Izibhebhe ze-Amaryl: imiyalo esetshenzisiwe

Amatafula e-Amaryl asetshenziselwa ukuguqula amazinga kashukela egazi. Ngesikhathi sokulashwa nalomenzeli, umphumela oqondile kumanyikwe uyakhishwa, ngenxa yalokho ukwenziwa kwe-insulin kuthuthukiswa.

Igama Lezwe elingafanele

I-Glimepiride.

Amatafula e-Amaryl asetshenziselwa ukuguqula amazinga kashukela egazi.

I-ATX

A10BB12

Ukwakheka

Isakhi samakhemikhali esisebenzayo yi-glimepiride. Ezinye izinto ekwakhiweni azivezi umsebenzi we-hypoglycemic futhi zisetshenziselwa kuphela ukuthola ukuvumelana kwesidakamizwa okufisayo:

• i-lactose monohydrate;
• povidone 25000;
• isitashi se-sodium carboxymethyl (uhlobo A);
• i-magnesium stearate;
• i-microcrystalline cellulose;
• amadayi;
• indigo carmine (E132).

Umthamo we-glimepiride kuthebhulethi eyi-1 ungahluka: 1, 2, 3, 4 mg. Ungawuthenga umkhiqizo ngamaphakethe ama-30 nama-90 ama-PC. Ukuze kube lula ukugcina izibhebhe, amabhulashi anikezwa (ama-pc ayi-15. Kulelo nalelo).

Isenzo se-Pharmacological

I-Amaryl ibhekisela kuma-hypoglycemic agents enzelwe ukusetshenziswa komlomo. Umuthi uvame kakhulu ukutholakala kwe-sulfonylurea. Leli thuluzi liyisizukulwane sokugcina, futhi ngenxa yalokho lingenakubalwa kokungafani ngokuqhathaniswa nokufana kwesizukulwane 2 noma 1. Umuthi awunawo nomthelela oqondile kushukela, kepha uyasiza ekuqedeni izimpawu ezibangelwa okuqukethwe okuphezulu kwalesi zinto ngokusebenzisana namaseli we-pancreatic.

I-Amaryl ingathengwa ngamaphakethe ama-30 nama-90 ama-pcs.,) Ukuze kube lula ukugcina amaphilisi, amabhulashi anikezwa.

Kulokhu, inqubo yokukhiqizwa kwe-insulin iyasebenza, ngenxa yokuthi izinga lokuhlushwa koshukela egazini lijwayelekile. Esinye isidakamizwa sinomthelela ekuzwisiseni kwezicubu zangaphakathi eziphathelene nemiphumela ye-insulin. Inikeza ukwanda kwesilinganiso sokuphendula komzimba ekukhuleni kwe-glucose ku-plasma.

Indlela yokukhiqizwa kwe-insulin ngokubamba iqhaza kwe-Amaril isuselwe ekuvaleni iziteshi ezisetshenziselwa i-potassium ezilandelwa yi-ATP. Ngenxa yalokhu, iziteshi ze-calcium zivulekile. Ngenxa yalokho, ukugcwala kwe-calcium emangqamuzaneni kukhuphuka kakhulu. Ukwanda kwesilinganiso se-insulin kungumphumela womjikelezo oqhubekayo wokuxhuma kwe-glimepiride ne-protein ye-beta cell of pancreas kanye ne-detachment yayo.

I-Amaryl ibuye ikhombise ezinye izakhiwo: i-antioxidant, i-antiplatelet, inciphisa ukumelana ne-insulin. Ngenxa yalokhu, umzimba uphendula nemithamo emincane ye-glimepiride. Ngesikhathi sokwelashwa, inqubo yokusetshenziswa kwe-glucose ngama-tishu e-peripheral iyasebenza, kuyilapho into ihanjiswa kumaseli emisipha kanye nama-adipocytes (amaseli we-adipose izicubu).

Ku-mellitus yesifo sikashukela sohlobo lwesibili, le nqubo incishisiwe, ngoba kunomkhawulo ngejubane lokuqalisa ukusebenza kwawo. I-Glimepiride isiza ukusheshisa ukusetshenziswa kwe-glucose, ngenxa yokuthi isimo somzimba sivamile nge-hypoglycemia. Ngasikhathi sinye nezinqubo ezichaziwe, kukhona ukwehla ekukhiqizeni ushukela esibindini.

Ukuphila kwesigamu kwesidakamizwa Amaryl emzimbeni kuthatha amahora amahlanu kuya kwayi-8.

Kodwa-ke, i-glimepiride ibonakala ngezenzo ezikhethiwe futhi ithinta umsebenzi we-cycloo oxygenase enzyme. Ngenxa yalokho, ubukhulu bokuguqulwa kwe-arachidonic acid ibe yi-thromboxane iyancipha. Ngenxa yalokhu, izinga lokwakheka kweziqeshana zegazi liyancipha, ngoba amapuleti agcinwe ngokuqinile ezindongeni zemithambo yegazi. Ngasikhathi sinye, ukwehla kobukhulu be-lipid oxidation kuyaphawulwa, kanye nokuhlushwa kwabo kujwayelekile.

I-Pharmacokinetics

Izinga lapho inani eliphakeme lokugcwala kwe-glimepiride lifinyelelwa egazini kuya ngethamo lomuthi nokuqukethwe kwento esebenzayo ekwakhiweni kwayo. Umuthi osebenzayo udonswa ngokulinganayo ngokushesha lapho kudliwa esiswini esingenalutho nangokudla. Inzuzo yesidakamizwa ibopha kakhulu amaprotheni e-plasma kanye ne-bioavailability ephezulu (100%).

Ingxenye esebenzayo iyakhululwa ngesikhathi sokuhamba kwamathumbu nokuchama. Ukuphila kwesigamu umuthi kuthatha amahora amahlanu kuya kwayi-8. Ngenkathi ithatha inani elikhulayo le-Amaril, inqubo yokususwa kwalo emzimbeni iyabambezeleka. Ngokuphikisana nesizinda sokukhula kwezifo zezinso, ukuqoqwa kwalesi sikhungo kuyancipha, ngenxa yokusheshisa kokuqedwa kwempilo yengxenye yayo.

Izinkomba zokusebenzisa amaphilisi we-Amaryl

Umuthi uyasebenza ekwelapheni isifo sikashukela sohlobo 2, kuyilapho ingozi yokuthola ukubonakaliswa okungalungile kanye nezinkinga incane. I-Amaryl isetshenziswa njengezinyathelo zokwelapha ezizimele noma kanye nezinye izindlela.

I-Amaryl ihlukaniswe notshwala obungamahlalakhona.

I-Coma kuwukuphikisana nokusetshenziswa kwe-Amaril.

I-Amaryl ayinqunyelwe idigri yesifo sikashukela 1.

Contraindication

Umuthi okukhulunywa ngawo awumiselwe izimo ezinjalo ze-pathological:

• ukungabekezeleli kunoma iyiphi ingxenye, ene-hypersensitivity to glimepiride most frequent development;
• thayipha i-1 isifo sikashukela;
• ukwephulwa kwe-carbohydrate metabolism, ehambisana nokwehla kwesilinganiso se-insulin;
• coma, i-precoma;
• utshwala obungamahlalakhona, ngoba kulokhu umthwalo esibindini uyakhuphuka;
• ukusabela okungekuhle kunoma yisiphi isidakamizwa esivela eqenjini le-sulfonylurea.

Ngokunakekela

Ukuqapha kufanele kusetshenziswe ezimweni ezinjalo ze-pathological eziphakamisa isidingo sokudlulisela isiguli ukwelashwa kwe-insulin: ukulimala ezindaweni ezinkulu zesikhumba ngenxa yokuchayeka okushisayo, ukungenelela kokuhlinzwa, ukuphazamiseka kokugaya ukudla kanye nokufakwa kancane kancane kokudla namakhemikhali odongeni lomgudu wokugaya ukudla.

Ungayisebenzisa kanjani i-Trulicity yezidakamizwa?

IMetformin 1000 inqunyelwe ukwehlisa ushukela wegazi. Funda kabanzi ngalesi sidakamizwa esihlokweni.

Ukusetshenziswa kweMetformin Zentiva kunconyelwe odokotela.

Ungawathatha kanjani amaphilisi e-Amaryl

Umuthi uphuzwa ngaphambi kokudla noma ngokudla. Isikhathi sokwelashwa sinqunywa ngokuya ngesimo sesiguli, izinga lokuthuthuka kwalesi sifo, kepha imvamisa inkambo yokwelashwa yinde.

Ngoshukela

Ekuqaleni kokwelashwa, akumele kuthathwe ngaphezu kwe-1 mg. Ukwelapha: amaphilisi athathwa isikhathi esisodwa ngosuku ngosuku ekuseni. Uma kudingeka, umthamo wansuku zonke wesidakamizwa uyanda, kepha lokhu kwenziwa ngezigaba: 1 mg yento ihlanganiswa njalo, esigabeni sokugcina - 6 mg. Kwenqatshelwe ukwedlula umthamo obonisiwe wesidakamizwa, ngoba inani laso lansuku zonke eliphelele li-6 mg.

I-Amaryl idliwa ngaphambi kokudla noma ngokudla.

Imiphumela emibi yamathebulethi e-Amaryl

Engxenyeni yesitho sombono

Ukulimazeka okubukwayo okubonakalayo ngenxa yokugcwala kwesikhashana kwamalensi. Ngenxa yalokhu, i-angle of refraction of changes changes.

Amapheshana wesisu

Isicanucanu, ukugabha, izinhlungu esiswini, ukuphazamiseka kwesisu, izimo eziningana zesibindi.

Izitho zeHematopoietic

Izinguquko ezimweni segazi nokwakheka, njenge-thrombocytopenia.

Ngasohlangothini lwe-metabolism

Ukuthatha lo muthi umbuzo kwesinye isikhathi kubangela ukwehla okubaluleke kakhulu emazingeni kashukela. Kulokhu, kuphakama izimpawu: ikhanda, isicanucanu, ukuhlanza, ubuthakathaka obujwayelekile, ukwanda kobudlova, ukunakwa kuyaphazamiseka, ukufikelwa yimizwa, ukudana, ukushintshashintsha kwenhliziyo, ukwethuka kuyaphawulwa, izinga lokucindezela lishintsha (phezulu).

Ngemuva kokuthatha umuthi, ezinye iziguli ziba ne-thrombocytopenia.

Ngemuva kokusebenzisa umuthi, isicanucanu kanye nokuhlanza kungenzeka.

Ngokuphikisana nesizinda somuthi wokulashwa kwezidakamizwa, ukudangala kungakhula.

Imvamisa kuba nekhanda, okuwuphawu lwemphumela eseceleni.

Isifo sohudo singumphumela we-Amaril.

Ngesikhathi sokulashwa nge-Amaril, ukwenzeka kobuhlungu besisu kuyaphawulwa.

Allergies

Ukuvela kaningi ngesikhathi sokwelashwa kwe-Amaril yi-urticaria, ephelezelwa ukugoqa, ukulunywa. Ngokuvamile, isimo sokushaqeka, i-vasculitis, i-dyspnea siyakhula.

Umthelela ekhonweni lokulawula izindlela

Kukhona ubungozi be-hypo- kanye ne-hyperglycemia, okungaholela ekunakekelweni okungaboni kahle, ushintsho olwazini, kanye nasekwenzeni imisindo ebuhlungu ye-psychomotor. Ukuqapha kufanele kusetshenziswe lapho ushayela.

Imiyalo ekhethekile

Ngokulashwa okuhlanganisiwe neMetformin, intuthuko kulawulo lwe-metabolic iyaphawulwa.

Esikhundleni seMetformin, kungenzeka ukuthi kunikwe i-insulin. Ngasikhathi sinye, inqubo yokulawula i-glucose metabolism nayo yenziwe lula.

Uma isiguli sihlakulela ukusabela ngakunye kulo muthi othathwe ngenani eliphansi (1 mg), kwanele ukulandela indlela yokudla ukuze ulondoloze amazinga evamile eglucose.

Ukwelashwa nalesi sidakamizwa kudinga ukuhlolwa njalo: hlola izindlela eziyisisekelo zesibindi negazi. Indima ebalulekile kulokhu idlalwa ngama-leukocytes namaplatelet.

Sebenzisa ebudaleni

Uhlobo lokwelashwa kanye nedosi kuyabuyekezwa, ngoba kaningi ezigulini zaleli qembu, umsebenzi wezinso uyaphazamiseka.

Ukuvela kaningi ngesikhathi sokwelashwa kwe-Amaril yi-urticaria, ephelezelwa ukugoqa, ukulunywa.

Ngesikhathi sokulashwa nge-Amaril kufanele kuqashelwe lapho ushayela imoto.

Lapho welapha i-Amaril esegugile, irejimeni lokwelashwa kanye nedosi kuyabuyekezwa.

Njengoba kunikezwe imininingwane ngokuphepha kwe-Amaril ekwelashweni kweziguli ezingaphansi kweminyaka engu-18, ngeke kusetshenziswe.

Isabelo sezingane

Njengoba kunikezwe imininingwane ngokuphepha kwezidakamizwa okukhulunywa ngayo ekwelashweni kweziguli ezingaphansi kweminyaka engu-18, ngeke isetshenziswe.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

I-Amaryl ayibekelwe abesifazane ngesikhathi sokuzala nokuncelisa.

Isicelo sokusebenza kokulimala kwezinso

Ithuluzi alisetshenziswa.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukulimala okukhulu kwalesi sitho kuwukuphikisana nokusetshenziswa kwe-Amaril. Uma ukukhula kwesibindi kukhula, ubungozi bezinkinga buyanda.

Ukweqisa

I-Hypoglycemia iyabonakala. Izimpawu zalesi simo ziqhubeka izinsuku ezingama-1-3. Ungaziqeda izimpawu ngokuthatha umthamo wama-carbohydrate. Ukubuyisela amazinga eglucose ngokushesha, kunconywa ukuthi uvuse futhi uphuze uketshezi oluningi.

Ngokweqile komuthi, isiguli sinezimpawu ze-hypoglycemia.

Uma kwenzeka umsebenzi wezinso ongasebenzi kahle, i-Amaryl ayisetshenziswa.

Ukulimala kwesibindi okukhulu kungukuphikisana nokusetshenziswa kwe-Amaril.

I-Amaryl ayibekelwe abesifazane ngesikhathi sokuzala nokuncelisa.

Ukuxhumana nezinye izidakamizwa

Kunethuba lokuncipha kwe-glucose uma, kanye ne-Amaril, insulin noma ama-ejenti omlomo we-hypoglycemic, i-Allopurinol, i-anabolics, iChloramphenicol, izidakamizwa eziqukethe ama-hormone, ama-ACE inhibitors enqunyelwe.

Umphumela ohlukile utholakala ngokuhlanganiswa kwe-Amaril nge-barbiturates, GCS, okokugcotshwa kweqembu le-thiazide, i-Epinephrine.

Umsebenzi we-coumarin derivatives ungancipha futhi ukhuphuke uma le mishanguzo inqunywe ngasikhathi sinye nomuthi okukhulunywa ngawo.

Ukuhambisana notshwala

Akunakwenzeka ukuphuza iziphuzo eziqukethe utshwala ngasikhathi sinye ne-Amaril, ngoba umphumela wokuhlanganiswa kwalezi zinto awunakulindeka: umphumela we-hypoglycemic ungaqina futhi ube buthaka.

Ama-Analog

Uma isiguli sithuthukise i-hypersensitivity kwento esebenzayo yesidakamizwa okukhulunywa ngayo, ezinye izidakamizwa zisetshenziswa esikhundleni salokhu:

• Maninil;
• I-Gliclazide;
• Isifo sikashukela;
• UGlidiab.

Imibandela yekhefu lekhemisi

Umuthi umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Cha.

Kubiza malini?

Intengo emaphakathi: 360-3000 rub. Izindleko zincike ekuhlolweni kwe-glimepiride kanye nenani lamathebulethi.

Izimo zokugcina zomuthi

Ukulawula okunconyelwe ukushisa: hhayi ngaphezu kuka- + 25 ° С. Ukutholakala kwezingane esikhungweni kufanele kuvalwe.

Isikhathi sokuphelelwa yisikhathi

Umuthi ugcina izakhiwo zawo iminyaka emi-3.

Umkhiqizi

I-Aventis Pharma Dhechland GmbH, eJalimane.

Enye indlela, ungakhetha i-Diabeteson.

Ukwakheka okufanayo iManinil.

I-Amaril ingathathelwa indawo ngomuthi onjengeGlidiab.

Uma kunesidingo, umuthi ungashintshwa nomuthi iGliclazide.

Ukubuyekezwa

U-Anna, oneminyaka engama-32 ubudala, uNovomoskovsk

Umuthi uyasebenza, ususa ngokushesha izimpawu ze-hypoglycemia. Kepha ngesikhathi sokwelashwa, amazinga kashukela anciphe izikhathi eziningana kakade.

U-Elena, oneminyaka engama-39, uNizhny Novgorod

Umuthi awuzange uwanane. Kubhekwa njengosebenza kakhulu esigabeni sayo, kepha ngiba nokuhlaseka lapho ngiqala ukuthatha amaphilisi. Futhi intengo iphakeme.