I-Lisinopril 20 - ikhambi lokukhululeka kwezimpawu ze-hypertension ye-arterial.
Igama Lezwe elingafanele
Lisinopril.
I-Lisinopril 20 - ikhambi lokukhululeka kwezimpawu ze-hypertension ye-arterial.
I-ATX
Ikhodi ye-ATX yi-C09AA03.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo sethebulethi. Amacwecwe aqukethe i-lisinopril ngendlela ye-dihydrate. Okuqukethwe kwento esebenzayo kungahluka. Ithebhulethi elilodwa liqukethe i-5 mg, 10 mg noma i-20 mg ye-lisinopril.
Isenzo se-Pharmacological
Into esebenzayo yomenzeli ingekaqembu le-angiotensin-converting enzyme inhibitors. Ngaphansi kwethonya lomuthi, okuqukethwe kwe-angiotensin 2 ne-aldosterone esegazini kuyancipha.
Ingcindezi yegazi nayo iyancipha ngenxa yoku secretion okusebenzayo kwe-bradykinin, into enomphumela we-vasodilating. IVasodilation iholela ekunciphiseni kokumelana kwemithambo yegazi. Umthwalo osemisipha yenhliziyo uyancishiswa, ongapompa inani elifanayo legazi ngeenkontileka ezimbalwa. Ukuqina kokugeleza kwegazi emithanjeni yezinso nakho kukhuphuka ngandlela thile.
Lapho uthathwa ngomlomo, izinga lomfutho wegazi liyancipha ngemuva kwehora eli-1. Umphumela omuhle utholakala ngamahora ayi-6.
Lapho uthathwa ngomlomo, izinga lomfutho wegazi liyancipha ngemuva kwehora eli-1. Umphumela omuhle utholakala ngamahora ayi-6. Isikhathi sokusebenza kuncike kunani lezinto ezisebenzayo ezithathiwe. Uma isetshenziswa kumithamo ejwayelekile, umsebenzi uthatha cishe usuku.
ILisinopril inomphumela ozinzile we-hypotensive kuyo yonke inkathi yokusetshenziswa. Ukuqothuka okwenziwe ngephutha kwemithi kungaholeli ekunciphiseni ngokushesha komfutho wegazi.
Ngaphandle kokuthi i-lisinopril ivimbela umsebenzi we-eniotensin-converting enzyme, ethinta i-metabolism yohlelo lwe-angiotensin-aldosterone, ngokusetshenziswa isikhathi eside, umuthi ubuye unciphise nengcindezi ezigulini ezinamazinga aphansi we-renin.
Ngaphezu komphumela we-hypotensive, umuthi ubuye wehlise inani le-albhamuin echweziwe emchameni. ILisinopril ayithinti amazinga kashukela we-plasma.
I-Pharmacokinetics
Ukuqunjelwa kwengxenye esebenzayo yomenzeli kwenzeka nge-mucosa yesisu esincane. I-bioavailability yomuthi incike ezimfanelweni zomzimba wesiguli. Kusuka ku-5 kuye ku-50%.
Ukuqina okusebenzayo kakhulu egazini lapho kuthathwa ngomlomo kubonwa ngemuva kwamahora angama-7. Ukutshala akuxhomekile esikhathini sokudla.
Ukuqina okusebenzayo kakhulu egazini lapho kuthathwa ngomlomo kubonwa ngemuva kwamahora angama-7.
Into esebenzayo ayihlanganisi kuma-peptides ezothutho lwe-plasma. Ukubopha kwenzeka kuphela nge-angiotensin yokuguqula i-enzyme. ILisinopril ingadlula i-BBB ngamanani amancane.
Ingxenye esebenzayo ayihambi ekuguqukeni kwe-metabolic. Ukuhoxiswa kwenzeka ngendlela yoqobo. Umchamo uyadedelwa. Isigamu sempilo singamahora ayi-12.
Ukucaciswa okujwayelekile kwe-renal creatinine ngu-50 ml / min. Ingxenye yomuthi idedelwa ngokushesha, ingxenye ehambisana ne-ACE ihlala egazini isikhathi eside.
Izinkomba zokusetshenziswa
ILisinopril imiselwe ukwelashwa kwezifo ezilandelayo:
- umfutho obalulekile we-arterial hypertension;
- ukwehluleka kwenhliziyo;
- I-AMI ezigulini ezinamapharamitha we-hemodynamic azinza;
- i-nephropathy ebangelwa ukuphazamiseka kwe-metabolic ku-mellitus engavikelekile kwe-insulin, umfutho wegazi ophakeme.
Umuthi ubekelwe ukwehluleka kwenhliziyo.
Kukuziphi izingcindezi?
Ukwelashwa nge-angiotensin-converting enzyme inhibitors, okubandakanya i-lisinopril, kukhonjiswa kuzo zonke iziguli ezinomfutho wegazi oshisayo. Zinqunyelwe zombili ngesilinganiso esiphansi sokwenyuka komfutho wegazi, nangomfutho wegazi ophansi futhi onamandla.
Izinga lokuqala lomfutho wegazi ophakeme libhekwa njengokwanda okuqhubekayo kwengcindezi ye-systolic ukuya ku-140-159 mm Hg. nokucindezela kwe-diastolic kuze kufike ku-90-99 mm Hg
Lapho usuthole ukwanda kwengcindezi yegazi kuya kulezi zinamba ezingenhla, ungazidabuli. Ama-inhibitors e-ACE kufanele anqunywe ngudokotela.
Contraindication
ILisinopril ayinqunyelwe emacaleni alandelayo:
- isiguli sine-hypersensitivity yomuntu ngamunye kwento esebenzayo noma ezinye izinto ezakha ukwakheka;
- i-angioedema;
- i-bilpatal renal stenosis;
- infarction myocardial;
- ukunganele kwe-bcc;
- ukwethuka kwe-cardiogenic;
- iziguli ngemuva kokufakwa kwezinso;
- ukwehluleka kwezinso;
- ukunciphisa i-lumen ye-aortic;
- i-hypertrophy yenhliziyo;
- i-mitral valve stenosis;
- hyperaldosteronism.
Kuya-contraindised ukuthatha umuthi we-myocardial infarction.
Ungayithatha kanjani iLisinopril 20
Ithuluzi lisebenzisa 1 isikhathi ngosuku. Ukuthatha umuthi akuxhomeki esikhathini sokudla kokudla. Ithebhulethi lithathwa ekuseni.
Umthamo nobude bendawo yokwelashwa kukhethwa udokotela, kucatshangelwa izici zomuntu ngamunye ogulayo. Isimo sezinso, imithi ethathiwe, kanye nezinga lokukhuphuka kwengcindezi yegazi kuyabhekwa.
Umthamo wokuqala wansuku zonke ngu-2,5 mg. Ukwanda kungenzeka ngemuva kwamaviki ama-2-4, lapho umphumela wokwelapha ubonakala. Umthamo ungakhuphuka kuze kube yilapho umuthi unikeza ukulawula okuzinzile kokucindezela kwegazi. Umthamo omkhulu onconywa nsuku zonke ngu-40 mg.
Ekwehlulekeni kwenhliziyo, ukwelashwa kuqala ngesilinganiso esilinganiselwe esilinganayo sansuku zonke, esingafika ekugcineni ezingeni lama-20 mg.
Kwi-infutection ebabazekayo ye-myocardial, kuqokwa i-5 mg ye-lisinopril. Kamuva, umthamo ukhuphuka ufinyelela ku-10 mg ojwayelekile. Ukwelapha kuthatha amasonto ayi-6. Uma umfutho wegazi we-systolic wegazi ungaphansi kwe-120 mm Hg, umthamo uncishiswa izikhathi ezi-2.
Umthamo nobude bendawo yokwelashwa kukhethwa udokotela, kucatshangelwa izici zomuntu ngamunye ogulayo.
Ngoshukela
Ukuqokwa komthamo wansuku zonke ubuncane kunconyiwe. Ukwanda kwenziwa ngaphansi kokuqondisa udokotela.
Iziguli ezinesifo sikashukela sohlobo 2 kanye nephropathy yesigaba sokuqala zithola u-10 mg umuthi. Umthamo omkhulu wansuku zonke ngu-20 mg.
Imiphumela emibi
Ezimweni eziningi, umuthi ubekezelelwa kalula. Izimpawu ezivame kakhulu yilezi: i-hypotension, ukukhuphuka kwenhliziyo, ukulahleka kwengqondo, ukuwa kwe-orthostatic. Ukubonakaliswa kwe-allergic njenge-anaphylaxis noma ukuvuvukala kobuso kungenzeka.
Amapheshana wesisu
Ngesikhathi sokwelashwa, kungavela izimpawu ezingathandeki ezilandelayo:
- umlomo owomile
- ukuguqulwa kwesitulo;
- ukuqhakaza;
- i-anorexia;
- umsebenzi we-hepatic okhubazekile;
- i-hepatitis;
- i-pancreatitis
- isicanucanu
- ukuhlanza
- Ubuhlungu besisu.
Izitho zeHematopoietic
Ukuboniswa okulandelayo kwe-pathological kungenzeka:
- i-thrombocytopenia;
- ukwehla kwenani lamaseli amhlophe egazi;
- i-anemia
- i-pancytopenia;
- i-pathology ye-lymph node;
- i-eosinophilia.
Isistimu yezinzwa ephakathi
Kwangathi kungaphendulwa ekwelashweni ngokubonakala kwezimpawu ezilandelayo:
- ukuphazamiseka kokulala;
- ukungahambi kahle;
- ukozela
- ukuphazamiseka komoya okucindezelayo;
- ukudideka kokwazi;
- tinnitus;
- i-peripheral neuropathy;
- iminyakazo
- umbono ophindwe kabili
- ukuthuthumela
- i-paresthesia;
- ukusebenzisana okungahambi kahle.
Kusuka ohlelweni lokuphefumula
Izimpawu ezilandelayo zingavela:
- ukukhwehlela
- ukuvuvukala kwe-bronchi;
- isifuba somoya
- i-sinusitis
- i-rhinitis;
- hemoptysis;
- spasm yemisipha ebushelelezi ye-bronchi;
- ubunzima bokuphefumula.
Engxenyeni yesikhumba
Isikhumba singaphendula ekwelashweni ngokubonakala kwe:
- i-hyperhidrosis;
- ukuzwela imisebe ye-UV;
- imishayo;
- Izinguquko ezinjenge-psoriasis;
- ukuhlukaniswa kwamapuleti ezipikili;
- i-alopecia;
- pemphigus;
- i-erythema;
- isikhumba.
Kusuka ohlelweni lwezitho zofuzo
Kungavela:
- i-oliguria;
- i-anuria
- ukuvuvukala kwezicubu zezinso;
- i-proteinuria;
- Arrester;
- kwehliswe i-sex drive;
- gynecomastia.
Uhlelo lwe-Endocrine
Izimpawu zesifo sikashukela zingenzeka.
Izimpawu zesifo sikashukela zingenzeka.
Imiyalo ekhethekile
Ama-inhibitors e-ACE angaholela ku-hyperkalemia kanye nokwehla kwamazinga e-sodium egazini. Lokhu kudinga ukubhekwa ngezikhathi ezithile kwamazinga we-electrolyte ngesikhathi sokwelashwa.
Sebenzisa ebudaleni
Iqoqo eliphezulu lomuthi elisebenza nge-plasma yegazi kubantu asebekhulile lidlula inkomba efanayo ezigulini ezisebasha ngezikhathi eziyi-1.5-2. Lokhu kungaba yisizathu sokulungiswa komthamo wansuku zonke wezidakamizwa.
Umthelela ekhonweni lokulawula izindlela
Ukuqapha kufanele kuvikelwe ngenkathi uthatha lo muthi, ngoba kungadala ukuvela kwezimpawu ze-pathological kusuka ohlelweni lwezinzwa. Ukwephula okungenzeka kokudidiyela kokunyakaza kanye nokunaka ukunakwa, okungaholela ebunzimeni bokushayela izimoto nezindlela eziyinkimbinkimbi.
Ukwephula okungenzeka kokusebenzisana kokunyakaza nokugxilwa ukunakwa, okungaholela ebunzimeni bokushayela.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelashwa nge-lisinopril kuyaphikiswa ngesikhathi sokukhulelwa. Ukuqokwa kwekhambi kwabesifazane abancelisayo akunconywa.
Ukunquma uLisinopril ezinganeni ezingama-20
Kwenziwe ucwaningo ngokusetshenziswa komuthi ekwelashweni kwe-hypotension ezinganeni ezineminyaka engu-6-18 ubudala. Izinga lokufakwa kuleli qembu leziguli licishe libe ngama-30%. Ukuphakanyiswa okusebenzayo okusebenzayo ekusebenzeni okujwayelekile kwezinso nesibindi akuhlukile kulokho kubantu abadala.
Uma kungabikho mibango, i-lisinopril ingabekelwa izingane.
Ukweqisa
Ukweqisa izidakamizwa kungaholela ekuweni, izimo zokushaqeka, ukungalingani kuma-electrolyte, ukulahlekelwa ukwazi, ukwehluleka kwe-renal acute.
Uma kusolwa i-overdose, kuyadingeka ukuthi uhlambe isisu sesiguli, sinikeze izangoma. Uma isiguli sinezimpawu ezinzima ze-pathological, ukulaliswa esibhedlela kuyadingeka. Esibhedlela, udinga ukuqapha ukusebenza kwenhliziyo nokusebenza kwamaphaphu, ubuyisele i-bcc, yenze ibhalansi ye-electrolyte ibe ngokwejwayelekile.
Ukweqisa izidakamizwa kungaholela ekulahlekelweni ukwazi.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa okuhlangene kwe-lisinopril kuphambaniswe ne:
- I-Aliskiren - ngenxa yengozi yokufa.
- I-Estramustine - ikhulisa ubungozi bokusabela okungekuhle kusuka emasosheni omzimba.
- I-Baclofen - inika amandla umphumela we-lisinopril, okungaholela ekwehleni okubukhali kwengcindezi yegazi.
- I-Sympathomimetics - yehlisa ukusebenza kwezokwelapha.
- Ama-anticepressants e-Tricyclic.
- Ama-antipsychotic.
- Izidakamizwa ze-anesthesia ejwayelekile.
Ngokunakekela
Ukuhlanganiswa kwe-lisinopril nge-potassium-sparing diuretics kungaholela ekwandeni kwezinga lale nto yokulandela emgodini wegazi. Inhlanganisela enjalo idinga ukuqashelwa ngezikhathi kwamazinga we-electrolyte.
Umuthi unamandla umphumela we-hypoglycemic wezidakamizwa ezethelwa isifo sikashukela. Ukwehlisa ushukela wegazi kungadinga ukulungiswa komthamo.
Ukuphuza utshwala akunconywa kubantu abane-hypertension.
Ukuhambisana notshwala
Ukuphuza utshwala akunconywa kubantu abane-hypertension. Ukuhlanganiswa ne-ACE inhibitors kungakhulisa izehlakalo zemiphumela emibi.
Ukuhlanganiswa nezidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala kunciphisa ukusebenza kwezokwelapha. Kungahle kube nokuwohloka kokusebenza kwezinso kuze kufike ekukhuleni kokungakwaneli kwalezi zitho zomzimba.
Ama-Analog
Izichasiso zalo muthi yilezi:
- I-Aurolyza;
- Vitopril;
- Dapril;
- Diroton;
- I-Zonixem;
- Irreg;
- ILysigamma;
- Lisighexal;
- Scopril;
- Solipril.
Izimo zeholide zeLisinopril 20 ezivela emakhemisi
Ikhishwa ngokuya ngommiselo kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo
Kuya ngendawo yokuthenga.
Izimo zokugcina zomuthi
Kufanele igcinwe emazingeni okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Kungeqi ngeminyaka engu-3 kusuka ngosuku lokukhishwa.
Umuthi uyatholakala emgqonyeni kadokotela.
Umkhiqizi uLisinopril 20
Kwenziwa yinkampani iRatiopharm.
Ukubuyekezwa mayelana neLisinopril 20
Odokotela
UMaxim Pugachev, udokotela wezifo zenhliziyo, eMoscow
ILisinopril iyindlela ephumelelayo yokwelapha umfutho wegazi ophezulu. Nginikeza iziguli zami zombili njenge-monotherapy, futhi zihlanganiswa namanye ama-ejenti. Ezigulini ezinefomu elinamandla lesifo, ngincoma ukwelashwa nge-diuretics kuhlangene ne-lisinopril. Ngokuqashwa okufanele ngudokotela, irejimeni enjalo yokwelapha ayisebenzi kuphela, kodwa futhi iphephile. Imayelana nokukhethwa okuyikho komthamo wezidakamizwa.
Imvamisa ngisebenzisa i-lisinopril + hydrochlorothiazide 12.5 mg regimen. Kuhle ukukhumbula ukuthi i-diuretic isusa i-sodium, engadinga ukuqapha okuqukethwe kwayo esegazini. Lokhu kwenziwa ngokumane kulawulwe inani likasawoti ekudleni.
U-Alla Galkina, udokotela wezifo zenhliziyo, eMoscow
Umuthi ojwayele ukwedlula yonke udokotela. Ama-inhibitors e-ACE anikezwa bonke abantu abane-hypertension ebalulekile, ngoba basiza ukulawula umfutho wegazi. Le ndlela ukuphela kwendlela, ngoba kusenzima ukwelapha lesi sifo ngokuphelele.
Ukuthatha iLisinopril kuyinto elula. Ithebhulethi elilodwa nje ngosuku lizosiza ukugcina umfutho wegazi ojwayelekile. Udinga nje ukukhetha isilinganiso esifanele. Kwesinye isikhathi kuyadingeka ukunquma ezinye izidakamizwa, kepha kuphela ezimweni ezinzima.
Kwenqatshelwe ukwenza ukwamukela kanyekanye ne-Aliskiren, njengoba kunengozi yokufa.
Iziguli
UPavel, oneminyaka engama-67, Ufa
Sekuphele isikhathi esingaphezu konyaka ngihlushwa ukugula kwenhliziyo okungalapheki kanye nomfutho wegazi ophakeme. Ngazama imishanguzo eminingi, kepha angitholanga lutho olungcono kuneLisinopril. Amaphilisi angabizi asiza ekugcineni umfutho wegazi ojwayelekile. Unganqikazi ukuthenga lesi sidakamizwa, ama-analogues angaphandle awangcono. Lokhu ukupompa okulula kwemali.
UZhanna, oneminyaka engama-54, u-Irkutsk
Ngigula yi-hypertension ye-arterial ye-2nd degree. Uqale ukuqaphela izimpawu eminyakeni engu-3 eyedlule, lapho kuqubuka khona ikhanda, isiyezi, ubuthakathaka, ukuzizwa kwe-palpitations. Ngiye kudokotela owathola ukwelashwa futhi wanginikeza ukwelashwa. Kusukela lapho bengilokhu ngithatha iLisinopril. Ithuluzi libhekana nomsebenzi walo, angiboni imiphumela emibi. Ngenisa zonke izivivinyo ngesikhathi bese ngiya kudokotela ukuze ngibonisane. Ngenkathi umuthi wanelisekile ngokuphelele.
UGennady, oneminyaka engama-59, uSamara
Ngithatha uLisinopril cishe izinyanga ezintathu. Inkambo yokwelashwa iqale ngokushesha ngemuva kokuthi udokotela ethole isifo se-arterial hypertension. Ngesikhathi sokwelashwa, izikhathi ezi-2 kwadingeka zikhuphule umthamo womuthi. Manje ukuthatha i-10 mg ngosuku. Bengilokhu ngilandela lomthamo amasonto ama-2 manje. Ingcindezi ibuyele kokujwayelekile. Ngiyethemba ukuthi umuthi uzosiza ukuwugcina phakathi kwemikhawulo ejwayelekile nasesikhathini esizayo.
