I-Neurorubin iqukethe amavithamini we-B. Ngenxa yalokhu kuhlanganiswa, umphumela omuhle ezinqubweni eziningi ze-biochemical uyabonakala. Ngesikhathi sokulashwa ngalo muthi, imetabolism iyabuyiselwa. Kunikezwa ngezindlela ezahlukahlukene: okuqinile, okuwuketshezi. Ngama-pathologies aqatha ngokwengeziwe, kwenziwa imijovo. Umuthi une-contraindication ezimbalwa, ngenxa yokuntuleka kwezinto ezinolaka ekwakhekeni. Kodwa-ke, kukhona inani elikhulu lokuphendula okungalungile. Lokhu kungenxa yokungabekezeleli kwamavithamini athile athathwe kwimithamo emikhulu.
Igama Lezwe elingafanele
I-Pyridoxine + cyanocobalamin + thiamine.
I-ATX
A11DB.
Ngenxa yokuqukethwe kwamavithamini we-B, umuthi iNeurorubin ubuyisela umzimba.
Khipha amafomu nokwakheka
Umuthi unikezwa ngezinguqulo ezimbili: amaphilisi nomjovo. Kuzona zozimbili lezi zinhlaka, kusetshenziswa inhlanganisela eyodwa yezakhi eziphambili, kepha umthamo wazo uhlukile. Izinto ezisebenzayo ezisebenzayo: thiamine, pyridoxine hydrochloride, cyanocobalamin.
Amaphilisi
Umuthi osefomini eliqinile unikezwa emaphaketheni ama-20 ama-pcs. (2 amahliki ama-10 ama-PC ngalinye). Inani lezithako ezisebenzayo kuthebhulethi engu-1:
- i-thiamine mononitrate - 200 mg;
- i-pyridoxine hydrochloride - 50 mg;
- i-cyanocobalamin - 1 mg.
Ngokwengeziwe, ukwakheka kufaka izinto ezingakhombisi umsebenzi:
- cellulose oluyimpuphu;
- i-hypromellose;
- isitashi pregelatinized;
- i-mannitol;
- i-microcrystalline cellulose;
- i-magnesium stearate;
- i-colloidal silicon dioxide.
Izinto ezisebenzayo ezisebenzayo muthi: thiamine, pyridoxine hydrochloride, cyanocobalamin.
Isixazululo
Umkhiqizo uketshezi unikezwa ngama-ampoules we-3 ml lilinye. Umthamo wezinto ezisebenzayo uhlukile kunani lezinto eziphambili ekwakhekeni kwamathebulethi. I-1 ampoule iqukethe:
- i-thiamine hydrochloride - 100 mg;
- i-pyridoxine hydrochloride - 100 mg;
- i-cyanocobalamin - 1 mg.
Ngaphezu kwalokho, ukwakheka kubandakanya amanzi omjovo, i-potasium cyanide, i-benzyl alcohol. Iphakethe liqukethe ama-ampoules ayi-5.
Isenzo se-Pharmacological
Ukuqanjwa kufaka inkimbinkimbi yamavithamini: thiamine (B1), pyridoxine (B6), cyanocobalamin (B12). Inkomba enkulu yokufaka isicelo i-normalization yezinqubo ze-metabolic, okuholela ekususweni kwezibonakaliso ezingezinhle ezivela ezithweni ezahlukahlukene kanye nohlelo oluphambili lwezinzwa futhi. Zonke izinto ezisebenzayo ekwakhiweni zisebenza ngokuhlukile, zithuthukisa umphumela womunye nomunye.
Isibonelo, i-Vitamin B1 noma i-thiamine iyi-coenzyme yendlela ye-pentose phosphate (transketolase). Kuyasebenza futhi - ubamba iqhaza kumetabolism yamandla. Kuyaphawuleka futhi ukuthi le vithamini iyisakhi esiyingxenye ye-alpha-keto acid dehydrogenase ebunjiwe ebambe iqhaza ku-catabolism ye-leucine, isoleucine ne-valine.
Ngaphezu kwalokho, i-Vitamin B1 iyingxenye ye-thiamine triphosphate. Le khompiyutha ibandakanyeka ekusakazweni kokufakwa kwezinzwa, ukwakheka kwesiginali yeselula. Kunobufakazi bokuthi i-thiamine triphosphate ithinta ukulawulwa kokusebenza kweziteshi ze-ion. Ngenxa yalokhu, ukujwayeza ukusebenza kohlelo lwezinzwa kuyaphawulwa, ukuqina kokubonakaliswa okuthile ezimweni zokwephulwa kwalolu hlobo kuyancipha. Le vithamini ivame ukubizwa ngokuthi yi-antineuritic. Kuqukethwe emikhiqizweni elandelayo: i-legumes, inyama, isinkwa esinsundu, okusanhlamvu, imvubelo.
IVithamini B6 ikhombisa umsebenzi ovuselelayo, isiza ukusheshisa imetabolism. Kuyi-coenzyme yamaprotheni abandakanyeka ekusebenzeni kwama-amino acid. Ngaphezu kwalokho, i-Vitamin B6 inegalelo ekuphuculeni i-digestibility yamaphrotheni. I-Pyridoxine iyasebenza ekwenzeni amaseli egazi, i-hemoglobin. Omunye umsebenzi ukuhlinzeka izicubu noshukela.
Ukuntuleka kwe-Pyridoxine: kungasiza ekwakhiweni kwezimo eziningi ze-pathological, phakathi kwazo lapho i-coronary artery atherosclerosis. Ukwelashwa ngama-antibiotic, ukuthatha imishanguzo ye-anti-TB, ukubhema, nezindlela zokuvimbela inzalo ngomlomo kusiza ukunciphisa ukunqwabelana kwe-Vitamin B6 kwezicubu. Ngakho-ke, kuyadingeka ukwandisa ukulethwa komzimba nge-pyridoxine ngaphansi kwethonya lezi zinto. Le vithamini itholakala esibindini, emideni, emvubeni, ezinsweni, enyameni, ezinkomeni. Ngaphansi kwezimo ezijwayelekile, i-pyridoxine ikhiqizwa yi-microflora yamathumbu.
IVithamini B12 ibandakanyeka kumthamo wamaprotheni, ama-carbohydrate, lipids. Ngaphansi kwethonya le-cyanocobalamin, ukuhamba kwegazi kuyabuyiselwa, ngoba ukwakheka kwegazi kuyathuthuka. Vitamin ibekwe njenge-antianemic, metabolic. Ngaphansi kwethonya lazo, ukuvuselelwa kwezicubu kuyasheshiswa, ukusebenza kwesibindi nohlelo lwezinzwa kuvamile.
Izakhiwo zegazi zenziwa zenziwa ngendlela ejwayelekile (amandla okubumbana ayabuyiselwa). Ngesikhathi sokuguqulwa (inqubo yenzeka esibindini), kukhululwa i-cobamide, okuyingxenye yama-enzyme amaningi. Ukuhlanganiswa kwala mavithamini kusiza ukunciphisa izinga lobuhlungu ezifweni ezahlukahlukene zesistimu yezinzwa.
I-Pharmacokinetics
Ukuqunjelwa kwenzeka emathunjini. Uma ingena esibindini, uvithamini B1 udonswa yilesi sitho, kodwa kuphela ingxenye, inani elisele liguqulwa ekwakhekeni kwama-metabolites. Izinso namathumbu kunesibopho sokuqothula. I-Pyridoxine nayo iguqulwa ngokuhlanganyela kwesibindi. Ngokwezinga elikhulu, i-vithamini B6 inqwabelana esibindini, emisipheni nasezintanjeni zohlelo lwezinzwa. Kuyaphawuleka ukuthi ubopha kakhulu amaprotheni e-plasma. IPyridoxine ikhishwa yizinso.
IVithamini B12 ngemuva kokufakwa emzimbeni ngezinga elikhulu iqongelela esibindini. Njengomphumela we-metabolism, kukhululwa ingxenye eyi-1. ICyanocobalamin ne-metabolite yayo zidlulwa ngokubamba iqhaza kwezinso, kanye ne-bile.
Izinkomba zokusetshenziswa
Kuyelulekwa ukusebenzisa ithuluzi elikhulunywa ngalo, ucabangele indlela yokukhishwa. Amacwecwe nesisombululo asetshenziswa ezimweni ezihlukile. Kepha kunezindlela eziningi zezimo zempilo lapho kuvunyelwe khona ukunquma zombili izinhlobo zeNeurorubin:
- isifo sikashukela se-polyneuropathy;
- i-neuralgia yama-etiologies ahlukahlukene;
- i-neuritis ne-polyneuritis.
Isisombululo sisetshenziselwa futhi i-hypovitaminosis, lapho kubhekwe khona ukusweleka kwamavithamini we-B, kanye nokwelashwa kwe-beriberi. Ngaphezu kwalokho, uhlobo lolo ketshezi lomuthi lungasetshenziswa nge-monotherapy.
Kubekwa amathebhulethi ngokudakwa kwemithi ehlukahlukene, kufaka phakathi leyo yotshwala. Ngaphezu kwalokho, lolu hlobo lwemithi lungasetshenziswa kuphela njengengxenye yokwelapha okuyinkimbinkimbi.
Contraindication
Kunemikhawulo embalwa ngokuphelele yesidakamizwa:
- hypersensitivity kunoma iyiphi ingxenye yeNeurorubin;
- ukudideka kwemvelo yokwaliwa.
Ngokunakekela
Iziguli ezine-psoriasis kufanele ziqaphe isimo senombolo engaphandle yangaphandle, ngoba ngalesi sifo, ukuthatha lesi sidakamizwa okukhulunywa ngaso kungadala ukwanda kokuqina kwezimpawu ezingezinhle. Imiphumela efanayo kwesinye isikhathi yenzeka ngomqubuko.
Ungayithatha kanjani i-neurorubin
Uhlobo lokwelashwa lomuthi osezinhlotsheni eziwuketshezi futhi oluqinile luhlukile. Ngakho-ke, uma udokotela ancome ukuthatha amaphilisi, umthamo wansuku zonke wama-1-2 ama-pc uthathwa njengonele Akufanele bahlafunwe. Kunconywa ukugwinya amaphilisi ngamanzi. Umuthi uphuzwa ngale ndlela nsuku zonke. Isikhathi sokwelashwa kuvunyelwana ngaso ngudokotela ngokwahlukana, okuthintwa yisimo sesiguli nokuba khona kwezinye izifo. Kodwa-ke, ezimweni eziningi, inkambo yokwelashwa iyinyanga eyi-1.
Imiyalo yokusebenzisa ikhambi yokuphatha kwabazali:
- umthamo wansuku zonke wokubonakaliswa okunamandla kwalesi sifo ngu-3 ml (i-1 ampoule), umuthi ungasetshenziswa hhayi nsuku zonke, kepha kanye njalo ezinsukwini ezi-2;
- imvamisa yokusetshenziswa kweNeurorubin iyancipha ngemuva kokwehla kobukhulu bezimpawu zesimo se-pathological, kuleli cala kuvunyelwe ukunika imijovo kungabi ngaphezu kwezikhathi eziyi-1-2 ngosuku (umthamo ofanayo - 3 ml ngosuku).
Ngoshukela
Umuthi ungasetshenziswa ukwelapha iziguli ezikuleli qembu. Umthamo unqunywa ngokulandelanayo ubhekisisa ubukhulu bezinga lentuthuko yesimo se-pathological, isithombe somtholampilo kanye nokuba khona kwezinye izinkinga.
Imiphumela emibi
Ukungathandeki okuyinhloko kweNeurorubin yimikhuba eminingi emibi eshukunyiswa ngesikhathi sokwelashwa. Ezimweni eziningi, umuthi ubekezelelwa kahle. Imiphumela emibi yenzeka lapho umzimba uthatha amandla kunoma iyiphi isakhi, ukuba khona kwezinye izifo, noma uma kwephulwa umthetho wethamo. Ukuzilapha nakho kungadala ukusabela okungekuhle.
Amapheshana wesisu
Ukubuzwa kwenhliziyo isicanucanu, ukugabha, ukopha emgodini wokugaya ukudla. Umsebenzi we-plasma glutamine oxaloacetin transaminase uyanda.
Isistimu yezinzwa ephakathi
Ukukhathazeka, ukungakhathaleli, ukuqhamuka ekhanda, i-peropheral sensory neuropathy iba.
Kusuka ohlelweni lokuphefumula
I-Cyanosis, i-edema ye-pulmonary edema.
Engxenyeni yesikhumba
Umqubuko, ukwanda kwesikhumba ngomqubuko.
Kusuka ohlelweni lwezinhliziyo
I-Tachycardia, ukuthuthuka kwesikhashana kokungapheleli komsebenzi wesistimu yezinhliziyo ngokusongelwa ngokufa.
Uhlelo lwe-Endocrine
Inqubo yokuphuma kwe-prolactin ivinjelwe.
Njengomphumela omubi wesidakamizwa, ukuthuthukiswa kwesikhashana kokungapheleli komsebenzi wohlelo lwezinhliziyo kuyaphawulwa.
Allergies
I-Urticaria, ukulunywa, i-rash, i-angioedema, ukushaqeka kwe-anaphylactic.
Umthelela ekhonweni lokulawula izindlela
Njengoba kunikezwe ukuthi ithuluzi okukhulunywa ngalo linomphumela ongemuhle ekusebenzeni kohlelo lwezinhliziyo (kukhubekisa i-tachycardia, ukuwa), akunconywa ukushayela izimoto ngesikhathi sokwelashwa.
Imiyalo ekhethekile
Ukwelashwa kweziguli okutholakala kokuhlukumezeka kwenhliziyo kufanele kwenziwe ngaphansi kokuqondisa udokotela.
Uma i-sensory neuropathy iba ngesikhathi sokwelashwa ngeNeurorubin, imiphumela emibi izonyamalala ngemuva kokumisa lo muthi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ayisetshenziswa.
Ukunquma i-Neurorubin ezinganeni
Kuvunyelwe ukusebenzisa lesi sidakamizwa okukhulunywa ngaso kuphela ekwelapheni iziguli ezingaphezu kweminyaka engu-18.
Sebenzisa ebudaleni
Umuthi ungasetshenziswa. Kodwa-ke, kunqunyelwe iziguli ngaphandle kokuphambuka emsebenzini wesistimu yenhliziyo. Esigabeni sokuqala ukwamukelwa, kufanele ubheke isimo somzimba. Uma kuvela izimpawu ezingezinhle, umuthi uyakhanselwa.
Isicelo sokusebenza kokulimala kwezinso
Ngokubona ukuthi izakhi zomuthi zivezwa ngokubamba iqhaza kwalesi sitho, kufanele kuqashelwe lapho kwenziwa ukwelashwa.
Sebenzisa umsebenzi wesibindi okhubazekile
Ithuluzi elibhekiwe lingasetshenziswa yiziguli ezinama-pathologies anjalo, noma kunjalo, kuyadingeka ukuqapha kakhulu izinguquko emzimbeni.
Uma kwenzeka ukuvela kokubi, ukwelashwa kufanele kuphazanyiswe.
Ukweqisa
Imiphumela emibi yenzeka uma imithamo emikhulu yesidakamizwa (500 mg ngosuku) igxiliswa emzimbeni isikhathi eside (izinyanga ezingaphezu kwezi-5 zilandelana). Kulesi simo, ingozi yokwanda kwe-sensor neuropathy iyanda, okukhonjiswa kobuhlungu emilenzeni, ekulahlekelweni kwemizwa, ekushiseni kwemizwa, ekuzwa umuzwa wokuwa. Lokhu kungumphumela wokunqotshwa kokuphela kwezinzwa eziningi. Izimpawu ezingezinhle ziyanyamalala ngemuva kokususwa kwezidakamizwa.
Ukuxhumana nezinye izidakamizwa
Ukusebenza kwezidakamizwa ze-antiparkinsonian kuncishisiwe. Ukwanda kwezinga lobuthi be-isoniazid kuyabonakala.
Izinto ezilandelayo ziphikisana: Theosemicarbazone ne-5-fluorouracil. Ukulungiselela kwe-Antacid kunciphisa izinga lokufakwa kwe-thiamine.
Isixazululo se-Neurorubin asikwazi ukuhlanganiswa nezinye izindlela, ngoba ukuhlanganiswa kwaso nezinye izinhlobo zezinto zokwelapha akuzange kufundwe ngokuphelele.
Ukuhambisana notshwala
Akunconywa ukuthatha umuthi futhi ngesikhathi esifanayo uphuze iziphuzo eziqukethe utshwala. Lokhu kungenxa yokuthi ngaphansi kwethonya lotshwala isilinganiso sokumuncwa kwamavithamini we-B siyancipha futhi nokuqothulwa kwabo okuvela emzimbeni kuyasheshiswa, okuholela ekushodeni kwezakhi zomzimba.
Ama-Analog
Ukufakwa esikhundleni okusebenzayo:
- IVitaxone;
- I-Nerviplex;
- Milgma.
Izimo zeholide zeNeurorubin kusuka ekhemisi
Umuthi osendaweni yesisombululo umuthi. Akudingeki ukuthi usebenzise incwadi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Yebo, kepha kuphela ngesimo esiqinile.
Intengo ye-neurorubin
Izindleko ezijwayelekile eRussia ngama-ruble ayi-1000. Intengo yesidakamizwa e-Ukraine iyahlukahluka phakathi kwama-ruble angama-230-550, okusho ngohlobo lwemali lukazwelonke yi-100-237 UAH.
Izimo zokugcina zomuthi
Ukushisa komoya okunconyelwe ngaphakathi akuyona phezulu kune- + 25 ° ะก. Umuthi kufanele ugcinwe endaweni eyomile. Izimo ezinjalo zilungele amaphilisi.
Isixazululo kufanele sigcinwe ekushiseni kwe + 2 ... + 8 ° C.
Isikhathi sokuphelelwa yisikhathi
Ifomu lethebhulethi lesidakamizwa lingasetshenziswa iminyaka emi-4. Isixazululo singasetshenziswa iminyaka emi-3 kusukela ngosuku lokukhishwa.
Umakhi we-Neurorubin
I-Wepha GmbH, eJalimane.
Ukubuyekezwa kweNeurorubin
UGalina, oneminyaka engama-29 ubudala, Perm
Udokotela uxwayise ngokuthi ngezifo zesicanucanu sesisu kungavela. Kodwa izimpawu ezingathandeki esimweni sami azange zibonakale ngokushesha (ngine-gastritis), kepha ziseduze maphakathi nenkambo (ngeviki lesibili lokwamukelwa). Umphumela wokwelashwa muhle: izinhlungu zinciphile, isimo senqondo esivamile sesithuthukile.
UVeronika, oneminyaka engama-37, uYaroslavl
Wasebenzise umuthi ukuwohloka kwemizwa. Isikhathi sokuqala selashwa ngemijovo. Emva kwalokho, izimpawu zaba kancane, ngakho-ke ngaphenduka amaphilisi. Imiphumela emibi ayenzekanga, umuthi ubekezelelwe kahle. Ngeke ngikwazi ukuthi kusebenza kahle kangakanani amaphilisi, ngoba ngiwathathe ngihlangana nezinye izidakamizwa.
