Ama-insulin asebenza isikhathi eside asetshenziselwa ukugcina inani elihlala njalo le-hormone ngohlobo 1 nohlobo 2 lwesifo sikashukela. Le mishanguzo ifaka iTresiba eyenziwe nguNovo Nordisk.
I-Tresiba isidakamizwa esuselwa kwi-hormone yesenzo esikhulu ngokweqile.
Kuyi-analogue entsha ye-basal insulin. Inikeza ukulawulwa okufanayo kwe-glycemic ngengozi encishisiwe ye-nocturnal hypoglycemia.
Izici nezenzo ze-pharmacological
Izici zalo muthi zifaka:
- ukuncipha okuzinzile futhi okubushelelezi kushukela;
- isenzo esingaphezu kwamahora angama-42;
- ukungafani okuphansi;
- ukuncipha okungaguquki kashukela;
- iphrofayili yokuphepha enhle;
- kungenzeka ukuthi kube noshintsho oluncane ngesikhathi sokuphathwa kwe-insulin ngaphandle kokuyekethisa impilo.
Umuthi ukhiqizwa ngohlobo lwama-cartridges - "Tresiba Penfil" kanye nesirinji lapho amasendeji ebekwa khona uphawu - "Tresiba Flexstach". Isithako esisebenzayo yi-insulin Degludec.
I-Degludec ibopha ngemuva kokuvunyelwa kumaseli wamafutha nemisipha. Kukhona ukufakwa kancane kancane nokuqhubekayo emgudwini wegazi. Ngenxa yalokho, kwakheka ukwehla okungaguquki kweglucose yegazi.
Umuthi ukhuthaza ukumunca ushukela ngama-tishu kanye nokuvinjwa kokukhipha kwawo kusuka esibindini. Ngokunyuka komthamo, umphumela wokwehlisa ushukela uyakhuphuka.
Iqoqo lokulinganisa le-hormone lakhiwa ngokwesilinganiso ngemuva kwezinsuku ezimbili zokusetshenziswa. Ukukhishwa okudingakalayo kwento kuhlala amahora angaphezu kwama-42. Ukuqedwa kwesigamu sempilo kwenzeka ngosuku.
Izinkomba zokusetshenziswa: uhlobo 1 no-2 sikashukela kubantu abadala, isifo sikashukela ezinganeni kusuka kunyaka owodwa.
Ukuxhumana kokuthathwa kokuthatha i-Tresib insulin: ukungezwani nezakhi zezidakamizwa, ukungabekezelelani kwe-Degludek.
Imiyalo yokusebenzisa
Umuthi uphathwa kangcono ngasikhathi sinye. Ukwamukela kwenzeka kanye ngosuku. Iziguli ezinesifo sikashukela sohlobo lwe-1 zisebenzisa i-Degludec ngokuhlangana nama-insulin amafushane ukuze zivinjelwe lapho zidingeka.
Iziguli ezinesifo sikashukela zithatha umuthi ngaphandle kokubheka ukwelashwa okwengeziwe. I-Tresiba iphathwa ngokuhlukile futhi ihlanganiswe nezidakamizwa ezibunjiwe noma enye i-insulin. Ngaphandle kokuguquguquka ekukhetheni isikhathi sokuphatha, isikhawu esincane kufanele okungenani sibe amahora angama-8.
Umthamo we-insulin ubekwa udokotela. Kubalwa ngokusekelwe kuzidingo zesiguli ezisehomoni ngokubhekisele ekuphenduleni kwe-glycemic. Umthamo onconyiwe amayunithi ayi-10. Ngezinguquko ekudleni, imithwalo, ukulungiswa kwayo kuyenziwa. Uma isiguli esinesifo sikashukela sohlobo 1 sithatha i-insulin kabili ngosuku, inani le-insulin elilawulwa linqunywa ngawodwana.
Lapho ushintshela eTresib insulin, ukugxilisa ushukela kulawulwa kakhulu. Kunakwa kakhulu izinkomba ngeviki lokuqala lokuhumusha. Isilinganiso esisodwa kuya kwesisodwa ukusuka kumthamo wangaphambilini womuthi siyasetshenziswa.
I-Tresiba ithelwa ngejubane kulezi zindawo ezilandelayo: ithanga, ihlombe, udonga lwangaphambili lwesisu. Ukuvimbela ukuthuthukiswa kokucasulwa nokudlanga, indawo iyashintsha impela endaweni efanayo.
Kuyenqatshelwa ukuphatha i-hormone emzimbeni. Lokhu kuvusa kakhulu i-hypoglycemia. Umuthi awusetshenziswa kumaphampu we-infusion naku-intramuscularly. Ukukhwabanisa okokugcina kungashintsha izinga lokufakwa.
Imiyalo yevidiyo yokusebenzisa ipeni lesirinji:
Imiphumela emibi kanye ne-overdose
Phakathi kokusabela okungekuhle ezigulini ezithatha i-Tresiba, okulandelayo kwabonwa:
- i-hypoglycemia - kaningi;
- lipodystrophy;
- i-edema yangaphandle;
- ukungahambi kahle kwesikhumba;
- ukusabela endaweni yokujova;
- ukuthuthukiswa kwe-retinopathy.
Ngenqubo yokuthatha umuthi, i-hypoglycemia yobunzima obuhlukahlukene ingavela. Izinyathelo ezahlukahlukene zithathwa ngokuya ngesimo.
Ngokuncipha okuncane kwe-glycemia, isiguli sisebenzisa ama-20 g kashukela noma imikhiqizo enokuqukethwe kwayo. Kunconywa ukuthi ngaso sonke isikhathi uphathe ushukela ngokweqile.
Ezimweni ezinzima, ezihambisana nokulahlekelwa ukwazi, kwethulwa i-glucagon ye-IM. Isimo esingaguquki, kwethulwa ushukela. Isiguli siqashwa amahora amaningi. Ukuqeda ukubuyela emuva, isiguli sithatha ukudla kwe-carbohydrate.
Iziguli Ezikhethekile Nezinkomba
Imininingwane yokuthatha umuthi eqenjini elikhethekile leziguli:
- I-Tresiba ivunyelwe ukusetshenziswa ngabadala. Lesi sigaba seziguli kufanele siqaphe amazinga kashukela kaningi.
- Azikho izifundo ngomphumela womuthi ngesikhathi sokukhulelwa. Uma kuthathwe isinqumo sokuphuza umuthi, kunconyelwa ukuthi kuqashwe kakhulu izinkomba, ikakhulukazi ku-2nd ne-3rd trimester.
- Futhi akukho datha emiphumeleni yesidakamizwa ngesikhathi sokuqunjelwa. Ngenqubo yokondla izingane ezisanda kuzalwa, ukusabela okubi akubhekwanga.
Lapho uthatha, ukuhlanganiswa kweDegludek nezinye izidakamizwa kuyabhekelelwa.
Ama-Anabolic steroid, i-ACE inhibitors, ama-sulfonamides, ama-adrenergic blockers, ama-salicylates, izidakamizwa ezinciphisa ushukela wethebhulethi, ama-inhibitors we-MAO anciphisa amazinga kashukela.
Imithi ekhulisa isidingo se-hormone ifaka phakathi i-sympathomimetics, glucocorticosteroids, Danazole.
I-Alcohol ingathinta isenzo seDegludek zombili izindlela zokunyusa futhi zinciphise umsebenzi wayo. Ngokuhlanganiswa kweTresib nePioglitazone, ukuhluleka kwenhliziyo, ukuvuvukala kungaqala ukukhula. Iziguli zingaphansi kokuhlolwa udokotela ngesikhathi sokwelashwa. Uma kwenzeka ukuthinteka kwenhliziyo kusebenza, isidakamizwa siyamiswa.
Kwezifo zesibindi nezinso ngesikhathi sokwelashwa nge-insulin, kukhethwa umthamo ngamunye. Iziguli kufanele zilawule ushukela kaningi. Kwezifo ezithathelwanayo, ukungasebenzi kahle kwe-yegilo, ukucindezelwa kwezinzwa, isidingo sokushintsha okusebenzayo komthamo.
Imithi enomphumela ofanayo, kepha ngesakhi esisebenzayo esihlukile, kufaka phakathi i-Aylar, iLantus, iTujeo (insulin Glargin) neLevemir (insulin Detemir).
Ekuhlolweni kokuqhathanisa kweTresib nezidakamizwa ezifanayo, ukusebenza okufanayo kunqunywe. Ngesikhathi sokutadisha, bekukhona ukuntuleka kwama-sukari ngokuzumayo, inani elilinganiselwe le-hypoglycemia yasesikhathini.
Ubufakazi besifo sikashukela futhi busebenza njengobufakazi bokusebenza nokuphepha kweTreshiba. Abantu baqaphela isenzo esibushelelezi nokuphepha komuthi. Phakathi kokuphazamiseka, kuqokonyiswa intengo ephezulu yeDegludek.
Ngibe nesifo sikashukela iminyaka engaphezu kwe-10. Muva nje ngishintshele kuTresibu - imiphumela mihle kakhulu isikhathi eside. Isidakamizwa sehlisa ukusebenza ngokulinganayo nangokushelela kukaLantus noLevemir. Ngivuka noshukela ojwayelekile ekuseni ngakusasa ngemuva komjovo. Akukaze kube ne-nocturnal hypoglycemia. Okuwukuphela "kodwa" inani eliphakeme. Uma imali ivumela, kungcono ukushintshela kulo muthi.
U-Oksana Stepanova, oneminyaka engama-38, eSt
I-Tresiba isidakamizwa esihlinzeka nge-basal secretion ye-insulin. Inephrofayli enhle yokuphepha, ihlisa ushukela kahle. Ukubuyekezwa kweziguli kuqinisekisa ukusebenza kwayo nokuqina. Intengo ye-Tresib insulin ingama-ruble angama-6000.
