I-Lysoril, noma i-lisinopril dihydrate, umuthi wethebhulethi osetshenziselwa ukwehlisa umfutho wegazi lapho ukhuphuka (umfutho wegazi ophakeme).
Igama Lezwe elingafanele
Lisinopril.
I-Lysoril, noma i-lisinopril dihydrate, umuthi osetshenziselwa ukwehlisa umfutho wegazi lapho ukhuphuka.
I-ATX
Umuthi une-encoding C09AA03 Lisinopril.
Khipha amafomu nokwakheka
Kutholakala ngezindlela ezifana namathebulethi anesilinganiso esingu-2,5; 5; 10 noma 20 mg ngamunye.
Njengengxenye yesidakamizwa, into esemqoka esebenzayo yi-lisinopril dihydrate. Izingxenye ezingeziwe yi-mannitol, i-calcium hydrogen phosphate dihydrate, i-magnesium stearate, isitashi sommbila, i-E172, noma i-iron ironideide.
Izibhebhe ziyindilinga, i-biconvex, ipinki ngombala.
Isenzo se-Pharmacological
Kubhekiswa ezidakamizweni ezithinta isimo sohlelo lwezinhliziyo. Umuthi uvimbela ukuguqulwa kwe-angiotensin 1 kuya ku-angiotensin 2, unomphumela we-vasoconstrictor futhi uvimbela ukwakheka kwe-adrenal aldosterone. Yehlisa ukumelana kwemithambo yegazi, umfutho wegazi, ingcindezi kuma-capillaries wamaphaphu, ukulayisha kuqala. Kuthuthukisa ukuphuma kwenhliziyo futhi kukhulisa ukubekezelela okune-myocardial kubantu abanokwehluleka kwenhliziyo.
Ukwehlisa umfutho wegazi kwenzeka ihora ngemuva kokuthatha umuthi.
Ngokusebenzisa isikhathi eside kweLizoril, ukwehla kwe-myocardial hypertrophy kanye nezindonga zempi zohlobo lokuphilayo kuyabonakala. Ukwehlisa umfutho wegazi kwenzeka ihora ngemuva kokuthatha umuthi. Umphumela omkhulu kakhulu utholakala ngemuva kwamahora ayi-6, isikhathi somphumela cishe usuku. Kuya ngethamo lento, isimo somzimba, umsebenzi wokusebenza wezinso nesibindi.
I-Pharmacokinetics
Ukuhlushwa okuphezulu kakhulu kugcinwa amahora angama-7 ngemuva kokuphatha. Isilinganiso esimaphakathi esithwelwe emzimbeni singama-25%, ubuncane bungama-6%, kanti isilinganiso singama-60%. Ezigulini ezinokwehluleka kwenhliziyo, i-bioavailability incishiswa ngo-15-20%.
Kukhishwe kumchamo kungashintshiwe. Ukudla akukuthinti ukumunwa. Izinga lokungena ngaphakathi kwe-placental and blood-brain barrain liphansi.
Izinkomba zokusetshenziswa
Umuthi unqunywe ezimweni ezinjalo:
- ukwelashwa kwesikhashana esifushane kwe-infutate ye-myocardial acute (kufika kumaviki ayi-6);
- i-arterial hypertension;
- isifo sikashukela i-nephropathy (ukuncishiswa kwamaprotheni kumchamo ezigulini ezinesifo sikashukela esinomfutho wegazi ojwayelekile nophakeme).
Contraindication
Akuvunyelwe ukuthatha uma kukhonjwa:
- I-Hypersensitivity kunoma iyiphi ingxenye yesidakamizwa noma yezidakamizwa eqenjini elifanayo le-pharmacological.
- I-Edema emlandweni wohlobo lwe-angioneurotic.
- I-hemodynamics engazinzile ngemuva kokuqanjwa kwe-myocardial infalction.
- Ukuba khona kwenani eliphakeme le-creatinine (ngaphezu kwe-220 μmol / l).
Umuthi lo we-contraindicated ezigulini eziphethwe yi-hemodialysis, kanye nabesifazane ngesikhathi sokukhulelwa nokuqunjelwa.
Ngokunakekela
Umuthi ubekelwa ngokucophelela lapho kukhona i-arterial stenosis noma ama-valve - ama-mitral kanye ne-aortic, izinso kanye nesibindi, isifo senhliziyo esibuhlungu, amazinga aphezulu e-potassium, ngemuva kokuhlinzwa nokulimala okusha muva nje, ngesifo sikashukela i-mellitus, izifo zegazi, ukungezwani komzimba.
Ungayithatha kanjani iLizoril?
Ngaphakathi isikhathi esingu-1 ngosuku. Umthamo wesidakamizwa ukhethwa ezimweni ngazinye. Imvamisa, ukwelashwa kuqala nge-10 mg. Bese ulungiswa uma kunesidingo.
Ngoshukela
Ezigulini ezinesifo sikashukela sohlobo 2, isilinganiso sokuqala somuthi singu-10 mg 1 isikhathi ngosuku.
Imiphumela emibi ye-Lizoril
Umuthi ungadala imiphumela emibi, eminye yayo ihambe yodwa, abanye badinga ukwelashwa.
Amapheshana wesisu
Umlomo owomile kanye nenausea, ukugabha, ukuqaqamba kwamathumbu, ukuhanjiswa yisisu, ukuqunjelwa, ukuqina kwamanyikwe, ukwehla kwesifiso sokudla, ukwehluleka kwesibindi, i-jaundice, i-cholestasis, i-angioedema yamathumbu, uhlobo lwe-hepatitis ye-hepatitis.
Izitho zeHematopoietic
Ukuncishiswa kwe-hematocrit ne-hemoglobin, ukuvimbela umsebenzi wamathambo abomvu, izinguquko ekuhambeni kwegazi lobuchopho, i-thrombocytopenia, i-agranulocytosis, i-neutropenia, i-leukopenia, izifo ze-autoimmune, i-lymphadenopathy, i-hemolytic hlobo anemia.
Isistimu yezinzwa ephakathi
Ukuqwashiswa okungenamsoco, ukufiphala, imisipha yemisipha, umuzwa wokuhogela, wehlise ukuqina okubonakalayo, i-tinnitus, umuzwa ongathandeki nokunambitha, izinkinga zokulala, ukushintshashintsha kwemizwelo, ukukhanda ikhanda nesiyezi, izinkinga ngokuxhumana.
Kusuka ohlelweni lokuphefumula
Izifo zokuphefumula ezikhuphukayo eziphezulu, ukukhwehlela, i-rhinitis, ukuphefumula kanye ne-spasm, ukuphefumula, ukuvuvukala kwesinono somoya, ukungezwani komzimba, inyumoniya.
Kusuka ohlelweni lwezinhliziyo
I-Orthostatic phenomena (i-arterial hypotension), unhlangothi, i-myocardial infarction, isifo sikaRaynaud, i-palpitations, ukushaqeka kwe-cardiogenic, ukuvimba kwenhliziyo ama-degree ama-1-3, ukukhuphuka kwengcindezi kuma-capillary we-pulmonary capillaries.
Allergies
Ukuvela okungenzeka okuvela esikhunjeni nasendlaleleni eshintshashintshayo efana nokugoqa, ukulunywa, ukuzwela okukhulayo - i-angioedema, ukuvuvukala kwezicubu zobuso nentamo, i-hyperemia, i-urticaria, i-eosinophilia.
Ukuvela okungenzeka okuvela esikhunjeni nasendleleni engasindi, njengokuhlikihla, ukulunywa.
Umthelela ekhonweni lokulawula izindlela
Ngoba lapho uthatha i-Lizoril, kungahle kube nesiyezi, ukulahleka kokuma, lapho-ke lapho usebenza nezinqubo eziyinkimbinkimbi nezimoto zokushayela, kufanele kuqashelwe ngokwedlulele noma lolu hlobo lomsebenzi luzoshiywa uma kungenzeka.
Imiyalo ekhethekile
Umthamo wesidakamizwa ungahlukahluka, kuya ngeminyaka, isimo esisebenzayo sezitho (inhliziyo, isibindi, izinso, imithambo yegazi).
Isifo senhliziyo, i-cerebrovascular pathology, ukuhluleka kwenhliziyo, ukushaya kwenhliziyo, unhlangothi, i-arterial hypotension. Ngakho-ke, ukulungiswa komthamo nokuqapha njalo kwesimo seziguli kuyadingeka.
Sebenzisa ebudaleni
Kudingeka ukulungiswa kwesilinganiso
Isabelo sezingane
Umuthi uphambaniswe ezinganeni, ngoba azikho izifundo zokwelashwa ezenziwayo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Musa ukuqoka.
Isicelo sokusebenza kokulimala kwezinso
Lapho kunqunywa imali ezigulini ezihluleka yizinso, irejimeni yemithamo inqunywa izinga le-creatinine egazini kanye nokuphendula komzimba ekwelashweni.
Lapho kunqunywa imali ezigulini ezihluleka yizinso, irejimeni yemithamo inqunywa izinga le-creatinine egazini kanye nokuphendula komzimba ekwelashweni.
Nge-bilateral renal stenosis, umuthi ungadala ukunyuka kwegazi le-urea kanye namazinga e-creatinine, umfutho wezinso wezinso, noma ukuqina kakhulu kwegazi kanye nokwehluleka kwe-renal okubi. Ngama-anamnesis anjalo, kuyasiza ukunquma ngokucophelela ukungena kwama-diuretics futhi uqaphe ngokunembile umthamo, ulawule izinga le-potassium, i-creatinine ne-urea.
Ngokuthuthukiswa kwe-myocardial infarction ezigulini ezinomsebenzi wezinso ongasebenzi kahle, i-Lizoril is contraindicated.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukusetshenziswa kwomuthi kuyaqabukela kungadala ukuphazamiseka kohlelo lwe-hepatobiliary. Kodwa-ke, kwesinye isikhathi ngesibindi esivele sengozini, i-jaundice, i-hyperbilirubinemia / hyperbilibinemia, kanye nokwanda komsebenzi we-hepatic transaminase kungaqalwa. Kulokhu, umuthi ukhanseliwe.
Ukweqisa kwe-lizoril
Izimpawu ziboniswa ngesimo sokwehla komfutho wegazi, ukungalingani kuma-electrolyte, ukwehluleka kwezinso, i-tachy noma i-bradycardia, isiyezi, ukukhwehlela, ukukhathazeka. Ukwelashwa okubonakalayo kuyenziwa.
Isiyezi singesinye sezimpawu zokweqisa.
Kuzodingeka ukuthi uhlambe isisu, uvuse ukugabha, unikeze izangoma noma ucofoze umzimba. Ezimweni ezinzima, ukwelashwa kwe-infusion kunqunyelwe, ama-catecholamines aphathwa ngokuhlinzwa.
Ukuxhumana nezinye izidakamizwa
Ama-diuretics: kukhona ukwanda komphumela wehlise umfutho wegazi.
I-Lithium: Ukusetshenziswa okuvumelanayo akunconywa. Ubuthi banda. Uma kunesidingo, lawula izinga le-lithiamu egazini.
Ama-NSAIDs: umphumela we-ACE inhibitors uyancipha, kukhona ukwanda kwe-potassium egazini, okwandisa ingozi yokulimala kwezinso.
Izidakamizwa zesifo sikashukela: ukwehla okunamandla kwe-glucose yegazi, ingozi ye-hypoglycemia ne-coma iyanda.
Ama-estrogens: gcina amanzi emzimbeni, ngakho-ke angehlisa umphumela wesidakamizwa.
Ezinye izidakamizwa zokunciphisa umfutho wegazi kanye nama-antidepressants: ubungozi bokwehla ngamandla kwengcindezi yegazi.
Ukuhambisana notshwala
Akukho. Mhlawumbe ukwanda komphumela we-hypotensive we-lisinopril, i-hypotension ye-arterial kungaqala ukukhula.
Ama-Analog
Izimpawu ezifanayo zeLysoril yiLisinoton, iLisinopril-Teva, i-Irumed, ne-Lisinopril, ne-Diroton.
Imibandela yekhefu lekhemisi
Ukwethulwa kwencwadi kadokotela edingekayo.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo
Izindleko zephakeji engu-1 zihlukile kuye ngenani lamathebulethi nomthamo. Ngakho-ke, intengo yamathebulethi angama-28 we-5 mg wezinto zingama-ruble ayi-106.
Izimo zokugcina zomuthi
Kunconywa ukugcina umkhiqizo endaweni lapho izingane zingafinyeleleki khona. Umbuso wokushisa akufanele udlule ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Akudluli iminyaka emithathu.
Umkhiqizi
Inkampani yaseNdiya Ipka limited Laboratories.
Umuthi uphambaniswe ezinganeni, ngoba azikho izifundo zokwelashwa ezenziwayo.
Ukubuyekezwa
U-Oksana, oneminyaka engama-53, uMinsk: "ILizoril yaqokwa eminyakeni emi-3 eyedlule ngenxa yomfutho wegazi ophakeme. Amaconsi ngalesi sikhathi abe esejwayelekile kakhulu. Noma ngabe izinga lokucindezela likhuphuka, aliphezulu kangako (ngaphambi kuka-180). Ngayeka ukwesaba ukuhlaselwa yisifo sohlangothi. akukho ukubonakaliswa okuvelile. "
UMaxim, oneminyaka engama-28 ubudala, uKrymsk: "Ngibe nomfutho we-hypertension kusuka ebuntwaneni. Ngazama imishanguzo eminingi ngalesi sikhathi, kepha ukucindezelwa kwengcindezi kwenzeka kaningi. Eminyakeni emibili eyedlule, udokotela wanikeza isifundo noLizoril. Izimpawu manje cishe azikhathazeki, okubaluleke kakhulu, akukho ukwehla okukhulu kakhulu ingcindezi, futhi ngaphambi kwalokho ngangihlala ngilahlekelwa yimizwa ngenxa yalokhu. I-Hypertension ilawulwa. nginelisekile. "
U-Ana, oneminyaka engama-58 ubudala, uSt. Petersburg: "Sekuyizinyanga eziyisithupha ngisebenzisa lesi sidakamizwa (ngokulawulwa kwe-creatinine). Izinga lokucindezela selibuyele kwesejwayelekile. Ubunzima bukhona lokuthi ngine-nephropathy ngokumelene nesizinda sohlobo lwe-2 yesifo sikashukela, ngakho-ke ngivame ukuvivinya futhi ngezikhathi ezithile udokotela Ishintsha imithamo. Kepha ngiyawuthanda umuthi ngoba akukho miphumela emibi futhi kulula ukuwuphuza kanye ngosuku. "
