Ungasisebenzisa kanjani isidakamizwa i-Lozap 50?

I-Lozap 50 isidakamizwa esibekelwe iziguli ezinezifo ze-CCC.

Igama Lezwe elingafanele

Losartan.

I-ATX

Ikhodi ye-ATX yi-C09C A01.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngesimo samathebulethi efilimu. Ithebhulethi ngayinye iqukethe u-50 mg wezithako ezisebenzayo. Isithako esisebenzayo somuthi yi-losartan.

Umuthi uyatholakala ngesimo samaphilisi aphekwe ngefilimu, ithebhulethi ngayinye iqukethe ama-50 mg wezithako ezisebenzayo.

Iithebhulethi ezinokuqukethwe okusebenzayo kwe-12.5 mg nazo ziyathengiswa. Izibhebhe zimhlophe ngombala, i-oblong biconvex ukuma.

Isenzo se-Pharmacological

I-Losartan yinto ebopha ama-receptors ku-angiotensin II. Isebenza ku-AT1 receptor subtype; ama-receptors asele we-angiotensin awabophisi.

Ingxenye esebenzayo yesidakamizwa ayivimbi umsebenzi wama-enzyme athinta ukuguqulwa kwe-angiotensin I ku-angiotensin II. Ukulawulwa kwengcindezi yegazi kuqinisekiswa ngokunciphisa amazinga e-aldosterone ne-adrenaline egazini. Akukho shintsho ekuhlushweni kwe-angiotensin II egazini.

Ngaphansi kwethonya le-Lozap, ukumelana kwemithambo yegazi yokwehla kuyancipha. Ithuluzi linciphisa ingcindezi emithanjeni yokujikeleza kwe-pulmonary, inomthelela ekwandeni kwe-diuresis.

Ukwehla kokulayishwa kwasemisipha yenhliziyo kuvimbela ukukhula kwezinguquko ze-hypertrophic ku-myocardium. ILosartan yehlisa umthwalo osenhlizweni ngesikhathi sokuzivocavoca kweziguli ezinenkinga yokugula okungapheli kohlelo lwezinhliziyo.

I-Lozap 50 isidakamizwa esibekelwe iziguli ezinezifo zenhliziyo.

Ukuthatha lesi sidakamizwa akuhambisani nokuqhekeka kwe-bradykinin. Imiphumela engathandeki ehambisana nale nqubo ayenzeki ngesikhathi sokwelashwa nge-Lozap. Ngenxa yokuthi umsebenzi we-eniotensin-converting enzyme awucindezelwanga, izehlakalo ze-angioedema nokunye ukusabela okuyingozi kwe-pathological kuncishiswa kaningi.

Umphumela we-antihypertensive wesidakamizwa uzibonakalisa ngokwengeziwe amahora angu-6 ngemuva kokuthatha iphilisi. Umphumela ugcinwa ngaphezulu kosuku olulandelayo, lwehla kancane kancane.

I-Lozap ikhombisa ukusebenza kahle okukhulu ngemuva kokuphathwa okuqhubekayo kwenyanga noma ngaphezulu. Kulokhu, ukwelashwa kuhambisana nokuncipha kokuvezwa kwamaprotheni e-plasma nama-immunoglobulins G omchamo ezigulini ezingaphethwe yisifo sikashukela i-mellitus.

Umuthi uholela ekuzinzeni kwe-urea ye-plasma. Akuthinti umsebenzi we-Reflex wohlelo lwezinzwa lwe-autonomic. Uma uthathwa ngaphakathi komthamo ojwayelekile, awaguquki amazinga kashukela egazini.

I-Pharmacokinetics

Ukuqunjelwa kwengxenye esebenzayo ye-ejenti kwenzeka emathunjini amancane. Ngesikhathi sokudlula kokuqala ngokusebenzisa ipheshana le-hepatobiliary, kutholakala ukuguqulwa kwe-metabolic. I-cytochrome CYP2C9 isoenzyme ibandakanyeka kule nqubo. Njengomphumela wokusebenzisana kwamakhemikhali, kwakhiwa i-metabolite esebenzayo. Kufika ku-15% womthamo othathwe oguquliwe.

Ukuphakama okuphezulu kwento esebenzayo kungaphezulu kwama-30%. Iqoqo le-plasma eliphumelela kakhulu libonwa ihora elilodwa ngemuva kokuphathwa ngomlomo. Isikhombi esifanayo se-metabolite esebenzayo sitholakala ngemuva kwamahora we-3-4.

Ingxenye esebenzayo ibopha cishe ngokuphelele kuma-peptides e-plasma. Ukungena nge-BBB kusezingeni elincane.

Odokotela banquma i-Lozap 50 yokwelashwa kokuhluleka kwenhliziyo okuhlala njalo.

Ingxenye esebenzayo yomuthi iyakhishwa ngaphakathi emathunjini naphakathi nasezinso. Ukuphila kwesigamu sento engashintshiwe cishe amahora angama-2, inkomba efanayo ye-metabolite esebenzayo isuka emahoreni ayi-6 kuye kwayi-9.

Yini edingekayo

I-Lozap ichazwe ngamacala alandelayo:

• nge-hypertension ebalulekile;
• ukunciphisa ubungozi bokuthuthukisa i-CVD pathologies kubantu abane-hypertension;
• nge-nephropathy ebangelwa ukuphazamiseka kwe-metabolic ku-mellitus engavikelekile kwe-insulin;
• ekwelapheni ukwehluleka kwenhliziyo okungamahlalakhona.

Contraindication

Ukuxhumana kokusebenzisa umuthi yilezi:

• hypersensitivity yomuntu ngamunye kwinto esebenzayo noma ezinye izinto ezakha ukwakheka;
• ukuhlanganiswa komuthi nge-aliskiren lapho kunesifo sikashukela noma ukuhluleka kwezinso;
• isikhathi sokukhulelwa;
• inkathi yokuhlanza;
• iminyaka yezingane ifinyelela eminyakeni eyi-18 (ukuqashwa okungenzeka kwezinye izimo).

Ukuqapha kumele kusetshenziswe lapho kuthathwa i-Lozap 50 ngesikhathi sesifo senhliziyo.

Ngokunakekela

Ukuqwashisa ikakhulukazi lapho uphuza umuthi kufanele ubonwe ezigulini ezine:

• hyperkalemia
• ukuhluleka kwenhliziyo okuhambisana nokungasebenzi kahle kwinso;
• izingozi ze-cerebrovascular;
• ukwehluleka kwenhliziyo okukhulu nama-pelo;
• i-renal vascular stenosis;
• isifo senhliziyo;
• i-hypertension ye-arterial;
• i-stenosis ye-mitral ne-aortic valve;
• i-hypertrophic cardiomyopathy;
• ukwehla kwenani lokujikeleza kwegazi;
• i-aldosteronism eyinhloko;
• ukuphazamiseka kubhalansi-wamanzi we-electrolyte.

Ukuqaphelisisa ikakhulukazi lapho uthatha umuthi kufanele ubonwe ezigulini ezinokuwohloka kokuzala kwengqondo.

Ungayithatha kanjani iLozap 50

Amacwecwe athathwa ngomlomo, kungakhathalekile isikhathi sokudla. Inhlanganisela yomuthi neminye imithi eyehlisa izinga lomfutho wegazi kungenzeka.

Umthamo ojwayelekile womuthi ezigulini ezingenayo i-concomitant pathologies ngu-50 mg. Umuthi uphuzwa nsuku zonke isikhathi esingu-1 ngosuku. Umphumela we-hypotensive omkhulu ubonwa ngokusetshenziswa okuhlala njalo kweLozap cishe inyanga eyi-1.

Uma kunesidingo, kungenzeka ukwandisa umthamo wansuku zonke ukuya ku-100 mg. Abantu abanokwehla kwegazi elijikelezayo bathola uhhafu wethamo elijwayelekile. Iziguli ezinomsebenzi wezinso oncishisiwe nazo zidinga ukuncishiswa komthamo.

Ekuhlulekeni kwenhliziyo okungapheli, kunconywa ukuqala ukwelashwa ngethamo lika-12,5 mg. Ngokusebenza okunganele, ingakhula njalo emavikini ayi-7. Inani lezidakamizwa ezisetshenziswayo kufanele libe njalo ukuze ligcine ukulingana phakathi kokusebenza kahle kokwelashwa nokungabikho kokungaphenduki okuhle.

Amacwecwe athathwa ngomlomo, kungakhathalekile isikhathi sokudla.

Ukuthatha umuthi wesifo sikashukela

Iziguli ezinesifo sikashukela esingancikileli i-insulin ziqala ukwelashwa ngomthamo ojwayelekile. Mhlawumbe ukukhuphuka kwayo kuye ku-100 mg / ngosuku. Ukuhlanganiswa ne-insulin nezinye izindlela zokulawula ushukela wegazi, ama-diuretics awenyusi ubungozi bemiphumela emibi.

Imiphumela emibi

Amapheshana wesisu

Indlela yokugaya ukudla ingaphendula ekwelashweni:

• ukubonakala kobuhlungu esifundeni se-epigastric;
• isihlalo sokucasuka;
• isicanucanu
• ukuhlanza
• ukwehla kwesifiso sokudla;
• i-gastritis;
• ukuqhakaza;
• umsebenzi owengeziwe wama-enzyme wezinso.

Izitho zeHematopoietic

Kwesinye isikhathi kuyabonakala:

• i-anemia
• ukwehla kwe-hemoglobin;
• i-thrombocytopenia;
• i-eosinophilia.

Indlela yokugaya ukudla ingaphendula ekwelashweni ngezitulo ezikhathazayo, isicanucanu, ukuhlanza, ukuqhakaza.

Ukusuka ohlelweni lwezinzwa, ukukhathala okwandayo, isiyezi, nokudangala kungenzeka.

Lapho uthatha i-Lozap 50, imiphumela emibi kwesinye isikhathi yenzeka ngendlela yokwehluleka kwezinso.

Isistimu yezinzwa ephakathi

Kusukela ohlelweni lwezinzwa kungenzeka:

• ukukhathala;
• Isiyezi
• izinkinga zokulala
• ukwephula ukunambitheka;
• Ukudana
• i-paresthesia;
• tinnitus;
• ukulahleka kwengqondo;
• ikhanda.

Kusuka ohlelweni lomchamo

Kwesinye isikhathi imiphumela elandelayo elandelayo iba khona:

• ukwehluleka kwezinso;
• izifo ezithinta umchamo

Kusuka ohlelweni lokuphefumula

Kungenzeka:

• ukuvuvukala kwe-bronchi;
• pharyngitis;
• i-sinusitis

Ukusuka ohlelweni lokuphefumula, ukuvuvukala kwe-bronchi kungenzeka, njengomthelela oseceleni wokuthatha i-Lozap 50.

Kukhona ubungozi bomphumela ongemuhle ngendlela yokuqhuma kwesikhumba.

Kusuka ohlelweni lwezitho zofuzo, umphumela ongemuhle ngendlela yokuntuleka kwamandla ungathinta.

Ngenkathi uthatha uLozap 50 ohlelweni lwezinhliziyo, izinhlungu ezingemuva kwe-sternum zingavela.

Engxenyeni yesikhumba

Kunengozi yokuthi:

• i-erythema;
• izimpandla;
• ukuzwela emisebeni ye-ultraviolet;
• isikhumba esomile;
• imishayo;
• hyperhidrosis.

Kusuka ohlelweni lwezitho zofuzo

Kungenzeka:

• ukungasebenzi kwe-erectile;
• ukungabi namandla.

Kusuka ohlelweni lwezinhliziyo

Kungenzeka:

• ukukhuphuka kwenhliziyo;
• ukukhuphuka kwenhliziyo;
• ukuwa kwamathambo;
• i-bradycardia;
• izinhlungu ngemuva kwe-sternum;
• i-vasculitis;
• ekhaleni.

Ukwelashwa kungahle kuhambisane nemiphumela engathandeki ngendlela yobuhlungu emisipha nasekuhlanganeni.

Imiphumela emibi efana namazinga aphezulu we-potassium potassium ingahle ibonwe.

Lapho uthatha i-Lozap 50, kunokungezwani komzimba ngendlela ye-angioedema.

Kusuka ohlelweni lwe-musculoskeletal

Ukwelashwa kungahle kuhambisane nemiphumela engemihle elandelayo:

• i-lumbalgia;
• iminyakazo
• ubuhlungu bemisipha;
• izinhlungu ezihlangene.

Ngasohlangothini lwe-metabolism

Imiphumela elandelayo emibi ingahle ivele:

• amazinga aphakeme e-potassium ku-plasma yegazi;
• ukukhiqiza i-creatinine;
• hyperbilirubinemia.

Allergies

Kungenzeka:

• ukusabela kwe-anaphylactic;
• i-angioedema;
• isithiyo Bronchial.

Imiyalo ekhethekile

Ukuhambisana notshwala

Akunconywa ukuhlanganisa iLozap notshwala. Utshwala bungaholela ekwehleni kwempumelelo yokwelashwa.

Akunconywa ukuhlanganisa iLozap notshwala.

Umthelela ekhonweni lokulawula izindlela

Ucwaningo olukhethekile alwenziwe. Kuyadingeka ukwenqaba ukwenza imisebenzi eyingozi edinga ukunakwa okwandisiwe uma kunemiphumela emibi evela ohlelweni lwezinzwa.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Akunconyelwe ukunikeza ikhambi kwabesifazane abakhulelwe. Akukho datha ethembekile yokuthi uLozap unomphumela we-teratogenic ku-fetus, kepha ngenxa yobungozi obandayo bemiphumela emibi, ayisetshenziswa kuleli qembu leziguli.

Abesifazane abakhulelwe abake bathola ama-inhibitors e-ACE ngaphambilini kufanele bashintshelwe kolunye usizo. Kuyadingeka ukufaka lesi sidakamizwa ngokushesha okukhulu ngemuva kokuthola iqiniso lokukhulelwa.

Akukho mininingwane ekwabiweni kwento esebenzayo ngobisi. Ukuntuleka kwedatha kuyisizathu sokwenqaba ukuncelisa ibele ekwelashweni kukamama uLozap. Ingane kufanele idluliselwe kokudla okungelona okwenziwe ngobuciko.

Lapho uthatha i-Lozap, kuyadingeka ukwenqaba ukwenza imisebenzi eyingozi edinga ukunakwa okwengeziwe.

Akunconyelwe ukunikeza ikhambi kwabesifazane abakhulelwe.

Umuthi i-Lozap 50 uvunyelwe ukusetshenziselwa ngesikhathi sokuqunjelwa.

Akunconyelwe ukuthi kunikezwe ikhambi lokwelashwa kwezingane ezingaphansi kweminyaka engu-18.

Ukuqokwa kwe-Lozap ezinganeni ezingama-50

Akunconyelwe ukuthi kunikezwe ikhambi lokwelashwa kwezingane ezingaphansi kweminyaka engu-18. Kwezinye izimo, kungenzeka ukuthi usebenzise umuthi ekwelapheni umfutho wegazi ophakeme ezinganeni ezingaphezulu kweminyaka engu-6. Ukuqokwa kukaLozap kuze kufike kulonyaka kubhalwe ngemithetho eqinile, ngoba akukho datha ngokuphepha kwezidakamizwa kuleli qembu leziguli.

Lapho inikezwe izingane ezinesisindo esingama-20-50 kg, umthamo wansuku zonke ½ wethamo labantu abadala elijwayelekile. Kwesinye isikhathi kungenzeka ukunquma ama-50 mg we-Lozap. Imvamisa, umthamo onjalo ubekelwe iziguli ezinesisindo somzimba ngaphezu kwama-50 kg.

Sebenzisa ebudaleni

Kubantu abangaphezu kweminyaka yobudala engama-75, kunconywa ukuthi umthamo wansuku zonke wehliselwe ku-25 mg. Ukuqashwa okwengeziwe kokusebenza kokulashwa kuyenziwa. Uma kunesidingo, umthamo uguqulwa udokotela.

Isicelo sokusebenza kokulimala kwezinso

Ukuthatha i-angiotensin-converting enzyme inhibitors kungakhulisa izimpawu zokungasebenzi kahle kwe-renal. Lokhu kuboniswa ngokwanda kokuhlushwa kwe-creatinine ne-urea egazini.

Sebenzisa umsebenzi wesibindi okhubazekile

Ngokuhluleka kwesibindi ngesikhathi sokubola, ushintsho ekugxilweni kwengxenye esebenzayo ku-plasma kungenzeka.

Kubantu abangaphezu kweminyaka yobudala engama-75, kunconywa ukuthi umthamo wansuku zonke wehliselwe ku-25 mg, uma kunesidingo, umthamo ulungiswa udokotela.

Ngokuhluleka kwesibindi ngesikhathi sokubola, ushintsho ekugxilweni kwengxenye esebenzayo ku-plasma kungenzeka.

Nge-overdose ye-Lozap, ukwehla okumaki kwengcindezi yegazi kwenzeka.

Sebenzisa ukwehluleka kwenhliziyo

Ukuhlukumezeka kwenhliziyo okungapheli kubeka engcupheni ye-hypotension enzima ezigulini ezithatha i-Lozap. Ukunakekelwa okukhethekile kufanele kuthathwe lapho kunikezwa umuthi kubantu abanenkinga efanayo.

Ukweqisa

Nge-overdose ye-Lozap, ukwehla okuphawulekile komfutho wegazi, ukwanda kwesilinganiso senhliziyo kwenzeka. Izimpawu ziqedwa ngokuqokwa kwe-diuretics, izimpawu zokwelapha.

Ukuxhumana nezinye izidakamizwa

Inhlanganisela yomuthi nezinye izidakamizwa ze-antihypertensive kungenzeka. Ukusetshenziswa okuhlanganayo ngama-antipsychotic kanye nama-antidepressants kuthuthukisa umphumela we-hypotensive.

Imithi ethinta umsebenzi we-CYP2C9 isoenzyme ingakhuphula noma inciphise ukusebenza kwezindlela zokwelapha. Akunconywa ukuhlanganisa ukuphathwa kwe-Lozap nezidakamizwa, isakhi esiyinhloko esisebenzayo sazo ezihlanganiswa yi-potassium.

Akunconywa ukuhlanganisa ukuphatha nama-angiotensin-converting enzyme inhibitors.

Inhlanganisela yomuthi nezinye izidakamizwa ze-antihypertensive kungenzeka.

Ama-Analog

Ama-ejenti alandelayo asetshenziselwa ukufaka lesi sidakamizwa esikhundleni:

• I-Angizap;
• Hyperzar;
• Closart;
• Cozaar;
• Xartan
• Losartan Sandoz;
• Ubungqingili;
• I-Lozap Plus;
• I-Lozap AM;
• ULorista
• Presartan;
• Pulsar
• Isikhungo;
• Tozaar;
• Rosan;
• I-Erinorm.

I-analogue yaseRussia yezidakamizwa zoju i-Lozap 50 ingaba umuthi weBlocktran.

Izithonjana zaseRussia zomuthi:

• I-blocktran;
• ILosartan Canon;
• I-Lortenza.

Amagama weholide ILozapa 50 evela emakhemisi

Ikhishwa ngokuya ngommiselo kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Cha.

Intengo

Izindleko zincike endaweni othenge kuyo.

Izimo zokugcina zomuthi

Kufanele igcinwe emazingeni okushisa angeqi ku-30 ​​° C.

Isikhathi sokuphelelwa yisikhathi

Ngokuya ngezimo zokugcina, umuthi ungasetshenziswa zingakapheli izinyanga ezingama-24 kusukela ngosuku lokukhishwa. Ukusetshenziswa okwengeziwe akunconywa.

Ukushintsha umuthi i-Lozap 50 sebenzisa i-Presartan yezidakamizwa.

Umkhiqizi uLozap 50

Umkhiqizo ukhiqizwa yinkampani yeSlovak iSaneca Pharmaceuticals.

Ukubuyekezwa ku-Lozap 50

Izazi zezenhliziyo

U-Oleg Kulagin, udokotela wezifo zenhliziyo, eMoscow

I-Lozap iyisidakamizwa esihle ekwelashweni kwe-hypertension ebalulekile. Ngenxa yokuthi umphumela wayo awuhlobene nokucindezelwa komsebenzi we-ACE, inemiphumela emibi emincane. Ithuluzi lidinga ukuqaphela lapho liyasetshenziswa. Iziguli ezinokulimazeleka kokusebenza kwezinso kufanele zihlolwe ngezikhathi ezithile ukuqapha isimo somzimba. Ungalokothi uthenge lo muthi ngaphandle kokuya kudokotela. Ukwenza ukwelashwa ngaphandle kwemiphumela emibi kuzosiza kuphela ukukhetha umthamo ofanele, okufanele uphathiswe uchwepheshe.

Ulyana Makarova, udokotela wezifo zenhliziyo, eSt

Ithuluzi lisiza kuphela ngokusetshenziswa okufanele. Babhekene namacala ahlukene kumkhuba wabo. Isiguli esisodwa esine-hypertrophy engakwesobunxele sinqume ukuzindla. Umthamo ojwayelekile awuzange usize ukulawula izinga lokucindezela, ngakho-ke waqala ukuthatha amaphilisi ama-3 ngosuku. Konke kuphele ngokuhlaselwa inhliziyo, ukuvuselelwa nokufa. Amacala anjalo awavamile, kepha izinkinga zempilo zingavinjelwa uma ulandela izeluleko nemiyalo kadokotela yokuthi uzisebenzise.

Iziguli

URuslan, oneminyaka engama-57, uVologda

Sekuphele iminyaka ngiphuza i-losartan. Imiphumela emibi yayiqabukela ngesikhathi sokwelashwa. Ingcindezi igcinwa ngaphakathi kwebanga elijwayelekile, kepha bekufanele nginyuse umthamo ngibe ngaphezulu. Kancane kancane umzimba ujwayela kunoma yimuphi umuthi, ngakho maduze kuzodingeka ufune omunye umuntu.

ULyudmila, oneminyaka engama-63, uSamara

Welapha umfutho wegazi ophezulu esebenzisa izindlela ezahlukahlukene. Lozap wasebenzisa eminyakeni emibili edlule. Okwesikhashana, ingcindezi yazinza, kepha yaqala ukukhuphuka futhi. Udokotela ungene esikhundleni salomuthi ngohlobo oluthile lwe-ACE inhibitor, engiyiphatha nge-diuretics. Mhlawumbe ikhambi belingahambelani nami kuphela ngenxa yobunzima balesi sifo, kodwa angikwazi ukusincoma.