Ungayisebenzisa kanjani isidakamizwa iGlyclazide Canon?

I-Gliclazide canon isidakamizwa esinomphumela we-hypoglycemic. Ngalo, ungenza ngokwejwayelekile amazinga eglucose, amapharamitha we-hematological kanye nemisebenzi ye-rheological yegazi. Ngaphezu kwalokho, umuthi unomphumela omuhle ekusakazweni kwegazi kanye ne-heestasis, isetshenziselwa ukuvikela i-micothrombosis nezinqubo zokuvuvukala ezindongeni ze-microvessels.

Igama Lezwe elingafanele

Imithi ye-INN: IGliclazide.

I-Gliclazide canon isidakamizwa esinomphumela we-hypoglycemic.

Ath

A10VB09.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngesimo samaphilisi, abonakala ngokukhishwa okuqhubekayo. Umenzi unikeza imithamo emi-2: 30 mg no-60 mg. Amacwecwe anomumo oyindilinga we-biconvex nombala omhlophe. Ukwakheka kwalo muthi kufaka phakathi:

• into esebenzayo (gliclazide);
• izithako ezingeziwe: i-colloidal silicon dioxide, i-cellulose microcrystals, i-magnesium stearate (E572), i-hydroxypropyl methylcellulose, i-mannitol, uwoyela wemifino we-hydrogenated.

Umuthi uyatholakala ngesimo samaphilisi, abonakala ngokukhishwa okuqhubekayo.

Isenzo se-Pharmacological

Umgomo wesidakamizwa ubhekiswe kumphumela kuma-receptors akhethekile amaseli we-beta wamanyikwe. Ngenxa yokusebenzisana kwamaselula, ulwelwesi lwamaseli luyachithwa futhi iziteshi ze-KatiF zivaliwe. Lokhu kuholela ekuvulekeni kweziteshi ze-calcium nokufakwa kwama-calcium ion kumaseli we-beta.

Umphumela uba ukukhishwa nokwanda kokuqashelwa kwe-insulin, kanye nokuhanjiswa kwayo ohlelweni lokujikeleza kwegazi.

Umphumela womuthi uyaqhubeka kuze kube yilapho izinsalela zokukhiqiza insulin ziphelile. Ngakho-ke, ngokwelashwa okuhlala isikhathi eside ngalezi zibhebhe, i-insulin synthesis iyancishiswa. Kepha ngemuva kokuthi umuthi ukhanseliwe, ukusabela kwamaseli we-beta kubuyela kokujwayelekile. Uma kungekho impendulo yokwelashwa, kungcono ukubonana nodokotela ngokushesha.

Umgomo wesidakamizwa ubhekiswe kumphumela kuma-receptors akhethekile amaseli we-beta wamanyikwe.

I-Pharmacokinetics

Umuthi udonswa emgodini wokugaya ukudla. Ngokusetshenziswa kanyekanye kokudla, izinga lokufakwa kwalo liyancipha.

Umphumela wokwelapha ubonwa ngemuva kwamahora angama-2-3. Ukuqoqwa okukhulu kwengxenye esebenzayo ku-plasma yegazi kuyabonakala ngemuva kwamahora angama-6-9. Isikhathi sokudalulwa - 1 usuku emva kokuphathwa ngomlomo. Umuthi ukhishwa emgodini wokugaya nasezinso.

Izinkomba zokusetshenziswa

Kubekwa amathebula ekwelapheni i-mellitus (i-2) yesifo sikashukela engatheni insulin. Ngaphezu kwalokho, umuthi usetshenziselwa ukuvimbela izinkinga zokukhuluphala, thayipha isifo sikashukela kanye nokwelashwa kwenkambo yesifo.

Ithebhulethi libekelwe ukwelashwa kwe-mellitus engavikelekile nge-insulin.

Contraindication

Ukusetshenziswa kwomuthi kuyaphulwa ezimeni ezinjalo:

• ifomu lokuncika kwe-insulin lesifo sikashukela i-mellitus (uhlobo 1);
• iminyaka engaphansi kweminyaka eyi-18;
• ukucaphuna nokukhulelwa;
• ukulimazeka okukhulu kwe-renal kanye ne-hepatic;
• coma;
• uhlobo lwesifo sikashukela ketoacidosis;
• UMA (hypersensitivity) kuya ku-sulfonamides kanye nokuphuma kwe-sulfanylurea;
• ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi.

E-coma, ukuphuza umuthi akuvunyelwe.

Ekulimaleni okukhulu kwe-renal and hepatic, ukuthatha i-Glyclazide Canon akuvunyelwe.

Umuthi awuchaziwe ngesikhathi sokukhulelwa nokuqunjelwa.

Izingane ezingaphansi kweminyaka engu-18 azivunyelwe ukuthatha lo muthi.

Ngokunakekela

Umuthi ungasetshenziselwa ukulimaza okulinganiselayo nokuncane kokusebenza kwezinso nezinso. Umuthi unqunyelwe ngokuqapha ku-pathologies nemibandela elandelayo:

• ukungalingani noma ukungondleki;
• izifo ze-endocrine;
• izifo ezinzima ze-CVS;
• ukusweleka kwe-glucose-6-phosphate dehydrogenase;
• utshwala;
• iziguli esezikhulile (iminyaka engama-65 nangaphezulu).

Ungayithatha kanjani iGlyclazide Canon?

Umuthi wokulawulwa ngomlomo wenzelwe kuphela iziguli ezindala. Umthamo ophakathi nosuku uvela kuma-30 kuye kwangama-120 mg. Umthamo oqondile unqunywa nguchwepheshe ngokususelwa esithombeni somtholampilo.

Umthamo wansuku zonke kunconywa ukuba uthathe isikhathi esingu-1 ngemuva kokuphuza ithebhulethi yonke. Ukuvimbela ukusabela okungafuneki, kungcono ukuthatha umuthi imizuzu engama-30 ukuya kwengama-40 ngaphambi kokudla.

Ukuvimbela ukusabela okungafuneki, kungcono ukuthatha umuthi imizuzu engama-30 ukuya kwengama-40 ngaphambi kokudla.

Ukwelashwa nokuvimbela isifo sikashukela

Umthamo wokuqala wesidakamizwa ekwelapheni isifo sikashukela esinga-insulin kanye nokusetshenziswa kwe-sulfonylurea akufanele udlule ku-75-80 g. Ngezinjongo zokuvimbela, umuthi usetshenziswa ku-30-60 mg / ngosuku. Kulokhu, udokotela kufanele aqaphe ngokucophelela ushukela wesiguli amahora 2 ngemuva kokudla nasesiswini esingenalutho. Uma kutholakala ukuthi umuthi awuzange usebenze, khona-ke uyanda ngaphezulu kwezinsuku ezimbalwa.

Imiphumela emibi

Umuthi unesifo esihle emzimbeni. Kodwa-ke, ngokusebenzisa isikhathi eside umuthi, iziguli zingathola ukusabela okubi.

Ngezinjongo zokuvimbela, umuthi usetshenziswa ku-30-60 mg / ngosuku.

Amapheshana wesisu

• isifo sohudo noma ukuqunjelwa;
• isifiso sokuhlanza;
• isicanucanu
• Ubuhlungu besisu nokungaphatheki kahle.

Izitho zeHematopoietic

• i-anemia (eguqukayo);
• i-leukopenia;
• i-agranulocytosis;
• i-thrombocytopenia (ezimweni ezingavamile).

Engxenyeni yesikhumba

• isikhumba esikhanyayo;
• ukuqhuma
• indlala yesikhumba;
• ukuvuvukala kobuso nemilenze.

Umuthi ungadala i-nausea, ukuhlanza.

Ngesikhathi sokwelashwa nge-Glyclazide Canon, isifo sohudo singenzeka.

I-Glyclazide Canon ingadala ubuhlungu besisu.

IGlyclazide Canon ingadala ukuqhuma kwesikhumba.

Ngesikhathi sokulashwa nomuthi, ukwanda komfutho wegazi kungenzeka.

Ngesikhathi sokwelashwa, i-hepatitis kungenzeka.

Ukungezelelwa kwengcindezi ye-intraocular kungumphumela ongemuhle wesidakamizwa.

Kusuka ohlelweni lwezinhliziyo

• ukukhuphuka kwenhliziyo (kufaka phakathi i-tachycardia);
• ukwanda kwengcindezi yegazi;
• ukuthuthumela.

Engxenyeni yesibindi ne-biliary

• i-hepatitis;
• i-cholestatic jaundice.

Engxenyeni yezitho zombono

• ukulahleka kokucaca kokuqonda;
• ukukhuphuka kwengcindezi ye-intraocular.

Imiyalo ekhethekile

Umuthi usetshenziswa uhlangana nokudla okuphansi kwe-carb.

Lapho uyithatha, isiguli kufanele sinikeze ukulawula kwe-glucose egazini.

Lapho uthatha umuthi, isiguli kufanele sinikeze ukulawula kwe-glucose egazini.

E-mellitus yesifo sikashukela esigabeni sokuhlaziya noma ngemuva kokungenelela kokuhlinzwa, kungenzeka ukuthi kucatshangelwe amalungiselelo e-insulin.

Ukuhambisana notshwala

Kwenqatshelwe ukuphuza utshwala ngenkathi ulashwa nomuthi.

Umthelela ekhonweni lokulawula izindlela

Ngenxa yobungozi be-hypoglycemia ezigulini ezithatha la maphilisi, kufanele ushiye okwesikhashana imisebenzi engaba yingozi nokushayela imoto.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Imiyalo yokusebenzisa umuthi iyenqabela ukuthi ithathwe abesifazane besesikhathini nangesikhathi beya ibele.

Ngenxa yobungozi be-hypoglycemia ezigulini ezithatha la maphilisi, kufanele ushiye okwesikhashana imisebenzi engaba yingozi nokushayela imoto.

Ukunquma i-Gliclazide Canon Yezingane

Umuthi uvunyelwe ukusetshenziswa yizingane ezincane.

Sebenzisa ebudaleni

Iziguli esezikhulile zivunyelwe ukusebenzisa umuthi ngemithamo emincane nangaphansi kokuqashwa ngokuseduze kwezokwelapha.

Isicelo sokusebenza kokulimala kwezinso

Kwenqatshelwe ukusebenzisa la maphilisi nge-hypoglycemic effect enezimpawu ezinzima ze-renal. Umthamo ukhethwa ngamunye ngokuya ngesimo seziguli ezinenkinga yokusebenza kwe-renal.

Sebenzisa umsebenzi wesibindi okhubazekile

Kuyinto engathandeki kakhulu ukusebenzisa umuthi kwizifo zesibindi ezinamandla nezingamahlalakhona.

Kuyinto engathandeki kakhulu ukusebenzisa umuthi kwizifo zesibindi ezinamandla nezingamahlalakhona.

Ukweqisa

Ukweqa umthamo wesidakamizwa kungadala i-hypoglycemia. Izimpawu ezisezingeni eliphansi (ngaphandle kwezimpawu zemizwa kanye nokulahlekelwa ukwazi) zenziwa ngokwejwayelekile ukusetshenziswa kwama-carbohydrate nangokwenza ushintsho ekudleni nasemthanjeni womuthi.

Ezimweni ezimbi kakhulu, kunengozi yokuvela okungathi sína kwe-hypoglycemic, okuhambisana nokuququdwa, ukoma kanye nokunye ukuphazamiseka kwemizwa. Isisulu kuleli cala sidinga ukulaliswa esibhedlela ngokuphuthumayo.

Izinqubo ze-Dialysis azisebenzi ngenxa yokuhlanganiswa kwento esebenzayo yamaphilisi anamaprotheni e-plasma.

Ukuxhumana nezinye izidakamizwa

Ngokusebenzisa kanyekanye umuthi neminye imishanguzo, ungahlangabezana nokuphendula okuhle nokubi. Uma kuvela izimpawu ezingezinhle, bonana nodokotela.

Inhlanganisela ehlanganisiwe

Kwenqatshelwe ukusebenzisa kanyekanye nge-miconazole, ngoba kwandisa umphumela we-hypoglycemic womuthi. Ngaphezu kwalokho, i-phenylbutazone akufanele inikezwe ngasikhathi sinye nalo muthi.

IPhenylbutazone akufanele ichazwe kanyekanye ne-Glyclazide Canon.

Akuhlanganisiwe ukuhlanganisa

Kuyinto engathandeki ukusebenzisa umuthi oqukethe i-ethanol nezidakamizwa ezenziwa nge-chlorpromazine ngasikhathi sinye nomuthi okukhulunywa ngawo.

I-Phenylbutazone, iDanazole notshwala yandisa umphumela we-hypoglycemic womuthi. Kulokhu, kungcono ukhethe umuthi ohlukile wokulwa nokuvuvukala.

Inhlanganisela edinga ukuqashelwa

Inhlanganisela yomuthi ne-Acarbose, i-beta-blockers, i-biguanides, i-Insulin, i-Enalapril, i-Captopril kanye neminye imishanguzo engeyona eye-steroidal nemithi equkethe i-chlorpromazine idinga ukunakekelwa okukhethekile, ngoba kulesi simo kunobungozi be-hypoglycemia.

I-Glycaside MV - i-analogue yesidakamizwa.

IGliclazide Canon ine-analogue ebizwa ngeDiabetes.

I-Oziklin iyi-analogue yesidakamizwa i-Oxide Canon.

Ama-Analog

Uma kwenzeka kune-contraindication noma ukungabikho komthi okuthengiswayo, ungathenga elinye lamagama afanayo:

• I-Glycaside MV;
• Isifo sikashukela;
• Osiklid et al.

Imibandela yekhefu lekhemisi

Umuthi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Akunakwenzeka ukuthenga umuthi ngaphandle kadokotela.

Akunakwenzeka ukuthenga umuthi ngaphandle kadokotela.

Intengo ye-Glyclazide Canon

Izindleko zomuthi emakhemisi aseRussia ziyehluka kusuka kuma-ruble ayi-110-150 ngephakethe ngalinye lamathebhulethi angama-60.

Izimo zokugcina zomuthi

Umuthi ugcinwa endaweni emnyama, eyomile futhi engafinyeleleki ezilwaneni nasezinganeni. Ukushisa - hhayi okuphakeme kuno- + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Kungeqi eminyakeni engama-2 ngemuva kokukhiqizwa.

Umkhiqizi

Inkampani yemithi yaseRussia iCanonfarm Production.

Ukubuyekezwa ku-Gliclazide Canon

Kumithombo ekhethekile ye-Intanethi, umuthi uvame ukuphendulwa kahle. Ukubuyekezwa okungalungile kuhlotshaniswa nokungahambisani nezincomo zezokwelapha.

Odokotela

USergey Shabarov (owelaphi), oneminyaka engama-45 ubudala, uVolgodonsk.

Umuthi omuhle uma usetshenziswa ngobuhlakani. Umthamo ukhethiwe umane - isikhathi esingu-1 ngosuku (ngokwesilinganiso). Izinga likashukela lilawula ngempumelelo. Ngaphezu kwalokho, umuthi unomphumela omuhle emsebenzini wokujikeleza kwegazi futhi wehlisa ubungozi bezinkinga zesifo sikashukela.

U-Anna Svetlova (owelaphi), oneminyaka engama-50 ubudala, eMoscow.

Iziguli ziyaneliseka lapho ngibanikeza la maphilisi. Angizange ngihlangabezane nemiphumela emibi ekhethekile. Enye yezinzuzo zomuthi izindleko zayo ezingabizi. Futhi ukusebenza kwayo kubuye ngaphezulu!

Isifo sikashukela

U-Arkady Smirnov, oneminyaka engama-46, uVoronezh.

Ukube bebengewona la maphilisi, khona-ke izandla zami ngabe zehlile kudala. Sekuphele isikhathi eside ngigula isifo sikashukela sohlobo 2. Lo muthi ulawula ushukela wegazi kahle. Emiphumeleni emibi, ngihlangabezwe yi-nausea kuphela, kepha wazidlula yena ngemuva kwezinsuku ezimbalwa.

U-Inga Klimova, oneminyaka engama-42, uLipetsk.

Umama wami unesifo sikashukela esingancike e-insulin. Udokotela wamyalela la maphilisi. Manje wayesephinda ejabule futhi enambitha impilo.