Ukusetshenziswa kwezidakamizwa uManinil noDiabeteson kuqeda ngempumelelo i-hyperglycemia, ekhula ngenxa yokuqhubeka kwesifo sikashukela sohlobo 2. Zombili lezi zidakamizwa zinezinzuzo nokubi. Lapho ukhetha umuthi, udokotela ubheka izici eziningi: izinga lokukhula kwalesi sifo, izimbangela zokubonakala kwaso, izici zomzimba ngamunye, imiphumela emibi.
Wenza kanjani uManinil
IManinil yi-ejenti yokuphikisana nesifo sikashukela okuyiyo isithako sayo esiyisisekelo esisebenzayo yi-glibenclamide.
IManinil yi-ejenti yokuphikisana nesifo sikashukela okuyiyo isithako sayo esiyisisekelo esisebenzayo yi-glibenclamide.
Kubandakanya:
- i-lactose monohydrate;
- i-gelatin;
- i-talc;
- i-magnesium stearate;
- isitashi samazambane;
- udayi.
Ifomu lokukhishwa libonisa amaphilisi weflethi-cylindrical, lapho izingcezu eziyi-120 zisemabhodleleni engilazi angenamibala afakwa kwiphakethe lekhadibhodi.
Umphumela wesidakamizwa emzimbeni ukuthi amaseli we-beta asebenze ukukhiqizwa kwe-insulin. Lokhu kwenzeka kumaseli we-pancreas ngemuva kokuba umuntu edlile, ngenxa yalokho izinga le-glycemia egazini lehla. Umphumela wokwelapha uhlala usuku. Umuthi udonswa ngokushesha futhi ucishe ufike ekugcineni. Ukuhlushwa kwayo okuphezulu kakhulu ngemuva kokusebenza kutholakala ngemuva kwamahora we-2,5.
Ingxenye eyinhloko iyakwazi ukubopha ngokuphelele amaprotheni e-plasma. I-metabolism yento esebenzayo yenzeka kumaseli wezicubu zesibindi, ngokwakhiwa kwama-metabolites ama-2 angasebenzi. Ukuhoxiswa okukodwa kwenziwa nge-bile, kanti okwesibili ngomchamo.
Maninil kukhonjiswa isifo sikashukela sohlobo 2. Ngaphezu kwalokho, isidakamizwa singasetshenziswa ngasikhathi sinye namanye ama-antidiabetic agents, ngaphezu kwama-sulfonylureas kanye ne-ironides.
Maninil kukhonjiswa isifo sikashukela sohlobo 2.
Ukuxhumanisa kungokulandelayo:
- Uhlobo 1 sikashukela;
- ukuvinjwa kwamathumbu, i-paresis yesisu;
- ukungasebenzi kahle kwe-renal kanye ne-hepatic;
- ngemuva kokuhlinzwa ukuze ususe ama-pancreas;
- isifo sikashukela sikashukela;
- isifo sikashukela nesifo sokuwa;
- i-leukopenia;
- ukuntuleka kwe-glucose-6-phosphate dehydrogenase;
- ukubuyiswa kwe-carbohydrate metabolism uma kushiswa, ukulimala, izifo ezithathelwanayo noma ngemuva kokuhlinzwa ngomuthi we-insulin obekiwe;
- iminyaka efinyelela eminyakeni eyi-18;
- ukukhulelwa nokuqunjelwa;
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi.
I-Manilin kufanele isetshenziswe ngokuqapha ezigulini eziphuza kakhulu i-alcohol, i-febrile syndrome, uphuzo oludakayo, isifo se-thyroid kanye nokulimala komzimba, i-hyperfunction ye-anterior pituitary noma i-adrenal cortex, iziguli ezingaphezulu kweminyaka engama-70.
Ukuthatha umuthi kungahle kuhambisane nokwakhiwa kwemiphumela emibi evela ku:
- ukugaya: isicanucanu, ukuhlanza, usizi esiswini, uhudo, ukunambitheka kwensimbi emlonyeni, Ubuhlungu besisu;
- i-hematopoietic: i-thrombocytopenia, i-leukopenia, i-erythropenia, i-agranulocytosis, i-pancytopenia, i-hemolytic anemia;
- immune: i-urticaria, ukulunywa, i-phenura, i-petechiae, ukwanda kwe-photosensitivity, ukungezwani komzimba, okuhambisana ne-proteinuria, jaundice, umkhuhlane, ukuqhuma kwesikhumba, i-arthralgia, i-alculgic vasculitis, ukushaqeka kwe-anaphylactic;
- i-metabolism: i-hypoglycemia, ebonakaliswa ukuthuthumela, ukulamba, ukozela, i-tachycardia, i-hyperthermia, ikhanda, ukukhathazeka okujwayelekile, ukuxhumana okungahambi kahle kokunyakaza, umswakama wesikhumba, umuzwa wokwesaba;
- isibindi kanye nepheshana le-biliary: i-hepatitis, i-choleraasis yangaphakathi.
Ngaphezu kwalokho, ngemuva kokuthatha umuthi, umbono ungathikamezeka, i-diuresis ingaqina, i-proteinuria yesikhashana, i-hyponatremia ingakhula. Usebenzisa iManinil, kufanele ulandele ngokuqinile imiyalo kadokotela, ubheke ukudla futhi ulawule izinga le-glucose egazini.
Umenzi walo muthi yiBerlin-Chemie AG, eJalimane.
Analogs of Maninil:
- I-Glibenclamide.
- I-Glibamide.
- I-Glidanil.
Isici sikashukela
I-Diabeteson yi-ejenti ekhishwe modified hypoglycemic. Isakhi esiyinhloko yi-gliclazide. Ukuqanjwa futhi kufaka: i-calcium hydrogen phosphate dihydrate, hypromellose, maltodextrin, magnesium stearate. Kutholakala ngesimo samaphilisi e-oval biconvex namaphilisi.
Umuthi wenzelwe abanesifo sikashukela abahlushwa isifo sikashukela sohlobo 2. Ngenxa yokusetshenziswa kwayo emzimbeni, umsebenzi wamaseli we-beta we-pancreas uyathuthukiswa, okwandisa ukukhiqizwa kwe-insulin.
I-Diabeteson inethonya elizuzayo ekuvulekeni kwezindonga zemithambo yegazi, ithuthukise noma iguqule isimo sayo.
Izakhi zomuthi zinciphisa inani le-cholesterol egazini, elinciphisa ubungozi bokuqalwa kwe-atherosulinosis kanye ne-micothrombosis. Inqubo ye-microcirculation yegazi yenziwe yenziwa yajwayelekile futhi ukuthuthukiswa kwe-nephropathy yesifo sikashukela kuvinjelwe. Umkhiqizo ukhishwa kanye nomchamo.
Umphumela emzimbeni wesidakamizwa ume ngalendlela elandelayo:
- Kwejwayelekile amazinga kashukela;
- kunciphisa isisindo;
- kuvimbela ukwakheka kweziqeshana zegazi;
- ibuyisela ukukhiqizwa kwe-insulin.
I-Diabeteson yi-ejenti ekhishwe modified hypoglycemic. Isakhi esiyinhloko yi-gliclazide.
Izinkomba zokusetshenziswa kweSifo sikashukela zingokulandelayo:
- uhlobo 2 sikashukela;
- ngezinhloso ze-prophylactic uma kunezifo zokujikeleza kwegazi.
Umuthi usetshenziswa kanye namanye ama-antidiabetic agents ekwelashweni okuyinkimbinkimbi kwesifo sikashukela.
Ukuphambana okuyinhloko:
- Uhlobo 1 sikashukela;
- ukusetshenziswa okuhlangene neDanazol, Phenylbutazone noma iMiconazole;
- ukwehluleka kakhulu kwe-renal noma kwe-hepatic;
- isifo sikashukela nesifo sokuwa;
- isifo sikashukela sikashukela;
- ukukhulelwa nokuqunjelwa;
- iminyaka efinyelela eminyakeni eyi-18;
- ukungabekezelelani komuntu ngamunye kushukela, i-galactose, i-lactose, kanye nezakhi zomuthi.
Ukuphulwa okuhlobene kufaka phakathi:
- utshwala;
- i-hypothyroidism;
- ukungapheleli kwepituational noma adrenal;
- izifo ezinzima zenhliziyo;
- ubudala
- ukwehluleka kwesibindi noma kwezinso;
- ukwelashwa isikhathi eside ngama-glucocorticosteroids;
- ushukela we-glucose-6-phosphate dehydrogenase.
Izinkinga zifaka phakathi ukuthuthukiswa kwe-hypoglycemia. Izimpawu zayo zifaka ikhanda, isicanucanu, ukuguga, ukuncipha kokunakwa, ukukhathala okwandayo, ukugabha, ukuphefumula okujulile, ukudideka, ukulahlekelwa ukuzithiba, ukudangala, ukusabela okuhamba kancane.
Ngaphezu kwalokho, umuntu angabona ukungaphatheki kahle, isiyezi, umuzwa wokungakwazi ukusiza, i-aphasia, umbono nokukhubazeka, i-bradycardia, iminyakazo, ubuthakathaka, ukulahlekelwa ukwazi, okungase kuhambisane nokwakhiwa komqondo.
Imiphumela emibi ifaka ukusabela kwe-adrenergic: i-arrhythmia, i-angina pectoris, ukwanda kwengcindezi yegazi, ukukhathazeka, i-tachycardia, ukukhuphuka kokujuluka kokujuluka.
Isistimu yokugaya ukudla ingahle iphazamiseke bese kuba nesicanucanu, ukugabha, nobuhlungu besisu, isifo sohudo, nokuqunjelwa kungavela. Ukuphazamiseka kweHematological kuyabonakala kusuka kuzitho ze-hemopoietic kanye nohlelo lwe-lymphatic: i-anemia, i-granulocytopenia, i-thrombocytopenia, i-leukopenia. Ukulunywa, okhalweni, ukusikeka, ukusabela okuxutshisayo, ukuqhuma kwe-maculopapular, i-edema kaQuincke, i-erythema kungenzeka. Izitho ezibonakalayo zingahlakulela ukuphazamiseka okubukwayo kwesikhashana.
Umenzi weDiabeteson yinkampani "uServier", eFrance. Ukufana kwalo kufaka phakathi: Glimepiride, Glibiab, Gliklazid-Akos, Glibenclamide, Glycvidon, Maninil.
Ukuqhathanisa kweManinil noDiabetes
Zombili lezi zidakamizwa zinokufana kakhulu, kodwa kunomehluko phakathi kwazo.
Ukufana
IManinil neDiabeteson igxiliswa kahle futhi inciphise ushukela wegazi. Babekelwe uhlobo 2 lwesifo sikashukela, bobabili baqinisekiswe ngohlobo 1. Banemiphumela emibi efanayo kanye ne-contraindication. Badedelwa ngaphandle kwemvume kadokotela.
Uyini umehluko
I-Maninil i-contraindised kubantu abakhuluphele, njengoba kuholela ekwandeni kwesisindo. Le mishanguzo inabakhiqizi abahlukile nokwakhiwa kwayo.
Yikuphi okushibhile
Intengo ephakathi yeManinil ngama-ruble ayi-131, kanti iDiabeteson ingama-ruble angama-281.
Yikuphi okungcono - Maninil noma Diabeteson
Ukukhetha ukuthi yikuphi okungcono - iManinil noma iDiabeteson, udokotela uhlola izici zomzimba wesiguli ngemuva kokuhlolwa nokuzimisela kwezinga le-glucose yegazi. Kuthatha kancane imiphumela yokuhlolwa, izifo ezikhona kanye ne-contraindication.
Ngoshukela
Njengoba unalesi sifo, odokotela bavame ukunquma iDiabeteson, ukuthathwa kwayo okunciphisa ingozi yokuthola ubunzima besifo sikashukela esibuthakathaka kanye nesifo sikashukela ngenxa yomphumela we-hemovascular effect. Lokhu kukuvumela ukuthi unwebe impilo yesiguli futhi uthuthukise ikhwalithi yayo.
I-Maninil i-contraindised kubantu abakhuluphele, njengoba kuholela ekwandeni kwesisindo.
Ukubuyekezwa kweziguli
UDmitry, oneminyaka engama-59, uVolgograd: "Sekuphele isikhathi eside nginesifo sikashukela. Isikhathi eside angikwazanga ukwehlisa ushukela wami wegazi, ngisho nokudla okuqinile. Udokotela ohambele loyaya uManinil, sibonga ukuthi ushukela wehle kanjani ukusuka kuma-17 kuya kwangama-7 ezinyangeni ezi-2. Ngicabanga ukuthi lokho kungumphumela omuhle. "
U-Irina, oneminyaka engama-65, eMoscow: "Sekuphele iminyaka ngigula nginesifo sikashukela, futhi izidakamizwa eziningi azange zisize. Muva nje, udokotela uyale uManinil. Ekuqaleni ngithathe i-1 ithebhulethi, kodwa-ke ngashintshela kwababili, ngoba ngihamba kancane futhi idosi elilodwa alinalo ushukela. akubanga namiphumela, yize bengibesaba. ”
U-Igor, oneminyaka engama-49, uRyazan: "Ngagula nginesifo sikashukela eminyakeni engu-3 eyedlule. Ngiqale ukulandela ukudla okuqinile, ngathatha iMetformin noGalvus. Kepha amazinga ami kashukela awanciphile. Udokotela watusa uDiabeteson. Ngakusebenzisa kusihlwa, kwathi ngemuva kokudonswa kathathu ushukela wehla waya ku-4. , Amayunithi ama-3. "
Ukubuyekezwa kodokotela ngeManinil neDiabeteson
U-Olga, ongumvikeli we-endocrinologist, eMoscow: "Nginikeza iManinil iziguli ezinesifo sikashukela kanye nokudla okwehlisa ushukela. Ngikhetha isilinganiso somuthi ngamunye ukuvimbela ukukhula kwemiphumela emibi."
UMaria, udokotela we-endocrinologist, uKemerovo: "Ngivame ukuchaza lesi sidakamizwa i-Diabeteson ezigulini ezinesifo sikashukela. Siphonsa ushukela wegazi ngokuphelele. Akunangozi yokuba ne-hypoglycemia, ngakho-ke singasetshenziswa yiziguli ezinezifo zesifo senhliziyo."
