Okuhle nezinzuzo zamathebulethi e-Amaril: bathini ngaye ngokubuyekezwa nokuthi bawusebenzisa kanjani umuthi?

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Abantu abaningi banesifo sikashukela. Ngaphezu kwalokho, minyaka yonke isibalo sabantu abahlaselwa yilesi sifo sikhula kuphela.

Akunakwenzeka ukwelapha ukugula okunjalo, noma kunjalo, kungenzeka ukuyilawula futhi ugcine isimo esijwayelekile somzimba.

Ukuze wenze lokhu, khiqiza izidakamizwa ezahlukahlukene, esinye kuzo yi-Amaryl. Ukubuyekezwa okuthatha lesi sidakamizwa kuvame ukuthi kube okuhle. Into esemqoka ukugcina umthamo nesikhathi sokuphatha. Funda kabanzi ngomuthi okule ndatshana.

Isenzo se-Pharmacological

Ukulungiswa kweqembu le-sulfonylurea kubhekisela kuma-hypoglycemic agents ekusebenziseni ngomlomo. Ngokuvimba iziteshi ezithembele ku-cytoplasmic potassium ATP zamaseli e-beta akuma-pancreas, ukugqugquzela kokucashuka kwenzeka.

Ngenxa yalokhu, i-insulin ikhishwa kumaseli e-beta, okubonisa umphumela we-pancreatic. Umphumela we-extrapancreatic uyabonakala futhi, ngoba isenzo se-insulin sithuthukiswa.

Amaril

Into esebenzayo yesidakamizwa iyakwazi ukuhlangana ngokushesha ngokwanele ne-beta-cell protein. Isisindo sayo samangqamuzana yi-65 kD / SURX. Kukhona i-exocytosis ye-insulin. Kubalulekile ukuthi okuqukethwe yi-hormone nomphumela wayo ongasho lutho kuyisihluthulelo sokunciphisa ubungozi be-hypoglycemia.

I-Amaryl futhi ine-antioxidant, antiplatelet, anti-atherogenic effect. Umphumela wayo udlulela ohlelweni lwezinhliziyo, unciphisa ukumelana ne-insulin. Ukusetshenziswa kweglucose ngemisipha ne-adipose izicubu kukhuphuka ngenxa yokuba khona kwamaprotheni athize okuhambisa.
Ngokwandisa umsebenzi wabo, ithuluzi lisiza ukuthathwa kwe-glucose engcono. I-Lipogenesis ne-glycogeneis nayo ihambelana.

Ukukhiqizwa kwe-hepatic glucose kuvinjiwe, ngenxa yokuthi inani le-fructose-2,6-bisphosphate ku-hepatocytes landa.

Ukufihlwa kwe-COX ngesikhathi sokuphatha umuthi kuvinjiwe, i-arachidonic acid inciphisa ukuguqulwa. Lokhu kusebenza ukwehlisa ukuhlangana kweplatelet, i.e. kunomphumela we-antithrombotic.

I-Alpha-tocopherol iyanda lapho ivezwa umuthi. Ngaphezu kwalokho, umsebenzi we-superoxide dismutase, i-catalase, i-glutathione peroxidase iyathuthukiswa, futhi ukusabela kwe-oxidative okwenzeka ku-mellitus yesifo sikashukela kuyancishiswa.

Izinkomba zokusetshenziswa

I-Amaryl yakhelwe kuphela ukusetshenziswa kuhlobo 2 sikashukela. Yisebenzise njenge-monotherapy, kanye nokwelashwa okuhlanganisayo. Umuthi i-Amaril wohlobo 2 sikashukela unezibuyekezo ezinhle lapho uthathwa nge-metformin noma i-insulin.

Ukwakheka komuthi, ifomu lokukhulula

I-Amaryl ikhiqizwa ngendlela yamathebulethi, angaba nomthamo ohlukile, okungukuthi, 1, 2, 3, 4 mg.

Umuthi osebenzayo lapha yi-glimepiride, futhi izinto ezisizayo zifaka i-lactose monohydrate, i-magnesium stearate, i-microcrystalline cellulose, udayi i-E132 ne-E172, i-povidone.

Ithebhulethi ngayinye inomugqa ohlukanisayo, kanye nokukhipha. Iphakethe lelo liqukethe amabhulashi amabili lapho kukhona khona amaphilisi ayi-15.

Kulula ukuhlukanisa amaphilisi ngemithamo ehlukene ngenxa yemibala yawo ehlukile. Amathebulethi anento esebenzayo i-1 mg epinki, 2 mg eluhlaza, 3 mg ophuzi, 4 mg oluhlaza okwesibhakabhaka.

Contraindication

I-Amaril akufanele ithathwe kumacala alandelayo:

  • ukucaphuna nokukhulelwa;
  • thayipha i-1 isifo sikashukela;
  • ukungabekezelelani komuntu ngamunye kwizakhi;
  • iminyaka yezingane;
  • isifo sikashukela sikashukela;
  • izifo zesibindi nezinso;
  • ukuntuleka kwe-lactose, i-glucose-galactose malabsorption.
Kubaluleke kakhulu ukuthi uthathe ngokucophelela ngesonto lokuqala. Kuhle ukuqapha isimo somzimba ukunciphisa ingozi yemiphumela emibi, kufaka phakathi i-hypoglycemia.

Imiphumela emibi

Ngokusebenzisa kabi umuthi, imiphumela eminingi emibi ingatholakala:

  • ukuphazamiseka kohlelo lwezinzwa: ukozela, ukuntuleka kokuxhumana, ukudangala, ukukhathala, ukudideka, isiyezi, i-paresis, ukwethuka, i-aphasia, ukukhathazeka, ukuphazamiseka okubukwayo nokuzwa, ulaka, ukuphazamiseka kokulala, ikhanda, ukulahlekelwa ukuzithiba, ukwehluleka;
  • uhlelo lwenhliziyo - i-tachycardia, i-angina pectoris, i-hypertension ye-arterial, i-bradycardia, ukuphazamiseka kwesigqi senhliziyo;
  • isifo se-metabolic - Ukuhlonza ukusabela kwe-hypoglycemic;
  • ipheshana emathunjini - Ubuhlungu besisu, ukugabha, i-jaundice, isifo sohudo, ukwehluleka kwesibindi, i-hepatitis, i-cholestasis;
  • uhlelo lokujikeleza - i-thrombocytopenia, i-granulocytopenia, i-agranulocytosis, i-erythrocytopenia, i-hemolytic noma i-aplastic anemia;
  • okunye ukusabela ukungasebenzi kahle kokuphefumula nokuphefumula okungashonile, i-hypersensitivity ngesimo sokulunywa, ukuqunjelwa isikhumba, i-urticaria, i-vasculitis ye-allergic.

Imiyalo yokusebenzisa

Udinga ukuthatha iphilisi elinjalo ngaphakathi ngaphandle kokuhlafuna. Isiphuzo kufanele okungenani sibe yingxenye yengilazi yamanzi.

Qiniseka ukuthi uphuza umuthi kufanele uboshwe ekudleni, ngaphandle kwalokho usongela ngokuncipha okubukhali koshukela wegazi.

Lokhu kusho ukuthi udinga ukuphuza iphilisi ngaphambi kokudla noma phakathi nale nqubo. Lokhu kwenziwa kangcono ekuseni, uma uhlelo lusebenza nsuku zonke, ukuze ukwazi ukulawula okuqukethwe ushukela.

Umthamo wokuqala womuthi ngu-1 mg wento ngosuku. Ngaphezu kwalokho, uma kunesidingo, kungenzeka ukwandisa umthamo ngokuhamba kwamaviki ama-1-2. Kulokhu, umthamo olandelayo ngu-2 mg, bese kuba ngu-3 mg, bese u-4 mg, bese kusetshenziswa ama-6 mg. Lomthamo ungaphezulu kakhulu, futhi akunconywa ukuba uwedlule.

Ukwanda komthamo kumele wenziwe ngudokotela, ngokusekelwe kumuntu ngamunye, indlela yokuphila yesiguli, inkambo yesifo.

I-Amaril ingathathwa ngokuhambisana nokwelapha ne-insulin noma i-metformin. Ezimweni lapho iMetformin ingalethi ukwehla okwanele kwamazinga kashukela, khona-ke i-Amaril iyabekwa.

Kulesi simo, iMetformin iyaqhubeka nokuphuzwa kumthamo wangaphambilini, futhi i-Amaryl iqala nokuphuza ngethamo elincane le-1 mg, elingakhuphuka kancane kancane liye ku-6 mg. Uma le nhlanganisela nayo ingasebenzi, khona-ke iMetformin ithathelwa indawo yi-insulin. Kulokhu, umthamo we-Amaril ushiywe ungashintshiwe, futhi i-insulin ithathwa ngenani elamukelekayo kancane kancane, kancane kancane ikhulisa umthamo.

Lapho uthatha izidakamizwa, ikakhulukazi ngokuhlanganiswa kwe-Amaryl-insulin, kuyadingeka ukuthi uhlole njalo ushukela. Kumele kukhunjulwe ukuthi uma usebenzisa i-Amaril, umthamo we-insulin uyadingeka u-40% ngaphansi kunasesimweni se-monotherapy.

Ukweqisa

Uma umthamo womuthi udluliwe, khona-ke isiguli sisongelwa nge-hypoglycemia, amahora angama-12-72 ahlala njalo.

Izimpawu zalo ziyefana nemiphumela emibi yesidakamizwa esishiwo ekuqaleni kuleyo ndatshana. Ezimweni ezibucayi, amathuba okuthola ukoma aphezulu.

Uma kwenzeka izimpawu ezinjalo, into yokuqala okudingeka uyidle ucezu ushukela, isiphuzo sejusi noma itiye elimnandi. Kubalulekile ngaso sonke isikhathi ukuphatha okungenani u-20 g we-glucose, ngokwesibonelo, kungaba izingcezu ezi-4 zoshukela. Ama-sweeteners kuleli cala azoletha ukusetshenziswa okuncane.

Uma icala likhulu, kulapho isibhedlela sizodingeka. Esibhedlela, kwenziwa i-gastric lavage, futhi ama-adsorbents nawo ayadingeka. Ukulawulwa kwe-glucose kubaluleke kakhulu. Ezinye izimpawu ezingathandeki ziqedwa ukwelashwa okubonakalayo.

Ukusebenzelana kwezidakamizwa

Ngezinye izidakamizwa, ukusetshenziswa kwe-Amaril kungaholela ekwandeni noma ekunciphiseni komphumela we-hypoglycemic.

Esimweni sokuqala, umphumela uzokwehla ngenkathi uthatha lezi zidakamizwa ezilandelayo: amahomoni we-thyroid, i-adrenaline, i-chlorpromazine, i-sympathomimetics, i-glucocorticosteroids, i-diazoxide, i-barbiturates, i-laxatives, i-saluretics, i-thiazide diuretics, i-glucagon, i-phenytoin, i-phenothiazine, i-acetazolamide acid. , ama-progestogens nama-estrogens, usawoti we-lithium.

Ukwanda komphumela we-hypoglycemic ubonwa lapho uthatha izidakamizwa ezinjena ne-Amaril: ezinye izidakamizwa zokwelapha i-hypoglycemia, angiotensin-converting factor inhibitors, allopurinol, anabolic steroids, i-coumarin derivatives, tritokvalin, izidakamizwa ezinama-hormone ocansi abesilisa, i-oxyphenbutazone, i-pentoxifylline , i-fibrate, i-pheniramidol, i-MAO inhibitors, i-azapropazone, i-fenfluramine, i-phenenecid, i-salicylates, i-sulfinpyrazone, i-tetracyclines, i-Tro-, i-cyclo-, isophosphamide, i-sulfonyls isenzo eside

Ukuhlanganiswa kwe-Amaril nezidakamizwa ezithile kungaholela kumphumela we-hypoglycemic ongalindelekile, ongathi kwezinye izimo unciphe, bese kuthi abanye bakhuphuke. Lokhu kubandakanya Reserpine, Clonidine.

Ukubuyekezwa mayelana nesidakamizwa Amaryl

Mayelana ne-Amaril yezidakamizwa, ukubuyekezwa kwabanesifo sikashukela kulungile. Iziguli ezithatha i-Amaryl zikholelwa ukuthi lesi sidakamizwa silwa ngempumelelo noshukela ophezulu kuhlobo 2 sikashukela.

Into esemqoka ukukhetha isilinganiso esifanele somuthi. Uhlangothi oluhle futhi umbala ohlukile wezibhebhe, ezisetshenziselwa imithamo ehlukene. Lokhu kukuvumela ukuthi ungadidanisi okulungile.

Kodwa-ke, kunokubuyekezwa okuningi okungahambi kahle, okuhambisana kakhulu nokuvela kaningi kwemiphumela emibi, njengokuthuthumela, ubuthakathaka, isiyezi, ukuthuthumela emzimbeni, isifiso sokudla. Kunezimo ze-hypoglycemia, ngakho-ke kubaluleke kakhulu ukuphatha amaswidi noma eminye imikhiqizo equkethe ushukela omkhulu.

Ukubuyekezwa okungalungile nakho kuzwakala kusuka kubashayeli abathatha i-Amaryl. Umuthi uthinta uhlelo lwezinzwa, ngakho-ke ukusabela kuyancishiswa, okuyingozi impela lapho ushayela. Ngaphezu kwalokho, ngaphandle kokuphumelela kwomuthi, izindleko zawo ziphakeme kakhulu kune-analogues.

Amavidiyo ahlobene

Ukubuyekezwa kwevidiyo ngomuthi i-Amaryl:

Ngakho-ke, isifo sikashukela ngaso sonke isikhathi asibangeli ukuphazamiseka okuningi kanye nokungaphatheki kahle. Izidakamizwa zohlobo lwe-Amaril zingaligcina kalula ushukela ojwayelekile.

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