I-Fenofibrate iyinhlangano yamakhemikhali enomphumela we-hypoglycemic. Kufakwe kwezinye izidakamizwa. Umuthi uhloselwe ukwelapha i-hyperlipidemia ne-hypercholesterolemia. Kusetshenziswa njengezinyathelo zokuvimbela ukwakheka kwamakhemikhali e-cholesterol noma izinguquko ze-atherosulinotic ezindongeni zemithambo yegazi.
Igama Lezwe elingafanele
NgesiLatini - Fenofibrate.
Igama lokuhweba nguTricor.
I-Fenofibrate iyinhlangano yamakhemikhali enomphumela we-hypoglycemic.
I-ATX
C10AB05.
Khipha amafomu nokwakheka
Umuthi wenziwa ngesimo samathebulethi e-membrane-camera. Iyunithi ngalinye lokulungiselela liqukethe i-fenofibrate engama-145, 160 noma i-180 mg ngendlela yama-nanoparticles. Njengoba kusetshenziswa izingxenye ezengeziwe:
- ushukela wobisi;
- i-microcrystalline cellulose;
- i-crospovidone;
- i-hypromellose;
- i-dehydrogenated silicon dioxide colloidal;
- sucrose;
- i-lauryl sulfate ne-dodium sodium;
- i-magnesium stearate.
Umuthi wenziwa ngesimo samathebulethi e-membrane-camera.
Igobolondo langaphandle liqukethe i-talc, i-xanthan gum, i-titanium dioxide, utshwala be-polyvinyl ne-soya lecithin. Izibhebhe ezimhlophe zinomumo obude ngokuqoshwa ezinhlangothini zombili zefomu lomthamo, okubonisa unobumba wokuqala wento esebenzayo nomthamo.
Indlela yokusebenza
Amathebhulethi e-Fenofibrate angawesiqhema sama-hypoglycemic agents futhi avela ku-fibroic acid. Le nto inamandla okuthinta izinga lama-lipid emzimbeni.
Izakhiwo ze-Pharmacological zibangelwa ukwenziwa kwe-RAPP-alpha (i-receptor eyenziwe nge-proxifis proliferator). Njengomphumela womphumela ovuselelayo, inqubo ye-metabolic yokuqhekeka kwamafutha kanye nokuchithwa kwama-low-density plasma lipoproteins (LDL) kuthuthukiswa. Ukwakhiwa kwama-apoproteins AI ne-AH kuyathuthukiswa, ngenxa yokuthi izinga lamazinga aphezulu we-lipoproteins (HDL) lenyuswa ngo-10-30% kanti i-lipoprotein lipase icushiwe.
Ngenxa yokubuyiselwa kwama-metabolism wamafutha uma kwenzeka wephula ukwakheka kwe-VLDL, i-fenofibrate complement ikhulisa ukumbiwa kwe-LDL, inciphisa inani lezinhlayiya ezishubile ze-lipoproteins ephansi ngosayizi omncane.
Amazinga e-LDL ayanda ezigulini ezisengozini yokuba nesifo senhliziyo esiku-coronary.
Umuthi usiza ukwehlisa i-cholesterol ngo-20-25% kanye ne-triglycerides ngo-40-55%. Lapho kukhona i-hypercholesterolemia, izinga le-cholesterol ehlobene ne-LDL lehla laya ku-35%, kuyilapho i-hyperuricemia ne-atherosclerosis lehla ekuhlakazweni kwe-uric acid egazini ngama-25%.
I-Pharmacokinetics
Lapho kuthathwa ngomlomo, i-fenofibrate efakwe emzimbeni inamathela engxenyeni esondelene yamathumbu amancane isebenzisa i-microvilli, isuka lapho ifakwe emithanjeni yegazi. Uma ingena emathunjini, into esebenzayo isivele ibola fenofibroic acid by hydrolysis nge esterases. Umkhiqizo obolile ufinyelela emazingeni aphezulu we-plasma kungakapheli amahora angama-2-4. Ukudla ngesilinganiso sokumuncwa kanye ne-bioavailability akuthinti ngenxa yama-nanoparticles.
Uma ingena emathunjini, into esebenzayo isivele ibola fenofibroic acid by hydrolysis nge esterases.
Emgodini wegazi, i-composed esebenzayo ibopha i-albhamu nge-plasma nge-99%. Umuthi awuhlanganyeli kwi-microsomal metabolism. Isigamu sempilo sifinyelela emahoreni angama-20. Ekuqulweni kokuvivinywa kwemitholampilo, azange kube namacala wokukhishwa ngokuphathwa okukodwa noma okuphathelene nesikhathi eside nomuthi. I-Hemodialysis ayisebenzi. Umuthi udalulwa ngendlela ye-fenofibroic acid ngokuphelele ezinsukwini eziyi-6 ngohlelo lobuchwepheshe.
Izinkomba zokusetshenziswa
Umuthi ubekwa phambi kwe-cholesterol ephezulu kanye nohlobo lwe-hypertriglyceridemia exubekile noma eyedwa. Isiza ngesifo samathambo. Kubalulekile ukukhumbula ukuthi lesi sidakamizwa senzelwe ukwelashwa ngokuhambisana nesizinda sokusebenza kancane kokulashwa kokudla, imisebenzi yomzimba neminye imisebenzi ehambisana nokulahlekelwa isisindo. Ikakhulu phambi kwezici zobungozi (umfutho wegazi ophakeme, imikhuba emibi) ene-dyslipidemia.
Isidakamizwa sisetshenziselwa ukuqeda i-hyperlipoproteinemia yesibili kuphela ngenkathi sigcina inkomba ye-lipoprotein ezingeni eliphakeme ngokumelene nesizinda sokwelashwa okusebenzayo kwenqubo enkulu ye-pathological.
I-dyslipidemia ku-mellitus yesifo sikashukela ingaba eyokugcina.
Contraindication
Umuthi awunqunyelwe ngenxa yokwephulwa okuqinile kwemithetho:
- hypersensitivity fenofibrate nezinye izinto ezihlelekile zomuthi;
- isifo sesibindi
- ukungasebenzi kahle kwezinso;
- i-galactosemia eyindlalifa ne-fructosemia, ukuntuleka kwe-lactase ne-sucrose, ukumuncwa kweglucose ne-galactose;
- umlando wezifo zemvelo zofuzo;
- izinzwa zokukhanya lapho ziphathwa ngeKetoprofen noma amanye ama-fibrate;
- inqubo ye-pathological gallbladder.
Abantu abane-anaphylactoid ukusabela kwamantongomane nebhotela lamantongomane akufanele bawuthathe umuthi.
Ngokunakekela
Ukuqapha kufanele kusetshenziswe ekulimaleni kwe-renal and hepatic, ukuhoxisa utshwala, izifo zemisipha eyindlalifa, i-hypothyroidism.
Ungayithatha kanjani i-Fenofibrate
Amacwecwe athathwe ngaphandle kokuhlafuna. Iziguli zabantu abadala zidinga ukuthatha i-145 mg yesidakamizwa ngosuku. Lapho ushintsha usuka kumthamo we-165, i-180 mg ukuya kumthamo wansuku zonke we-145 mg, ukulungiswa okwengeziwe kwesimo sansuku zonke akudingeki.
Kunconywa ukuthatha umuthi isikhathi eside ngokumelene nesizinda sokulashwa okufanele kokudla. Ukusebenza kokwelashwa kufanele kuhlolwe njalo ngudokotela ohambayo kuye ngokuqukethwe kwe-serum lipid.
Amacwecwe athathwe ngaphandle kokuhlafuna.
Ukuthatha umuthi wesifo sikashukela
Ngaphambi kokuthatha i-Fenofibrate, kuyadingeka ukuqeda i-hypercholesterolemia yesibili ngokumelene nesizinda sohlobo lwe-2 yesifo sikashukela esinga-insulin. Kamuva, isidakamizwa sisetshenziswa kumthamo ojwayelekile.
Imiphumela emibi
Imiphumela emibi ikhula ngohlobo olungafanele lomthamo noma lapho ichazwa yizici zangaphandle: ezinye izifo zezitho nezinhlelo, ubunzima benkambiso ye-pathological, ukuthinteka kwezicubu zomuntu ngamunye ukufukama ngamandla.
Amapheshana wesisu
Ubuhlungu be-Epigastric, ukugabha, kanye nohudo olude olude. Amacala okubikwa kwe-pancreatitis abikiwe.
Izitho zeHematopoietic
Ukuphazamiseka kwemisipha okungenzeka kufaka phakathi i-venous thromboembolism. Ezimweni ezingavamile, ukwanda kokuhlushwa kwe-leukocytes kanye nezinga le-hemoglobin egazini kungenzeka.
Isistimu yezinzwa ephakathi
Ukungasebenzi kwe-Erectile nekhanda lekhanda kungavela nemiphumela enobuthi ohlelweni lwezinzwa.
Kusuka ohlelweni lwe-musculoskeletal
Ezimweni ezingavamile, phambanisa ubuhlungu bemisipha, i-arthritis, ubuthakathaka kanye nokulimeka kwemisipha, futhi kunengozi yokuthola i-necrosis yemisipha eyingozi
Kusuka ohlelweni lwezitho zofuzo
Azikho izinguquko ezingezinhle emsebenzini wohlelo lokuchama.
Allergies
Esikhathini esiningi, kuqhamuke isikhumba, i-photosensitivity (ukuzwela ukukhanya), ukulunywa noma okhalweni okuncane kakhulu. Ezimweni ezingavamile, ukulahleka kwezinwele, ukubonakala kwe-erythema, iziqubu noma amaqhubu wezicubu ezixhumayo ngaphansi kwethonya lemisebe ye-ultraviolet kuyabonakala.
Umthelela ekhonweni lokulawula izindlela
Ukwemukelwa kwe-Fenofibrate akukuthinti ukushushiswa, ukusabela ngokomzimba nangokwengqondo, ngakho-ke, ngesikhathi sokwelashwa okwehlisa i-lipid, ukushayela imoto nokusebenza namadivayisi ayinkimbinkimbi kuvunyelwe.
Ngesikhathi sokuthatha umuthi, ukushayela nokusebenza ngamadivayisi ayinkimbinkimbi kuvunyelwe.
Imiyalo ekhethekile
Izinga lomphumela wokwelapha lihlaziywa ngesisekelo sezinkomba zokuqukethwe kwe-lipid: i-serum LDL, i-cholesterol ne-triglycerides. Uma kungabikho ukusabela komzimba kulo muthi kungakapheli izinyanga ezi-3 zokwelashwa, kuyadingeka ukubonana nodokotela ngokuqokwa enye indlela yokwelashwa.
Ukuvela kwe-hyperlipidemia yesibili ngemuva kokuthatha ama-estrogens, izidakamizwa zama-hormonal nezindlela zokuvimbela inzalo ezisuselwa kuma-hormone ocansi abesifazane kungahle kuhlotshaniswe nezinga lokukhula le-estrogen. Amazinga we-Fibrinogen anciphisa.
Ukwanda komsebenzi we-hepatocytic transaminases ezimeni eziningi yi-asymptomatic yesikhashana. Izinyanga zokuqala eziyi-12 zokwelashwa kulesi simo, kunconywa ukuthatha izivivinyo zezinga lama-hepatic aminotransferase njalo ezinyangeni ezi-3. Ngokwanda kokuhlungwa kwama-transaminases ngezikhathi ezi-3 noma ngaphezulu, kuyadingeka ukuyeka ukuthatha i-Fenofibrate.
Ngesikhathi sokulashwa, kwaqoshwa amacala okuthuthukiswa kwe-pancreatitis. Ezimbangela zokulimala okungenzeka, kukhona:
- cholelithiasis, ehambisana ne-cholestasis;
- ukusebenza okuncane kwesidakamizwa kwe-hypertriglyceridemia enzima;
- ukwakheka kokudonsa inyongo gallbladder.
Ngesikhathi sokulashwa nomuthi, kwaqoshwa amacala okuthuthukisa i-pancreatitis.
Mhlawumbe ukuthuthukiswa kwemiphumela enobuthi yesidakamizwa emisipha, okuholela ku-rhabdomyolysis. Ingozi yokuthola lesi sifo kanye nezinkinga zaso ikhuphuka ngokubhekene nesizinda sokuhluleka kwezinso kanye nokwehla kwenani le-albhamuin ku-plasma. Kuyadingeka ukwenza inhlolokhono ukuthola umphumela onobuthi weFenofibrate emthanjeni wamathambo kwizikhalazo zobuthakathaka, ubuhlungu bemisipha, i-myositis, ama-cramp, izicubu zomsipha, ukwanda komsebenzi we-creatine phosphokinase amahlandla ama-5 noma ngaphezulu. Uma imiphumela yokuhlolwa inethemba, umuthi uyamiswa.
Ngokwenyuka kwamazinga we-creatinine angaphezu kwama-50% wesilinganiso, kunconyelwa ukumisa ukwelashwa kwe-Fenofibrate. Ngokuqhubeka kokulashwa kwezidakamizwa, kunconyelwa ukuthi ukugxilwa kwe-creatinine kugadwe izinsuku ezingama-90.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ocwaningweni lomtholampilo ezilwaneni, akukho miphumela ye-teratogenic etholakele. Ocwaningweni olwenziwa ngaphambi kokubelethisa, ubuthi emzimbeni womama nengozi yengane buqoshwe, ngakho-ke, ukuthatha lo muthi kwenziwa kuphela uma umphumela omuhle kowesifazane okhulelwe udlula ubungozi bokuthola ukungalingani kwe-intrauterine enganeni.
Ukuncelisa ibele ngesikhathi sokwelashwa kukhanseliwe.
Kunquma i-Fenofibrate ezinganeni
Lesi sidakamizwa asinconywa ezinganeni nakwentsha engaphansi kweminyaka eyi-18 ngenxa yokushoda kolwazi ngomphumela weFenofibrate ekukhuleni nasekuthuthukisweni komzimba.
Sebenzisa ebudaleni
Abantu abaneminyaka engaphezu kwengu-70 ubudala abadingi ukulungisa uhlobo lomthamo.
Ukweqisa
Akukaze kube namacala okweqa ngokweqile ngenxa yokusebenzisa kabi izidakamizwa. Akunasizinda esithile esiphikisayo. Ngakho-ke, uma isiguli esinomthamo owodwa wethamo eliphakeme siqala ukuzizwa singasebenzi, ukwanda noma imiphumela emibi yenzeka, kuyadingeka ukufuna usizo lodokotela. Ngokulaliswa esibhedlela, izinkomba ezibonakalayo ze-overdose ziyaqedwa.
Ukuxhumana nezinye izidakamizwa
Lapho uhlanganisa i-fenofibrate nama-anticoagulants ekuphathweni komlomo, ukusebenza ngempumelelo kwomuthi okukhulunywa ngakho kuyakhuphuka. Ngale ndlela yokuxhumana, ingozi yokuphuma kwegazi ikhuphuka ngenxa yokudluliselwa kwe-anticoagulant kusuka kumaprotheni egazi e-plasma.
Ngokusetshenziswa okufanayo kwe-HMG-CoA reductase blockers, ingozi yomphumela onobuthi kumisipha yemisipha inyuka, ngakho-ke uma isiguli sithatha ama-statins, kubalulekile ukukhansela umuthi.
I-cyclosporine inegalelo ekonakaleni kwezinso, ngakho-ke uma uthatha i-Fenofibrate, kumele uhlole njalo isimo somzimba. Uma kunesidingo, ukuphathwa kwesidakamizwa se-hypolipidemic kukhanseliwe.
Ukuhambisana notshwala
Ngesikhathi sokulashwa ngeFenofibrate, kuyenqatshelwe ngokuphelele ukuphuza utshwala. I-ethyl utshwala yenza buthaka umphumela wezokwelapha wesidakamizwa, ithuthukisa imiphumela enobuthi kumaseli wesibindi, isistimu yezinzwa ephakathi nokugeleza kwegazi.
Ama-Analog
Ukufana kwezidakamizwa kufaka phakathi izidakamizwa ezinendlela efanayo yokusebenza:
- Tricor
- I-Atorvacor;
- I-Lipantyl;
- I-Ciprofibrate;
- Canon Fenofibrate amaphilisi;
- I-Livostor;
- Ukuqothuka;
- I-Trilipix.
Ukushintshela komunye umuthi kwenziwa ngemuva kokubonisana nodokotela.
Fenofibrate Imibandela Yeholide Yokhemisi
Umuthi awuthengiswa ngaphandle kwencwadi yesi-Latin.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngenxa yobungozi obukhona be-rhabdomyolysis, ukuthengiswa kwamahhala kwefenofibrate kunqatshelwe.
Malini
Ngamathebulethi we-145 mg, izingcezu ezingama-30 ngephakethe ngalinye, inani eliphakathi kwama-ruble angama-482-541.
Izimo zokugcina zomuthi
Kunconywa ukugcina umuthi emazingeni okushisa aze afike ku-25 ° C endaweni eyomile, etholakala kude nokukhanya kwelanga.
Kunconywa ukugcina umuthi emazingeni okushisa aze afike ku-25 ° C endaweni eyomile, etholakala kude nokukhanya kwelanga.
Isikhathi sokuphelelwa yisikhathi
Amaphilisi we-145 ne-160 mg angagcinwa iminyaka emi-3, ama-180 mg iminyaka emi-2.
Umkhiqizi we-Fenofibrate
I-Fournier Laboratories, e-Ireland.
Fenofibrate Ukubuyekezwa
Kukhona imibono ekhuthazayo evela kosokhemisi neziguli.
Odokotela
U-Olga Zhikhareva, udokotela wezifo zenhliziyo, eMoscow
Iphumelela ekulweni nama-triglycerides aphezulu. Ngincoma ukusebenzisa izinhlobo IIa, IIb, III ne-IV ze-hyperlipoproteinemia. Ekusebenzeni kwemitholampilo, nginquma isikhathi sokuphathwa kanye nomthamo ngamunye. Akukho miphumela emibi eye yabonwa. Akunamphumela omenyezelwe wehlise i-cholesterol.
I-Afanasy Prokhorov, isondli, iYekaterinburg
Ngokukhuluphala kanye ne-cholesterol ephezulu, i-fenofibroic acid isiza kahle. Ikakhulu ekusebenzeni okuphansi kokuzivocavoca nokudla. Ngesikhathi sokulashwa, ngincoma ukuyeka imikhuba emibi futhi ngilandele izincomo zikadokotela ukuze ngisebenze kahle.
Iziguli
UNazar Dmitriev, oneminyaka engama-34 ubudala, Magnitogorsk
Ikhambi elihle. AmaLipid ayi-5.4.Ngokusetshenziswa njalo kweFenofibrate, izinga lamafutha lehle laya ku-1.32. IBorderline yayingu-1.7. Ayikho imiphumela emibi eye yaphawulwa.
U-Anton Makaevsky, oneminyaka engama-29 ubudala, eSt
Wathatha cishe unyaka esikhundleni seTorvacard ngenxa yokuqukethwe okuphansi kwe-HDL. Ngemuva kwezinyanga ezingama-4-5 zokuthatha, ukuhlaselwa kwenhliziyo nobuhlungu esiswini engenhla kwaqala ukubonakala. Ngemuva kwezinyanga eziyi-8-9, basebenzela ukuhlinzwa ukuze basuse i-gallbladder. Kutholakale amatshe e-Viscous bile namatshe axegayo. Ngemuva kokuhlinzwa, ukuhlaselwa kuyema.
UMikhail Taizhsky, oneminyaka engama-53 ubudala, u-Irkutsk
Umuthi uphuze ukuqinisa izindonga zemithambo, kepha angikwazi ukusho ngalesi senzo. Izitsha azizwakali. Ngosizo lomuthi, isisindo sehlile ngenxa yendlala, kepha isikhumba saqina kakhulu. Umsebenzi wokutakula uyadingeka. Ngigculisekile ngomphumela.
