ILangerin isetshenziselwa ukwehlisa ushukela wegazi. Lesi isidakamizwa se-hypoglycemic eqenjini le-Biguanide. Kubekelwe ukwelashwa kwe-mellitus yesifo sikashukela sohlobo lwesibili, lapho kungadingeki i-insulin.
Igama Lezwe elingafanele
Igama lomhlaba wonke liyahlangana negama lento esebenzayo - Metformin (metformin).
ILangerin isetshenziselwa ukwehlisa ushukela wegazi.
I-ATX
Ikhodi ye-ATX - Inombolo ye-A10BA02.
Khipha amafomu nokwakheka
Umuthi utholakala kuphela ngesimo samathebulethi okuphatha ngomlomo. Kunezinhlobo ezinjengalezi - isenzo esihlanganisiwe, esisebenza isikhathi eside, esimbozwe ngesikhumba sefilimu, ngokuhlanganiswa okuhlanganayo.
Isakhiwo esikhulu esisebenzayo yi-metformin hydrochloride. Abahambeli bakhona: isitashi sommbila, isitashi se-magnesium, i-macrogol 6000, i-anhydrous colloidal silicon dioxide, i-povidone 40, i-titanium dioxide, i-starch sodium glycolate, i-hypromellose, i-monstearate-2000-macrogol.
Isenzo se-Pharmacological
Umuthi unciphisa ukwakheka kweglucose "entsha" esibindini, ukumuncwa kwayo emgodini wokugaya ukudla. Okuhle ukuthi akukuthinti ukukhiqizwa kwe-insulin futhi kuyaqabukela kudala izimo ze-hypoglycemic.
I-Pharmacokinetics
Lapho ufaka umuthi ngaphakathi, i-metformin igxiliswa ngokuphelele emapheshana, kuyilapho kuze kufinyelele kokuthathu kukhishwe emzimbeni ngezindunu. Ukuqoqwa okukhulu kwento kufinyelelwa ngemuva kwamahora amabili nesigamu. Egazini, umuthi empeleni awuzihlanganisi namaprotheni; kuma-cytoplasm amaseli abomvu amaseli, isakhi esisebenzayo siqongelela ngesimo samatshana.
Kuze kuthathe ingxenye yesithathu yezidakamizwa ikhishwa emzimbeni inezinduku.
Izinkomba zokusetshenziswa
Umuthi usetshenziswa uma kwenzeka ukungasebenzi kahle kwezindlela zokudla kanye nokuzivocavoca ngokomzimba, une-glycemia ephezulu kushukela lohlobo lwesibili, ikakhulukazi ukukhuluphala ngokweqile.
Contraindication
I-Metformin ayivunyelwe ukusetshenziswa ezimweni ezinjalo:
- hypersensitivity kuzakhi;
- ngokulimala okuqinile kwe-renal kanye ne-hepatic;
- ngotshwala;
- ngezifo zohlelo lokutheleleka kanye nenhliziyo;
- izinhlobo ezahlukahlukene ze-acidosis;
- ukukhulelwa nokuqunjelwa;
- ukusetshenziswa kwe-iodine ehlukile;
- ngendlala nokuphelelwa ngamandla.
Ungamthatha kanjani uLangerin
Umuthi uthathwa ngokubheka izinga le-glucose egazini, okufanele isiguli sililinganise kaningana ngosuku: ekuseni, ngemuva kokudla ngakunye, kusihlwa ngaphambi kokulala.
Ukwemukelwa - ngomlomo ngenkathi udla ukudla noma emva kwawo. Umthamo wokuqala usuka ku-500 mg uye kuma-850 2 noma kathathu ngosuku. Ngemuva kwamaviki ama-2, umthamo kufanele ulungiswe ngokuya ngemiphumela yokuhlaziywa kwe-glycemic.
Umthamo omkhulu awunakudlula ama-3000 mg, uhlukaniswe amahlandla ama-3.
Ezinganeni ngemuva kweminyaka eyi-10 ubudala, umthamo ngu-500-850 mg ngosuku 1 isikhathi. Umthamo omkhulu ngu-2000 mg, ohlukaniswe izikhathi ezingama-2-3.
Ngoshukela
Imiyalo yokusetshenziswa ihlukanisa ukwelashwa ku-monotherapy kanye nokuhlanganiswa ne-insulin. Umthamo wokuqala ungama-500-850 mg kabili nsuku zonke ngokudla noma ngemuva kokudla. Emavikini amabili kamuva, ukulungiswa komthamo kwenziwa ngaphandle kwemiphumela yokulawulwa ushukela. Sonke lesi sikhathi, isiguli kufanele sigcine iphrofayili ye-glycemic. Umthamo omkhulu ovunyelwe yi-3 g, ohlukaniswe ngemithamo emithathu.
Ku-mellitus yesifo sikashukela, imiyalo yokusebenzisa umuthi ihlukanisa ukwelashwa ku-monotherapy kanye nokuhlanganiswa ne-insulin.
Imiphumela emibi yeLangerin
Izimo ezingezinhle ezivela ezithweni ezahlukahlukene nasezinhlelweni zingase zikhule.
- Isikhumba: ukuqhuma okuvundayo, okhalweni.
- Umthelela ohlelweni lwe-hepatobiliary: i-hepatitis, umsebenzi wesibindi ongasebenzi kahle.
- Izimpawu ze-Neurological: ukuphazamiseka kokunambitha.
- Ukusuka emgudwini wokugaya ukudla: umuzwa wokucanuzelelwa kwenhliziyo, ukuhlanza, isifo sohudo, ukuntuleka kokudla, ubuhlungu besisu, ukuqhakaza, ukunambitheka kwensimbi emlonyeni.
- Akuvamile ukuthi kube noshintsho egazini - i-megaloblastic anemia, ukuntuleka kwevithamini B12.
Ukubonakaliswa kwemitholampilo kunyamalala ngokwabo ngemuva kokuhoxiswa kwezidakamizwa. Ezimweni ezingavamile, ukwelashwa okubonakalayo kuyadingeka.
Umthelela ekhonweni lokulawula izindlela
Uma usebenzisa iLangerin njenge-monotherapy, kunobungozi obuncane bokuqhamuka nezimo ze-hypoglycemic, uma zihlanganiswa nezinye izidakamizwa ezinciphisa ushukela, ziyanda. Ngakho-ke, kungenzeka ukunciphisa ukunakwa lapho usebenza ngamamishini noma ushayela.
Imiyalo ekhethekile
Zihlanganisa ukulungisa umthamo (imvamisa ithebhulethi ihlukaniswe ama-halves) futhi itadisha ukuthi kungenzeka yini ukuthi iqokwe emaqenjini ahlukahlukene abantu.
Sebenzisa ebudaleni
Kubantu asebekhulile, izindawo ezisebenzayo zezinhlelo eziningi (izinso, ukungasebenzi kwenhliziyo) zivame ukuhlupheka, ngakho-ke iziguli eziningi zisebenzisa izidakamizwa ukuze zizilondoloze. Futhi uma kunokungafani kwemishanguzo, khona-ke kufanele ulahle i-Langerin noma ushintshe umthamo wawo (uma kunesidingo, wephula ithebulethi libe isigamu, uthathe elilodwa).
Isabelo sezingane
Umuthi ubekelwe izingane ezingaphezulu kweminyaka eyishumi. Emncane, ezinye izidakamizwa ziyakhethwa. Ukuhlolwa kwalesi sidakamizwa ebuntwaneni akukaze kwenziwe, ngakho-ke akukho datha ngemiphumela yawo ekukhuleni, ekukhuleni nasekukhuleni kwezingane, ikakhulukazi ekusebenziseni isikhathi eside. Ngakho-ke, kufanele isetshenziswe ngokuqapha eqenjini lobudala beminyaka eyi-10-12.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Lapho uhlela ukukhulelwa, udinga ukuyeka ukuthatha uLangerin futhi wazise udokotela wakho ngalokhu. Uzocacisa umthamo ofanele we-insulin, ozodinga ukusetshenziswa sonke isikhathi sokukhulelwa. Umphumela we-metformin kwi-fetus uhlukaniswa njengesigaba B.
Lapho uhlela ukukhulelwa, udinga ukuyeka ukuthatha uLangerin futhi wazise udokotela wakho ngalokhu.
Izifundo ngesikhathi sokuncelisa ibele azange zenziwe, akukho datha ekungeneni kwama-metabolites obisini, ngenxa yalokho, ngesikhathi sokuqunjelwa, udinga ukuwuyeka umuthi.
Isicelo sokusebenza kokulimala kwezinso
Uma kwenzeka umsebenzi we-renal ophazamisekile, ukuhlolwa kokulawula kufanele kwenziwe ukuze kutholakale izinga le-creatinine ne-urea. Ngokusho kwemiphumela, imithamo yomuthi iyashintshwa noma ishiywe.
Sebenzisa umsebenzi wesibindi okhubazekile
Kuyadingeka ukuqapha isimo sesibindi. Ngokudilizwa, umuthi kufanele ukhanselwe, ngoba ubungozi bokuqhamuka ne-lactic acidosis luphezulu. Kwezinye izimo, kungenzeka uguqule umthamo womuthi ngaphansi kokuqondisa kukadokotela.
Ukweqisa kwe-langerin
Lapho usebenzisa umthamo ophakeme kunesidingo, kuba nezimpawu zokukhula: i-lactic acidosis, umuzwa womile emlonyeni, ulwelwesi lwama-mucous, isikhumba, izinhlungu emisipha nasesifubeni, ukuphefumula ngokushesha, ukuphazamiseka kokulala, izimpawu zokuqina, ukuphazamiseka kwemizwa, ubuhlungu besisu, ukugabha, ukuphazamiseka kwenhliziyo, i-oliguria, i-ICE. Ngaphezu kwalokho, izimo ze-hypoglycemic azikhuli. Akukho ukwelashwa okuthile. Njengokwelashwa, i-dialysis ne-hemodialysis isetshenziswa ngempumelelo, futhi ukwelashwa okubonakalayo nakho kwenziwa. Ukuhoxiswa okuphuthumayo kwemithi kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Kunezimo lapho izidakamizwa zengeza imiphumela yomunye nomunye futhi kukhona ukwanda kokunciphisa ushukela - lesi yisimo esiyingozi. Ngakho-ke, ezinye izinhlanganisela zingavinjelwa noma zisetshenziswe njengesidingo esibalulekile.
Inhlanganisela ehlanganisiwe
Uma kudingekile ukwenza inqubo ezosetshenziswa ama-iodine aqukethe ama-iodine umehluko, kufanele uyeke ukuthatha iLangerin ngezinsuku ezimbili. Futhi ukuqaliswa kabusha kwesidakamizwa kungenzeka ezinsukwini ezi-2 ngemuva kocwaningo, ngaphambi kwalokhu, kufanele kwenziwe ukuhlola ukuhlola isimo sokusebenza kohlelo lwezinso. Ngaphandle kwalokho, ingahlakulela ukwehluleka kwezinso, ubungozi be-lactic acidosis.
IGlatiniin ingaba yi-analogue yesidakamizwa.
Umuthi uDanazol awusetshenziswa ekwelapheni uLangerin. Lokhu kugcwele ngokuqukethwe ushukela omningi, i-acidosis, kanye nengozi eyengeziwe yokukhohlisa. Ngakho-ke, i-glycemia kufanele ibhekwe.
Akuhlanganisiwe ukuhlanganisa
Lapho uthatha i-Langerin, akunconywa ukuphuza utshwala noma ezinye iziphuzo nemikhiqizo equkethe utshwala.
Inhlanganisela edinga ukuqashelwa
Ngokuqapha ngokweqile, umuthi kufanele usetshenziswe ngokuhambisana ne-systemic noma i-topical glucocorticosteroids, i-ACE inhibitors, i-diuretics, i-beta-2-sympathomimetics - la maqembu emithi anganciphisa ushukela wegazi. Ngakho-ke, kufanele uxwayise isiguli ngalokhu, futhi ulungise umthamo weLangerin.
I-Chlorpromazine ne-antipsychotic nayo iyimithi, ngokuhambisana lapho kufanele kusetshenziswe khona isilinganiso se-metformin esetshenzisiwe.
Ukuhambisana notshwala
Akuhambisani notshwala. Lapho kuhlanganiswa ne-ethanol, ubungozi bokukhula kwesimo se-lactic acidotic luyanda, ikakhulukazi ngezinkinga zesibindi (ukwehluleka kwesibindi) noma ukungondleki okwanele.
Ama-Analog
Izikhwanyana ezingezansi zeLangerin yizidakamizwa ezinjalo:
- Glyformin;
- Ukwanda kwesikhathi;
- IGlucophage;
- I-Metformin;
- Metfogamm;
- IFommetin;
- I-Siofor kumithamo ehlukahlukene (1000, 800, 500);
- IVero-Metformin;
- IGlycomet 500.
Imibandela yekhefu lekhemisi
Umuthi lo uvunyelwe ukunqunyelwa.
Ngingakwazi ukuthenga ngaphandle kadokotela
Amanye amasayithi athembisa ukuthenga umuthi ngaphandle kadokotela, kepha umuthi.
Intengo kaLangerin
Uhla lwamanani luhlukahluka kusuka kuma-ruble ayi-100 kuye kwangama-700., Kuya ngomthamo. Izindleko zama-analogues zihlukile.
Izimo zokugcina zomuthi
Kufanele igcinwe ngaphandle kwezingane, izimo ezikhethekile azidingeki.
Isikhathi sokuphelelwa yisikhathi
Igcinwe iminyaka engu-5.
Umkhiqizi
Umkhiqizi yiJSC "Zentiva", etholakala eSlovak Republic, Hlohovec, ul. I-Nitryanskaya 100.
Ukubuyekezwa mayelana neLangerin
U-Anton, oneminyaka engama-48, u-Orel: "Sekuphele iminyaka engu-3 nginesifo sikashukela sohlobo 2. Udokotela uwunikeze umuthi. Ngijabule ukuthi ayikho imiphumela emibi, futhi nezinga likashukela alikhuphuki."
U-Ana, oneminyaka engama-31 ubudala, eMoscow: "Nginesifo sikashukela sohlobo 2, sengigule cishe iminyaka emihlanu. Ngonyaka wokuqala ngagcina amazinga eglucose ngokuzivocavoca nangokudla. Kodwa-ke, lokho akuphumelelanga. Udokotela wawunikeza lo muthi nge-850 mg kabili ngosuku. Ayikho imiphumela emibi. "
UVasily, oneminyaka engama-28 ubudala, uKrasnodar: "Isifo sikashukela sohlobo 2 satholakala esikhathini esingaphezu konyaka edlule. Ngithatha lo muthi. Udokotela wathi usebenza kahle futhi ugcina amazinga e-glucose ejwayelekile. Ukhethe isilinganiso esiphansi sika-500 mg. Umuthi kufanele ube khona njalo, kwakungekho miphumela emibi ngakho-ke ngicabanga ukuthi umuthi muhle. "
