Ukusetshenziswa kweTelsartan, kanye nezinye izidakamizwa ezingabaphikisi bohlobo lwe-angiotensin zokupheka, kuboniswa kwizimo ezithile ze-pathological ezihambisana nokwanda komfutho wegazi. Leli thuluzi linomphumela owenziwe isikhathi eside. Umphumela ngemuva kokusetshenziswa kwawo uyaqhubeka amahora angama-48. Leli thuluzi kufanele lisetshenziswe kuphela njengoba kuchazwe udokotela nakwimithamo engadluli leyo ebekiwe kwimiyalo.
Igama Lezwe elingafanele
Umuthi we-INN - iTelmisartan.
I-ATX
Kuhlukaniswa kwe-ATX yamazwe omhlaba, umuthi unekhodi C09CA07.
Ukusetshenziswa kwe-telsartan kuboniswa ngezimo eziningana ze-pathological, ezihambisana nokwanda komfutho wegazi.
Khipha amafomu nokwakheka
Isakhi esisebenzayo somuthi yi-telmisartan. Izakhi ezisizayo zeTelsartan zibandakanya i-polysorbate, i-magnesium stearate, i-meglumine, i-sodium hydroxide, i-mannitol, i-povidone. Kunezinto ezahlukahlukene ezihlanganisiwe zalo muthi. Umuthi i-Telsartan N, ngaphezu kwe-telmisartan, uhlanganisa i-hydrochlorothiazide.
Umuthi uyatholakala ngesimo sethebulethi. Ngokuya kumthamo, i-40 noma i-80 mg yento esebenzayo ingaqukelwa kwithebhulethi eyodwa. Amathebulethi anomumo obala ngokuhlukaniselana ingozi nomthamo ohlanganisiwe. Mhlophe. Ukuqhuma kungenzeka kube namatafula ayi-7 noma ayi-10. Esiqeshini sekhadibhodi, ama-2, 3 noma ama-4 ama-blits angaba khona. Ukwakhiwa kwesidakamizwa i-Telsartan AM, ngaphezu kwe-telsimartan, kufaka ne-amlodipine.
Isenzo se-Pharmacological
Isenzo sikaTelsartan, okuyi-antigotin yohlobo 2 angiotensin, sincike ekutheni lesi sakhi sokufakelwa sinokufana okukhulu nalolu hlobo lwe-receptor. Into esebenzayo isebenza ngokungakhethi. Kungalahla i-angiotensin kusuka ekubophweni kuma-receptors e-AT1.
Umuthi uyatholakala ngesimo sethebulethi.
Kulesi simo, into esebenzayo yalo muthi ayinakho ukufana okubonisiwe namanye ama-subtypes e-AT receptors. Ngakho-ke, lapho uthatha umuthi ongu-80 mg, umuthi osegazini wento esebenzayo wanele ukuvimba ngokuphelele umphumela wegazi wohlobo 2 angiotensin.
Kulokhu, umuthi awuvimbeli i-retin futhi ungaphazamisi ukusebenza kweziteshi ze-ion. Ngaphezu kwalokho, leli thuluzi linciphisa ukuqoqwa kwe-aldosterone. Into esebenzayo yalesi sidakamizwa ayivimbi i-ACE, ngakho-ke, uma usebenzisa iTelsartan, ayikho imiphumela emibi evela emsebenzini we-bradykinin. Into esebenzayo yesidakamizwa ayisithinti kabi isilinganiselo senhliziyo. Ukusetshenziswa kwomuthi kunciphisa ubungozi bokushona kweziguli.
I-Pharmacokinetics
Lapho uthatha umuthi, isakhi sawo esisebenzayo simunwa ngokushesha. I-Bioavailability ifinyelela ku-50%. Iqoqo eliphezulu lomuthi osegazini emadodeni nakwabesifazane litholakala emahoreni ama-3 ngemuva kokuphathwa. Umuthi ubopha amaprotheni e-plasma. I-metabolism yesidakamizwa iqhubeka nokubamba iqhaza kwe-glucuronic acid. Ama-metabolites adalulwa ezindlini kungakapheli amahora angama-20.
Izinkomba zokusetshenziswa
Ukusetshenziswa kweTelsartan kuchazwe njengokwelashwa okubonakalayo kwezifo ezahlukahlukene zesistimu yenhliziyo, kuhambisana nokwanda kwengcindezi yegazi. Umuthi ungasetshenziswa ekwelapheni abantu abanezimpawu ze-thrombosis. Kuyasebenza ekwelapheni iziguli ezinomonakalo we-ischemic myocardial.
Ukusetshenziswa kweTelsartan kuchazwe njengokwelashwa okubonakalayo kwezifo ezahlukahlukene zesistimu yenhliziyo, kuhambisana nokwanda kwengcindezi yegazi.
Ithuluzi lisiza ukubhekana nomfutho wegazi ophakeme ovelile ngemuva kwesizinda sohlangothi. Phakathi kokunye, i-ejenti ivame ukubekelwa ekwelapheni umfutho wegazi ophakeme ezigulini ezihlushwa i-atherosulinosis yemithambo yegazi yangaphakathi. Uma kunesidingo, umuthi ungasetshenziswa ekwelapheni iziguli ezinesifo sikashukela sohlobo 2.
Contraindication
Umuthi akufanele usetshenziswe lapho kukhona i-hypersensitivity ezingxenyeni ezisebenzayo zeTelsartan. Ngaphezu kwalokho, awukwazi ukusebenzisa lo muthi ukwelapha iziguli ezinesifo sikashukela sohlobo 1 ezihlala zijova i-insulin. Ngaphezu kwalokho, ukusetshenziswa komuthi wokwelashwa kweziguli ezine-nephropathy yesifo sikashukela ukuthatha inhibitors ye-ACE akunconywa.
Awukwazi ukusebenzisa lo muthi ukwelapha iziguli ezinesifo sikashukela sohlobo 1 ezihlala zijova i-insulin.
Ngokunakekela
Ukwelapha nge-telsartan kudinga ukuqapha ngokweqile ku-renal artery stenosis. Ngaphezu kwalokho, iziguli ezine-mitral ne-aortic valve stenosis ngesikhathi sokwelashwa ngeTelsartan zidinga ukunakwa okukhethekile kubasebenzi bezokwelapha. Ukunakekelwa okukhethekile kufanele kuthathwe nge-hypokalemia ne-hyponatremia. Kungenzeka ukusebenzisa lesi sidakamizwa kuphela ngaphansi kokuqashwa osondelene nodokotela futhi uma isiguli sinomlando wokufakelwa kwezinso.
Ungayithatha kanjani i-telsartan?
Ithuluzi kufanele lithathwe isikhathi esingu-1 ngosuku, kangcono kakhulu ekuseni. Ukudla akuphazamisi ukumuncwa kwento esebenzayo yesidakamizwa. Ukuqeda umfutho wegazi ophakeme, kuthathwa umthamo wokuqala we-20 mg nsuku zonke. Ngokuzayo, umthamo ungakhuphuka ube ngu-40 noma u-80 mg.
Ngoshukela
Ezigulini ezinesifo sikashukela sohlobo 2, umuthi unqunywe kumthamo wokuqala ka-20 mg. Ngokuzayo, umthamo wansuku zonke ungangezelelwa ube ngu-40 mg.
Ukudla akuphazamisi ukumuncwa kwento esebenzayo yesidakamizwa.
Imiphumela emibi yeTelsartan
Ukusetshenziswa kwe-telsartan kuhlotshaniswa nengozi yemiphumela emibi eminingana. Iziguli zivame ukuzwa ama-vertigo, ubuthakathaka, izinhlungu esifubeni kanye ne-flu-like syndrome.
Amapheshana wesisu
Ukusetshenziswa kweTelsartan kuvame ukuholela ekubukekeni kobuhlungu besisu nokuphazamiseka komqondo.
Kusukela ohlangothini lwe-metabolism kanye nokudla okunempilo
Ezigulini ezinesifo sikashukela i-mellitus, ukusetshenziswa kwe-telsartan kungavusa i-hypoglycemia ne-hyperkalemia.
Isistimu yezinzwa ephakathi
Ithuluzi lingaholela ekukhuleni kwesifo sokuwa. Kungenzeka kufiphale.
Kusukela ohlangothini lwesistimu yezinzwa ephakathi, imiphumela emibi ngendlela yokufikelwa kungenzeka.
Kusuka ohlelweni lomchamo
Ukuthatha i-Telsartan kungadala ukwehluleka okukhulu kwe-renal.
Kusuka ohlelweni lokuphefumula
Ukwelashwa kweTelsartan kungadala ukukhwehlela kanye nokuphefumula. Isifo samaphaphu esingejwayelekile singakhula. Ngenxa yokwehla kokungazinzi komzimba ngenkathi uthatha umuthi, izifo zokuphefumula eziphezulu zingaqhamuka.
Engxenyeni yesikhumba
Ngesikhathi sokwelashwa ngeTelsartan, ukuthuthukiswa kwe-hyperhidrosis kuvame ukubonwa ezigulini.
Kusuka ohlelweni lwezitho zofuzo
Ezinye iziguli zakha i-cystitis. Ezimweni ezingavamile, ngokumelene nesizinda sokutheleleka okukhulu kohlelo lwezitho zofuzo, i-sepsis ingavela.
Ezinye iziguli zakha i-cystitis.
Kusuka ohlelweni lwezinhliziyo
Ngokulashwa ngeTelsartan, ukushaya kwenhliziyo kungakhuphuka. Kukhona amathuba okukhulisa i-bradycardia kanye nokwehlisa umfutho wegazi. Ngaphezu kwalokho, i-anemia ingakhula.
Kusuka ohlelweni lwe-musculoskeletal kanye nezicubu ezithintekayo
Lapho welapha nge-Telsartan, kubuhlungu emuva nangemisipha imisipha kungenzeka. Ngaphezu kwalokho, ukuhlaselwa kwe-myalgia ne-arthralgia kungenzeka.
Engxenyeni yesibindi ne-biliary
Kuqabukela kakhulu ekwelashweni kweTelsartan ukuthi kukhona ukwephulwa kwesibindi nepheshana elihlanganisiwe.
Kuyivelakancane ngesikhathi sokwelashwa ngeTelsartan ukuthi kukhona ukwephulwa komsebenzi wesibindi.
Allergies
Uma isiguli sine-hypersensitivity, kungavela ukungezwani komzimba, kuvezwe njengokuqhuma kwesikhumba nokulunywa, kanye ne-edema kaQuincke.
Umthelela ekhonweni lokulawula izindlela
Njengoba kunikezwe amandla umuthi wokubangela ukozela nesiyezi, ukunakekelwa kufanele kuthathwe lapho ushayela.
Imiyalo ekhethekile
Lo muthi akufanele uthathwe abesifazane abahlela ukukhulelwa kungekudala. Ingxenye esebenzayo yento inomphumela omubi wenzalo. Ngaphezu kwalokho, ukuqaphela kufanele kusetshenziswe kubantu abane-immune immune encishisiwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelashwa ngeTelsartan yabesifazane kuwo wonke ama-trimesters okukhulelwa akwamukeleki. Akunconyelwe ukusebenzisa umuthi ukuncelisa ibele.
Ukwelashwa ngeTelsartan yabesifazane kuwo wonke ama-trimesters okukhulelwa akwamukeleki.
Ukunquma iTelsartan ezinganeni
Njengoba kunikezwe ukuthi ukuphepha kweTelsartan ezinganeni nasebusheni akufundwanga, akunconywa ukusebenzisa umuthi ukwelapha iziguli ezinje.
Sebenzisa ebudaleni
Umuthi lo ungasetjenziswa ekwelapheni abantu abadala. Kulokhu, ukulungiswa komthamo akudingeki.
Isicelo sokusebenza kokulimala kwezinso
Ukusetshenziswa kwe-telsartan kuvunyelwe ekwelashweni kweziguli ezinokulimazeka kwe-renal function. Kunobufakazi bokusetshenziswa ngempumelelo kwalesi sidakamizwa ekwelapheni abantu abahlushwa i-hemodialysis njalo. Lokhu kudinga ukucwaningisisa kahle kwezinga le-potassium esegazini.
Sebenzisa umsebenzi wesibindi okhubazekile
Umuthi awunakusetshenziswa ekwelapheni abantu abanezifo zesibindi, okuhambisana nokuvinjezelwa kwendlela yokuphelelwa yisibindi ne-cholestasis.
Umuthi awunakusetshenziswa ekwelapheni abantu abanezifo zesibindi, okuhambisana nokuvinjezelwa kwendlela yokuphelelwa yisibindi ne-cholestasis.
Ukweqisa kweTelsartan
Ngomthamo owodwa omkhulu kakhulu wethamo lomuthi, i-bradycardia ne-tachycardia kungavela. Ezimweni ezingavamile, kukhona ukwehla komfutho wegazi. Uma kwenzeka kweqa ngokweqile, kunikezwa ukwelashwa okubonakalayo.
Ukuxhumana nezinye izidakamizwa
Lapho uthatha i-Telsartan ngasikhathi sinye ngemithi ye-immunosuppression, COX-2 inhibitors, heparin, kanye ne-diuretics, ingozi yokuthuthuka kwe-hyperkalemia iyanda. Ukusetshenziswa ngokubambisana nezidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala kunciphisa umphumela we-antihypertensive weTelsartan.
Ngaphezu kwalokho, inhlanganisela yesidakamizwa se-antihypertensive esine-diuretics eyenziwe nge-loop, kufaka phakathi IFurasemide ne-hydrochlorothiazide, yandisa ingozi yokuthuthuka kokuphazamiseka kubhalansi lwe-electrolyte yamanzi kanye nokwehla okungatheni komfutho wegazi. Ukusetshenziswa okuhlangene kwe-telsartan nge-lithium kwandisa umphumela onobuthi owenziwa kamuva. Ngokusetshenziswa ngasikhathi sinye kweTelsartan ene-corticosteroids ehlelekile, ukubonwa kokwehla komphumela we-antihypertensive kuyabonakala.
Ukuhambisana notshwala
Kufanele wenqabe ukuphuza utshwala ngenkathi welashwa noTelsartan.
Kufanele wenqabe ukuphuza utshwala ngenkathi welashwa noTelsartan.
Ama-Analog
Tonyartan bomcondvomshini onomphumela ofanayo wokwelapha ufaka:
- UMikardis.
- Lezi.
- I-Telmitarsan.
- I-Prirator.
- I-Irbesartan.
- IsiNortian.
- Amakhandlela.
- Kosaaar.
- Teve.
- I-Telpres.
Imibandela yekhefu lekhemisi
Lesi sidakamizwa singathengwa ekhemisi ngemithi.
Intengo ye-telsartan
Izindleko zeTelsartan emakhemisi zisuka kuma-ruble angama-220 kuye kwangama-260.
Izimo zokugcina zomuthi
Gcina umuthi endaweni yokushisa yasekamelweni.
Gcina umuthi endaweni yokushisa yasekamelweni.
Isikhathi sokuphelelwa yisikhathi
Ungawusebenzisa umuthi iminyaka engu-2 kusukela ngosuku lokukhiqizwa.
Umkhiqizi
I-Telsartan yakhiqizwa nguDkt Reddy's Laboratories Ltd., eNdiya.
Ubufakazi obuqhamuka kodokotela nasezigulini ngeTelsartan
UMargarita, oneminyaka engama-42, uKrasnodar
Lapho ngisebenza njengodokotela wenhliziyo, ngivame ukuhlangana neziguli ezinezikhalazo zokucindezela kwegazi okuphezulu. Ikakhulu kaningi, kuba nenkinga efanayo kubantu abangaphezulu kweminyaka engama-40 ubudala, lapho ukwanda kwengcindezi yegazi kuholela ekuwohlokeni okuphawuliwe enhlalakahleni futhi kudale izimfuneko zokubonakala kwezimo ezimbi kakhulu, kufaka phakathi ukushaya kwenhliziyo. Ezimweni ezinjalo, ngivame ukunquma iTelsartan yeziguli. Umuthi ubekezelelwa kahle ngumzimba futhi akuvamile ukuthi ucasule ukuvela kwemiphumela emibi. Kulokhu, umuthi unomphumela obizwa ngokuthi yi-hypotensive.
U-Igor, oneminyaka engama-38, e-Orenburg
Imvamisa nginquma iTelsartan ezigulini ezinezikhalazo zokucindezela kwegazi okuqhubekayo. Lesi sidakamizwa sinomphumela omnene we-antihypertensive. Kulokhu, umuthi ungafakwa ekwelashweni okuyinkimbinkimbi. Umuthi ungasetjenziswa ukuvikela ukuthuthukiswa kwe-pathologies yesistimu yehliziyo nethambo. Lo muthi awusisi sibi isimo seziguli ezinesifo sokuqina kwemithambo yemithambo yegazi.
UVladimir, oneminyaka engama-43, uRostov-on-Don
Ukusetshenziswa kweTelsartan kuvame ukunconywa kwiziguli ezinomfutho wegazi ophakeme onomlando wohlobo 2 sikashukela. Ukusetshenziswa kweTelsartan ezigulini ezinjalo akuholeli ekuwohlokeni kwesimo esejwayelekile futhi ngasikhathi sinye kunciphisa umfutho wegazi. Ukwelashwa ezigulini ezinjalo kunciphisa ingozi yezinkinga ezinzima ezivela ohlelweni lwezinhliziyo.
UMarina, oneminyaka engama-47, eMoscow
Inkinga yokugxuma kumfutho wegazi ebenginayo ngaphezu kweminyaka eyi-10 eyedlule. Ngalesi sikhathi ngizame izidakamizwa eziningi. Cishe iminyaka emi-2 eyedlule, njengoba kuyalelwe udokotela, waqala ukuthatha iTelsartan. Umuthi waba insindiso yami. Ithebhulethi elilodwa ngosuku lanele ukugcina ingcindezi ijwayelekile usuku lonke. Ngaphezu kwalokho, noma ngikhohlwa ukuthatha umuthi, angikaze ngibone ukwanda okukhulu komfutho wegazi usuku lonke. Ngenelisekile ngomphumela wokusetshenziswa kweTelsartan. Angibonanga zimpawu ezingezinhle.
UDmitry, oneminyaka engama-45 ubudala, eSt
Ukwemukelwa kukaTelsartan kwaqala ngokuncoma kwesifo sezinhliziyo. Kimi, lesi sidakamizwa sifanelwe kahle. Uma, lapho ngisebenzisa ezinye izidakamizwa, umfutho wegazi lami weqa kakhulu, obe nomthelela ongemuhle enhlalakahleni yami esejwayelekile, lapho-ke ngemuva kokuthatha iTelsartan ngikhohliwe ngenkinga yomfutho wegazi ophakeme. Angigcinanga nayimiphi imiphumela emibi evela ekusetshenzisweni kwalo muthi isikhathi esingaphezu konyaka sokusebenzisa umuthi ngendlela ehlelekile.
UTatyana, oneminyaka engama-51, uMurmansk
Umfutho wegazi ophakeme usungikhathaze iminyaka engaphezu kwengu-15. Ngisebenzise imishanguzo ehlukahlukene kanye nenhlanganisela yayo njengoba kuyalelwe odokotela, kodwa umphumela wawuhlala ungowesikhashana. Eminyakeni engaba ngu-1.5 edlule, udokotela wenhliziyo wamisa uTelsartan. Ngithatha leli khambi nsuku zonke kuze kube manje. Umphumela waneliseke ngokuphelele. Ingcindezi isizinzile, azikho i-surges. Akukho miphumela emibi eye yabonwa.
