I-Clopidogrel-Teva iyisidakamizwa esicindezela ukuhlanganiswa kweplatelet futhi sinciphise nemikhumbi e-coronary. Ithuluzi lisetshenziselwa ukwelashwa kanye nokuvinjezelwa kwama-pathologies wezinhliziyo.
Igama Lezwe elingafanele
INN - Clopidogrel.
I-Clopidogrel-Teva iyisidakamizwa esicindezela ukuhlanganiswa kweplatelet futhi sinciphise nemikhumbi e-coronary.
I-ATX
Ikhodi ye-ATX: B01AC04.
Khipha amafomu nokwakheka
Umuthi usesimweni samacwecwe amade ombala opinki okhanyayo. Umuthi osebenzayo yi-clopidogrel hydrosulfate (ngenani lama-75 mg).
Abahambeli:
- i-lactose monohydrate;
- i-microcrystalline cellulose;
- i-hyprolosis;
- i-crospovidone;
- uwoyela we-hydrogenated yemifino yohlobo I;
- sodium lauryl sulfate.
Igobolondo lefilimu liqukethe lezi zinto ezilandelayo:
- i-lactose monohydrate;
- i-hypromellose 15 cP;
- titanium dioxide;
- i-macrogol;
- ama-oxide abomvu naphuzi (odayi bensimbi);
- indigo carmine.
Umuthi uyatholakala ngesimo samathebulethi.
Isenzo se-Pharmacological
Into esebenzayo yesidakamizwa inciphisa ukuhlanganiswa kweplatelet. Ama-nucleotides e-ADP (adenosine diphosphates) athambekele ekusebenziseni i-glycoprotein inhibitors futhi abopha ngamaplatelet. Ngaphansi kwethonya le-clopidogrel, lezi zinqubo ziyaphazamiseka bese kuthi lapho-ke ukuhlangana kweplatelet (inhlangano) kuncishiswe. Umsebenzi (PDE) we-phosphodiesterase awuguquli into.
Umphumela we-antiplatelet wesidakamizwa uhlala kuwo wonke umjikelezo wokuphila wama-platelet (cishe izinsuku ezingama-7).
I-Pharmacokinetics
Lapho kuthathwa ngomlomo, amaphilisi adonswa ngokushesha emgudwini wokugaya ukudla. I-Clopidogrel ine-bioavailability ephezulu, kepha engashintshiwe ayisebenzi (lokhu kuyi-prodrug). Isegazini isikhashana futhi ifakwa ngokushesha esikhunjeni ngokwakhiwa kwama-metabolites asebenzayo futhi angasebenzi. Ngemuva kwalokho i-clopidogrel kanye ne-metabolite esebenzayo ibopha cishe ngokuphelele kumaprotheni egazi.
Ihora eli-1 ngemuva kokuthatha umuthi egazini, inani eliphakeme le-metabolite engasebenzi ye-clopidogrel ku-plasma, elitholakala ku-carboxylic acid, liyabonakala.
Umuthi ukhishwa emchameni nasezindlini kungakapheli izinsuku ezi-5. I-metabolite esebenzayo ikhishwa ngaphakathi kwamahora ayi-16.
Izinkomba zokusetshenziswa
Umuthi unqunyelwe ukuvimbela izinkinga zenhliziyo emacaleni alandelayo:
- I-Myocardial infarction.
- Is stroke.
- I-acute coronary syndrome ngaphandle kokukhuphuka engxenyeni ye-ST.
- I-Thrombosis (isetshenziswe ngokuhlanganiswa ne-acetylsalicylic acid).
- I-Thromboembolism.
- I-fibrillation ye-Atrial.
- Lapho kukhona imibiko yokusetshenziswa kwama-anticoagulants wesenzo esingaqondile.
Contraindication
Amatafula ayenqatshelwe ukuthatha ezigulini ezinokwehluleka kwesibindi (inkambo enzima), i-hypersensitivity kuloyo muthi noma ukopha kakhulu.
I-Contraindication ibuye ikhulelwe, i-lactation nezingane ezingaphansi kweminyaka engu-18.
Ngokunakekela
Ngokuqapha, umuthi unqunyelwe ukusebenza kokulimala kwe-renal (ukungakwaneleki ngokuqanjwa kwe-creatinine ye-5-15 ml / min), ukopha okwandayo (hematuria, menorrhagia), kanye nangemva kokuhlinzwa, ukulimala nokwehluleka ohlelweni lwe-he hetatic.
Ekwelashweni kweziguli ezinezifo zesibindi, kwenziwa i-coagulogram njalo ukusebenza kwesibindi kuqashelwe.
Ngokuqapha, umuthi ubekelwe ukusebenza kokulimala kwezinso.
Ungayithatha kanjani i-clopidogrel-teva?
Iziguli ezake zathola i-myocardial infarction zinqunywa i-75 mg yomuthi (1 ithebhulethi) ngosuku izinsuku ezingama-7 ukuya ku-35. Ngemuva kokushaywa unhlangothi, umuthi uphuzwa ngendlela efanayo, kepha inkambo yokwelapha ingahlala izinyanga eziyisithupha.
Iziguli ezine-acute coronary syndrome ngaphandle kokukhuphuka engxenyeni ye-ST zinconywa ukuthatha i-300 mg ngosuku njengethamo lokuqala. Ngemuva kwalokho umthamo wehliswa ube ngu-75 mg ngosuku, kepha inhlanganisela ye-antiplatelet ene-acetylsalicylic acid ihlanganiswe. Ukwelashwa kwenziwa unyaka owodwa.
Ngoshukela
Ezigulini ezinesifo sikashukela i-mellitus, ukwanda okuhlanganisiwe kweplatelet kuvame ukubonwa. Ngokuvimbela isifo se-coronary syndrome kanye nesifo se-coronary, 75 mg se-clopidogrel-Teva sinqunyelwe ngosuku.
Isikhathi sokuphatha kanye nethamo le-Insulin kufanele linqunywe ngudokotela, kuya ngesimo sesiguli.
Imiphumela emibi ye-clopidogrel-Teva
Engxenyeni yezitho zombono
Emuva kokuphuza umuthi, i-ocular hemorrhages (i-retinal ne-conjunctival) kungenzeka.
Kusuka ezicutshini zemisipha
Umphumela omubi ohlelweni lwe-musculoskeletal awuvamile. Isifo samathambo, i-arthralgia kanye ne-myalgia kungenzeka.
Umuthi ungaholela ekukhuleni kwe-colitis.
Amapheshana wesisu
Umphumela wamapheshana emathunjini uboniswa ngokulandelayo:
- izinhlungu zesisu;
- ukopha emgodini wokugaya ukudla;
- isicanucanu nokuhlanza
- isifo sohudo
- izilonda zokulimala;
- i-gastritis;
- izihlakala;
- i-hepatitis;
- i-pancreatitis
- i-stomatitis
- ukwehluleka kwesibindi.
Izitho zeHematopoietic
Kusukela ohlangothini lwalesi simiso kuyabonakala:
- i-thrombocytopenia;
- leukocytopenia;
- i-eosinophilia.
Isistimu yezinzwa ephakathi
Umuthi empeleni awuthinti uhlelo lwezinzwa. Ezimweni ezingavamile, kuvela ikhanda, isiyezi, nokudideka.
Kusuka ohlelweni lomchamo
Imiphumela emibi evela ezithweni zomchamo:
- i-hematuria;
- glomerulonephritis;
- ukukhuphuka kwe-creatinine egazini.
Kusuka ohlelweni lokuphefumula
Imiphumela ohlelweni lokuphefumula:
- amacembe;
- i-pulmonary hemorrhage;
- i-bronchospasm;
- i-pneumonitis ephakathi nendawo.
Kusuka ohlelweni lwezitho zofuzo
Imiphumela emibi ayethulwanga.
Kusuka ohlelweni lwezinhliziyo
Kusukela ohlelweni lwezinhliziyo kuyabonakala:
- ukopha
- i-hypertension ye-arterial;
- i-vasculitis.
Allergies
Ukuphendula okulandelayo komzimba kungavela:
- I-edema kaQuincke;
- ukugula kwe-serum;
- i-urticaria;
- ukulunywa
Ngokuphikisana nesizinda sokuphuza umuthi, kungavela ukusabela komzimba.
Umthelela ekhonweni lokulawula izindlela
Ezinye iziguli ziba nobuhlungu bekhanda nesiyezi lapho zithatha uClopidogrel-Teva. Ukuqapha kufanele kusetshenziswe lapho kulawulwa imishini noma kwenziwa umsebenzi odinga ukunakwa okukhulu.
Imiyalo ekhethekile
Ngaphambi kokuhlinzwa, umuthi kufanele uyekwe (izinsuku ezingama-5-7 ngaphambi kokuhlinzwa) ngenxa yengozi enkulu yokopha.
Sebenzisa ebudaleni
Umuthi usetshenziselwa ukwelapha iziguli esezikhulile. Kepha kulokhu, ukwelashwa kwenziwa ngaphandle komthamo wokulayisha (umthamo owodwa olingana no-300 mg) ekuqaleni kwezokwelapha.
Ukunquma uClopidogrel-Teva wezingane
Umuthi lo uvunyelwe izingane ezingaphansi kweminyaka engu-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukukhulelwa nokuncelisa ibele kungukuphikisana nokusetshenziswa kwalesi sidakamizwa.
Awukwazi ukusebenzisa umuthi ngesikhathi sokukhulelwa.
Sebenzisa umsebenzi wesibindi okhubazekile
Iziguli ezine-pathologies yesibindi (i-cirrhosis, ukwehluleka kwesibindi) zinikezwa umuthi ngokuqapha. Ukuze ugweme ukuphuma kwesibindi, ukwelashwa kufanele kuhambisane nokuhlola ukusebenza kwesibindi.
I-Clopidogrel-Teva okweqile
Ngokuphathwa komlomo okukodwa komthamo omkhulu wesidakamizwa (aze afike ku-1050 mg), akubanga namiphumela emibi emzimbeni.
Ukusetshenziswa isikhathi eside kumthamo omkhulu kungaholela ekhipha ukopha.
Ukuxhumana nezinye izidakamizwa
Ngenxa yengozi yokuphuma kwegazi, kwenqatshelwe ukuthatha lesi sidakamizwa ngokuhambisana nezidakamizwa ezinjengokuthi:
- Ama-Anticoagulants.
- I-Glycoprotein IIa / IIIb inhibitors.
- Ama-NSAIDs.
Ukuqapha kufanele kuhlanganiswe ne-heparin.
Ukuqapha kufanele kuhlanganiswe ne-thrombolytics ne-heparin. Ngokusetshenziswa kanyekanye ne-omeprazole, esomeprazole namanye ama-proton pump inhibitors, ukwehla komphumela we-antiplatelet kwenzeka.
Ukuhambisana notshwala
Umuthi awunconywa ukuhlanganiswa nokusetshenziswa kotshwala. Ukudakwa okungenzeka komzimba, okubonakaliswa ngokuhlanza, uhudo, ukuquleka, umkhuhlane, ukwehluleka ukuphefumula kanye ne-palpitations.
Ama-Analog
Izidakamizwa ezidumile ezinomphumela ofanayo yile:
- I-Lopirel.
- I-Plavix.
- I-Sylt.
- I-Plagril.
- I-Aggregal.
- I-Egithromb.
Into esebenzayo yalawa ma-analogu yi-clopidogrel.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ngokusho kwemiyalo, umuthi ungaphansi kadokotela.
Intengo ye-Clopidogrel-Teva
Izindleko zephakethe lamathebhulethi ayi-14 zisukela kuma-ruble angama-290 kuya kwangama-340, amaphilisi angama-28 - ama-ruble angama-600-700.
Izimo zokugcina zomuthi
Ukugcinwa kufanele kwenziwe endaweni emnyama emazingeni okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Umuthi ufanele iminyaka emi-2.
Umkhiqizi
Umkhiqizi - uTeva (u-Israyeli).
Umuthi usatshalaliswa ngugqirha.
Ukubuyekezwa kwe-clopidogrel-Teva
U-Irina, oneminyaka engama-42 ubudala, eMoscow.
Lapho ngivivinya igazi, ngithole amazinga akhuphuka ama-platelet. Udokotela unqume i-clopidogrel. Ngithathe lo muthi amasonto ama-3, futhi ukubalwa kwe-platelet egazini kwabuyela kokujwayelekile.
U-Alexander, oneminyaka engama-56, Izhevsk.
Ngiqale ukuthatha lo muthi ngokunconywa udokotela ngemuva kokushaywa unhlangothi. Sekuyizinyanga ezimbili ngiyithatha futhi angikhaleli ngenhlala-kahle yami. Akunamiphumela emibi eye yenzekile. Umuthi ufanele imali.
ULeonid, oneminyaka engama-63, uVolgograd.
Ngisebenzise la maphilisi ukuvikela izinkinga ngemuva kokuhlinzwa komgogodla. Esikhathini sokusebenza, umuthi usizile ukuvikela ukuqhekeka kwegazi. Ngakubekezelela ukwamukelwa kwakhe kahle, azange ngithole lutho olubi.
