Isikhathi sokuthatha isinqumo sokuthi yikuphi okungcono: i-Liprimar noma i-Atorvastatin, okokuqala, bahlaziya ukusebenza kwale mishanguzo. Ukuze wakhe owakho umbono mayelana nethonya lomphumela wawo emzimbeni, udinga ukutadisha ukwakheka (okokuqala, uhlobo lwezinto ezisebenzayo), izincomo zokusebenzisa, ukuphambana, futhi uthole nokuthi umthamo. Izimali ezithathwa njengezesigaba sezidakamizwa ezisehlisa i-lipid.
Isici se-Liprimar
Umkhiqizi - "Pfizer" (USA). Hlangana ngokuthengisa leli thuluzi lingaba ngesimo esisodwa sokukhishwa - amaphilisi. Umuthi uqukethe i-atorvastatin. Kwithebhulethi elilodwa, ukuhlangana kwale ngxenye kungahluka: 10, 20, 40, 80 mg. Ekwenzeni umuthi, le nto isetshenziswa ngendlela ye-calcium hydrochloride. Inani lamathebulethi kuphakethe liyahluka: 10, 14, 30, 100 ama-PC.
Umphumela omkhulu wokwelapha onikezwe umuthi ukwehlisa izinga le-triglycerides ne-cholesterol.
Umphumela omkhulu wokwelapha onikezwe umuthi ukwehlisa izinga le-triglycerides ne-cholesterol. Lezi zinto zimelela iqembu le-VLDL. Bangena kwi-plasma yegazi, bese bangena ezicutshini eziyingozi. Lapha, ukuguqulwa kwe-triglycerides ne-cholesterol ku-low density lipoproteins (LDL) kwenzeka.
I-Atorvastatin isidakamizwa sesizukulwane sesithathu. Uyilungu leqembu lama-statin. Indlela yokusebenza yesidakamizwa isuselwe ekuvinjelweni komsebenzi we-enzyme HMG-CoA reductase. Kulokhu, ukugcwala kwama-lipoprotein, kanye ne-cholesterol kuyancishiswa. Lo mphumela usiza ukuqeda noma ukunciphisa ubukhulu bezibonakaliso ezingezinhle zesimo se-pathological, esihambisana nezinguquko ze-atherosulinotic emithanjeni yegazi. Ngokunciphisa ukuqoqwa kwe-LDL, ubungozi bezifo zohlelo lwethambo luyancishiswa.
Ngenxa yezinqubo ezichaziwe, ukuvela kwe-cholesterol esibindini kuyasebenza. Ngaphezu kwalokho, inani lama-lipoproteins aphansi kakhulu ebusweni bezindonga zamaseli liyakhuphuka, okufaka isandla ekunyukeni kwesilinganiso sabo sokubamba nge-catabolism elandelayo. Ngokuphikisana nesizinda sentuthuko yalezi zinqubo, izinga le-cholesterol "elibi" liyancipha.
Inzuzo ye-atorvastatin yikhono lokuthonya okuqukethwe kwe-LDL ezigulini ezinesifo esatholakala sofuzo - i-hypercholesterolemia. Kulokhu, abanye abenzeli abakhombisa umphumela wehlise i-lipid abanikezi imiphumela oyifunayo. Ngaphezu kwalokho, ngokwehla kwe-cholesterol, i-LDL, i-triglycerides ne-apolipoprotein B, kukhona ukwanda kwenani le-HDL ne-apolipoprotein A.
Ngenqubo yokwelashwa, uhlelo lwezinhliziyo luyathuthuka. Ingozi yezinkinga ze-ischemic iyancishiswa. Ngosizo lwalesi sidakamizwa, ukuvimbela i-atherossteosis, isifo sohlangothi esibulalayo, ukufa ngenxa ye-myocardial infarction, ukuhluleka kwenhliziyo kuyenziwa.
Inani eliphakeme lomsebenzi we-atorvastatin livela imizuzu engama-60-120 ngemuva kokuthatha iphilisi lokuqala. Njengoba kunikezwe ukuthi ngesikhathi sokwelashwa nalesi ejenti umthwalo welesibindi uyanda, ukugcotshwa kwengxenye esebenzayo kukhuphuka kakhulu ngokumelene nesizinda sezifo zalo. I-Atorvastatin ibopha amaprotheni e-plasma acishe agcwele - ama-98% womthamo ophelele.
Ithuluzi livunyelwe ukusetshenziswa uma ukudla kanye nokuzivocavoca komzimba kungazange kusize ekulinganiseni isimo somzimba. Izinkomba ezisetshenziswayo:
- i-hyperlipidemia exubile, i-hypercholesterolemia, isidakamizwa sithathwa ekudleni, kuyilapho inhloso yokwelapha ukunciphisa i-cholesterol ephelele, i-apolipoprotein B, i-triglycerides;
- dysbetalipoproteinemia, izimo ze-pathological ezihambisana nokwanda kokuhlushwa kwe-serum triglycerides;
- ukuvimbela ukwenzeka kwama-pathologies we-vascular and cerebrovascular pathologies.
Ngokwanda komsebenzi we-CPK (i-creatine phosphokinase enzyme), inkambo yokwelashwa kufanele iphazanyiswe. I-Liprimar ayisetshenziswa kwezinye izimo:
- isifo sesibindi
- isikhathi sokuhlela ukukhulelwa;
- ukucaphuka
- hypersensitivity kunoma iyiphi ingxenye ekwakhiweni;
- ukukhulelwa
Umuthi awubekelwe izingane, ngoba ukuphepha kwawo akuqalwa lapho kusetshenziswa iminyaka engaphansi kwengu-18. Imiphumela emibi:
- ukuqunjelwa;
- isicanucanu
- isihlalo sokukhubazeka ngenxa yesifo se-dyspeptic;
- ukwakhiwa kwegesi kakhulu;
- ubunzima be-stool discharge;
- Ubuhlungu bemisipha
- ubuthakathaka emzimbeni;
- ukukhubazeka kwenkumbulo;
- Isiyezi
- i-paresthesia;
- i-neuropathy;
- isifo sesibindi
- isifo se-anorexic;
- izinhlungu emuva
- ushintsho kushukela emzimbeni;
- ukwephulwa kohlelo lwe-hematopoietic (kuboniswe yi-thrombocytopenia);
- isisindo somzimba;
- ukuthikamezwa kwezindlebe;
- ukwehluleka kwezinso;
- ukungezwani komzimba
Isici se-Atorvastatin
Abakhiqizi: ICanonfarm, iVertex - Izinkampani zaseRussia. Umuthi ungathengwa kwifomu lethebhulethi. Zimbozwe ngomhede ovikelayo. Ngenxa yalesi sici, izinga lomthelela ongemuhle endaweni yokugaya ukudla liyancishiswa. Umuthi i-analogue eqondile yeLiprimar. Iqukethe into efanayo esebenzayo. Umthamo: 10, 20, 40 mg. Ngakho-ke, i-Atorvastatin neLiprimar zibonakaliswa yisimiso esifanayo sokwenza.
I-Liprimara ne-Atorvastatin:
Ukufana
Ukulungiselela kuqukethe into efanayo eyisisekelo. Umthamo wayo uyefana kuwo womabili la macala. I-Liprimar ne-Atorvastatin zitholakala kwifomu lethebhulethi. Ngokunikezwe ukuthi aqukethe into efanayo esebenzayo, laba bantu banikeza umphumela ofanayo wokulapha. Iziphakamiso zokusetshenziswa kanye ne-contraindication yezidakamizwa nazo ziyefana.
Uyini umehluko?
Amatafula e-Atorvastatin ahlanganiswe. Lokhu kunciphisa ubungozi bemiphumela emibi evela emgodini wesisu. I-Liprimar itholakala kumathebulethi angaxutshiwe.
Ukulungiselela kuqukethe into efanayo eyisisekelo. Umthamo wayo uyefana kuwo womabili la macala.
Yikuphi okushibhile?
Izindleko ezimaphakathi ze-Atorvastatin: ama-ruble angama-90-630. Amanani athinteka ngenani lamathebulethi ngephakethe ngalinye kanye nomthamo wesithako esisebenzayo. Intengo ephakathi yeLiprimar: ama-ruble angama-730- 2400. Ngakho-ke, i-atorvastatin ishibhile kakhulu.
Yini engcono: Liprimar noma Atorvastatin?
Ngokubona ukuthi ukwakheka kwale mishanguzo kufaka phakathi into efanayo, ekhombisa ukwehliswa kwe-lipid, kanti umthamo wayo awufani kuwo womabili amacala, khona-ke lezi zimali ziyalingana ngokusebenza kahle.
Ngoshukela
Umuthi ungasetshenziswa ekwelapheni iziguli ezinesifo sikashukela sohlobo 2. Kuyasetshenziswa futhi uma kutholakala isifo sikashukela sohlobo 1. Kodwa-ke, kufanele kukhunjulwe ukuthi ama-statin, iqembu elimelelwa yi-Atorvastatin, anomthelela ekushintsheni kwamazinga kashukela egazini. Ngalesi sizathu, ukwelashwa kwenziwa ngaphansi kokuqondisa udokotela.
I-Atorvastatin iyatholakala ngesimo samathebhulethi efakiwe. Ku-mellitus yesifo sikashukela, isidakamizwa esinjalo sinconyelwa kakhulu, ngoba kusiza ukunciphisa ingozi yokuthola ukubonakaliswa okuthile okungekuhle.
Ukubuyekezwa kweziguli
UVera, oneminyaka engama-34, uStary Oskol
I-Atorvastatin isebenza ngokushesha, isiza ngokuphelele. Ngiyithatha ngezikhathi ezithile lapho kukhuphuka izinga le-cholesterol. Nginanzelela nje ukuthi akuhlali kunethonya kuma-triglycerides. Ukuze wehlise izinga lokuqukethwe kwabo, udokotela wengeza ezinye izidakamizwa.
U-Elena, oneminyaka engama-39, uSamara
Udokotela watusa ukuthatha i-Liprimar ngemuva kokuhlaselwa yisifo senhliziyo. I-cholesterol yami yayikhuphuka ngaphambili, kodwa yayihlala iba nezimpawu ezingemnandi, futhi isimo esijwayelekile somzimba sisheshe sibuyele kokujwayelekile. Manje iminyaka ayifani: Ngokushesha ngizwa zonke izinguquko ezingezinhle kimi. Ukugcina imithambo yenhliziyo nemithambo yegazi isesimweni esijwayelekile, esisebenzayo, ngithatha lesi sidakamizwa ngezikhathi ezithile. Kepha ungathandi intengo ephezulu.
Ukubuyekezwa kodokotela mayelana neLiprimar ne-Atorvastatin
I-Zafiraki V.K., isazi sezinhliziyo, i-Perm
I-Liprimar ifana ne-atorvastatin ngokuya ngokusebenza kahle. Angikukhuthazi ukuthola amanye ama-generics, ngoba avame ukuvusa ukuthuthukiswa kwenani elikhulu lokubonakaliswa okungalungile. I-Liprimar ibhekana kahle nomsebenzi wayo oyinhloko: yehlisa i-cholesterol.
UValiev E.F., udokotela ohlinzayo, u-Oryol
I-Atorvastatin ivelele ezincwadini zayo ngenxa yesilinganiso esisezingeni lekhwalithi yamanani. Umuthi unesandla ekuthuthukiseni inani elikhulu lemiphumela emibi. Kodwa-ke, ekusebenzeni, kuvela ukuthi ukunamathela kwirejimeni yepilisi kusiza ukunciphisa ubukhulu bokubonakaliswa okungalungile.
