Ungayisebenzisa kanjani isidakamizwa i-Neyrolipon

I-Neyrolipon umuthi onemiphumela ye-antioxidant kanye ne-hepatoprotective uma isetshenziswa. Isidakamizwa sisetshenziswa kwezokwelapha ukwelashwa kanye nokuvinjelwa kwe-polyneuropathy okucasulwe ukudakwa kotshwala noma isifo sikashukela. Izilonda eziningi zezinzwa zepherishi zithola ukwelashwa ngenxa yesenzo se-thioctic acid, esinethonya elihle ku-metabolism ye-neurons.

Igama Lezwe elingafanele

I-Thioctic acid.

I-Neyrolipon umuthi onemiphumela ye-antioxidant kanye ne-hepatoprotective uma isetshenziswa.

NgesiLatini - Neurolipon.

I-ATX

I-A16AX01.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngamafomu omthamo ama-2: ngesimo samakhompiyutha nanjengesidingo sokulungiselela imijovo ye-intravenous. Ngokubukeka, amaphilisi embozwe igobolondo elinzima le -gelatin ye-hue ekhanyayo ephuzi, iqukethe ngaphakathi kwento enobuthi enobuthi evela emigodini ephuzi. Iyunithi lokulungiselela liqukethe i-300 mg yento esebenzayo - i-thioctic acid. Njengezinto ezisizayo ekukhiqizweni kokusebenzisa:

• i-hypromellose;
• i-magnesium stearate;
• i-colloidal silloon dioxide enamanzi;
• ushukela we-lactose;
• i-microcrystalline cellulose.

Igobolondo langaphandle liqukethe i-gelatin, titanium dioxide. Umbala we-capsule ufakwa kudayi ophuzi osuselwa ku-iron oxide.

Umuthi uyatholakala ngesimo samaphilisi.

Gxila

Ukugxila kumelwa ngokusobala uketshezi olusobala oluvalelwe ku-ampoules yengilazi emnyama enomthamo we-10 noma 20 ml. Umuthi uyadingeka ukulungiselela isixazululo somjovo we-intravenous. Ifomu lomthamo ligxila ku-30 ​​mg we-thioctic acid ngendlela ye-meglumine thioctate njengendawo esebenza ngayo.

Phakathi kwezingxenye ezisizayo yilezi:

• i-meglutin ekuguqukweni kwe-N-methylglucamine;
• i-macrogol (polyethylene glycol) 300;
• amanzi omjovo 1 ml.

Emabhodleleni, kuboniswa iphuzu lekhefu.

Uhlobo olungekho

Umuthi awutholakali kwifomu lethebhulethi, uthengiswa kuphela ngefomu le-capsule. Lokhu kungenxa yokuthi amaphilisi awakwazi ukunikeza isilinganiso esidingekayo sokufaka kanye ne-bioavailability eyanele ukufeza umphumela wokwelapha.

Isenzo se-Pharmacological

Into esebenzayo yesidakamizwa inomphumela we-antioxidant kwizakhi zamaselula omzimba futhi isiza ukuhlanza izicubu zobuthi. Ngasikhathi sinye, isakhi esisebenzayo somuthi sivikela amaseli wesibindi ekulayelweni ngokweqile kanye nemiphumela ebuhlungu yamakhemikhali.

Ingxenye esebenzayo yesidakamizwa ivikela amangqamuzana esibindi ekulayelweni ngokweqile nasemiphumeleni enobuthi yamakhemikhali.

I-Thioctic acid yakhiwa emzimbeni ngamanani amancane, ngoba Kudingeka ikhemikhali ebambe iqhaza ku-oxidative decarboxylation yama-alpha-keto acid (kumjikelezo weKrebs). Ngenxa yezakhiwo ze-coenzyme, i-thioctacid idlala indima enkulu ekugayweni kwamandla kwamaseli.

Inhlanganisela yamakhemikhali isebenza njenge-antioxidant ye-endo native esebenza futhi isebenze yinkimbinkimbi ngama-radicals mahhala. Yenza umsebenzi we-coenzyme ekuguqulweni kwezinto futhi ihlangana nemiphumela ye-antitoxic. Ngaphezu kwalokho, i-alpha lipoic acid iyakwazi ukubuyisa amanye ama-antioxidants, ikakhulukazi ngokumelene nesizinda sikashukela i-mellitus. Ezigulini, lapho uthatha umuthi, ukumelana ne-insulin kuyancipha, ngenxa yokuthi lapho ikhemikhali ivimbela ukulimala ohlelweni lwezinzwa oluyingozi.

Umuthi unciphisa ukugcwala koshukela emzimbeni futhi kuvimbela ukwakheka kwe-glycogen kuma-hepatocytes. I-Tactic acid ibandakanyeka kuma-metabolism wamafutha ne-carbohydrate, inciphisa i-cholesterol ephelele futhi inciphise nengozi yezindawo ezinamafutha atherosselotic odongeni lwemithambo yegazi. Lapho uthatha i-Neyrolipona, kukhona ukuthuthukiswa kokusebenza kwesibindi ngenxa yomphumela we-hepatoprotective.

Umphumela we-antitoxic ubangelwa umphumela wengxenye esebenzayo yesidakamizwa kumakhompiyutha we-toxin. I-Acid isheshisa ukuqhekeka kwezinto ezinobuthi, izinhlobo ze-oksijini ezisebenzayo, izinhlanganisela zezinsimbi ezisindayo, usawoti futhi isheshise ukuphuma kwazo lapho ibamba iqhaza kwi-mitochondrial cell metabolism.

I-Pharmacokinetics

Lapho ihanjiswa ngomlomo, i-thioctic acid imunca ngokushesha amathumbu amancane nge-100%. Ngokufakwa okufanayo kanyekanye kokudla, izinga lokufaka liyancipha. I-Bioavailability ingama-30-60% ngemuva kokudlula kokuqala kumaseli wesibindi. Uma ingena egazini, isakhi esisebenzayo sifinyelela isilinganiso saso kungakapheli imizuzu engama-30.

Lapho ihanjiswa ngomlomo, i-thioctic acid imunca ngokushesha amathumbu amancane nge-100%.

Umuthi uguqulwa kuma-hepatocytes ngokuhlangana kanye nokuphendula okuvela ku-oxidative. I-Thioctic acid kanye nemikhiqizo yayo ye-metabolic ishiya umzimba ngohlobo lwawo lwangempela ngo-80-90%. Isigamu sempilo yimizuzu engama-25.

Okunqunyelwe

Umuthi usetshenziselwa ukwelapha nokuvikela i-polyneuropathy yotshwala kanye ne-neuropathy yesifo sikashukela.

Contraindication

Ezimweni ezikhethekile, lesi sidakamizwa asinconywa noma asinqatshelwe ukusetshenziswa:

• izingane nentsha engaphansi kweminyaka eyi-18;
• isikhathi sokukhula kombungu kanye nokuncelisa;
• ukwanda kokucasuka kwezicubu ezingxenyeni zezakhi zomuthi;
• Ifa elenzelwe ukubekezelela i-lactose, galactose, ukuntuleka kwe-lactase kanye ne-malabsorption yama-monosaccharides emzimbeni.

Ngokunakekela

Kunconywa isifo sikashukela i-mellitus, izilonda ezihlasela izilonda zesisu kanye ne-duodenum, hyperacid gastritis.

Izingane nentsha engaphansi kweminyaka engu-18 ubudala kungukuphula umthetho ekusebenziseni umuthi.

Isikhathi sokukhula kombungu kuwukuphikisana nokusetshenziswa komuthi.

Umuthi uthathwa ngokuqapha kushukela.

Ungayithatha kanjani iNeroLipone

Lapho ihanjiswa ngomlomo, ngendlela yamaphilisi, iyadingeka ukuphuza amayunithi omuthi ngaphandle kokuhlafuna. Umuthi usetshenziswa esiswini esingenalutho imizuzu engama-30 ngaphambi kokudla kwithamo lansuku zonke le-300-600 mg. Isikhathi sokwelashwa sinqunywa uchwepheshe wezokwelapha. Kwezifo ezinzima, kunconywa ukuthi uqale ngokusetshenziswa komuthi njengabazali.

Ukuphathwa kwe-Intravenous kwenziwa ku-600 mg ngosuku kumuntu omdala. Kuyadingeka ukuphatha ukumnika kancane - hhayi ngaphezulu kwama-50 mg ngomzuzu. Ukulungiselela isixazululo esidonsela phansi, kuyadingeka ukufaka i-600 mg yokugxila ku-50-250 ml wesisombululo se-isotonic sodium chloride engu-0.9%. Isingeniso senziwa isikhathi esi-1 ngosuku. Ezimweni ezinzima zesifo, umthamo unyuka ufike kuma-1200 mg. Isixazululo esilungiselelwe kufanele sivikeleke ekuchayweni yimisebe yelanga nemisebe ye-ultraviolet.

Isikhathi sokwelashwa singamaviki angama-2-4, ngemuva kwalokho baphendukela ekwelashweni kokulondolozwa (ukuthatha amaphilisi) ngomthamo ongu-300-600 mg ngosuku izinyanga eziyi-1-3. Ukuhlanganisa umphumela wokwelapha, uvunyelwe ukuphinda izikhathi ezi-2 ngonyaka.

Isikhathi sokwelashwa sinqunywa uchwepheshe wezokwelapha.

Ngoshukela

Lapho kukhona isifo sikashukela, kubalulekile ukubheka njalo ushukela emzimbeni. Ezimweni ezikhethekile, udinga ukubonisana nodokotela wakho mayelana nokulungiswa kwamthamo kwama-ejenti we-hypoglycemic ekuvimbeleni i-hypoglycemia.

I-Thioctic acid iholela ekushintsheni kwe-plasma concentration ye-pyruvic acid esegazini.

Imiphumela emibi ye-neuroleipone

Njengomphumela oseceleni, kuvela izimbambo zesikhumba.

Umthelela ekhonweni lokulawula izindlela

Umuthi awuthinti umsebenzi wesistimu yezinzwa ephakathi nethintekile. Ngesikhathi sokwelashwa neNeololipon, ukuxhumana nezinqubo eziyinkimbinkimbi, ukushayela neminye imisebenzi edinga ukugxilwa nokushesha kokuphendula kuvunyelwe.

Imiyalo ekhethekile

Iziguli zithambekele ekubonakalisweni kokuphendula kwe-anaphylactic, ngaphambi kokuqala ukwelashwa kwezidakamizwa, kunconyelwa ukwenza ukuhlolwa kwe-allergic ukubekezelela ukuhlanganiswa kwamakhemikhali.

Sebenzisa ebudaleni

Umuthi awunawo nomthelela oqondile ohlelweni lwezinzwa nolwemizwa ephakathi nendawo, kepha ngenxa yokuthi kungenzeka ukuthi kube nemiphumela emibi kubantu abaneminyaka yobudala engama-50 ngesikhathi sokwelashwa ngezidakamizwa, kucwayiswa ngokuqapha lapho usebenzisa umuthi. Ukulungiswa okwengeziwe komthamo wansuku zonke akudingeki.

Abantu abaneminyaka engaphezu kwengama-50 ubudala ngesikhathi sokwelashwa ngezidakamizwa bayelulekwa ukuthi baqaphele lapho besebenzisa umuthi.

Ukunquma iNeurolypone ezinganeni

Umuthi uvunyelwe ukusetshenziswa kuze kube iminyaka eyi-18, ngoba akukho datha evela ezifundweni ezanele ekhonweni lamakhemikhali e-thioctic acid ethinta ukukhula komuntu nentuthuko ebuntwaneni nasebusheni.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

I-Neyrolipona yamakhemikhali esebenzayo is contraindication ukuthi isetshenziswe ngesikhathi sokuthuthukiswa kwe-embryonic, njengoba izinhlanganisela zomuthi ziyakwazi ukungena ekuvinjelweni kwe-placental futhi ziphazamise ukubeka kwezitho nezinhlelo. Ukuphuza umuthi kwenziwa kuphela ezimweni ezibucayi, lapho ingozi empilweni yowesifazane okhulelwe idlula amathuba we-intrauterine pathologies esibelethweni.

Musa ukunquma ngesikhathi se-HB.

Isicelo sokusebenza kokulimala kwezinso

Ukuqapha kuyelulekwa lapho kukhona ukwehluleka okungamahlalakhona noma okubucayi bezinso, njengoba I-80-90% yezidakamizwa ishiya umzimba ngenxa yokucwatshwa komoya kanye nokuqothuka kweshubhu.

Ukuqwashisa kuyelulekwa lapho kukhona ukwehluleka okungamahlalakhona noma okulimazayo kwe-renal.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukwephulwa okukhulu komsebenzi wamaseli wesibindi, kuyadingeka ukunquma inqubo evamile yansuku zonke nokuqapha ngokucophelela kwezokwelapha lapho uthatha umuthi. Umuthi unomphumela we-hepatoprotective, kepha isakhi esisebenzayo sakhiwe ngokwengxenye kuma-hepatocytes.

Ngokulimala kwesitho esilinganiselwe nesimnene, ukulungiswa kwemithamo eyengeziwe akudingeki.

Ukweqisa kwe-neuroleipone

Ngokusebenzisa kabi izidakamizwa, kuvela izimpawu zomtholampilo ze-overdose:

• isicanucanu
• ukuqunjelwa;
• ikhanda kanye nesiyezi;
• izicubu zomsipha;
• ukungahambi kahle kwe-acid-base kanye nokulinganisa kwe-electrolyte yamanzi, okuhambisana ne-lactic acidosis;
• ukuphazamiseka okukhulu kwegazi nokhula kwesikhathi se-prothrombin;
• ukuthuthukiswa okungenzeka kwe-hypoglycemic coma nokufa.

Isicanucanu ngesinye sezimpawu zokweqisa.

Uma isiguli sithathe umthamo omkhulu womuthi emahoreni angama-4 edlule, isisulu sidinga ukugeza, sihlanza isisu sinikeze umuthi wokungenisa (i-charcoal activated) ukuvikela ukumuncwa kwe-Neuro lipon okuqhubekayo. Uma kungekho into ethile ephikisayo, ukwelashwa okungalawuleki kuhloswe ukuqeda isithombe esibonisa uphawu lwe-overdose.

I-Hemodialysis ne-dialysis yabazali ayisebenzi, ngoba indawo yezidakamizwa ayihlanganisi namaprotheni e-plasma.

Ukuxhumana nezinye izidakamizwa

Ngokusebenzisa kanyekanye i-Neyrolipon neminye imithi, lokhu kusabela okulandelayo kuyabonakala:

1. Ngokuphikisana nesizinda se-thioctic acid, sikhulisa umphumela wokwelapha (umphumela wokulwa nokuvuvukala) we-glucocorticosteroids.
2. Ukusebenza kweCisplatin kuncishisiwe.
3. Izidakamizwa eziqukethe i-Ethanol zenza buthaka umphumela wezokwelapha we-neuroleptone.
4. Ngokuhambisana ne-insulin, izidakamizwa ze-hypoglycemic zokuphathwa komlomo, i-synergism iyabhekwa (imithi ithuthukisa umphumela wemithi womunye nomunye).
5. Inhlanganisela yamakhemikhali i-Neyrolipona iyinhlangano eyinkimbinkimbi enezinsimbi, ngakho-ke lesi sidakamizwa asinconywa ukuba sithathwe kanye nama-ejenti aqukethe insimbi (amalungiselelo ngokuba ne-magnesium, iron, calcium calcium). Isikhathi sokuthatha umuthi kufanele sibe okungenani amahora ama-2

Ukuhambisana notshwala

Ukwemukelwa kotshwala ngesikhathi sokwelashwa nge-Neyroliponom kunqatshelwe. I-ethyl utshwala yenza buthaka umphumela wokwelapha umuthi futhi ithuthukise ubuthi kumaseli wesibindi.

Ukwemukelwa kotshwala ngesikhathi sokwelashwa nge-Neyroliponom kunqatshelwe.

Ama-Analog

Le mithi elandelayo ihlobene nokufakwa esikhundleni sokwakheka kwama-analogues anethonya elifanayo le-pharmacological emzimbeni:

• ICorilip;
• I-Berlition 300 ne-600 eyenziwe ngeBerlin-Chemie, eJalimane;
• UCorilip Neo;
• I-Lipoic acid;
• I-Lipothioxone;
• I-Oktolipen;
• I-Thiogma;
• I-Thioctacid 600.

Akunconyelwe ukwenza inguquko ezimele yokuthatha omunye umuthi. Ngaphambi kokufaka esikhundleni salomuthi, ukubonisana nodokotela wakho kuyadingeka.

Imibandela yekhefu lekhemisi

Umuthi uthengiswa ngomuthi onikezwe wona.

Umuthi uthengiswa ngomuthi onikezwe wona.

Ngingakwazi ukuthenga ngaphandle kadokotela

Cha.

Intengo ye-neuroleipone

Izindleko ezijwayelekile zamakhompiyutha eRussia (izingcezu eziyi-10 ngazinye emaphepheni ama-blister, ama-3 maletha ebhokisini lekhadibhodi) zingama-ruble angama-250, kumabhodlela agxilisiwe, kusuka ku-170 (nge-ampoules eyi-10 ml) kuya kuma-ruble angama-360. (umthamo ngamunye ongu-20 ml).

Izimo zokugcina zomuthi

Kunconywa ukugcina umuthi endaweni eyomile, unqunyelwe kusuka ezinganeni futhi uvezwa ukukhanya kwelanga, emazingeni okushisa afinyelela ku + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Iminyaka engu-5 kusukela ngosuku lokukhululwa. Kuyenqatshelwe ngokuphelele ukuthatha lesi sidakamizwa ngemuva kosuku lokuphelelwa isikhathi oluboniswe kuphakethe.

Umkhiqizi

I-PJSC Farmak, e-Ukraine.

Ukubuyekezwa mayelana ne-neuroleptone

U-Eugene Iskorostinsky, udokotela wezokwelapha, uRostov-on-Don

Ngicabanga amakhompiyutha futhi ngigxila kweNegolipona esezingeni eliphakeme futhi esebenza ngempumelelo i-generic alpha-lipoic acid. Ngisebenzisa umuthi ngaso sonke isikhathi ekunakekelweni kwami ​​kwemitholampilo. Ngiqoka iziguli ukuthi zithuthukise imizwa yezinzwa ezilondweni zesistimu ye-peripheral neva, ikakhulukazi ngokumelene nesifo sikashukela kanye nokungasebenzi kahle kwe-erectile. Ngiyathanda ukuthi ukusetshenziswa kwesidakamizwa isikhathi eside kungenzeka, futhi akukho ukusabela okungekuhle.

U-Ekaterina Morozova, oneminyaka engama-25 ubudala, u-Arkhangelsk

Isidakamizwa esikhonjelwe ngokumelene nesifo sikashukela se-polyneuropathy. Ngathatha amaphilisi amabili ngesikhathi esisodwa mayelana nemiyalo yokusetshenziswa kwezokwelapha. Isimo sakhe sathuthuka, ushukela wabuyela kwesejwayelekile. Ngesikhathi sokugula, ngaphelelwa yimizwa (ngisho nemizwa ethambile emilenzeni yanyamalala), kepha lapho ngiphuza umuthi, imizwa yabuya - hhayi ngokushesha, phakathi nezinyanga ezi-2. Esontweni lokuqala, bengifuna ukuyeka ukwelashwa ngenxa yokwehla kancane, kepha ngemuva kokubonisana nodokotela ngabona ukuthi lokhu kwakujwayelekile. Kwakungekho ukusabela komzimba noma okunye ukusabela okubi ngesikhathi sokwelashwa.