IGlulin insulin iyi-ejenti ye-hypoglycemic, i-analogue ye-insulin yabantu ekhiqizwa ama-pancreas. Yithole ngokuphindaphinda kwamagciwane e-DNA enhlobo ye-Escherichia coli.
Igama Lezwe elingafanele
Igama elingelona okuphathelene nomhlaba ngomuthi yi-insulin glargine.
Kutholakala ngohlobo lwamapeni wesirinji aqukethe i-cartridge engu-100 IU / ml 3 ml lilinye (ama-300 PIECES).
Ath
Ikhodi ye-ATX yi-A10AE04.
Khipha amafomu nokwakheka
Amaphilisi
I-Lantus insulin esefomini yethebhulethi ayitholakali.
Amaconsi
Amaconsi awatholakali.
Powder
I-insulin ehlanganisiwe ayitholakali.
Isixazululo
Isixazululo sokuphatha ngokulawula okuwukuphela kwendlela yokukhululwa yalesi sidakamizwa. Kutholakala ngohlobo lwamapeni wesirinji aqukethe i-cartridge engu-100 IU / ml 3 ml lilinye (ama-300 PIECES). Ama-cartridge agxotshwe nge-aluminium cap ngakolunye uhlangothi kanye ne-brkidutyl plunger kolunye. I-carton eyodwa iqukethe amapeni ama-syringe ayi-5. I-1 ml yesisombululo iqukethe i-100 IU ye-insulin glargine.
Amakhandlela
I-Insulin Lantus SoloStar kwifomu le-capsule ayitholakali.
Amafutha
I-insulin ngendlela yokugcoba ayitholakali.
Okuwukuphela kwenkomba yokusetshenziswa kwamapeni weLantus SoloStar insulin syringe uhlobo lwesifo sikashukela 1.
Isenzo se-Pharmacological
I-insulin glargine inomphumela we-hypoglycemic, okungukuthi, yehlisa ushukela wegazi. Ukwehla kwe-glucose kwenzeka ngenxa yokubopha kwe-insulin elungiselelwe kuma-receptors ayo, ngaleyo ndlela kuthinte i-metabolism ye-glucose. Njengomphumela walesi senzo, ngenxa yokwanda kokusetshenziswa kwe-glucose kwezicubu ze-peripheral, izinga layo egazini liyancipha.
I-Pharmacokinetics
Isenzo se-insulin senzeka ngenxa yokuvezwa okuhleliwe kwe-metabolite M1. Kwiziguli eziningi ezifundwe ngesifo sikashukela i-mellitus, i-insulin ne-metabolite M2 azitholakalanga ohlelweni lokujikeleza kwegazi. Kepha ezimweni ezingavamile, lapho kutholakala i-metabolite M2 ne-insulin egazini, ukugcotshwa kwalaba bobabili bekungaxhomekeki kulimala we-insulin glargine.
Izinkomba zokusetshenziswa
Okuwukuphela kwenkomba yokusetshenziswa kwamapeni weLantus SoloStar insulin syringe uhlobo lwesifo sikashukela 1.
Contraindication
- Ukungabekezelelani komuntu ngamunye ku-insulin glargine kanye nababukeli.
- Izingane ezingaphansi kweminyaka engu-2 ubudala (ngenxa yokuntuleka kwezifundo zemitholampilo).
- Sebenzisa ngokuqapha ngesikhathi sokukhulelwa.
Ungayithatha kanjani iLantus SoloStar
I-insulin ilawulwa ngokungaziphathi kanye ngosuku, ngasikhathi sinye. Njengoba i-insulin esebenza isikhathi eside, ukuphatha kusihlwa kuvame ukunqunyelwa, ikakhulukazi ngemuva kokudla kokugcina. Ukuhlushwa ushukela wegazi, umthamo kanye nesikhathi sokuphathwa kweLantus SoloStar kunqunywa ngokuhlukile esigulini ngasinye.
Ngokushintshwa kwesisindo, indlela yokuphila nezinye izimo eziphathelene nesimo somzimba, kufanele kulungiswe umthamo wansuku zonke. Kodwa noma yiluphi ushintsho ngesikhathi nangesilinganiso kufanele lwenziwe ngokucophelela ngaphansi kokuqashwa kwe-endocrinologist.
Ungayisebenzisa kanjani ipeni yesirinji
Indawo yomjovo akufanele ifane; isayithi lomjovo kufanele liguqulwe. Indawo enconyelwe umjovo we-insulin ingamafutha angaphansi kwamahlombe, amathanga, noma isisu. Amapeni wesirinji asetshenzisiwe kufanele alahlwe. Ukusebenzisa kwabo kabusha akuvunyelwe. Ukugwema ukutheleleka, ipeni elilodwa kufanele lisetshenziswe yisiguli esisodwa.
Ngaphambi kokusebenzisa isirinji ngezizathu zokuphepha, kuyadingeka ukuthi utadishe ngokucophelela imiyalo futhi uqinisekise ubuqotho bokupakishwa kanye nebhokisi lebhokisi lesisombululo, kanye nokubheka ilebula ukuhambisana nalo. ILantus SoloStar ngesimo se-pen-syringe kufanele ibe mpunga ngombala ngenkinobho yokujova onsomi. Isixazululo akufanele siphethe noma yiluphi udaba lwangaphandle. Uketshezi kufanele lube sobala, njengamanzi.
Ngemuva kokuhlola isirinji, kufanele ufake inalithi. Kungasebenza izinaliti ezikhethekile ezihambisana naleli peni. Izinaliti ziyaguquka ngomjovo ngamunye we-subcutaneous.
Masinyane ngaphambi kokufaka inaliti, qiniseka ukuthi azikho izimbumbulu zomoya kusisombululo. Ukwenza lokhu, linganisa i-2 ml yesisombululo, susa izixazululo zenaliti bese usetha isirinji eqondile ngenaliti phezulu. Linda kuze kube yilapho wonke ama-bubble angaphezulu ephezulu, eshaya isibambo. Kuphela lapho ucindezela inkinobho yokufaka ukuze ufike lapho izohamba khona.
Lapho nje kuvela i-insulin esicucwini senaliti, lokhu kuyosho ukuthi inaliti ifakwe kahle, futhi ungaqhubeka nomjovo.
Umthamo omncane kunayo yonke ipeni yesirinji iyunithi eli-1, inani eliphakeme lingasethelwa kumayunithi angama-80 uma kunesidingo sokuphatha umthamo ongaphezu kwamayunithi angama-80, kufanele kunikezwe imijovo emi-2. Ngemuva kokuphothula, u- "0" kufanele aboniswe kuwindi lomthamo, futhi kuphela ngemuva kwalapho kungaba kusetshenziswe umthamo omusha.
Lapho uphatha i-insulin ngokweqile, isiguli kufanele sazi imithetho yokuhlatshwa udokotela ngudokotela oholayo.
Ukwelashwa nge-insulin uLantus SoloStar kunqunywe ngudokotela ohambelayo, ukuzilawula kwakhe ngemijovo ye-insulin akwamukeleki.
Ngemuva kokuthi i-insulin ikhishwe, inaliti kufanele ilahlwe. Ukuwusebenzisa kabusha akwamukeleki. Ngemuva kokususa inaliti futhi uqedele inqubo, vala isicucu sepeni yesirinji.
Ukwelashwa kwesifo sikashukela
Ukwelashwa nge-insulin uLantus SoloStar kunqunywe ngudokotela ohambelayo, ukuzilawula kwakhe ngemijovo ye-insulin akwamukeleki. Ezigulini ezinesifo sikashukela, kufanele kuqashelwe amazinga kashukela egazini. Lokhu kuzosiza ukukhetha isilinganiso esifanele nesikhathi sokuphathwa kwe-insulin.
Imiphumela emibi yeLantus SoloStara
Engxenyeni ye-metabolism
Imvamisa, umphumela ovela ubonakala ngendlela ye-hypoglycemia. Kwenzeka lapho kudlula umthamo odingekile womuthi olungiselelwe.
Izimpawu ze-hypoglycemia zizoba: umuzwa wokukhathala ongazelele, ubuthakathaka bomzimba, isiyezi kanye nenausea.
Kusuka emasosheni omzimba
Ezimweni ezingavamile, ukungezwani komzimba kungenzeka ngesimo sokuqhuma kwesikhumba, i-angioedema, i-bronchospasm, noma yehlise umfutho wegazi.
Isistimu yezinzwa ephakathi
Akuvamile ukuthi kube nezimo zokwephula noma ukuhlanekezela ukunambitheka, okungukuthi i-dysgeusia.
Kusuka ohlelweni lwe-musculoskeletal kanye nezicubu ezithintekayo
Ukuphendula okungafani ngesimo se-myalgia kuyaqabukela.
Ukuphendula okungafani ngesimo se-myalgia kuyaqabukela.
Engxenyeni yezitho zombono
I-retinopathy, imvamisa - ukukhubazeka okubukwayo.
Engxenyeni yesikhumba
Ukusabela okuvame kakhulu ngendlela ye-lipodystrophy, i-adipose izicubu zelungu.
Allergies
Esizeni somjovo, redness, pain, itching, burning, reaction allergic ngendlela ye-urticaria, edema noma ukuvuvukala kungenzeka.
Umthelela ekhonweni lokulawula izindlela
Akuthinti amandla okulawula izindlela nezimoto, ngokuya ngemithamo ebekiwe.
Imiyalo ekhethekile
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukusetshenziswa kwe-insulin glargine kwabesifazane ngesikhathi sokukhulelwa kungenzeka phambi kwezinkomba zomtholampilo.
Ukusetshenziswa kwe-insulin ngesikhathi sokukhipha isisu kungenzeka kuphela ngemuva kokubonana nodokotela oguqula uhlelo lokulinganisa nesikhathi.
Ukusetshenziswa kwe-insulin ngesikhathi sokukhipha isisu kungenzeka kuphela ngemuva kokubonana nodokotela oguqula uhlelo lokulinganisa nesikhathi.
Ukuqokwa kweLantus SoloStar ezinganeni
ILantus SoloStar ikhonjiswa abasebasha nezingane ezisukela eminyakeni emibili.
Sebenzisa ebudaleni
Iziguli esezikhulile ziyelulekwa ukuthi zisebenzise umthamo wokuqala olinganiselayo, ziwukhulisa kancane kancane.
Isicelo sokusebenza kokulimala kwezinso
Isidingo somuthi ezigulini ezinomsebenzi wezinso ongasebenzi kahle singancishiswa ngenxa yokuqothulwa kwawo kancane. Ezigulini esezikhulile ezinokwehluleka kwe-renal, kukhona ukuncipha okuqhubekayo kwesidingo somjovo womuthi.
Isidingo somuthi ezigulini ezinomsebenzi wezinso ongasebenzi kahle singancishiswa ngenxa yokuqothulwa kwawo kancane.
Sebenzisa umsebenzi wesibindi okhubazekile
Ezigulini ezinokukhubazeka kakhulu kwe-hepatic, isidingo sokuphathwa kwezidakamizwa naso sincishisiwe.
Ukweqisa kweLantus SoloStar
I-overdose ingaholela ezinhlotsheni ezinzima ze-hypoglycemia, ukuthuthukiswa kwe-neuroglycopenia, okungasongela impilo yesiguli. Ngezimpawu zokuqala zokwehla okunamandla koshukela wegazi, isiguli sizwa ubuthakathaka obujwayelekile bomzimba, ukugxila okungahambi kahle, ukozela nesiyezi. Ukwelashwa kuqukethe ukungenisa ama-carbohydrate ashesha ukugaya. Ezimweni ezibucayi kakhulu, kuzodingeka ukujova umjovo we-intramuscular or subcutaneous solution we-glucose solution.
Ukuxhumana nezinye izidakamizwa
Akumele kube neminye eminye imithi ekhefini lesixazululo. Ukuxubana okunjalo kwezidakamizwa kungathinta isikhathi sokufakwa kwe-insulin esikhanyayo, okuzosithinta kabi isimo sesiguli.
Ukusetshenziswa okuhlangana nezidakamizwa ze-hypoglycemic zomlomo kungakhuphula umphumela we-insulin glargine. Izidakamizwa ze-diuretic, i-phenothiazine derivatives, ama-hormone okukhula, ama-estrogen nama-gestagen, ngokuhlukile, enza buthaka umphumela we-hypoglycemic womuthi olawulwa.
Ukuhambisana notshwala
Ukuphuza utshwala kungakhulisa futhi kwehlise umphumela we-hypoglycemic womuthi.
Ukuphuza utshwala kungakhulisa futhi kwehlise umphumela we-hypoglycemic womuthi.
Ama-Analog
Phakathi kokufana kwezidakamizwa, odokotela bahlukanisa iTujeo SoloStar.
Imibandela yekhefu lekhemisi
Ikhishwa ngokuqinile ngomuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ukuthenga i-Lantus yezidakamizwa, kufanele unikeze iphepha elibhalwe ngencwadi yomtholampilo.
Malini uLantus SoloStar
Intengo yesidakamizwa iyahlukahluka kusuka kuma-ruble angama-2900. kuze kufike ku-3400 rub. ukupakisha.
Izimo zokugcina zomuthi
Umuthi ugcinwa emazingeni okushisa angaphansi kwe- + 2 ° C futhi ungabi ngaphezu kuka-8 ° C, akumele ube yiqhwa. Gcina ipeni lokuthosa eliqalekile endaweni yokushisa yasekamelweni kude nezingane.
Isikhathi sokuphelelwa yisikhathi
Amaphakeji avaliwe agcinwa iminyaka emi-3 kusukela ngosuku lokukhishwa. Kuvulwe amapeni wesirinji - amaviki ama-4.
Umkhiqizi
- EJalimane, iSanofi-Aventis Deutschland GmbH. I-Industrialpark Hoechst, D-65926, iFrankfurt.
- ISanofi Aventis, eFrance.
Ukubuyekezwa mayelana neLantus SoloStar
USvetlana S., oneminyaka engama-46, uNizhny Novgorod: “Lapho kutholwa umuntu omthandayo enesifo sikashukela sohlobo lwe-I, bengazi ukuthi benzeni, basiphathe kanjani nokuthi ngabe siyalashwa yini isifo sikashukela. bhala imishanguzo yemithi ehlukile. Kwakuyi-insulin glargine ne-isofan. Enye yezidakamizwa kwakunguLantus SoloStar, udokotela wasinquma ngokusobala isikhathi sokuphatha.baqala ngokufaka ingxenyeni yamafutha esiswini kusihlwa maduze nje ngaphambi kokulala. Lokhu kuyi-insulin esebenza kancane. namanje "yinde".
Ngemuva kwezinyanga eziyisithupha, kwesinye sezikhathi zokuqokwa, udokotela wathi uLantus wayengekho emakhemisi njengamanje, wabe esebeka omunye umuthi ofanayo. Njengoba besijwayelene nalesi sifo esikhathini esedlule kakhulu, asikwazanga ngisho nokucabanga ukuthi omunye umuthi ungasithinta kanjani. Ngenkathi bemjova uLantus, ababonanga zinkinga ngezinga likashukela, bahlala belilinganisa ngokuqinile izinga layo egazini, balandele ukudla futhi balondoloze nokuzivocavoca komzimba. Isimo sasinelisa.
Kepha sekuyizinsuku eziningana sisebenza kwesinye isidakamizwa, futhi into engaqondakali yenzeka ngezinga le-glucose. Uma ushukela weLantus wawungama-5-7, manje usungu-12-15. Sizothenga iLantus ngezindleko zethu kuze kuba ivela emakhemisi akhethekile. "
UKirill K., oneminyaka engu-32 ubudala, u-Ust-Katav: "Ngiye ngazama ama-analog amaningi we-Lantus insulin, phakathi kwawo iTujeo SoloStar. Angisho ukuthi kusebenza kahle ukuthi enye ingcono kanti enye imbi kakhulu. Ukulungiswa komthamo kuyadingeka lapho usebenzisa lokhu noma le-insulin. Uma ukubala kahle isikhathi sokuphatha kanye nerejimeni ye-dosing, khona-ke izinkinga zingavikeleka. Kubalulekile ukunakekela ukudla, ngasikhathi sinye kungagcini ngamaprotheni futhi uqaphele ukubusa komzimba. "
