Ukwelashwa kweVasotenz kuvame ukubekelwa abantu abaphethwe yi-arterial hypertension. Ngenxa yesenzo esihlanganisiwe, lesi sidakamizwa asigcini ngokufaka umfutho ekucindezelweni kwegazi, kodwa futhi sandisa amandla emzimbeni ngesikhathi sokuzivocavoca futhi sinciphisa nengozi yokudlondlobala kwezifo eziningi zesistimu yethambo nenhliziyo. Leli thuluzi kufanele lisetshenziswe njengoba kuyalelwe udokotela kwithamo elingadluli eliboniswe emiyalweni enamathiselwe kumuthi.
Igama Lezwe elingafanele
INN yesidakamizwa yi-losartan.
Ukwelashwa kweVasotenz kuvame ukubekelwa abantu abaphethwe yi-arterial hypertension.
I-ATX
Kuhlukaniso lwe-ATX lwamazwe omhlaba, lo muthi unekhodi C09CA01.
Khipha amafomu nokwakheka
Isithako esikhulu esisebenzayo eVazotens yi-potassium losartan. Izingxenye ezingeziwe zemithi zifaka i-croscarmellose sodium, mannitol, hypromellose, magnesium stearate, talc, propylene glycol, njll. Ukwakheka kweVazotenza N, ngaphezu kwe-losartan, kufaka i-hydrochlorothiazide.
IVasotens iyatholakala ngesimo samacwecwe ngomthamo ka-25, 50 no-100 mg. Amathebhulethi ayindilinga ngesimo. Zimbozwe ngegobolondo elimhlophe futhi zibizwa ngokuthi "2L", "3L" noma "4L" ngokuya ngomthamo. Zigcwele emabhulashini ama-7 noma ama-10 ama-PC. Ebhokisini lekhadibhodi kuneziqubu ezi-1, 2, 3 noma 4 nephepha lokufundisa elinolwazi mayelana nomuthi.
IVasotens iyatholakala ngesimo samacwecwe ngomthamo ka-25, 50 no-100 mg.
Isenzo se-Pharmacological
Izici ze-pharmacological zesidakamizwa kungenxa yomsebenzi we-Vototenz ophikisiwe, isakhi esisebenzayo esiyinhloko sohlobo lwe-angiotensin receptor antagonist. Ngonyango lwe-vasotenz, into esebenzayo yesidakamizwa isiza ukunciphisa i-OPS. Umuthi wehlisa ukugcwala kwe-aldosterone ne-adrenaline ku-plasma yegazi. Lo muthi unomphumela ohlangene, onomthelela ekujuleni kokucindezela kokujikeleza kwe-pulmonary kanye nokujikeleza kwe-pulmonary.
Ngaphezu kwalokho, izingxenye ezisebenzayo zomuthi zinciphisa umthwalo ohlelweni lwezinhliziyo futhi zibe nomphumela okhulunywayo we-diuretic. Ngenxa yomphumela oyinkimbinkimbi, ukwelashwa ngama-vasotens kunciphisa ubungozi be-myocardial hypertrophy. Lo muthi usiza ukukhulisa ukubekezelela kweziguli ezinezimpawu ezinzima zokwehluleka kwenhliziyo.
Umuthi awukuvimbeli ukuvela kohlobo 2 kinase. Le enzyme inethonya elimazayo kwi-bradykinin. Lapho uthatha lo muthi, ukwehla kwengcindezi yegazi kubonakala ngemuva kwamahora ayi-6. Ngokuzayo, umsebenzi wento esebenzayo yesidakamizwa uyancipha kancane kancane ngaphezulu kwamahora angama-24. Ngokusetshenziswa okuhleliwe, umphumela omkhulu ubonwa ngemuva kwamasonto angama-3-6. Ngakho-ke, umuthi udinga ukusetshenziswa kwesikhathi eside kokuhleleka.
I-Pharmacokinetics
Into esebenzayo ye-vasotenza igxiliswa ngokushesha ezindongeni zepheshana lesisu. Kulokhu, i-bioavailability ye-ejenti ifinyelela cishe ku-35%. Ukuqoqwa okuphezulu kwengxenye esebenzayo egazini kufinyelelwa ngemuva kwehora elingu-1. I-metabolism yomuthi yenzeka esibindini. Ngokuzayo, cishe ama-40% womthamo udalulwa emchini futhi cishe ama-60% ezindundwini.
Izinkomba zokusetshenziswa
Ukusetshenziswa kwe-vasotenz kuboniswa ekwelashweni kwegazi elinamandla. Leli thuluzi lisetshenziselwa ukuvikela izingqinamba ze-hypertensive ne-myocardial hypertrophy. Phakathi kokunye, umuthi uvame ukubekelwa ekwelapheni ukwehluleka kwenhliziyo. Ngama-pathologies anjalo wesistimu yenhliziyo, umuthi usetshenziswa njengengxenye yokwelapha okuhlanganayo. Ngaphezu kwalokho, ukusetshenziswa kwama-vazotens kunobulungiswa ekwelashweni kweziguli ngokubekezelela komuntu ngamunye kuma-inhibitors e-ACE.
Ukusetshenziswa kwe-vasotenz kuboniswa ekwelashweni kwegazi elinamandla.
Contraindication
Awungeke uwusebenzise lo muthi uma isiguli sinokungakwazi ukubekezelela izingxenye ezithile zaso. Ukwelashwa kweVasotens akunconyelwanga uma isiguli sinokuthambekela kokwehla okukhulunywayo komfutho wegazi. Lesi sidakamizwa asikwazi ukusetshenziswa lapho kukhona i-hyperkalemia, ngoba lokhu kungenza isimo sesiguli sibe sibi. Ngaphezu kwalokho, umuthi akufanele usetshenziswe uma kunezimpawu zokuphelelwa ngamandla.
Ngokunakekela
Uma isiguli sinezimpawu zokungasebenzi kahle kwesibindi nezinso, ukwelashwa ngeVazotens kudinga ukunakwa okukhethekile kudokotela. Ngaphezu kwalokho, ukunakekelwa okukhethekile kudinga ukusetshenziswa kwama-vazotens ekwelapheni abantu abahlaselwa yisifo seShenlein Genoch. Kulokhu, ukulungiswa komthamo ojwayelekile komuthi kuyadingeka ukunciphisa ingozi yokuthola izinkinga ezinkulu.
Ungawathatha kanjani ama-vasotens?
Lo muthi wenzelwe ukuphathwa ngomlomo. Ukufeza umphumela wokwelapha, isiguli kufanele siphuze umthamo obekiwe 1 isikhathi ekuseni. Ukudla akuphazamisi ukumuncwa umuthi. Ukuzinzisa umfutho wegazi futhi ulondoloze ngokwejwayelekile, iziguli zikhonjiswa zithatha i-Vazotenza ngethamo lika-50 mg ngosuku. Uma kunesidingo, umthamo ungakhushulwa ufike ku-100 mg ngosuku.
Uma isiguli sinezimpawu zokuhluleka kwenhliziyo, kuyanconywa ukwenyuka kancane kancane komthamo we-vasotenz. Okokuqala, isiguli sinikezwa umuthi ngethamo lika-12,5 mg ngosuku. Ngemuva cishe kwesonto, umthamo unyuka ufike kuma-25 mg. Ngemuva kwezinye izinsuku eziyi-7 zokuphuza umuthi, umthamo wawo ukhuphuka ufike kuma-50 mg ngosuku.
Uma isiguli sinezimpawu zokungasebenzi kahle kwesibindi, ukwelashwa ngeVazotens kudinga ukunakwa okukhethekile kudokotela.
Ngoshukela
Leli thuluzi lingasetshenziswa ukwelapha iziguli ezinesifo sikashukela sohlobo 2 ezingenazo izimpawu zokuphazamiseka kwalesi sifo. Ngalesi sifo, umuthi uvame ukubekwa kumthamo we-50 mg ngosuku.
Imiphumela emibi ye-vasotenza
Ingxenye esebenzayo yeVazotens ibekezelelwe kahle, ngakho-ke, ukuthuthukiswa kwemiphumela emibi akuvamile kakhulu.
Amapheshana wesisu
Lapho welapha neVasotens, isiguli singathola ukuhlaselwa isicanucanu kanye nobuhlungu besisu. Ukuphazamiseka kwe-Stool, umlomo owomile, i-flatulence, i-anorexia kuyaqabukela kwenzeka ngenxa yokuthatha i-vasotenz.
Kusuka ohlelweni lwe-musculoskeletal
Lapho welapha ngama-vasotens, i-arthralgia ne-myalgia kungenzeka. Iziguli azivami ukuzwa izinhlungu emilenzeni, esifubeni, emahlombe nasemadolweni.
Isistimu yezinzwa ephakathi
Cishe i-1% leziguli ezithola i-vasotens therapy zinezimpawu ze-asthenia, ikhanda, nesiyezi. Ukuphazamiseka kokulala, ukozela kwasekuseni, ukuqina kwemizwelo, izimpawu ze-ataxia ne-peripheral neuropathy ezimweni ezingavamile zingavela phakathi nokwelashwa ne-vazotens. Ukuphulwa okungenzeka kokunambitheka kanye nokukhubazeka okubukwayo. Ngaphezu kwalokho, kunengozi yokuzwa kwezitho zomzimba ezithambile.
Kusuka ohlelweni lokuphefumula
Imiphumela emibi evela ohlelweni lokuphefumula iyivelakancane kakhulu. Ukuxineka nokuxinana kwamakhala kungenzeka. Ukusetshenziswa kwe-vasotenza kungadala izimo zokuthuthuka kwezifo zokuphefumula eziphezulu. Kuyaqabukela, i-rhinitis, i-bronchitis ne-dysapnea ibonwa kanye nokwelashwa ngalesi sidakamizwa.
Engxenyeni yesikhumba
Mhlawumbe ukubonakala kokujuluka kokujuluka noma isikhumba esomile. Ezimweni ezingavamile, ukuthuthukiswa kwe-erythema nokuzwela okwengeziwe kokukhanya kuyabonakala. Uma usebenzisa i-vasotenz, i-alopecia kungenzeka.
Kusuka ohlelweni lwezitho zofuzo
Ukuthatha i-vasotenza kungadala izimo zokuthuthuka kwezifo ezithathelwanayo zomgudu wokuchama. Ezimweni ezingavamile, iziguli zikhononda ngokuchama kaningi nomsebenzi wezinso ongasebenzi kahle. Emadodeni, nge-vasotenz therapy, ukwehla kwe-libido kanye nokuthuthukiswa kokungabi namandla kungabonakala.
Mhlawumbe ukubukeka kwesikhumba esomile.
Kusuka ohlelweni lwezinhliziyo
Ngokulashwa kwe-vasotenz isikhathi eside, isiguli singakhula sibe ne-orthostatic hypotension. Ukuhlaselwa kwe-Angina ne-tachycardia kungenzeka. Ezimweni ezingavamile, ukuthatha lo muthi kubangela i-anemia.
Allergies
Imvamisa, ukusetshenziswa kwe-vasotenz kubangela ukungahambi kahle komzimba, okuvezwa ukulunywa, i-urticaria, noma ukuqhuma kwesikhumba. Akuvamile ukubona ukuthuthukiswa kwe-angioedema.
Umthelela ekhonweni lokulawula izindlela
Umuthi ungadala ukozela kanye nokwehla kokugxiliswa ukunakwa, ngakho-ke, lapho welapha ngeVazotens, ukunakekelwa kumele kuthathwe lapho kulawulwa izindlela eziyinkimbinkimbi.
Imiyalo ekhethekile
Ngaphambi kokuqala ukwelashwa kwe-vasotenz, ukulungiswa kwamanzi emzimbeni kufanele kwenziwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukusebenza nokuphepha kokusetshenziswa kwe-vasotenza ngesikhathi sokukhulelwa akufundiswanga ngokuphelele. Ngaphezu kwalokho, kunobufakazi bomphumela ongemuhle wento esebenzayo yesidakamizwa ku-fetus ku-2nd ne-3rd trimester yokukhulelwa. Lokhu kwandisa ingozi yengane ekhula ngokulimala okubi kakhulu nokufa kwe-intrauterine. Uma ukwelashwa kudingekile, ukuncelisa ibele kunganconywa.
Ngokulashwa kwe-vasotenz isikhathi eside, isiguli singakhula sibe ne-orthostatic hypotension.
Ukunquma i-vasotenza ezinganeni
Lo muthi awubekelwe izingane kanye nentsha engaphansi kweminyaka eyi-18.
Sebenzisa ebudaleni
Ekwelapheni asebekhulile, kuyadingeka ukulawula izinga le-potassium esegazini. Udinga ukuqala ukuthatha umuthi ngethamo elincane elisebenzayo lokwelapha.
Isicelo sokusebenza kokulimala kwezinso
Ithuluzi lingasetshenziswa ekwelapheni iziguli ezinenkinga yezinso emsebenzini, kepha kulokhu, ukwanda kwezinga le-uric egazini kungenzeka. Ngaphezu kwalokho, ukulawulwa kwezinga le-potassium egazini leziguli ezinjalo kuyadingeka.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngama-pathologies ahambisana nokungasebenzi kahle kwesibindi, kufaka phakathi i-cirrhosis, iziguli zibekelwa umthamo we-vasotenza oncishisiwe, ngoba izifo zalesi sitho zibangela ukwanda kokuhlakazwa kwento esebenzayo yesidakamizwa egazini.
Ukweqiwa kwe-vasotenza
Uma isilinganiso somuthi osinconyelwayo sidluliwe, iziguli zingathola i-tachycardia enzima. Mhlawumbe ukwehla okunamandla komfutho wegazi. Lapho kuvela izimpawu zokweqisa kwe-overdose, kunqunywa ukwelashwa okubonakalayo nokwelashwa okuphoqelelwe, ngoba i-hemodialysis kuleli cala ayisebenzi.
Lo muthi awubekelwe izingane kanye nentsha engaphansi kweminyaka eyi-18.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kwama-vazotens kuhlangene nezinye izidakamizwa ze-antihypertensive kuvunyelwe. Ezigulini ezihlangabezana nokwelashwa kwe-diuretic, ukwehla okubucayi kwengcindezi yegazi kungenzeka. Ukwamukelwa i-Vazotenza kuthuthukisa isenzo se-sympatholytics kanye ne-beta-blockers. Ngokusetshenziswa okuhlangene kwe-vasotenza ngokulungiswa kwe-potassium, ubungozi bokuthuthukisa i-hyperkalemia luyanda.
Ukuhambisana notshwala
Ngesikhathi sokulashwa nge-vasotenz, akunconywa ukuthatha iziphuzo ezinotshwala.
Ama-Analog
Izidakamizwa ezinomphumela ofanayo wokwelapha zibandakanya:
- I-Lozap.
- I-Cozaar.
- Presartan.
- I-Losocor.
- ULorista.
- I-Zisakar.
- I-Blocktran.
- I-Lozarel, njll.
Imibandela yekhefu lekhemisi
Umuthi uyathengiswa.
Ngingakwazi ukuthenga ngaphandle kadokotela
Lo muthi ungathengwa ngaphandle kadokotela.
Intengo yama-vasotens
Izindleko zomuthi emakhemisi zisukela kuma-ruble ayi-115 kuye kwangama-300, kuya ngomthamo.
Izimo zokugcina zomuthi
Umkhiqizo kumele ugcinwe endaweni emnyama emazingeni okushisa afinyelela ku- + 30 ° C.
Isikhathi sokuphelelwa yisikhathi
Ungasisebenzisa lesi sidakamizwa iminyaka emi-3 kusukela ngosuku lokukhishwa.
Umkhiqizi
Umuthi wakhiqizwa i-AKTAVIS JSC.
Ukubuyekezwa mayelana neVasotense
Lo muthi uvame ukusetshenziswa, ngakho-ke unezibuyekezo eziningi ezivela kubo bobabili odokotela kanye neziguli.
Izazi zezenhliziyo
UGrigory, oneminyaka engama-38, eMoscow
Emsebenzini wami wezokwelapha, ngivame ukunquma ukusetshenziswa kwama-vazotens ezigulini ezinomfutho we-arterial hypertension. Ngenxa yomthelela ohlanganisiwe we-hypotensive ne-diuretic, umuthi awugcini ngokufaka ekucindezelweni kwegazi ngokwejwayelekile, kepha futhi ukhulisa ukubekezelelana kwesineke ekusebenzeni ngokomzimba futhi kunciphisa nobunzima be-edema. Umuthi ubekezelelwa kahle ngisho neziguli esezikhulile. Ngaphezu kwalokho, ilungele ukufakwa ekwelashweni okuyinkimbinkimbi isebenzisa izidakamizwa ezengeziwe ze-antihypertensive.
U-Irina, oneminyaka engama-42, uRostov-on-Don.
Sekuphele iminyaka engaphezu kwengu-15 ngisebenza njengodokotela wezinhliziyo, futhi iziguli ezithola izikhalazo zegazi eliphezulu zivame ukunquma i-Vazotens. Umphumela walo muthi ezimweni eziningi kwanele ukugcina ingcindezi ejwayelekile ngaphandle kwesidingo sokusebenzisa i-diuretics ngaphezulu. Lesi sidakamizwa sibekezelelwa kahle yiziguli futhi kuyaqabukela kudala imiphumela emibi. Ngenxa yalokhu, ungayisebenzisa ngempumelelo kwizifundo ezinde.
U-Igor, oneminyaka engama-45 ubudala, e-Orenburg
Imvamisa ngincoma ukusetshenziswa kwe-vasotenza kweziguli ezinokwehluleka kwenhliziyo. Umuthi ukuvumela ukuthi ufezekise ngobumnene i-normalization yengcindezi yegazi futhi unciphise nobunzima be-edema yemikhawulo engezansi. Ithuluzi lihlanganiswe kahle nezinye izidakamizwa ezisetshenziswa ekwelapheni lesi simo se-pathological. Eminyakeni yami eminingi yokuzilolonga, angikaze ngihlangabezane nokuvela kwemiphumela emibi ezigulini ezisebenzisa ama-vazotens.
Lapho usebenzisa umuthi, ukunakekelwa kufanele kuthathwe ukuphatha izindlela eziyinkimbinkimbi.
Iziguli
UMargarita, oneminyaka engama-48, uKamensk-Shakhtinsky
Sekuyiminyaka engaphezu kwengu-15 ngijwayela inkinga yomfutho wegazi ophakeme. Ekuqaleni, odokotela bancoma ukunciphisa isisindo, behamba njalo emoyeni omusha futhi bedla kahle, kepha inkinga yaya ngokuya ikhula. Ngenkathi ingcindezi iqala ukuqina ngo-170/10, odokotela baqala ukubeka imishanguzo. Eminyakeni engu-3 edlule ngiphathwe neVazotens. Ithuluzi linikeza umphumela omuhle. Ngiyithatha ekuseni. Ingcindezi isizinzile. Ukudumba kwemilenze wanyamalala. Waqala ukuzizwa ejabule kakhudlwana. Ngisho nokukhuphuka izitebhisi manje kunikezwa ngaphandle kokuphefumula.
U-Andrey, oneminyaka engama-52, uChelyabinsk
Wathatha imishanguzo ehlukahlukene ukuze acindezelwe. Cishe unyaka, udokotela wezinhliziyo unikeze ukusetshenziswa kwama-vazotens. Ithuluzi linikeza umphumela omuhle. Udinga ukusithatha isikhathi esisodwa ngosuku. Ingcindezi ibuyele kokujwayelekile emasontweni ama-2 kuphela wokudla. Manje ngiphuza lesi sidakamizwa zonke izinsuku. Angibonanga imiphumela emibi.
