikashukela sikashukela.
Uma umuntu egule isikhathi eside, uzibeka ngokuzimela lezi zimpawu futhi ngokushesha athathe izinyathelo ezidingekayo.
Ekuqaleni kokwelashwa, umbala wesikhumba endaweni yomjovo ungashintsha. I-edema yesikhathi esifushane kungenzeka.
Mhlawumbe ukuthuthukiswa kwe-atrophy yezicubu ze-adipose, uma indawo yokulawulwa kwemithi ingashintshile. Kuyaqabukela kakhulu kube nokusabela okwenziwa ngendlela yokwanda kwesikhumba, okuthi kamuva kudlule ngokwako. Mhlawumbe ukuwohloka okujwayelekile esimweni sesiguli okuhambisana nokushintshashintsha kwamazinga kashukela, ezimeni eziningi ngokuthambekela kokuncipha.
Uma isiguli sithuthuke i-erythema, imivimbo kanye namashayo kuvela esikhunjeni esingahambi sodwa, kufanele unqume ukuthi ungawususa umuthi yini noma uguqule umthamo.
Umthelela ekhonweni lokulawula izindlela
Ngokuthuthukiswa kwe-hypoglycemia ngesikhathi sokulashwa nalesi sidakamizwa, kubalulekile ukukhawula ukushayela noma ukulawula ezinye izindlela. Lokhu kungenxa yokuthi isimo esinjalo sibanga ukungahambi kahle kanye nokwehla kokugxilwa ukunakwa.
Ukwehluleka ukulandela ukudla noma umthamo ophuthelwe we-insulin kubangela i-hypoglycemia enkulu.
Imiyalo ekhethekile
Ngaphambi kokuqala ukwelashwa, udinga ukwenza zonke izivivinyo zomzimba ezidingekayo ukuthola ukuthi umzimba uzolubona kanjani lolu hlobo lwe-insulin. Ingozi ye-hypoglycemia yanda lapho isiguli siveza izifo zenhliziyo nemithambo yegazi, ukulimala kwamehlo. Ukwehluleka ukulandela ukudla noma umthamo ophuthelwe we-insulin kubangela i-hypoglycemia enkulu.
Sebenzisa ebudaleni
Ukuqapha kunconywa ngoba ubungozi be-hypoglycemia kulesi sigaba seziguli buyanda. Umthamo omncane osebenza kahle kufanele unqunywe. Uma isimo esivamile siba sibi kakhulu, khona-ke ukwelashwa kuyakhanselwa ngokushesha.
Isabelo sezingane
Kwenqatshelwe ngokuphelele ukuphatha izingane ngomuthi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi lo ungasetjenziswa ngesikhathi sokuthinta nangesikhathi sokuncelisa ibele. Umiselwe umthamo omncane ovunyelwe Imiphumela yocwaningo ayizange iqinisekise umphumela we-mutagenic wesidakamizwa esibelethweni. Uma umphumela womthamo wokuqala obekiwe awubonwa, ungangezelelwa. Kepha kulokhu, udinga ukubhekisisa njalo amazinga kashukela egazini ukuze uvikele ukukhula kwe-hypoglycemia.
Kwenqatshelwe ngokuphelele ukuphatha izingane ngomuthi.
Isicelo sokusebenza kokulimala kwezinso
Kudingeka ukulungiswa kwesilinganiso Uma kukhona ushintsho ekuhlaziyeni, khona-ke inani lemithi liyancishiswa. Uma kungekho umphumela omuhle, ukwelashwa kukhanseliwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukunakekelwa okukhethekile kufanele kuthathwe ekuhlulekeni kwe-renal okungamahlalakhona. Uma ukuwohloka kwamasampula wesibindi kukhonjisiwe, kungcono ukukhansela ukwelashwa.
Ukweqisa kweVosulin
Ngokuphuza kanye nemithamo efanele yemiphumela emibi akufanele yenzeke. Ngokusebenzisa ngezikhathi ezithile umthamo omkhulu we-Vosulin, izimpawu ze-hypoglycemia zinganda kakhulu:
- ubuqili;
- ukukhuphuka kokujuluka;
- ukoma okungapheli;
- pallor
- ikhanda
- ukuthuthumela
- isicanucanu ngokuhlanza;
- ukudideka.
Ukwelashwa kwe-hypoglycemia emnene kuqukethe ukuzilawula kweglucose. Kuvunyelwe ukudla nje ucezu kashukela. Kulokhu, kungadingeka idosi noma ukulungiswa kokudla.
I-hypoglycemia elinganiselwe imiswa ukuphathwa kwe-glucose noma kwe-intravenous kwe-glucose. Isiguli sinikezwa ama-carbohydrate asheshayo.
I-hypoglycemia enkulu, ehambisana nokuqunjelwa noma ukoma, imiswa kuphela ukuphathwa okuphathelene ne-gluconate. Kulokhu, ukungena esibhedlela kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Lapho kuhlanganiswa ne-insulin, amphetamine, ama-block adrenergic, ama-steroid, ama-mao inhibitors, ama-tetracyclines angathuthukisa i-hypoglycemia.
Isenzo se-insulin senziwa buthaka ngenkathi sisetshenziswa nge-diazoxide, inzalo yokuvimbela inzalo, i-diuretics yomuntu ngamunye, isoniazid, i-heparin, i-nicotinic acid, ama-hormone e-thyroid, ama-tetracyclines kanye nama-audiathomimetics athile.
Ukusetshenziswa kotshwala ngesikhathi sokwelashwa nge-insulin kuholela ezingeni elithile le-hypoglycemia, okuthinta kabi umsebenzi wazo zonke izitho nezinhlelo.
Kulabo bantu abadinga ukwelashwa kanyekanye ne-insulin kanye ne-clonidine, i-reserpine ne-salicylates, umphumela wokusebenzisa umuthi ungakhuphuka noma unciphe.
Ukuhambisana notshwala
Ukusetshenziswa kotshwala ngesikhathi sokwelashwa nge-insulin kuholela ezingeni elithile le-hypoglycemia, okuthinta kabi umsebenzi wazo zonke izitho nezinhlelo.
Ama-Analog
Kunezindlela eziningi zokufana kweVosulin, ezifanayo kwento esebenzayo nomphumela wokwelapha. Ngoba Kunzima ukuthola le-insulin manje, esikhundleni sayo kunqunywe i-analogues:
- B-Insulin;
- IGensulin;
- I-Insuman Rapid;
- I-Monodar;
- I-Diclovit;
- IMonotard NM;
- I-Rinsulin-R;
- I-Farmasulin;
- I-Humulin NPH.
Imibandela yekhefu lekhemisi
Kudingeka ukuthenga umuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo yeVosulin
Manje i-Vosulin ayikho esizindeni somphakathi. Intengo ye-analogues yayo isukela kuma-ruble angama-400. Ibhodlela ngalinye lifinyelela kuma-ruble angama-4000-4500. ukupakisha.
Izimo zokugcina zomuthi
Endaweni emnyama ekufundweni kwezinga lokushisa lika +2 kuya ku- + 8 ° C, kugweme ukubanda. Lapho usebenzisa ibhodlela elivulekile, ungagcina amanye amasonto ayi-6 emazingeni okushisa we- + 15 ... + 25 ° C. I-cartridge ingagcinwa emazingeni okushisa afanayo kumaviki amane ngemuva kokuvula. I-cartridge, esivele ifakiwe esibayeni sesirinji, akufanele igcinwe esiqandisini.
Ukuthenga umuthi, kufanele wethule incwadi kadokotela.
Isikhathi sokuphelelwa yisikhathi
Hhayi iminyaka engaphezu kwemi-2 kusuka ngosuku lokukhipha olukhonjiswe kwiphakheji yangempela. Ngemuva kwalesi sikhathi, umuthi awukwazi ukusetshenziswa.
Umkhiqizi
I-Wockhardt Limited (Wokhard Limited), eNdiya.
Inkampani Yezokukhiqiza: I-LLC "Inkampani Yezemithi" Yezempilo ", iKharkov, i-Ukraine.
Ukubuyekezwa mayelana neVosulin
U-Irina, oneminyaka engama-38, eKiev: "Bengijwayele ukwelapha isifo sikashukela ngeVosulin. Ngemuva kwalokho bayeka ukusikhipha, futhi ngashintshela kuRinsulin. Imiphumela yabo icishe ifane. Nokho iRinsulin ibiza okuthe xaxa."
UPavel, oneminyaka engama-53, uKharkov: "IVosulin ayisathengiswa manje, futhi ngiyajabula ngalokho. Bekumele ngiphathe imithamo emikhulu, ngakho-ke ngazizwa ngingenalusizo. Bakhetha uHumulin NPH ukuthi ayisuse esikhundleni. Ngijabule ngayo."
UKarina, oneminyaka engama-42, uPavlograd: "Sekuphele iminyaka eminingi ngihlaselwa yisifo sikashukela sohlobo 1. Ngaphandle kwalokho, ngibuye ngikhuluphele ngokweqile. Ukudla akusizi. Ngifaka injoka uVosulin futhi ngajabula ngakho. Ngaphelelwa yisisindo kahle noshukela uqhubeka isikhathi eside. level. Kepha manje useye emakhemisi, ngiyaxolisa, udokotela unikeze esinye isidakamizwa. "
