Imiphumela yokusetshenziswa kwe-Captopril-AKOS kwisifo sikashukela

I-Captopril-Akos isidakamizwa se-antihypertensive esinconyelwe ukunciphisa ngokushesha umfutho wegazi.

Igama Lezwe elingafanele

I-Captopril.

I-Captopril-Akos isidakamizwa se-antihypertensive esinconyelwe ukunciphisa ngokushesha umfutho wegazi.

I-ATX

C09AA01.

Khipha amafomu nokwakheka

Amathebulethi amhlophe angaphansi amhlophe. Ukuze kuthathwe kalula imithamo, zingaba nengozi yokuhlukanisa. Iphilisi ngalinye liqukethe i-12.5 mg, 25 mg, noma i-50 mg ye-Captopril. Amaphakethe wezinto ezingama-20 nezingama-40.

Isenzo se-Pharmacological

Inomphumela we-antihypertensive nekhono lokucindezela umsebenzi we-ACE. Inciphisa ukubonakaliswa kwe-hypertension ye-arterial. Yehlisa ukuqina kwe-angiotensin 2 eyenziwe kusuka ku-angiotensin 1, futhi imise ukusebenza kwayo kwe-vasoconstrictor. Yehlisa ukuthumela- nokulayisha kuqala emikhunjini yangaphandle. Isiza ukwehlisa ithoni yama-arterioles asebenza kahle we-glomeruli yezinso futhi ithuthukise i-intracranial hemodynamics. Ivimbela ukwakheka kwe-nephropathy yesifo sikashukela.

I-Pharmacokinetics

Lapho isisekugayweni kokugaya ukudla, imunwa ngokushesha isuka kumathumbu aphezulu. Amazinga okugcotshwa okuphezulu kakhulu ku-serum yegazi anqunywa ngaphakathi kwamahora we-0.5-1,5 ngemuva kokusetshenziswa. Ukudla kanyekanye kubambezela ukumuncwa kwengxenye esebenzayo. Biotransformed esibindini. Kuqala ukushiya umzimba amahora ama-3 ngemuva kokuwusebenzisa ngomchamo. Ngesifo sezinso, isikhathi sokususa isigamu singakhuphuka sibe ngamahora angama-32.

I-Captopril-Akos inomphumela we-antihypertensive nekhono lokucindezela umsebenzi we-ACE.

Ukukhishwa kwefomu - amaphilisi amhlophe acwebile, anengozi yokuhlukanisa.

Amazinga okugcotshwa okuphezulu kakhulu ku-serum yegazi anqunywa ngaphakathi kwamahora we-0.5-1,5 ngemuva kokusebenzisa umuthi.

Okusizayo

Kubekelwe ukwephula umfutho wegazi obangelwa yi-pathologies enjengokuthi:

• i-arterial hypertension;
• ukwehluleka kwenhliziyo okungapheli;
• infarction myocardial;
• ukuncipha kokusebenza kwe-ventricle yangakwesobunxele;
• isifo sikashukela se-nephropathy.

Contraindication

Ayinqunyelwe uma umlando wezokwelapha uqukethe imininingwane ngezimo ezinjengokuthi:

• ukungabekezelelani komuntu ngamunye kulesi sidakamizwa nezinye i-ACE inhibitors;
• ukungasebenzi kwezinso, ukwehluleka kwezinso;
• ukufakelwa kwezinso;
• i-pathology yesibindi, ukwehluleka kwesibindi;
• hyperkalemia
• i-angioedema;
• i-bilpatal renal stenosis;
• ukuphuma kwegazi.

Umuthi awunakuthathwa nge-pathology yesibindi.

Umuthi awubekelwe uma kukhona imininingwane mayelana nokungasebenzi kwezinso emlandweni wezokwelapha.

Umuthi ubekwa ngokuqapha esimweni esifana nesifo sikashukela.

Umuthi awubekelwe ukugeleza kwegazi okungenampilo.

Umuthi awunconywa kubantu abangaphansi kweminyaka engu-18.

I-Captopril-Akos ayinqunyelwe ngesikhathi sokukhulelwa.

Ayinqunyelwe ngesikhathi sokukhulelwa nangesikhathi sokuzala. Akunconyelwe abantu abangaphansi kweminyaka engu-18 ubudala.

Kunqunywa ngokuqapha ezimeni ezinjengokuthi:

• i-ischemia;
• ukuphazamiseka kwe-cerebrovascular;
• i-hyperaldosteronism;
• i-pathology yezicubu ezithintekayo;
• isifo sikashukela mellitus.

Kudinga ukulungiswa kwamthamo lapho kunqunyelwe iziguli ezineminyaka yobudala, kanye nabantu abanokulimazeka kwegazi lokulimala kwe-renal kanye ne-hemodialysis.

Umthamo

Uhlobo kanye nesikhathi sokusetshenziswa kunqunywa ngudokotela uqobo.

Nge-infyoction ye-myocardial

Nquma ngemuva kwezinsuku ezimbili ngemuva kokuphela kwesigaba esibuhlungu. Isikimu Esinconyiwe:

• ezinsukwini zokuqala ezingama-3, thatha u-6.25 mg kabili ngosuku;
• ngesonto elilandelayo - 12,5 mg kabili ngosuku;
• bese kuba ngamaviki ama-2-3 - ama-12.5 kathathu ngosuku.

Ngokubekezelela okuhle kwe-captopril, ukwelashwa isikhathi eside kuchazwe kumthamo we-25-50 mg kathathu ngosuku.

Ekucindezelweni, umthamo wokuqala wesidakamizwa ngu-12.5 mg njalo emahoreni ayi-12.

Ngaphansi kwengcindezi

Umthamo wokuqala wesidakamizwa ngu-12.5 mg njalo emahoreni ayi-12. Ivolumu eyodwa ingakhuphuka ngemuva kwamasonto angama-3-4 wokuphatha. Ngomfutho wegazi ophakeme ojwayelekile, kunqunywa kumthamo wokwelapha we-0,05 g 2 noma kathathu ngosuku. Umthamo omkhulu yi-0.15 g ngosuku.

Ukwehluleka kwenhliziyo okungapheli

Kunqunywe emarejimeni okwelashwa okuyinkimbinkimbi kanye nama-diuretics. Umthamo wokuqala ngu-6.25 mg kathathu ngosuku. Uma kunesidingo, umthamo ungakhula kancane kancane ufike ku-25-50 mg (izikhathi ezingama-2-3 ngosuku).

Nge-diphicathy yesifo sikashukela

Emazingeni okuqala ekwelashwa, iziguli ezithembela i-insulin zibekwa kumthamo omncane. Kancane kancane, inani lenyuka laya ku-25 mg njalo emahoreni ayi-8 noma eyi-0,05 g njalo emahoreni ayi-12.

Ungayithatha kanjani i-Captopril-Akos

Kuthunyelwa ngomlomo ihora eli-1 ngaphambi kokudla.

Ukuphathwa kwe-sublingual kusetshenziselwa ukumisa inkinga ye-hypertensive.

Ngaphansi kolimi noma isiphuzo

Ayikho imininingwane esemthethweni mayelana nendlela yokuphatha. Kukholakala ukuthi ukuphatha ngokweqile kusheshisa ukuqala kwalo muthi. Le ndlela isetshenziselwa ukumisa isimo esibucayi esinegazi.

Kuthatha isikhathi esingakanani

Umphumela omuhle kwenzeka ngaphakathi kwamahora we-0.5-1,5 ngemuva kokufaka isicelo.

Ngingaphuza kangaki

Thatha njalo amahora angama-8-12.

Imiphumela emibi ye-Captopril-Akos

Ukuthatha umuthi kungakudonsa ukwehla kwengcindezi yegazi, izimpawu ze-tachycardia ne-hypotension. Ukubonakaliswa okungenzeka kokunye ukusabela okubi.

Amapheshana wesisu

Ukungajabuli epigastrium, isicanucanu, ukuphazamiseka emgodini wokugaya ukudla, ukunambitha ukungasebenzi kahle (receptor dysfunction), umsebenzi owengeziwe wama-hepatic transaminases. Ezimweni ezingavamile, ukuqala kwezimpawu ze-hepatitis, pancreatitis.

Ukuthatha umuthi kungahle kwehle umfutho wegazi.

Ngemuva kokuthatha umuthi, isicanucanu kungenzeka.

Ezinye iziguli ziba nemizwa.

Lapho usebenzisa umuthi, kuvela izimpawu ze-tachycardia ne-hypotension.

Ubuhlungu bekhanda buwuphawu oluseceleni lohlelo lwezinzwa oluphakathi.

Ezinye iziguli ziba nobuthakathaka obujwayelekile ngemuva kokuthatha umuthi.

Izitho zeHematopoietic

Ukuthuthukiswa kwe-neutropenia, i-anemia, i-thrombocytopenia, i-agranulocytosis.

Isistimu yezinzwa ephakathi

Ubuhlungu bekhanda, isiyezi, ubuthakathaka obujwayelekile, ukuncipha kokuxineka, ukubonakaliswa kwe-paresthesia.

Kusuka ohlelweni lomchamo

Ukunyuka kokuhlushwa kwe-urea ne-creatinine emzimbeni.

Kusuka ohlelweni lokuphefumula

Ukukhwehlela kweParoxysmal.

Engxenyeni yesikhumba

Ukuqunjelwa kwesikhumba, ukulunywa, ukuqubuka okushisayo, umuzwa womkhuhlane, i-lymphadenopathy.

Kusuka ohlelweni lwezitho zofuzo

I-Oliguria, ukungabi namandla.

Engxenyeni yesikhumba, ukuqubuka kwesikhumba, ukulunywa,

Ukusuka ohlelweni lokuphefumula, kuvela ukukhwehlela kwe-paroxysmal.

Ukusuka ohlelweni lwezitho zofuzo, ukungakwazi ukuvela kungenzeka.

Ukusabela kokungezwani nomuthi kukhonjiswa edema likaQuincke.

Ngemuva kokusebenzisa umuthi, kuba nomuzwa wokushisa.

Allergies

I-Stevens-Johnson syndrome, i-edema ka-Quincke ka-Quincke, ukwethuka kwe-anaphylactic, njll.

Umthelela ekhonweni lokulawula izindlela

Dinga ukuqaphela ezigabeni zokuqala zokusebenzisa.

Imiyalo ekhethekile

I-Arterial hypotension ebonakala ngemuva kokuthatha lo mkhiqizo we-pharmacological isuswa ngokunxephezela umswakama emzimbeni.

Ngokuphikisana nesizinda sokuthatha umuthi, ukuvela okungamanga kokuzimisela ekuzimiseleni kwemizimba ye-ketone kungenzeka.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Akunconyelwe.

Ukuhambisana notshwala

Ayihambelani.

Ukweqisa kwe-Captopril-Akos

Ukwephulwa kwe-dosing regimen yalesi sidakamizwa kuholela ekuqhamukeni kwe-hypotension okwenzeka ngokuqhamukayo kuze kube ekwakhiweni kwehluleka kwenhliziyo ((ukulahleka kokuqwashisa kanye nosongo lokufa), ukufakwa kwe-myocardial, ukuphazamiseka kwegazi okuyisa ebuchosheni, ukuntuleka komoya-mpilo we-thromboembolic.

Ukuthuthukiswa kwalezo zimo kudinga ukunakekelwa kwezokwelashwa okuphuthumayo.

ICaptopril ayihambelani notshwala.

Ukwephulwa kwe-dosing regimen yalesi sidakamizwa kuholela ekuphulweni kokuhlinzekelwa kwegazi kubuchopho.

Ngesikhathi sokuqunjelwa, umuthi awanconywa.

ICaptopril-Akos ayisetshenziswanga ezinhlelweni ezihlanganayo nemithi equkethe i-potassium.

Ukuxhumana nezinye izidakamizwa

Ungasebenzisi ama-regimens ahlanganisiwe nezidakamizwa eziqukethe i-potassium (ezigulini ezine-renal pathology kanye nasezigulini ezincike kuma-insulin).

Ngokuhambisana nokusetshenziswa kwama-immunosuppressants nama-cytostatics, kungavusa ukuthuthukiswa kwe-leukopenia.

Kuhlanganiswe nama-NSAIDs, kukhulisa amathuba okungasebenzi kahle kwezinso.

Ngokuhambisana ne-Azathioprine, inomthelela ekuthuthukiseni i-anemia.

Ngokuhambisana ne-Allopurinol, kwandisa amathuba okuthuthukisa ukungasebenzi kwegazi nemiphumela emibi eyandayo.

Ukungafakwa komuthi kuyancipha ngokusetshenziswa kwe-erythropoietins, indomethacin ne-ibuprofen.

Isiza ukukhulisa ukugcwaliswa kwegazi nge-digoxin.

Kuthuthukisa ukwakheka kwe-hypoglycemia ngethamo elilodwa eline-insulin kanye nabenzeli be-hypoglycemic yomlomo.

Ama-Analog

Izihloko ezingezansi zi:

• I-Alkadil;
• I-Angiopril-25;
• I-blockordil;
• I-Vero-Captopril;
• Kapoten
• I-Captopril;
• Catopil;
• U-Epsitron et al.

I-Kapoten iyi-analogue ephumelelayo ye-Captopril-Akos.

Ungabuyisela umuthi umuthi onjenge-Epsitron.

I-Captopril yigama elifanayo ne-Captopril-Akos elinegama elifanayo elikhishwe abakhiqizi abahlukile.

Ngokwakheka kwezindawo esikhundleni kukhona umehluko kumithamo yento esebenzayo, ngakho-ke ingcindezi ingehla kakhulu ngokuqinile nangaphezulu.

Uyini umehluko phakathi kweCaptopril neCaptopril-Akos

Ziyakwazi ukuvumelanisa amagama nokwakheka okufanayo okukhishwe abakhiqizi abahlukahlukene.

Imibandela yekhefu lekhemisi

Imishanguzo ngesiLatini.

Ngingakwazi ukuthenga ngaphandle kadokotela

Amanye amakhemikhali aku-inthanethi anga-odolwa ngaphezulu kwe-counter.

Intengo ye-Captopril acos

Izindleko eziphansi emakhemisi aseRussia ama-ruble ayi-8 nangaphezulu.

Izimo zokugcina zomuthi

Ebangeni lokushisa 0 ... + 25 ° C. Fihla ezinganeni.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-5 kusukela ngosuku lokukhiqizwa.

Umkhiqizi

I-Synthesis OJSC, eRussia.

Ukubuyekezwa kodokotela neziguli nge-Captopril-Akos

I-Telegin A.V., i-Therapist, i-Omsk

Ingabe uhlobo olujwayelekile lweKapoten. Kusetshenziswa iziguli ezinengcindezi ekhuphukayo kanye nokukhululeka kwenhlupheko ye-hypertensive, kepha ezimeni eziningi kwehliselwa okungokwangempela ngokuya ngokusebenza kahle.

U-Alina, oneminyaka engama-26, eNovosibirsk

Umama wami une-hypertension. Lesi sidakamizwa sinconyelwe kuye ngudokotela emtholampilo. Ngemuva kwenkambo yokuthatha lo muthi, isimo sakhe sathuthuka. Manje umama uyithatha kuphela ngokunyuka okungazelelwe kwengcindezi futhi ukholelwa ukuthi lesi sidakamizwa simsiza kahle.