Umuthi we-hypoglycemic Glemaz unqunyelwe iziguli ezinesifo sikashukela sohlobo 2 futhi ungoweqembu elithathwe esizalweni sesithathu. Isetshenziselwa ukulawula ukuhlangana kweglucose egazini.
Igama Lezwe elingafanele
I-Glimepiride (glimepiride).
Umuthi we-hypoglycemic Glemaz unqunyelwe iziguli ezinesifo sikashukela sohlobo 2.
I-ATX
A10BB12.
Khipha amafomu nokwakheka
Umuthi uthengiswa ngohlobo lwamacwecwe wamaxande wamaqhuqhuva wesimo esingunxande nokukhanya okuluhlaza ngombala, 4 mg we-glimepiride (element asebenzayo) kokukodwa. Izindawo ezincane: i-magnesium stearate, udayi ophuzi we-quinoline, udayi wedayimane oluhlaza okwesibhakabhaka, i-microcrystalline cellulose, i-croscarmellose sodium, cellulose.
Ephuthwini le-aluminium / PVC ama-5 noma ayi-10 amaphilisi. Ephaketheni lamakhadibhodi awugqinsi ama-3 noma ama-6 ama-contour.
Isenzo se-Pharmacological
Umuthi ungoweqembu le-hypoglycemic yomlomo. Ingxenye yayo esebenzayo ivuselela amaseli we-pancreatic beta, ithuthukisa ukukhiqizwa kwe-insulin futhi ivimbele i-gluconeogeneis. Umuthi wehlisela i-hyperglycemia ngaphandle kokuthinta ukuhlangana kwe-insulin.
Umphumela we-extrapancreatic wesidakamizwa usekelwe ekwandiseni ukuzwela kwezicubu ezithinta izicubu ze-insulin. I-Hypoglycemic ine-antiatherogenic, antiplatelet nomsebenzi we-antioxidant.
I-Pharmacokinetics
Ngemuva kokuthatha umuthi ongu-4 mg, umuthi ophakeme kakhulu we-ingredient yawo esebenzayo kwi-plasma ubonwa ngemuva kwamahora ayi-2,5. I-Glimepiride ine-bioavailability engu-100% uma idakwe. Ukudla akuzithinti kakhulu izakhiwo ze-pharmacokinetic ze-hypoglycemic.
Cishe i-60% yezidakamizwa ikhishwa yizinso.
Cishe i-60% yezidakamizwa ikhishwa yizinso, 40% ngamathumbu. Emchamweni, into ayitholakali ngendlela engaguquki. Ingxenye yempilo yayo isuka emahoreni amahlanu kuya kwayi-8. Lapho udla izidakamizwa ngemithamo ephezulu ezigulini ezinomsebenzi we-renal okhubazekile (nge-creatinine clearance engaphansi kwama-30 ml / min), kukhona ukwanda kokucaca kanye nokwehla kokuxineka kwe-plasma kanye nomphumela we-glimepiride, okubangelwa ukuthungwa okusheshayo komuthi ngenxa yokuncipha kokubopha kwawo amaprotheni e-plasma.
Izinkomba zokusetshenziswa
I-ejog ye-hypoglycemic imiselwe iziguli ezinesifo sikashukela sohlobo lwe-2 futhi zingasetshenziswa zombili ku-monotherapy futhi zihlanganiswa ne-metformin ne-insulin.
Contraindication
I-Hypoglycemic icutshwe kulezo zimo nokuphazamiseka:
- Uhlobo 1 sikashukela;
- i-leukopenia;
- ukulimazeka okukhulu kwezinso ezigulini ezihlangabezana ne-hemodialysis;
- i-pathologies yesibindi enzima;
- esemncane;
- ukuncelisa kanye nokuthinta;
- i-ketoacidosis yesifo sikashukela kanye nesifo sikashukela nesifo sikashukela;
- komzimba ekwakhekeni kwemithi ye-hypoglycemic.
Umuthi ubekiwe ngokucophelela ezimweni ezidinga ukudluliselwa kwesiguli ukwelashwa kwe-insulin (ukufakwa kokulimala kwezidakamizwa nokudla emgodini wokugaya ukudla, ukusebenza kanzima, ukushiswa nokulimala).
Ungamthatha kanjani uGlemaz?
Umuthi usetshenziswa ngomlomo. Umthamo wansuku zonke kufanele uthathwe ngesikhathi sokudla noma ngaphambi kokudla. Ithebhulethi lithathwa liphelele futhi ligezwa phansi ngengxenye yengilazi yamanzi.
Ngoshukela
Ezinsukwini zokuqala, umuthi ubekwe kumthamo wethebhulethi eyi-1/4 (1 mg yento) 1 isikhathi / usuku. Uma kungekho zinto ezisebenzayo ezinhle, umthamo ungakhuphukela ku-4 mg. Ezimweni ezihlukile, kuvunyelwe ukwedlula imithamo ye-4 mg, kepha kungaphezu kuka-8 mg womuthi onqatshelwe ngosuku.
Imvamisa nenombolo yemithamo ngosuku inqunywa ngokwahlukana, kucatshangelwa indlela yokuphila yesiguli. Ukwelapha kusekude, kufaka ukubhekwa njalo kwamazinga kashukela we-plasma.
Imiphumela emibi Glemaza
Engxenyeni yesitho sombono
Kunethuba lokulimazeka okubonakalayo kwesikhashana ngendlela yombono ophindwe kabili nokulahleka kokucaca kokuqonda.
Kusuka ezicutshini zemisipha
Kukhona ubungozi bokulimala kwemisipha.
Amapheshana wesisu
Imiphumela emibi ibonakaliswa umuzwa wokungakhululeki kanye nosizi esifundeni se-epigastric, ukuhlanza, isicanucanu, ukwanda komsebenzi wama-enzyme wesibindi ne-hepatitis.
Izitho zeHematopoietic
Kwezinye izimo, ukuthuthukiswa kwe-hemolytic kanye ne-aplastic anemia, i-agranulocytosis, i-pancytopenia, i-erythrocytopenia ne-thrombocytopenia kuyaphawulwa.
Isistimu yezinzwa ephakathi
Ezimweni ezingavamile, kukhona ukuwohloka kokuphendula kwengqondo, ikhanda, nokuncipha kokuhlushwa.
Ngasohlangothini lwe-metabolism
Imiphumela yokusabela ye-Hypoglycemic ivela ngokushesha ngemuva kokusebenzisa umuthi. Zingahle zibe nzima.
Allergies
Ngesikhathi sokulashwa ngomuthi, iziguli zingathola imichilo, ukulunywa, ukusabela okuvela emzimbeni kanye ne-sulfonamides nezinye izinto ezifanayo, kanye nefomu le-vasculitis.
Umthelela ekhonweni lokulawula izindlela
Ngokunikezwe ukuthi umuthi ungadala ukuphazamiseka kwe-psychomotor, kunconywa kakhulu ukugwema ukusebenza kwezindlela eziyinkimbinkimbi ngesikhathi sokuphatha kwawo.
Imiyalo ekhethekile
Ukuvela kwe-hypoglycemia ngesikhathi sokusebenzisa umuthi kumithamo ye-1 mg kukhombisa ukuthi i-glycemia ingalawulwa kuphela ngokwelashwa kokudla.
Ezimweni ezicindezelayo, ukudluliselwa kwesikhashana kwesiguli ekwelashweni kwe-insulin kungadingeka.
Ngokudla okunganele ngenkathi uthatha umuthi, ubungozi bokukhula kwe-hypoglycemia luyanda.
Ezimweni ezicindezelayo, ukudluliselwa kwesikhashana kwesiguli ekwelashweni kwe-insulin kungadingeka.
Sebenzisa ebudaleni
Ukuphathwa kwe-Hypoglycemic akubandakanyi ukulungiswa kwamthamo.
Isabelo sezingane
Emazwaneni wezingane, i-ejenti ye-hypoglycemic ayisetshenziswa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa, kwenqatshelwe ukusebenzisa umuthi we-hypoglycemic.
Isicelo sokusebenza kokulimala kwezinso
Ekuphazanyisweni okuqinile kwesitho, umuthi uphambaniswe.
Sebenzisa umsebenzi wesibindi okhubazekile
Kuphikisiwe ukusebenzisa amaphilisi we-pathologies wesibindi asebusweni.
Izimpawu ezingenzeka ze-hypoglycemia nge-overdose yesidakamizwa.
I-overdose Glemaza
Kungaba nezimpawu ze-hypoglycemia (ukujuluka, i-tachycardia, ukukhathazeka, izinhlungu zenhliziyo, ikhanda elibuhlungu, ukukhuphuka kwesifiso sokudla, ukudangala).
Ukwelashwa kufaka phakathi ukwenziwa kokuhlanza, ukudla ama-adsorbents nokuphuza kakhulu. Ezimweni ezimbi kakhulu, ukungezwa kwekhambi le-dextrose kunqunyelwe futhi ngokuqapha ngokucophelela i-glucose okuhlushwa. Ezinye izehlakalo ziyimpawu.
Ukuxhumana nezinye izidakamizwa
Ngokusetshenziswa kanyekanye kwezidakamizwa ezinama-ejenti omlomo we-hypoglycemic, ama-anabolics, i-Metformin, i-Insulin, i-Ifosfamide, i-Fluoxetine kanye neminye eminye imishanguzo, ukwanda komsebenzi we-hypoglycemic kungabonakala.
Ngaphansi kwethonya leReserpine, iGuanethidine, iClinidine ne-beta-blockers, ukungabikho noma buthaka kwezimpawu ze-hypoglycemia kuyaqoshwa.
Ukuhambisana notshwala
Kuyinto engathandeki ukuxubaniswa notshwala ngenxa yokusabela okungalindeleki komzimba.
Ama-Analog
Umuthi we-hypoglycemic ungathathelwa indawo ngama-analogues aphumelelayo nalawo angabizi:
- I-Diamerid;
- I-Glimepiride Canon;
- I-Glimepiride;
- Amaril.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ungathenga i-hypoglycemic kuphela ngokubhaliswa.
Intengo
Ngamathebhulethi angama-30 udinga ukukhokha inani lama-ruble ayi-611-750.
Izimo zokugcina zomuthi
Gcina i-hypoglycemic isuka kude nemisebe yelanga, umswakama ophansi kanye lokushisa kwegumbi. Ubuqotho be-Blister (imifantu) akufanele kwephulwe.
Isikhathi sokuphelelwa yisikhathi
Izinyanga ezingama-24.
Umkhiqizi
Inkampani "Kimika Montpellier S.A." (I-Argentina).
Ukubuyekezwa
Odokotela
UVictor Smolin (owelaphi), oneminyaka engama-41 ubudala, u-Astrakhan.
Lesi sidakamizwa se-hypoglycemic akuyona into entsha emakethe yezokwelapha namuhla. Kuthengisiwe ungathola ama-analogue angasebenzi kahle. Kodwa-ke, odokotela abaningi bakhetha le khambi, ngoba umphumela wayo wokwelapha uhlolwe ngesikhathi uqobo.
Iziguli
U-Alisa Tolstyakova, oneminyaka engama-47, uSmolensk.
Bengilokhu ngiphuza la maphilisi wokuqinisa ushukela isikhathi eside (cishe iminyaka emi-3). Kwakungekho miphumela emibi ngalesi sikhathi. Isimo sami sihle impela, angihleleli ukufaka umuthi esikhundleni salokho, futhi asikho isidingo saso, ngoba izindleko zaso zingifanele ngokuphelele.
Ukulahlekelwa isisindo
U-Antonina Voloskova, oneminyaka engama-39, eMoscow.
Ngalesi sidakamizwa, ngakwazi ukunciphisa isisindo esincane. Naphezu kweqiniso lokuthi anginaso isifo sikashukela, isenzo sakhona sangivumela ukuthi ngilinganise izinga le-glucose egazini, ngenxa yalokho engaqala ukushisa amanoni kakhulu. Umuthi omuhle. Ngathenga amaphakethe amaningana esitokisini ngasikhathi sinye.
