I-TELSARTAN 80 - IMIYALO YOKUSEBENZISA, INTENGO, UKUBUYEKEZWA KANYE NAMA-ANALOGUES

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I-Telsartan 80 iyisidakamizwa esingabaphikisi be-angiotensin. Isetshenziselwa ukwelapha i-hypertension namanye ama-pathologies.

Igama Lezwe elingafanele

I-Telmisartan.

I-ATX

Ikhodi ye-ATX yi-C09C A07.

Khipha amafomu nokwakheka

Kuyatholakala ngesimo sethebhulethi. Isakhi esisebenzayo somuthi yi-telmisartan. Ithebhulethi elilodwa liqukethe i-80 mg yento esebenzayo, imhlophe ngombala ne-capsule-shape. Amathebhulethi akahlanganiswa, ngalinye lawo linomfanekiso obhalwe ngenombolo 80 ohlangothini olulodwa.

Njengezinto ezisizayo, i-sodium hydroxide, amanzi, i-povidone, i-meglumine, i-magnesium stearate kanye ne-mannitol isenzo.

I-Telsartan 80 yisidakamizwa esisetshenziselwa ukwelapha i-hypertension kanye nezinye izifo ze-pathologies.

Isenzo se-Pharmacological

Umphumela we-antihypertensive wezinto ezisebenzayo uqinisekiswa ukuvimba okungafunekiyo kwama-receptors emikhumbi ethinta i-angiotensin 2. I-telmisartan molecule inesakhiwo esifanayo samakhemikhali, ngakho-ke sinamathela kuma-receptors esikhundleni se-hormone, esivimba umphumela wawo. Ithoni ye-Vascular ayikhuphuki, okuvimba ukwenyuka komfutho wegazi.

Ingxenye esebenzayo yesidakamizwa ibopha ama-receptors isikhathi eside. Ngokuziphatha, ama-receptors e-AT1 subtype ayavinjwa. Amanye ama-subtypes ama-angiotensin receptors ahlala ekhululekile. Indima yabo ngqo emzimbeni ayizange ifundwe ngokuphelele, ngakho-ke akudingeki ukuba benziwe bavunyelwe ukulawula umfutho wegazi.

Ngaphansi kwethonya lomuthi, ukukhiqizwa kwe-aldosterone yamahhala nakho kuvinjelwe. Ngesikhathi esifanayo, inani le-renin lihlala lifana. Iziteshi ze-membrane zamaseli ezibhekele ezokuhamba kwe-ion azithinteki.

I-Telsartan akuyona i-angiotensin eguqula i-enzyme inhibitor. Lokhu kwenza ukuthi kungenzeki ukuthi kube nezimpawu ezithile ezingathandeki, ngoba le enzyme nayo inesibopho sokuqhekeka kwe-bradykinin.

I-Pharmacokinetics

Ngokuphathwa komlomo umuthi, isakhi esisebenzayo sidlula ngokushesha nge-mucosa yesisu esincane. Kucishe kubopha ngokuphelele ukuthutha ama-peptide. Iningi lihanjiswa ngokuhlanganyela ne-albhamuin.

I-bioavailability ephelele yesidakamizwa icishe ibe ngama-50%. Kungehla ngemithi ngokudla.

Umshini oyinhloko wenguquko ye-metabolic yesidakamizwa emzimbeni yi-conjugation to glucuronide. Into ephumayo ayinawo umsebenzi we-pharmacological.

Iningi lezinto ezisebenzayo lithululiwe ngohlobo lwalo lwangempela. Isigamu sempilo singamahora angama-5-10. Ingxenye esebenza ngokugcwele ishiya umzimba emahoreni angama-24.

Izinkomba zokusetshenziswa

Ithuluzi lisetshenziselwa:

i-hypertension therapy;
ukuvimbela ukufa kwe-CVD pathologies kubantu abaneminyaka yobudala engama-55 abanobungozi obukhulu bokukhula kwabo ngenxa yokuphazamiseka kohlelo lwezinhliziyo;
ukuvimbela kwezinkinga ezigulini ezinenkinga yesifo sikashukela esingavikelekile i-insulin etholakele ngomonakalo wesitho sangaphakathi ohambisana nesifo esikhona.

Contraindication

Ukuxhumana kokuqokwa kwalo muthi yilezi:

hypersensitivity kwisithako esiyisisekelo esisebenzayo noma ezinye izinto ezakha ukwakheka;
ukuvimbela kwe-bile duct;
ukungakwaneli komsebenzi we-hepatic ngenkathi yokubola;
ifa le-Fermentopathy ngokungabekezelelani kwe-fructose;
iminyaka efinyelela eminyakeni eyi-18;
ukukhulelwa nokukhipha umunyu.

Ukuze uvimbele ukufa kwe-CVD pathologies kubantu abaneminyaka yobudala engama-55, kubekwa iTelsartan.

I-Telsartan isetshenziselwa ukuvimba izinkinga ezigulini ezine-mellitus engavikeleki nge-insulin.

Ukuxhumana kokuqokwa kwalo muthi kuneminyaka engu-18 ubudala.

Ithuluzi lisetshenziswa ekwelapheni umfutho wegazi ophakeme.

Ngokuqapha, i-Telsartan ibekelwe iziguli ezinobunzima be-hepatic insuffence.

Ngokuvinjezelwa kwepheshana le-biliary, iTelsartan is contraindified.

I-Telsartan i-contraindicated kwabesifazane ngesikhathi sokukhulelwa.

Ngokunakekela

Ngokuqapha, umuthi ubekelwe iziguli ezinobunzima be-hepatic insuffence.

Ungayithatha kanjani iTelsartan 80

Amaphilisi athathwa nsuku zonke. Ungayithatha kungakhathalekile isikhathi sokudla, ngenani lamanzi elifunekayo.

Umthamo wokuqala ngu-40 mg. Uma inani elinjalo lomuthi lingakuvumeli ukulawulwa okugcwele kwezinga lomfutho wegazi, umthamo uyandiswa.

Isilinganiso esiphezulu sansuku zonke singama-80 mg. Ukunyuka okuthe xaxa akunamsebenzi ngoba akuholeli ekwandeni kokusebenza kwomuthi.

Kufanele kukhunjulwe ukuthi umphumela womuthi awaveli ngokushesha. Umphumela omuhle utholakala ngemuva kwezinyanga eziyi-1-2 zokusetshenziswa okuqhubekayo.

I-Telsartan kwesinye isikhathi ihlanganiswa ne-thiazide diuretics. Le nhlanganisela ingaphinde yehlise ingcindezi.

Ezimweni ezinzima ze-hypertension, i-160 mg ye-telmisartan ingahle ichazwe ngokuhambisana ne-12.5-25 mg ye-hydrochlorothiazide.

Ngoshukela

Kuhlobo 2 sikashukela i-mellitus, iTelsartan ingathathwa ukuvikela izinkinga ze-vascular ezinso, enhliziyweni nase-retina. Umuthi unqunywe kumthamo ka-40 noma wama-80 mg, ngokuya ngosizi lwezimpawu zokubonisa umfutho wegazi ophezulu.

Umuthi uthathwa isikhathi eside. Izifundo zemitholampilo zikhombisa ukuthi umfutho wegazi we-systolic ne-diastolic wehla ngo-15 no-11 mm Hg lapho uthathwa emasontweni ayi-8 kuye kwayi-12. Ubuciko. ngokufanele.

Iziguli ezinesifo sikashukela ne-hypertension zingahlanganiswa ne-amlodipine. Le nhlanganisela ikuvumela ukuba ugcine izinga lomfutho wegazi ngaphakathi kwemikhawulo ejwayelekile.

Ngaphambi kokuthatha umuthi, kufanele uthintane nodokotela njalo. Umthamo kanye nesikhathi sokwelashwa kufanele kukhethwe ngakunye.

Kuyadingeka ukubonana nodokotela. Umthamo kanye nesikhathi sokwelashwa kufanele kukhethwe ngakunye.

Imiphumela emibi yeTelsartan 80

Ucwaningo luye lwabonisa ukuthi imvamisa yemiphumela emibi eyenzeka lapho kuthathwa i-Telsartan icishe ilingane nemvamisa yokuphendula kwe-pathological kwiziguli ezithola i-placebo. Wayengacabangi nobudala kanye nobulili babantu.

Amapheshana wesisu

Ukusuka ohlelweni lokugaya ukudla kuyabonakala:

Ubuhlungu besisu
umlomo owomile
isifo sohudo
isicanucanu
ukuhlanza
isifo se-dyspeptic;
ukuthopha.

Izitho zeHematopoietic

Kusukela ezithweni ze-hemopoietic kungavela:

i-anemia
i-thrombocytopenia;
i-eosinophilia;
ukwehla kwezinga le-hemoglobin.

Eminye yemiphumela emibi yeTelsartan ukwehla kwamazinga e-hemoglobin.

Isistimu yezinzwa ephakathi nendawo ingaphendula ngokuthatha umuthi ngokwenzeka kokuqwasha.

Ukuphazamiseka kwengcindezi kwenzeka lapho kuthatha iTelsartan.

Uhudo lungabangelwa ukuthatha i-telsartan.

Isicanucanu, ukugabha yimiphumela emibi yeTelsartan.

Kusukela ekuthatheni iTelsartan, ukozela akuyona into engjwayelekile.

I-Flatulence yenzeka ngenxa yokuthatha iTelsartine.

Isistimu yezinzwa ephakathi

Isistimu yezinzwa ephakathi nendawo ingaphendula umuthi ngokubonakala kwe:

ukuphazamiseka komoya okucindezelayo;
ukuqwasha
izimo zokukhathazeka;
ukozela
ukungaboni kahle
isiyezi.

Kusuka ohlelweni lomchamo

Umuthi ungadala:

umsebenzi wezinso ongonakalisiwe;
ukwehluleka kwezinso okulimazayo.

Kusuka ohlelweni lokuphefumula

I-Telsartan ingadala:

ukuphefumula
ukukhwehlela
izifo zokuphefumula eziphansi.

Engxenyeni yesikhumba

Kungenzeka:

ukujuluka ngokweqile;
ukulunywa
ukuqhuma
i-erythema;
ukuvuvukala
dermatitis;
i-urticaria;
eczema

Engxenyeni yohlelo lokuphefumula, i-telsartan ingadala ukukhwehlela.

Uhlelo lwe-musculoskeletal lungaphendula ekwelashweni nge-Telsartan ngokubonakala kokuthakathi.

Engxenyeni yesikhumba, iTelsartan ibanga ukulunywa nokuqhuma.

I-Telsartan ingadala izifo zokuphefumula.

Uma usebenzisa i-telsartan, i-eczema ingavela.

I-dermatitis yenzeka ngenxa yokwelashwa nge-Telsartan.

Ukwanda kokujuluka kungenxa yokuthatha iTelsartan.

Kusuka ohlelweni lwezitho zofuzo

Umsebenzi wezocansi awuhlupheki lapho uthatha iTelsartan.

Kusuka ohlelweni lwezinhliziyo

i-hypertension ye-arterial;
i-orthostatic hypotension;
i-tachy, bradycardia.

Kusuka ohlelweni lwe-musculoskeletal kanye nezicubu ezithintekayo

Uhlelo lwe-musculoskeletal lungaphendula ekwelashweni ngokubonakala kwe:

imisipha nobuhlungu obuhlangene;
izinhlungu ze-tendon;
ukubanjwa
lumbalgia.

Engxenyeni yesibindi ne-biliary

Ngaphansi kwethonya le-telmisartan, izinga lomsebenzi wama-enzyme wesibindi lingashintsha.

Allergies

Ukuvela kwe-anaphylactic kulo muthi kungenzeka.

Umthelela ekhonweni lokulawula izindlela

Ucwaningo lwethonya lomuthi ekhonweni lokulawula izindlela alwenziwanga. Kunconywe ukunciphisa isikhathi esichithwa ekushayweni lapho kuvela izimpawu eziseceleni zesistimu yezinzwa ephakathi.

Ngesikhathi sokwelashwa ngeTelsartan, kunconywa ukunciphisa isikhathi esichithwa esondweni.

Imiyalo ekhethekile

I-Hypotension ingahle ihambisane nomthamo wokuqala wesidakamizwa ezigulini ezingenele umthamo wegazi onganele noma amazinga aphansi we-plasma sodium.

I-hyputeension ye-arterial hypotension ingaba khona uma isiguli sine-renal vasen stenosis noma ukuhluleka kwenhliziyo kwehlule.

I-Telmisartan ayisebenzi ekwelapheni iziguli ezine-hyperaldosteronism eyisisekelo.

Ngokuqapha, umuthi ubekelwe abantu abane-aortic noma i-mitral valve stenosis.

Ukusetshenziswa kwomuthi kungadala ukwanda kwezinga le-potassium egazini. Amanye amaqembu eziguli angadinga ukubhekwa ngezikhathi ezithile kwama-electrolyte e-plasma.

Kukhona ubungozi be-hypoglycemia kubantu abathola i-insulin noma ezinye izidakamizwa ze-antidiabetes. Kuyafaneleka ukubheka lokhu lapho ukhetha umthamo wale mishanguzo. Kuyadingeka ukubheka njalo ukugcwala kwe-glucose egazini.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ukwelashwa kweTelmisartan akunakunikezwa ngesikhathi sokukhulelwa. Uma kunesidingo esiphuthumayo sokuqhubeka nokwelashwa kwe-antihypertensive, kuyadingeka ukubonana nodokotela. Uzokhetha imishanguzo efanelekile ayisuse.

Uma kunesidingo, ukusetshenziswa komuthi ekwelashweni kwabesifazane ngesikhathi sokuqunjelwa kuyanconywa ukuthi kudluliselwe ingane ekuondleni okungelona iqiniso. Lokhu kuqapha kungenxa yokuntuleka kolwazi ngomphumela we-telmisartan, ongatholwa ubisi, emzimbeni wezingane.

Ukunquma uTelsartan ezinganeni ezingama-80

Umuthi awusetshenziselwa ukwelapha iziguli ezingaphansi kweminyaka engu-18.

Sebenzisa ebudaleni

Ukusetshenziswa kweTelsartan ekugugeni akunazici lapho kungekho khona ukungqubuzana kweziguli.

Isicelo sokusebenza kokulimala kwezinso

Ukwehla komsebenzi wezinso kuholela eqinisweni lokuthi ingxenye esebenzayo yomenzeli ibopha kuma-plasma peptides yi-100%. Ukuhoxiswa kwe-telmisartan ngezindlela ezithobekile futhi ezilinganiselayo zokwehluleka kwezinso akuguquki.

Sebenzisa umsebenzi wesibindi okhubazekile

Ngokunciphisa ukwehluleka kwesibindi okulinganiselayo, umthamo wansuku zonke wezidakamizwa akufanele ube ngaphezu kwama-40 mg.

Ukweqisa kweTelsartan 80

Imininingwane eku-overdose inomkhawulo. Hypotension, ukushesha noma ukwehla kokushaya kwenhliziyo kungenzeka.

Uma usola ngokweqile kwe-telmisartan, kufanele uthintane nodokotela. Kulokhu, kunconywa ukwelashwa okubonakalayo. I-Hemodialysis ayisebenzi.

Ukuxhumana nezinye izidakamizwa

Ithuluzi linika amandla ezinye izidakamizwa ze-antihypertensive.

Ukuhlanganiswa kweTelsartan ngama-statins, i-paracetamol akuholeli ekubukeni kweminye imiphumela emibi.

Ithuluzi lingakhuphula inani eliphakeme kakhulu le-digoxin esegazini. Lokhu kudinga ukuqapha okuqukethwe.

Akunconyelwe ukusebenzisa i-Telsartan ene-potassium-sparing diuretics nemithi, isakhi esisebenzayo esiyinhloko se-potassium. Ukuhlanganiswa okunjalo kungaholela ku-hyperkalemia.

Ukuhlanganiswa namalungiselelo aqukethe usawoti we-lithium kukhulisa ubuthi bawo. Ukusetshenziswa kwenhlanganisela enjalo kuyadingeka kuphela ngaphansi kwesimo sokuqapha ngokucophelela okuqukethwe kwe-lithium esegazini.

I-Acetylsalicylic acid nezinye izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala zinganciphisa ukusebenza komuthi. Ama-NSAIDs avimbela umsebenzi we-cycloo oxygenase ngokuhlangana ne-telmisartan kungaholela ekubonakala kokukhubazeka komsebenzi wezinso kwamanye amaqembu eziguli.

I-Acetylsalicylic acid nezinye izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala zinganciphisa ukusebenza komuthi.

Ama-glucocorticosteroids ama-systemic anciphisa umphumela we-antihypertensive womuthi.

Ukuhambisana notshwala

Akunconyelwe ukuphuza noma yiluphi uhlobo lotshwala ngesikhathi sokwelashwa ngeTelsartan.

Ama-Analog

Ama-analoggs aleli thuluzi yilawa:

UMikardis;
I-Prirator;
I-Telmisartan-Ratiopharm;
I-Telpres
I-Telmista;
I-Tsart
I-Hipotel.

I-Hipotel iyi-analogue yeTelsartin.

I-Telpres iyi-analogue yeTelsartin.

Phakathi kokufana kweTelsartin, kuvezwa isidakamizwa iTelmisartan-Ratiopharm.

Indawo ebambekayo iTelsartin nguMvikeli wezidakamizwa.

Isidakamizwa uMikardis sifana noTelsartan.

I-Telmista iyi-analogue yeTelsarpan.

Imibandela yekhefu lekhemisi

Ikhishwa ngokuya ngommiselo kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Cha.

Intengo yeTelsartan 80

Izindleko zezimali zincike endaweni okuthengwa kuyo.

Izimo zokugcina zomuthi

Kufanele igcinwe endaweni eyomile emazingeni okushisa angadluli + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Umkhiqizo ulungele ukusetshenziswa kungakapheli iminyaka emi-2 kusukela ngosuku lokukhishwa.

Umkhiqizi

Lesi sidakamizwa senziwa yinkampani yaseNdiya iReddis Laboratories Ltd.

Umuthi i-Telsartan usatshalaliswa ekhemisi kuphela ngomuthi odingekayo.

Ukubuyekezwa ku-Telsartan 80

Odokotela

UGrigory Koltsov, udokotela wezokwelapha, oneminyaka engama-58, uTula

Umuthi omuhle osiza ukubhekana nezimpawu zokubonisa umfutho wegazi ophakeme. Nginikeza zona zombili iziguli ezinezinga eliphansi, futhi ezimweni ezinzima kakhulu. Kuphephile, imiphumela emibi ayivelakancane. Okuhlukile kungaba ngabantu abanokulimala kwe-renal noma i-hepatic function. Ezimweni ezinjengalezi, ngiza kuqokelwa ukuqapha kakhulu ngokuqokwa.

U-Artem Yanenko, udokotela wezokwelapha, oneminyaka engama-41, eMoscow

Isixazululo eshibhile kulabo abadinga ukubheka njalo umfutho wegazi labo. Ngaphandle kokuthi umkhiqizo wenziwa eNdiya, hhayi eGermany noma kwelinye izwe laseYurophu, ikhwalithi yalo ihlangabezana nokulindelwe.

Ukukhetha imithamo efanele kuzosiza ukuqhuba ukwelashwa ngaphandle kwemiphumela engathandeki. Angikukhuthazi ukuqala ukwelashwa ngokwakho. Ukuzilapha kungaholela empilweni engeyinhle, ngakho-ke qiniseka ukuthi uthinte uchwepheshe ngaphambi kokuqala ukwelashwa.

Iziguli

U-Arina, oneminyaka engama-37, u-Ulyanovsk

Ngithathe lesi sidakamizwa ngaze ngaphela ehlobo. Ngihlushwa umfutho we-hypertension obalulekile kusukela ngisemncane, ngakho-ke ngangijwayele ukusetshenziswa njalo kwamaphilisi.

Ehlobo eledlule, kwadingeka ngilahle iTelsartan ngemuva kokuya kudokotela we-gynecologist. Udokotela ukuqinisekisile ukuthi ngikhulelwe. Uthe ngesikhathi sokukhulelwa, futhi ikakhulukazi ku-trimester yokuqala, leli khambi akufanele lithathwe. Kwakudingeka ngiye kuchwepheshe ukuze ngisebenzise umuthi esikhundleni somuthi.

Ngemuva kokuqeda ukondla ingane, ngizoqala ngiphuze iTelsartan futhi.Leli thuluzi libhekana ngokuphelele nomsebenzi walo. Imiphumela emibi ayizange ibonwe ngesikhathi sokuphatha.

UVictor, oneminyaka engama-62, eMoscow

Ngisaphuza lesi sidakamizwa njalo. Iminyaka eminingi, ngihlushwa ukwehluleka kwezinso kanye nomfutho wegazi ophakeme. Ngonyaka ophelile, izinso bekufanele zidluliselwe kwezinye izindawo ngoba zenqaba ngokuphelele, kanti owesibili wahluleka ukuhlanza umzimba wedwa.

Ngemuva kokufakelwa kwezinso, kwaqala izinkinga ezincane. Kuvelile ukuvela. Kwadlula izivivinyo zokuqonda ukuthi kwenzekani. Udokotela wachaza ukuthi lokhu kuquleka kubangelwa amazinga aphezulu e-potassium egazini. Kwadingeka ngimshiye okwesikhashana uTelsartan. Kamuva, wabuyela ekwamukelweni. Eminyakeni yokusebenza, azikho izikhalazo ezivelile. Ngingancoma kubo bonke abantu abane-hypertension ye-arterial hypertension.

U-Evgenia, oneminyaka engama-55, iSt

Ezinyangeni ezimbalwa ezedlule, udokotela unikeze leli khambi. Muva nje ngithole ukuthi une-hypertension, ngakho angikaze ngiphuze umuthi wawo ngaphambili.

Izinkinga zaqala kusukela ezinsukwini zokuqala zokuthatha iTelsartan. Kwakukhona isicanucanu, i-dyspepsia. Isikhumba sifafazwe ngezinduna ezincane. Ngaya kudokotela. Wachaza ukuthi ngangingabekezeleli umuthi. Bekumele ngifune ukungena esikhundleni. Angikwazi ukuncoma iTelsartan, ngoba akuzona izinkumbulo ezimnandi kakhulu ezihambisana nayo.

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