Ukwelashwa kwezifo zamapheshana emathunjini kanye nokuphazamiseka komzimba kuthatha ama-metabolic agents. Umuthi owodwa osebenzayo yi-thioctic (alpha lipoic) acid.
Igama Lezwe elingafanele
I-Thioctic acid.
Ukwelashwa kwezifo zamapheshana emathunjini kanye nokuphazamiseka kwe-metabolic, i-thioctic acid iyathathwa.
I-ATX
I-A16AX01
Ukwakheka
Ukuqanjwa kwethebhulethi eyi-1 kufaka phakathi u-300 mg no-600 mg we-thioctic acid (isakhi esisebenzayo). Ukuhlanganiswa kwefilimu kwethebhulethi kuqukethe izinto ezifana ne-hypromellose, titanium oxide, silicon oxide, dibutylsebacate, talc. Umuthi ufakwa emaphaketheni amakhadibhodi.
Isenzo se-Pharmacological
Umuthi unemiphumela enjalo emzimbeni njengoku:
- antioxidant;
- hypocholesterolemic;
- ukwehliswa kwe-lipid;
- i-hepatoprotective;
- detoxation.
Amathebhulethi e-Thioctic acid yi-antioxidant ye-endo native. Ngohlobo lwesenzo se-biochemical, umuthi useduze namavithamini we-B. Umuthi usiza ukuthuthukisa i-trophism yama-neurons, unciphise ukugcwala kwe-glucose egazini, ukhuphule okuqukethwe kwe-glycogen esibindini, futhi unciphise ukumelana ne-insulin.
Umuthi lo ubandakanyeka ekuphatheni umthetho we-metabolism.
Umuthi ubamba iqhaza ekuphatheni umthetho we-metabolism (lipid ne-carbohydrate), uthuthukisa imetabolism ye-cholesterol, uthuthukisa ukusebenza kwesibindi. I-Alfa-lipoic acid nayo ibandakanyeka ku-mitochondrial metabolism ngaphakathi kweseli.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, umuthi udonswa ngokushesha kusuka emgudwini wesisu. I-C max itholakala ngemuva kwe-0.5 -1 h. I-Bioavailability ingama-30-60% njengomphumela we-presystemic biotransformation. Iyacolisiswa futhi ihlanganiswe esibindini, futhi ivezwa yizinso ngamaphesenti angama-80-90 ngendlela yama-metabolites.
Ayini amaphilisi we-thioctic acid?
Lesi sidakamizwa singasetshenziswa ukwelapha i-pathologies elandelayo:
- i-hepatitis engamahlalakhona;
- ukwehluleka kwesibindi okukhulu
- ukuqina kwesibindi;
- ukudakwa kwamakhowe;
- i-coronary atherosclerosis;
- ifomu elingamahlalakhona le-cholecystopancreatitis;
- i-jaundice ene-hepatitis yegciwane;
- utshwala ne-polyneuropathy yotshwala;
- dyslipidemia;
- i-pancreatitis engapheli ebangelwa ukudakwa;
- ubuthi ngamaphilisi okulala, i-carbon tetrachloride, izinsimbi ezisindayo noma i-carbon;
- isifo sesibindi esinamafutha;
- umfutho wegazi ophansi;
- ukutheleleka ngegciwane;
- ukukhuluphala.
Contraindication
Ungasebenzisi umuthi:
- ngesikhathi sokuncelisa;
- phambi kokubekezelelwa komuntu ngamunye ezingxenyeni zomuthi;
- abesifazane abakhulelwe;
- izingane ezingaphansi kweminyaka engu-6.
Ungawaphuza kanjani amaphilisi we-thioctic acid
Uma ufuna ukunciphisa umzimba, udinga ukudla umuthi ongu-50 mg ngaphambi kokudla kwasekuseni noma ngemuva kokudla kwasekuseni.
Lapho kukhona izifo zesibindi nokunxila, ziphuza ngomlomo izikhathi ezingama-50 mg 3-4 ngosuku ngosuku (abadala). Izingane ezineminyaka engu-6 ubudala - 12-24 mg kathathu ngosuku. Amaphilisi athathwa imizuzu engama-30 ngaphambi kokudla. Inkambo yokwelashwa ihlala izinsuku ezingama-20 kuye kwezingama-30.
Ekwakheni umzimba
Abasubathi abadala kufanele baphuze ama-50 mg izikhathi ezingama-3-4 ngosuku ngemuva kokudla. Ngokuzivocavoca okukhulu komzimba, umthamo wansuku zonke ukhuphuka ufike kuma-300-600 mg.
Abasubathi abadala badinga ukuphuza umuthi ngama-50 mg izikhathi ezingama-3-4 ngosuku ngemuva kokudla.
Imvamisa ekwakhiweni kwemizimba, la macwecwe ahlanganiswa ne-Levocarnitine ne-vitamin complexes, njengoba asiza ukukhipha amanoni emangqamuzaneni, kuvusa ukusetshenziswa kwamandla.
Ngoshukela
Abantu abanesifo sikashukela kufanele bathathe izidakamizwa ezingama-600 mg ngosuku, baphuze ithebhulethi ngamanzi ahlanzekile. Ukwelapha kuqala kuphela ngemuva kwenkambo yamaviki ama-2-4 yokulawulwa kokungena kwezidakamizwa. Isikhathi esincane sokwelashwa ngamathebulethi siyizinsuku ezingama-90.
Imiphumela emibi yamathebulethi e-thioctic acid
Ngokuphikisana nesizinda sokuphuza umuthi, okulandelayo kungavela:
- isicanucanu
- ukuhlanza
- ukushisa kwenhliziyo;
- ukwethuka kwe-anaphylactic;
- i-urticaria;
- I-hypoglycemia (ukungasebenzi kahle kwe-glucose metabolism);
- ukukhuphuka kwengcindezi ye-intracranial;
- i-diplopia (ukufiphaza kwezinto ezibonakalayo);
- ukukhomba ama-hemorrhages esikhunjeni kanye nolwelwesi lwama-mucous;
- ukuthambekela kokuphuma kwegazi ngenxa yokuphazamiseka kwemisebenzi ye-platelet.
Imiyalo ekhethekile
Lapho usebenzisa amaphilisi ezigulini ezinesifo sikashukela, kuyadingeka ukulawula ushukela wegazi kaningi. Uma kunesidingo, ukunciphisa umthamo wezidakamizwa ezilwa nesifo sikashukela.
Isabelo sezingane
Umuthi awubekelwe intsha eneminyaka engaphansi kwengu-18 ekwelashweni kwesifo sikashukela nesiphuzo esidakayo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akunconyelwe ukusebenzisa umuthi ngesikhathi sokukhulelwa nokuqunjelwa.
Ukuhambisana notshwala
Umuthi awukwazi ukuhlanganiswa nokuphuza utshwala, ngoba buthaka umphumela we-thioctic acid.
Umthelela ekhonweni lokulawula izindlela
Umuthi awuthinti amandla okulawula izindlela.
Ukweqisa
Uma umthamo ovumelekile womuthi udluliwe, lokhu okulandelayo kungenzeka:
- isifo sohudo
- isicanucanu
- Ubuhlungu be-epigastric;
- ubunzima bokuphefumula
- ukuqhuma kwesikhumba;
- i-migraine
- ukuzindla kwenhliziyo.
Ukuxhumana nezinye izidakamizwa
Umuthi ngendlela yamathebulethi uthuthukisa umphumela wokwelapha wezidakamizwa we-hypoglycemic womlomo kanye ne-insulin.
Umuthi ungakhuthaza umphumela we-glucocorticosteroids futhi uvimbele umsebenzi we-cisplatin.
Lawa mathebhulethi awanconywa ukuba ahlanganiswe nemithi equkethe i-ion yensimbi.
Ama-Analog
Uhlu lwe-analogues:
- I-Alpha lipoic acid (i-powder);
- Tiolepta;
- I-Thiogma;
- I-Thioctacid;
- I-Espa-Lipon (ikhambi lokujova).
Imibandela yekhefu lekhemisi
Iholide elinikezwa.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo
Izindleko zepakethe elilodwa lemithi (amaphilisi angama-50) angama-ruble angama-60.
Izimo zokugcina zomuthi
Kuyadingeka ukugcina izidakamizwa ekushiseni kwe- + 15 ... + 25 ° C endaweni eyomile, emnyama futhi engafinyeleleki ezinganeni.
Kuyadingeka ukugcina izidakamizwa ekushiseni kwe- + 15 ... + 25 ° C endaweni eyomile, emnyama futhi engafinyeleleki ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Izinyanga ezingama-36 kusukela ngosuku lokwenziwa, oluboniswa ebhokisini lekhadibhodi.
Umkhiqizi
I-OJSC "Marbiopharm", eRussia.
Ukubuyekezwa
Odokotela
UPetr Sergeevich, oneminyaka engama-50 ubudala, ongumondli wezempilo, uVolgograd
I-Thioctic acid isheshisa ukuguqulwa kwama-carbohydrate angenasidingo abe amandla. Ngenxa yalokhu, amadiphozithi wamafutha aqala ukuncipha, futhi isifiso sokudla siyancipha. Kwabantu abakhuluphele ngokweqile, ngincoma ukuthatha lo muthi ngokuhambisana nokudla okufanele kanye nokuzivocavoca umzimba.
UMaria Stepanovna, oneminyaka engama-54, udokotela wezokwelapha, uYalta
Lezi zibhebhe ziyithuluzi elisebenzayo ekwelapheni izifo eziningi. Isenzo salo muthi sihloselwe ukulawula i-carbohydrate kanye ne-lipid metabolism, silinganise amazinga we-cholesterol, kanye nokwenza umsebenzi wesibindi kanye nokulwa ukudakwa kwemvelaphi ehlukahlukene. Umuthi ubekezelelwa kahle, ezimweni ezingandile, kunezikhalazo zokukhanda ikhanda kanye nenausea.
U-Ekaterina Viktorovna, oneminyaka engama-36 ubudala, udokotela wobuchopho, uSaratov
Nginikeza lo muthi ezigulini ezinesifo sikashukela se-polyneuropathy. Ngasikhathi sinye, ngiqapha ngokucophelela izinga le-glucose egazini, ikakhulukazi ekuqaleni kokwelashwa. I-Thioctic acid ikhombisa ukusebenza kahle okuphezulu ekwelapheni lesi sifo.
Iziguli
UVictor, oneminyaka engama-45, uTuapse
Ngiphuza la maphilisi njengoba kuchazwe ngudokotela ukwehlisa i-cholesterol yegazi. Umuthi awususi kuphela ama-acid agcwele amabi emzimbeni, kodwa futhi uthinta umzimba wonke. Ngemuva kwenkambo yokwelashwa, isimo saba ngcono. Ngemuva kwezinsuku eziyi-14 zokuthatha la maphilisi, amazinga e-cholesterol anciphile.
UGrigory, oneminyaka engama-42 ubudala, uNovorossiysk
Wathola ukwelashwa ngalo muthi ekuncomeni kadokotela ukuthi ajwayele ushukela wegazi. Ngokwezinkomba zaselabhorethri - okujwayelekile, isidakamizwa sithokozela ukusebenza kwaso. Manje ngiphuza la maphilisi kanye ngonyaka ngezinjongo zokuvimbela, ngoba kunokuthambekela kofuzo kushukela.
